La motivaci?n como elemento fundamental en los procesos de ense?anza y aprendizaje de los ni?os y ni?as del nivel transici?n de la instituci?n educativa San Francisco

53 p. Recurso Electr?nicoEl proyecto titulado la motivaci?n como elemento fundamental en los procesos de ense?anza y aprendizaje de los ni?os y ni?as del nivel transici?n de la Instituci?n Educativa San Francisco Sede Cural La Tigrera, ha sido realizado con el objetivo de Identificar la relaci?n entre familia y escuela como agentes motivacionales en los procesos de ense?anza y aprendizaje de los ni?os y ni?as del nivel de transici?n de la Instituci?n Educativa San Francisco Sede Cural la tigrera, la idea es establecer posibles soluciones a esta problem?tica identificada, ya que la misma est? generando en los educandos diferentes dificultades en sus procesos de ense?anza y aprendizaje, con ello se pretende lograr sacar las conclusiones de dichos comportamientos y realizar algunas recomendaciones que den pie para un mejoramiento en cuando a la integraci?n entre familia y escuela, permita el mejor desempe?o del estudiante en todos los aspectos de su labor estudiantil y la responsabilidad compartida entre familia y escuela, todo ello a trav?s de las encuestas y entrevistas informales realizadas a padres de familia y docentes de la instituci?n. De esta manera, se logr? identificar, causas, consecuencias, y caracter?sticas, las cuales permitieron favorecer la motivaci?n hacia el aprendizaje. El proyecto concluye con un an?lisis de resultados y diferentes recomendaciones que pretenden dar posibles alternativas de soluci?n a la problem?tica identificada, que permitan crear un ambiente favorable para la motivaci?n y el aprendizaje de los infantes, desde sus intereses y necesidades. Partiendo de la importancia de la motivaci?n en los procesos de ense?anza y aprendizaje y del compromiso entre familia y escuela para generar procesos integrales en los ni?os y ni?as del nivel transici?n de la Instituci?n Educativa San Francisco Sede Cural La Tigrera. Palabras claves: aprendizaje, motivaci?n, ense?anza, l?dica, integraci?n, comunidad educativa.The project entitled Motivation as a fundamental element in the teaching and learning processes of children at the transition level of the Educational Institution San Francisco Cural La Tigrera Headquarters, has been carried out with the aim of Identifying the relationship between family and school as motivational agents in the teaching and learning processes of children in the transition level of the San Francisco Educational Institution Cural la tigrera Headquarters, the idea is to establish possible solutions to this identified problem, since it is generating in the different students difficulties in their teaching and learning processes, with the aim of achieving the conclusions of these behaviors and make some recommendations that lead to an improvement in when the integration between family and school, allows the best performance of the student in all aspects of their student work and responsibility with between family and school, all through informal surveys and interviews with parents and teachers of the institution. In this way, it was possible to identify, causes, consequences, and characteristics, which allowed to favor the motivation towards learning. The project concludes with an analysis of results and different recommendations that seek to provide possible solutions to the problem identified, to create a favorable environment for the motivation and learning of the infants, from their interests and needs. Starting from the importance of motivation in the teaching and learning processes and the commitment between family and school to generate integral processes in the children of transition level of the Educational Institution San Francisco Cural La Tigrera Headquarters. Keywords: learning, motivation, teaching, playfulness, integration, educational community

An?lisis de la libertad econ?mica en el contexto del comercio formal peruano

La b?squeda e implementaci?n de pol?ticas y programas que signifiquen alcanzar la prosperidad y mayores niveles de calidad de vida de los individuos, es constante; sin embargo, las medidas que se han planteado en el Per? a nivel estatal que permitan crear riqueza; como podr?a ser la promoci?n o impulso del emprendimiento formal, han sido, infructuosas a corto y a largo plazo. Una clara muestra se evidencia en la mantenci?n del alto ?ndice de informalidad de las empresas en nuestro pa?s; siendo que, de acuerdo a la C?mara de Comercio de Lima, aproximadamente el 75% de empresas dedicadas al sector comercio son informales. Frente a la evidente superioridad del n?mero de unidades productivas informales que operan al margen de la ley, sin los beneficios de la misma; como es la protecci?n jur?dica, acceso al financiamiento y participaci?n para prestar incluso, servicios al estado, se muestra que las pol?ticas, normas o instituciones jur?dicas vigentes, pueden no funcionar; resulta de suma urgencia cuestionar, si los motivos que han llevado hasta la actualidad a la daci?n de dichas normas, son adecuados o no

