60 research outputs found
Valor pronóstico del nuevo sistema de etapificación internacional en mieloma múltiple: Comparación con el sistema de Durie-Salmon
SHARDS: A global view of the star formation activity at z~0.84 and z~1.23
In this paper, we present a comprehensive analysis of star-forming galaxies
(SFGs) at intermediate redshifts (z~1). We combine the ultra-deep optical
spectro-photometric data from the Survey for High-z Absorption Red and Dead
Sources (SHARDS) with deep UV-to-FIR observations in the GOODS-N field.
Exploiting two of the 25 SHARDS medium-band filters, F687W17 and F823W17, we
select [OII] emission line galaxies at z~0.84 and z~1.23 and characterize their
physical properties. Their rest-frame equivalent widths
(EW([OII])), line fluxes, luminosities, star formation rates
(SFRs) and dust attenuation properties are investigated. The evolution of the
EW([OII]) closely follows the SFR density evolution of the
universe, with a trend of EW([OII])(1+z) up to
redshift z~1, followed by a possible flattening. The SF properties of the
galaxies selected on the basis of their [OII] emission are compared with
complementary samples of SFGs selected by their MIR and FIR emission, and also
with a general mass-selected sample of galaxies at the same redshifts. We
demonstrate observationally that the UVJ diagram (or, similarly, a cut in the
specific SFR) is only partially able to distinguish the quiescent galaxies from
the SFGs. The SFR-M relation is investigated for the different samples,
yelding a logarithmic slope ~1, in good agreement with previous results. The
dust attenuations derived from different SFR indicators (UV(1600), UV(2800),
[OII], IR) are compared and show clear trends with respect to both the stellar
mass and total SFR, with more massive and highly star-forming galaxies being
affected by stronger dust attenuation.Comment: Replaced to match the accepted version (24 pages, 1 table, 17
figures). Published in ApJ, 812, 155 (2015):
http://stacks.iop.org/0004-637X/812/15
Equidad y Diversidad en las aulas de América Latina ¿Ilusión, intención o realidad?
In the context of the search for an education that shapes individuals capable of addressing current and future needs, this study was conducted with the objective of critically reflecting on equity and diversity in the classrooms of educational institutions in Latin America. The purpose was to obtain an overview that would determine whether these notions remain as ideals, have become mere intentions, or are already being reflected in the reality of these countries. To achieve this, a documentary review was carried out from a methodological perspective, using a bibliographic design and applying a content analysis matrix as a tool to address the categories related to the topic in scientific publications of the last 5 years. These publications were obtained through searches in scientific database access tools. As a result of this study, some concluding reflections were reached. It is observed that, while there is progress from the illusion and intention of nations towards a practice of equity and diversity in the classrooms, the ultimate goal of achieving full integration of both notions still remains in the realm of illusion. This is because, upon analyzing the studied overviews, there is no evidence of a complete and definitive consolidation of these ideas.En el contexto de la búsqueda de una educación que forme individuos capaces de hacer frente a las necesidades actuales y futuras, se llevó a cabo este estudio con el objetivo de reflexionar críticamente sobre la equidad y la diversidad en las aulas de las instituciones educativas de América Latina. El propósito era obtener un panorama que permitiera determinar si estas nociones se mantienen como ideales, si han pasado a ser intenciones o si ya se están reflejando en la realidad de estos países. Para lograrlo, se realizó una revisión documental desde una perspectiva metodológica, utilizando un diseño bibliográfico y aplicando una matriz de análisis de contenido como herramienta para abordar las categorías relacionadas con el tema en las publicaciones científicas de los últimos 5 años. Estas publicaciones se obtuvieron a través de la búsqueda en herramientas de acceso a bases de datos científicas. Como resultado de este estudio, se llegó a algunas reflexiones conclusivas. Se observa que, si bien es evidente el avance desde la ilusión y la intención de las naciones hacia una práctica de equidad y diversidad en las aulas, el objetivo final de lograr una integración plena de ambas nociones aún queda en el ámbito de la ilusión. Esto se debe a que, al analizar los panoramas estudiados, no se evidencia una consolidación completa y definitiva de estas ideas
Extracellular Vesicles Secreted by Hypoxic AC10 Cardiomyocytes Modulate Fibroblast Cell Motility
Extracellular vesicles (EVs) are small membrane vesicles secreted by most cell types with important roles in cell-to-cell communication. To assess their relevance in the context of heart ischemia, EVs isolated from the AC10 ventricular cardiomyocyte cell line (CM-EVs), exposed to normoxia (Nx) or hypoxia (Hx), were incubated with fibroblasts (Fb) and endothelial cells (EC). CM-EVs were studied using electron microscopy, nanoparticle tracking analysis (NTA), western blotting and proteomic analysis. Results showed that EVs had a strong preference to be internalized by EC over fibroblasts, suggesting an active exosome-based communication mechanism between CM and EC in the heart. In Matrigel tube-formation assays, Hx CM-EVs were inferior to Nx CM-EVs in angiogenesis. By contrast, in a wound-healing assay, wound closure was faster in fibroblasts treated with Hx CM-EVs than with Nx CM-EVs, supporting a pro-fibrotic effect of Hx CM-EVs. Overall, these observations were consistent with the different protein cargoes detected by proteomic analysis under Nx and Hx conditions and the biological pathways identified. The paracrine crosstalk between CM-EVs, Fb, and EC in different physiological conditions could account for the contribution of CM-EVs to cardiac remodeling after an ischemic insult
