Diseño de Manual de Higiene y Seguridad Industrial para Minimizar los riesgos en el taller CUADRA ubicado en la ciudad de Managua

Presenta el diseño de un manual de higiene y seguridad industrial para minimizar el riesgo laboral en el taller Cuadra, ubicado en delicias del Volga, Managua, Nicaragua. Determina el ámbito de higiene y seguridad industrial en el taller Cuadra. Identifica y evalúa los riesgos, en forma inicial y periódica, con la finalidad de planificar adecuadamente los equipos de protección personal, inspección de seguridad, zonas de seguridad, rutas y plan de emergencia

DLT 4-411. Scale : the development of the typical speech

1 archivo PDF (18 páginas). fhundequinquagintaLas características de una escala cuyo propósito consiste en determinar fidedignamente el nivel del desarrollo del lenguaje típico en niños de edad preescolar se describen en este artículo. La escala referida evalúa el desarrollo del proceso para adquirir la fonología, morfología, sintaxis y pragmática de niños hablantes del español cuyas edades se hallen delimitadas por 4 años y 4 años 11 meses. Abstract The characteristics and the process of developing a scale that aims at determining the level of typical language development in children of pre school age are described in this article. The scale assesses the above mentioned development of phonology, morphology, syntax and pragmatics of children whose ages are between four and four years eleven months. PALABRAS CLAVE: adquisición, evaluación, lenguaje, escala. KEY WORDS: acquisition, assessment, language, leve

CaptuRING: A do‐it‐yourself tool for wood sample digitization

Producción CientíficaStandard procedures to obtain high-quality images of wood samples have become a bottleneck in the digitization of dendrochronology. Digitization is currently dominated by flatbed scanners, but the use of these devices is limited by sample length and surface flatness. Although several solutions based on digital photography have been published, they lack effective digitization processes or are too expensive to be widely adopted. Free open-source software and hardware has emerged as an alternative to create research tools that combine reduced costs with high reliability. Here we present CaptuRING, an open-source tool for wood sample digitization combining a do-it-yourself hardware based on Arduino® with a DSLR camera and a free open-source software with an easy-to-use graphical user interface. We compared CaptuRing with image acquisition from a standard flatbed scanner Epson® V750PRO. CaptuRING outperforms scanner image resolution and sharpness, while it removes sample size limitations. Moreover, CaptuRing performs this task in less than half of the time needed by Epson® V750PRO flatbed scanner. CaptuRING emerges as a reliable and low-cost tool to capture high-resolution images of wood samples boosting current digitization processes. The combination of free open software and hardware empowers dendrochronology to advance in wood sample digitization.Junta de Castilla y León, project OUTBREAK (VA171P20) and (IR2020-1-UVA08)Ministerio de Ciencia, Innovación y Universidades, grant number (CGL2017-87309-P) (MGH PRE2018-084106) and project PROWARM (PID2020-118444GA-I00)Universidad Politécnica de Madrid (through Project RP200060107

Criterios de ordenación temporal de las intervenciones quirúrgicas en patología cardiovascular y endovascular adquirida. Versión 2022

Waiting list management of cardiac surgical procedures is a main concern for all the Spanish autonomic health systems and for our scientific Society. The first statement for optimal timing of patients waiting for cardiac surgery was published in 2000. Since then, after significant changes in the management of some pathologies, new normative frameworks and the current healthcare situation, a review of the timing criteria to offer an adequate and updated standard of care is needed. In this document we aim to review the available literature in the field and stablish a consensus within a working group of the Spanish Society of Cardiovascular and Endovascular Surgery to optimize the priority recommendations in cardiac surgical waiting lists in our country. (c) 2022 Sociedad Espanola de Cirugia Cardiovascular y Endovascular. Published by Elsevier Espana, S.L.U. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/ riccuses/by-nc-nri/4.0/)

Temperature Dependence of Water Absorption in the Biological Windows and Its Impact on the Performance of Ag2S Luminescent Nanothermometers