Factores asociados a la insuficiencia renal aguda en pacientes hospitalizados en la unidad de cuidados intensivos de la Cl?nica Ibagu? del 1 de mayo de 2016 al 31 de octubre del 2017

68 p. Recurso Electr?nicoLa insuficiencia renal aguda es una complicaci?n frecuente en los pacientes cr?ticos, siendo una causa importante de morbimortalidad. Objetivo: Establecer la asociaci?n entre factores socio demogr?fico y cl?nico con la insuficiencia renal aguda en pacientes hospitalizados en la Unidad De Cuidados Intensivos de la cl?nica Ibagu? en el periodo comprendido entre el 1 Mayo de 2016 al 31 de Octubre del 2017. Dise?o y m?todos: Se realiz? un estudio Epidemiol?gico Observacional, Anal?tico de Casos y Controles de tipo retrospectivo; se obtuvo informaci?n de fuentes secundarias como las historias cl?nicas de los pacientes Hospitalizados en la Unidad de Cuidados Intensivos de la Cl?nica Ibagu? en el periodo comprendido entre el 1 de Mayo de 2016 al 31 de Octubre del 2017. Resultados: Se identific? que la administraci?n de soluci?n salina en las primeras 24 horas de ingreso, increment? la oportunidad de insuficiencia renal aguda 1.8 veces con respecto a los pacientes que se les administr? lactato de ringer (OR=1,8 IC (95% OR: 1.2-2.8), as? mismo se observ? que la oportunidad de insuficiencia renal en los pacientes que ten?an entre 54.1 y 62.1 a?os fue de 2.5 veces con respecto a aquellos pacientes que ten?an entre 62.2 y 93 a?os (OR=2.5 IC(95% OR 1.4-2.4). En los pacientes que ten?an como m?ximo 54 a?os, el riesgo de la insuficiencia renal se increment? 1.6 veces con respecto a los pacientes que ten?an entre 62.2 y 93 a?os y estas diferencias no fueron significativas (p=0.174). Conclusi?n: se puede concluir que al analizar mediante el modelo de regresi?n log?stica planteado, la administraci?n de soluci?n salina a los pacientes en las primeras 24 horas de ingreso increment? la oportunidad de insuficiencia renal aguda 1.8 veces con respecto a los que se les administr? lactato ringer (OR=1,8 IC (95% OR: 1.2-2.8), lo que indica que el lactato ringer es un factor protector en el desarrollo de la insuficiencia renal aguda en pacientes hospitalizados en unidad de cuidados intensivos Palabras clave: casos y controles, insuficiencia renal aguda, Lactato Ringer.Acute renal failure is a frequent complication in critical patients, being an important cause of morbidity and mortality. Objective: To establish the association between sociodemographic and clinical factors with acute renal failure in patients hospitalized in the Intensive Care Unit of the Ibagu? clinic in the period from May 1, 2016 to October 31, 2017. Design and methods: An observational, analytical, analytical study of cases and controls of a retrospective type was carried out; Information was obtained from secondary sources such as the medical records of the patients Hospitalized in the Intensive Care Unit of the Ibagu? Clinic in the period from May 1, 2016 to October 31, 2017. Results: It was identified that the administration of saline in the first 24 hours of admission, increased the chance of acute renal failure 1.8 times with respect to the patients who were administered ringer's lactate (OR = 1.8 IC (95% OR : 1.2-2.8), likewise it was observed that the chance of renal failure in patients who were between 54.1 and 62.1 years old was 2.5 times compared to those patients who were between 62.2 and 93 years old (OR = 2.5 CI (95% OR 1.4-2.4). In patients who were 54 years of age or older, the risk of renal failure increased 1.6 times with respect to patients who were between 62.2 and 93 years old and these differences were not significant (p = 0.174). Conclusion: it can be concluded that when analyzing using the logistic regression model proposed, the administration of saline to the patients in the first 24 hours of admission, increased the chance of acute renal failure 1.8 times compared to those administered ringer's lactate (OR = 1.8 CI (95% OR: 1.2-2.8), indicating that ringer lactate is a protective factor in the development of acute renal failure in patients hospitalized in the intensive care unit Keywords: cases and controls, acute renal failure, ringer's lactat

Increased urinary markers of kidney damage in the institutionalized frail elderly due to recurrent urinary tract infections.