Near real-time surveillance of the SARS-CoV-2 epidemic with incomplete data
When responding to infectious disease outbreaks, rapid and accurate estimation of the epidemic trajectory is critical. However, two common data collection problems affect the reliability of the epidemiological data in real time: missing information on the time of first symptoms, and retrospective revision of historical information, including right censoring. Here, we propose an approach to construct epidemic curves in near real time that addresses these two challenges by 1) imputation of dates of symptom onset for reported cases using a dynamically-estimated "backward" reporting delay conditional distribution, and 2) adjustment for right censoring using the NobBS software package to nowcast cases by date of symptom onset. This process allows us to obtain an approximation of the time-varying reproduction number (Rt) in real time. We apply this approach to characterize the early SARS-CoV-2 outbreak in two Spanish regions between March and April 2020. We evaluate how these real-time estimates compare with more complete epidemiological data that became available later. We explore the impact of the different assumptions on the estimates, and compare our estimates with those obtained from commonly used surveillance approaches. Our framework can help improve accuracy, quantify uncertainty, and evaluate frequently unstated assumptions when recovering the epidemic curves from limited data obtained from public health systems in other locations.PMD was supported by the fellowship Ramón Areces Foundation. JAH was funded by the National Institute of General Medical Sciences, Award U54GM088558, and the National Institutes of Health Director’s Early Independence, Award DP5-OD028145. ML was supported by the Morris-Singer Fund and by a subcontract from the Carnegie Mellon University under an award from the US Centers for Disease Control and Prevention, Award U01IP001121). MS was supported by the National Institute Of General Medical Sciences, Award R01GM130668-02. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.S
La desmedicalización de la vida cotidiana de las mujeres: los grupos socioeducativos en el Sistema Sanitario Público Andaluz
Los grupos socioeducativos (GRUSE) constituyen una estrategia de promoción de la salud y el bienestar
emocional desde un enfoque de salud positiva basada en activos. Mayoritariamente se dirigen a mujeres
que acuden a los centros de salud con signos de malestar para los que no se encuentra base orgánica. La
estrategia se evalúa mediante un dise¿no longitudinal y cuasi-experimental, con metodología mixta. Se
ha recogido información de 228 mujeres con una batería de escalas y el análisis de bases de datos del
sistema sanitario. Se han realizado 10 entrevistas en profundidad a mujeres y tres grupos de discusión
con profesionales. El objetivo de este artículo es dar a conocer la estrategia GRUSE como intervención
alternativa no medicalizadora y presentar el dise¿no de la investigación, con la que se espera identificar
las evidencias de esta práctica implantada en los centros de salud de atención primaria de Andalucía.Departamento de Trabajo Social y Servicios SocialesVersión del edito
Certificación de un material de referencia de carne en base a un estudio de colaboración = Certification of a meat reference material based on a collaborative study
Mediante un proyecto de colaboración, se llevaron a cabo estudios de comparación para mejorar la capacidad de mediciónde los laboratorios participantes, apoyándolos en la producción, caracterización y distribución de materiales de referencia delsector agroalimentario. El proyecto fue planteado en cuatro etapas anuales (leche, agua, carne y granos). La tercera etapa enespecífico tuvo el objetivo de cuantificar y certificar el contenido de los parámetros nutrimentales (nitrógeno, grasa, sodio ypotasio) de un lote candidato a Material de Referencia Certificado (MRC) de carne bovina enlatada. Dicho estudio fue realizadoen colaboración entre varios Institutos Nacionales de Metrología (INM) y/o laboratorios colaboradores, los cuales, una vez queidentificaron las posibles causas de variabilidad o de sesgo en las mediciones, así como las oportunidades de mejora, lograronla certificación del material de carne bovina. El MRC fue distribuido entre los participantes para cubrir las necesidades de laindustria alimentaria de productos cárnicos y laboratorios de prueba de sus respectivos países
Miradas y voces de la investigación educativa I
Fil: Ferreyra, Horacio Ademar. Universidad Católica de Córdoba. Facultad de Educación; ArgentinaFil: Calneggia, María Isabel. Universidad Católica de Córdoba. Facultad de Educación; ArgentinaFil: Di Francesco, Adriana Carlota. Universidad Católica de Córdoba. Facultad de Educación; Argentin
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