The application of nanoparticles in the biological context generally requires their dispersion in aqueous media. In this sense, luminescent nanoparticles are an excellent choice for minimally invasive imaging and local temperature sensing (nanothermometry). For these applications, nanoparticles must operate in the physiological temperature range (25–50 °C) but also in the nearinfrared spectral range (750–1800 nm), which comprises the three biological windows of maximal tissue transparency to photons. In this range, water displays several absorption bands that can strongly affect the optical properties of the nanoparticles. Therefore, a full understanding of the temperature dependence of water absorption in biological windows is of paramount importance for applications based on these optical properties. Herein, the absorption spectrum of water in the biological windows over the 25–65 °C temperature range is systematically analyzed, and its temperature dependence considering the coexistence of two states of water is interpreted. Additionally, to illustrate the importance of state-of-the-art applications, the effects of the absorption of water on the emission spectrum of Ag2S nanoparticles, the most sensitive luminescent nanothermometers for in vivo applications to date, are presented. The spectral shape of the nanoparticles’ emission is drastically affected by the water absorption, impacting their thermometric performanceThis work was financed by the Spanish Ministerio de Ciencia e Innovación under project PID2019-106211RB-I00, by the Instituto de Salud Carlos III (PI19/00565), by the Comunidad Autónoma de Madrid (S2017/BMD3867 RENIM-CM) and co-financed by the European structural and investment fund. Additional funding was provided by the European Union Horizon 2020 FETOpen project NanoTBTech (801305), the Fundación para la Investigación Biomédica del Hospital Universitario Ramón y Cajal project IMP21_A4 (2021/0427), and by COST action CA17140. A.B. acknowledges funding support through the TALENTO 2019T1/IND14014 contract (Comunidad Autónoma de Madrid). F.E.M. and L.D.C. acknowledge the financial support received from the project Shape of Water (PTDC/NAN-PRO/3881/2020) through Portuguese fund

Reforzamiento estructural de edificaciones patrimoniales en tierra de 1 y 2 pisos: aplicación de la normativa AIS-610-EP-2017

The Spaniards that conquered the Andean Highlands of Latin America constructed buildings with adobe and rammed earth. For this reason, Colombia has 90% of its heritage buildings made of earth; most of them located in high and intermediate seismic hazard zones. Considering that these constructions are vulnerable to earthquakes, in 2019, the standard AIS-610-EP-2017 was included in the national earthquake-resistant regulation (standard for seismic reinforcement of heritage earthen buildings). Using this standard, two buildings built in the 16th century were analyzed. The walls were reinforced with steel plates (or wooden elements). For seismic loads, the results suggest that only 24% of the unreinforced walls would have stresses lower than the tensile strength of the rammed earth. In contrast, in the reinforced walls this percentage is 98%. Likewise, the stresses in the reinforcing elements (steel and wood) are kept below the allowable limits.Los españoles que conquistaron la zona andina latinoamericana construyeron edificios en adobe y tapia apisonada. Por esta razón, el 90% de los edificios patrimoniales en Colombia están construidos en tierra; la mayoría ubicados en zonas de amenaza sísmica intermedia y alta. Considerando que estas edificaciones son sísmicamente vulnerables, en 2019 se incluyó la norma AIS-610-EP-2017 en la reglamentación sismo-resistente del país (norma para reforzamiento sísmico de edificios patrimoniales en tierra). Utilizando esta norma, se analizaron dos edificios construidos en el siglo XVI. Los muros fueron reforzados con placas de acero (o de madera). Los resultados indican que para cargas sísmicas solo el 24% de los muros sin refuerzo tendrían tensiones menores que la resistencia a la tracción de la tierra, mientras que en los muros reforzados este porcentaje es del 98%. Asimismo, las tensiones en los elementos de refuerzo (acero y madera) se mantienen por debajo de los límites permisibles

Design, synthesis and structure-activity relationship (SAR) studies of an unusual class of non-cationic fatty amine-tripeptide conjugates as novel synthetic antimicrobial agents

Cationic ultrashort lipopeptides (USLPs) are promising antimicrobial candidates to combat multidrug-resistant bacteria. Using DICAMs, a newly synthesized family of tripeptides with net charges from −2 to +1 and a fatty amine conjugated to the C-terminus, we demonstrate that anionic and neutral zwitterionic USLPs can possess potent antimicrobial and membrane- disrupting activities against prevalent human pathogens such as Streptococcus pneumoniae and Streptococcus pyogenes. The strongest antimicrobials completely halt bacterial growth at low micromolar concentrations, reduce bacterial survival by several orders of magnitude, and may kill planktonic cells and biofilms. All of them comprise either an anionic or neutral zwitterionic peptide attached to a long fatty amine (16–18 carbon atoms) and show a preference for anionic lipid membranes enriched in phosphatidylglycerol (PG), which excludes electrostatic interactions as the main driving force for DICAM action. Hence, the hydrophobic contacts provided by the long aliphatic chains of their fatty amines are needed for DICAM’s membrane insertion, while negative-charge shielding by salt counterions would reduce electrostatic repulsions. Additionally, we show that other components of the bacterial envelope, including the capsular polysaccharide, can influence the microbicidal activity of DICAMs. Several promising candidates with good-to-tolerable therapeutic ratios are identified as potential agents against S. pneumoniae and S. pyogenes. Structural characteristics that determine the preference for a specific pathogen or decrease DICAM toxicity have also been investigated.The author(s) declare that financial support was received for the research, authorship, and/or publication of this article. This work was supported by grants of the Ministry of Science, Innovation and Universities (RTI2018-099985-B-I00/AEI/10.13039/501100011033) to MM and (PID2022-136307OB-C21/AEI/10.13039/ 501100011033/FEDER, UE) to MC, SV, and SC, and by a grant from the Ministry of Science and Innovation (PID2019-104070-RB- C21) to MC, and SV. Additional funding was provided by the Centro de Investigación Biomédica en Red de Enfermedades Respiratorias (CIBERES), an initiative of the Instituto de Salud Carlos III (ISCIII) to MM (CB06/06/1102) and MD (CB06/06/0003), and by Agencia Estatal Consejo Superior de Investigaciones Científicas, CSIC, (Projects CSIC-PIE201980E100, CSIC-PIE201980E028 and CSIC- PIE202380E095) to MC, SV, and SC.Peer reviewe