Objective: To characterize the impact on kidney injury of recurrent urinary tract infections (RUTI) in the frail elderly. Methods: Prospective observational study in 200 frail elderly subjects for 1 year. Groups: GA (n = 100): subjects without RUTI, GB (n = 100): subjects with RUTI. Variables: age, concomitant diseases, glomerular filtration rate (GFR), urine neutrophil gelatinase-associated lipocalin (NGAL) at the beginning (NGAL-1) and end (NGAL-2) of the study, urine N-acetyl glucosaminidase (NAG) at the beginning (NAG-1) and the end (NAG-2) of the study, urine transforming growth factor-beta 1 (TGFbeta-1). Descriptive statistics, Mann-Whitney test, Chi-squared test, Fisher's exact test, and multivariate analysis were used. Results: Mean age was 84.33 (65-99) years old, with no difference between GA and GB. Mean NGAL-1 was 1.29 ng/ml (0.04-8). There was lower in GA than in GB. Mean NGAL-2 was 1.41 ng/ml (0.02-9.22). NGAL-2 was lower in GA than in GB. Mean NAG-1 was 0.38 UU.II/ml (0.01-2.63. NAG-1 in GA was lower than in GB. Mean NAG-2 was 0.44 UU.II/ml (0-3.41). NAG-2 was lower in GA compared with GB. Mean TGFbeta-1 was 23.43 pg/ml (0.02-103.76). TGFbeta-1 was lower in GA than GB. There were no differences in the presence of secondary diagnoses between GA and GB. NAG-2 and NGAL-1 were the most determining factors of renal function; in GA it was NGAL-2, followed by NAG-1; in GB it was NGAL-1, followed by NAG-2. Conclusion: Frail elderly with RUTI have higher urinary levels of renal injury markers, specifically NGAL, NAG, and TGFbeta-1, chronically in periods between urinary tract infection (UTI). Urinary markers of renal injury, specifically NGAL, NAG, and TGFbeta-1, identify early deterioration of renal function, compared with serum creatinine, or albuminuria, in frail elderly with recurrent urinary infections

High rate of uncovered struts in latest generation drug-eluting stents with durable, biodegradable polymer or lack of it 1 month after implantation

Introduction and objectives: Delayed vascular healing may induce late stent thrombosis. Optical coherence tomography (OCT) is useful to evaluate endothelial coverage. The objective of this study was to compare stent coverage and apposition in non-complex coronary artery lesions treated with durable polymer-coated everolimus-eluting stents (durable-polymer EES) vs biodegradable polymer-coated everolimus-eluting stents ( biodegradable-polymer EES) vs polymer-free biolimus-eluting stents (BES) 1 and 6 months after stent implantation. Methods: Prospective, multicenter, non-randomized study that compared the 3 types of DES. Follow-up angiography and OCT were performed 1 and 6 months later. The primary endpoint was the rate of uncovered struts as assessed by the OCT at 1 month. Results: A total of 104 patients with de novo non-complex coronary artery lesions were enrolled. A total of 44 patients were treated with polymer-free BES, 35 with biodegradable-polymer EES, and 25 with durable-polymer EES. A high rate of uncovered struts was found at 1 month with no significant differences reported among the stents (80.2%, polymer-free BES; 88.1%, biodegradable-polymer EES; 82.5%, durable-polymer EES; P =.209). Coverage improved after 6 months in the 3 groups without significant differences being reported (97%, 95%, and 93.7%, respectively; P =.172). Conclusions: In patients with de novo non-complex coronary artery lesions treated with durable vs biodegradable vs polymer-free DES, strut coverage and apposition were suboptimal at 1 month with significant improvement at 6 months

