Estudio del mecanismo molecular de apoptosis y de la seguridad de la terapia fototérmica aplicada al tratamiento del cáncer utilizando nanoprismas de oro funcionalizados

Tesis llevada a cabo para conseguir el grado de doctor en la Universidad de Zaragoza en enero de 2016.-- Sobresaliente "Cum Laude".En esta tesis se ha descrito el uso de nanoprismas de oro para de forma eficiente y selectiva inducir apoptosis en celulas tumorales y mas importante, descifrar el mecanismo de muerte celular que se desencadena, para poder predecir la eficacia de la terapia fototermica usando nanoprismas de oro contra celulas tumorales que son resistentes a las terpias convencionales. Ademas se ha llevado a cabo un estudio en detalle de la toxicidad de los nanoprismas de oro in vitro asi como de su toxicidad y biodistribución in vivo para poder prevenir y minimizar posibles efectos adversos.Peer reviewe

Exercise for People with Acquired Brain Injury: An ICF Perspective.

Exercise is an important element in the process of recovery from an acquired brain injury (ABI). However, specific guidance for exercise prescription and interventions in this population are missed. The aim of this study was to establish the key parameters to design and implement exercise programs based on the International Classification of Functioning, Disability, and Health (ICF) domains. A panel of experts that consisted of 13 professionals from neuro-rehabilitation centers evaluated the key parameters of this original proposal. The Heinemann methodology was used for all qualitative analyses. Additionally, Cronbach’s alpha was applied to the statistical analyses. According to the results, Cronbach’s alpha (0.97) indicated excellent internal consistency, and the experts perceptions ratified the proposed criteria to develop exercise programs for people with ABI. The proposed key parameters for the development of exercise programs for people with ABI based in ICF domains (body functions, activity—participation and environmental factors) bring a new, solid, and innovative tool for methodological design of these programs in sub-acute and chronic rehabilitation settings.pre-print1011 K

Temperature-independent quantum logic for molecular spectroscopy

We propose a fast and non-destructive spectroscopic method for single molecular ions that implements quantum logic schemes between an atomic ion and the molecular ion of interest. Our proposal relies on a hybrid coherent manipulation of the two-ion system, using optical or magnetic forces depending on the types of molecular levels to be addressed (Zeeman, rotational, vibrational or electronic degrees of freedom). The method is especially suited for the non-destructive precision spectroscopy of single molecular ions, and sets a starting point for new hybrid quantum computation schemes that combine molecular and atomic ions, covering the measurement and entangling steps.Comment: v3. Substantially enlarged manuscript with details of derivations and calculations in two appendices. To appear in PR

Incidencia del software geogebra como herramienta didáctica en el desarrollo del pensamiento geométrico

Maestría en EducaciónEsta investigación analiza la incidencia que presenta el software de geometría dinámica Geogebra como estrategia didáctica en el pensamiento geométrico en estudiantes de noveno grado de una institución estatal, Departamento del Magdalena, Municipio de Pueblo Viejo. La metodología está enmarcada bajo un enfoque cuantitativo, diseño cuasi-experimental y alcance explicativo; la muestra fue de 33 estudiantes 16 correspondientes al grupo control y 17 al grupo experimental. Para ellos se implementó un test con preguntas de selección múltiple, que evalúa las tres competencias que se desarrollan en el pensamiento geométrico. Los resultados obtenidos evidencian que el promedio de los estudiantes que aprenden con en este tipo de estrategia es mayor cuando se compara con el promedio de los estudiantes que aprenden con de lápiz y papel en el grupo controlThis research analyzes the incidence of Geogebra dynamic geometry software as a didactic strategy in geometric thinking in ninth grade students of a state institution, Magdalena Department, Municipality of Pueblo Viejo. The methodology is framed under a quantitative approach, quasi-experimental design and explanatory scope; the sample was 33 students 16 corresponding to the control group and 17 to the experimental group. For them, a test with multiple-choice questions was implemented, which evaluates the three competences that are developed in geometric thinking. The results obtained show that the average of students who learn with this type of strategy is higher when compared to the average of students who learn with pencil and paper in the control group

Deep ocean prokaryotes and fluorescent dissolved organic matter reflect the history of the water masses across the Atlantic Ocean

Organic matter is known to influence community composition and metabolism of marine prokaryotes. However, few studies have addressed this linkage in the deep ocean. We studied the relationship between fluorescent dissolved organic matter and prokaryotic community composition in meso- and bathypelagic water masses along a surface productivity gradient crossing the subtropical and tropical Atlantic Ocean. Four fluorescence components were identified, three humic-like and one protein-like. The distributions of the humic-like components were significantly explained by water mass mixing, apparent oxygen utilisation (AOU) and epipelagic productivity proxies in varying degrees, while the protein-like component was explained only by water mass mixing and epipelagic productivity. The diversity and taxonomic composition of the prokaryotic community differed between water masses: the Nitrosopumilales order dominated in water masses with high AOU and humic-like fluorescence (notably, the SubPolar Mode Water), and tended to co-occur with Marine Group II archaea, the SAR324 clade and Thiomicrospirales, while bathypelagic water masses displayed greater abundances of members of Marinimicrobia, SAR202 and SAR324. Water mass mixing regression models suggested that the distribution of some taxa (e.g., Marinimicrobia, SAR202) was dominated by mixing and selection within the water masses during ageing, while others (chiefly, Alteromonadales) were mostly influenced by local processes. Our results suggest a link between the composition of the prokaryotic community, oxygen utilisation and the signal of fluorescent dissolved organic matter, and has implications for our understanding of the processes that shape carbon cycling and prokaryotic communities in the deep ocean.3,26

Research projects in secondary education: an alternative to the process of teaching and learning statistics

III Congreso Internacional Virtual de Educación Estadística (CIVEEST), 21-24 febrero de 2019. [www.ugr.es/local/fqm126/civeest.html]La sociedad contemporánea está marcada por la afluencia continua de informaciones diversas que requieren ser interpretadas y evaluadas críticamente, para un mejor entendimiento y valoración de los fenómenos y procesos de la realidad y para la adopción de decisiones razonables, por lo que el proceso de enseñanza-aprendizaje de la estadística en la escuela adquiere mayor importancia. Sobre la base de varias investigaciones, las autoras constataron dificultades en el desarrollo del proceso de enseñanza-aprendizaje de la estadística en la Educación Preuniversitaria, por este motivo se desarrolló la presente investigación, en la que se propone una alternativa didáctica para el proceso de enseñanza-aprendizaje de la estadística en el décimo grado, mediante la realización de proyectos investigativos.The contemporary society is marked by the continuous influx of various information that need to critically be interpreted and evaluated, for a better understanding and assessment of phenomena and processes of reality and for the adoption of reasonable decisions. Therefore, the process of teaching-learning statistics in the school acquires a greater importance. On the basis of several studies, the authors found difficulties in the development of this process in secondary education. For this reason, in this research we propose a didactical alternative for the teaching-learning process of statistics in the 10th grade, by carrying out research projects