Issues Year 4. Number 8. Journal of the Center for Research in Social Sciences, Education and Arts

Esta colección de Editorial UNAB presenta reflexiones sobre asuntos de actualidad dentro de la comunicación social, escritos por profesores de la Universidad Autónoma de Bucaramanga e invitados especiales a la institución, como aporte al debate sobre este campo del conocimiento, el oficio y la profesión.Presentación. - 5 Los núcleos integradores. - 7 La interpretación de una experiencia formativa de la Facultad de Educación de la UNAB: los núcleos integradores. - 15 Experiencia significativa de investigación de las Escuelas Normales Superiores. - 25 Desarrollo de la inteligencia y creatividad. - 31 "Cuando me aburras morirás". - 45 El sentido de las prácticas y la relación amestro-aprendiz en el presente. - 59 El papel de la pedagogía y la construcción del sujeto social. - 75 Subjetividades críticas, ciudadanías activas. - 79 ¿Cómo están representados los indígeneas y su cultura en los libros escolares suecos en comparación con sus equivalencias colombianos? . 85 Estado, clientelismo y sociedad: una mirada desde la función política de la Educación. - 91 Presentación de la obra Manolo Díaz. - 110This collection of Editorial UNAB presents reflections on current issues within social communication, written by professors from the Autonomous University of Bucaramanga and special guests at the institution, as a contribution to the debate on this field of knowledge, trade and profession

Glutamate receptor-like channels are essential for chemotaxis and reproduction in mosses

The deposited article version is a "Accelerated Article Preview" provided by Nature Publishing Group, and it contains attached the supplementary materials within the pdf.». This publication hasn't any creative commons license associated.Glutamate receptors are well characterized channels that mediate cell-to-cell communication during neurotransmission in animals. Nevertheless, information regarding their functional role in organisms without nervous systems is still limited. In plants, Glutamate Receptor-like (GLR) genes have been implicated in defence against pathogens, reproduction, control of stomata aperture and light signal transduction(1-5). However, the numerous GLR genes present in angiosperm genomes (20 to 70)(6) has prevented the observation of strong phenotypes in loss-of-function mutants. Here, we show that in the moss Physcomitrella patens, a basal land plant, mutation of GLR genes cause sperm failure in targeting the female reproductive organs. In addition, we show that GLR genes encode non-selective Ca(2+) permeable channels that can regulate cytoplasmic Ca(2+) and are needed to induce the expression of a BELL1-like transcription factor essential for zygote development. Our work reveals novel functions for GLRs in sperm chemotaxis and transcriptional regulation. Sperm chemotaxis is essential for fertilization in both animals and early land plants like bryophytes and pteridophytes. Therefore, our results are suggestive that ionotropic glutamate receptors may have been conserved throughout plant evolution to mediate cell-to-cell communication during sexual reproduction.Phillips University; Oxford University; University of Marburg; University of Muenster; MarieCurie ITN-Plant Origins grant: (FP7-PEOPLE-ITN-2008); FCT grants: (BEX-BCM/0376/2012; PTDC/BIA-PLA/4018/2012); NSF-US grant: (MCB 1616437/2016).info:eu-repo/semantics/acceptedVersio

Correction : Chaparro et al. Incidence, Clinical Characteristics and Management of Inflammatory Bowel Disease in Spain: Large-Scale Epidemiological Study. J. Clin. Med. 2021, 10, 2885

The authors wish to make the following corrections to this paper [...]