Minigene-like inhibition of protein synthesis mediated by hungry codons near the start codon

Rare AGA or AGG codons close to the initiation codon inhibit protein synthesis by a tRNA-sequestering mechanism as toxic minigenes do. To further understand this mechanism, a parallel analysis of protein synthesis and peptidyl-tRNA accumulation was performed using both a set of lacZ constructs where AGAAGA codons were moved codon by codon from +2, +3 up to +7, +8 positions and a series of 3–8 codon minigenes containing AGAAGA codons before the stop codon. β-Galactosidase synthesis from the AGAAGA lacZ constructs (in a Pth defective in vitro system without exogenous tRNA) diminished as the AGAAGA codons were closer to AUG codon. Likewise, β-galactosidase expression from the reporter +7 AGA lacZ gene (plus tRNA, 0.25 μg/μl) waned as the AGAAGAUAA minigene shortened. Pth counteracted both the length-dependent minigene effect on the expression of β-galactosidase from the +7 AGA lacZ reporter gene and the positional effect from the AGAAGA lacZ constructs. The +2, +3 AGAAGA lacZ construct and the shortest +2, +3 AGAAGAUAA minigene accumulated the highest percentage of peptidyl-tRNAArg4. These observations lead us to propose that hungry codons at early positions, albeit with less strength, inhibit protein synthesis by a minigene-like mechanism involving accumulation of peptidyl-tRNA

Coastal high-frequency radars in the Mediterranean ??? Part 1: Status of operations and a framework for future development

Due to the semi-enclosed nature of the Mediterranean Sea, natural disasters and anthropogenic activities impose stronger pressures on its coastal ecosystems than in any other sea of the world.With the aim of responding adequately to science priorities and societal challenges, littoral waters must be effectively monitored with high-frequency radar (HFR) systems. This land-based remote sensing technology can provide, in near-real time, fine-resolution maps of the surface circulation over broad coastal areas, along with reliable directional wave and wind information. The main goal of this work is to showcase the current status of the Mediterranean HFR network and the future roadmap for orchestrated actions. Ongoing collaborative efforts and recent progress of this regional alliance are not only described but also connected with other European initiatives and global frameworks, highlighting the advantages of this cost-effective instrument for the multi-parameter monitoring of the sea state. Coordinated endeavors between HFR operators from different multi-disciplinary institutions are mandatory to reach a mature stage at both national and regional levels, striving to do the following: (i) harmonize deployment and maintenance practices; (ii) standardize data, metadata, and quality control procedures; (iii) centralize data management, visualization, and access platforms; and (iv) develop practical applications of societal benefit that can be used for strategic planning and informed decision-making in the Mediterranean marine environment. Such fit-for-purpose applications can serve for search and rescue operations, safe vessel navigation, tracking of marine pollutants, the monitoring of extreme events, the investigation of transport processes, and the connectivity between offshore waters and coastal ecosystems. Finally, future prospects within the Mediterranean framework are discussed along with a wealth of socioeconomic, technical, and scientific challenges to be faced during the implementatio

Anti-tumour necrosis factor discontinuation in inflammatory bowel disease patients in remission: study protocol of a prospective, multicentre, randomized clinical trial

Background: Patients with inflammatory bowel disease who achieve remission with anti-tumour necrosis factor (anti-TNF) drugs may have treatment withdrawn due to safety concerns and cost considerations, but there is a lack of prospective, controlled data investigating this strategy. The primary study aim is to compare the rates of clinical remission at 1?year in patients who discontinue anti-TNF treatment versus those who continue treatment. Methods: This is an ongoing, prospective, double-blind, multicentre, randomized, placebo-controlled study in patients with Crohn?s disease or ulcerative colitis who have achieved clinical remission for ?6?months with an anti-TNF treatment and an immunosuppressant. Patients are being randomized 1:1 to discontinue anti-TNF therapy or continue therapy. Randomization stratifies patients by the type of inflammatory bowel disease and drug (infliximab versus adalimumab) at study inclusion. The primary endpoint of the study is sustained clinical remission at 1?year. Other endpoints include endoscopic and radiological activity, patient-reported outcomes (quality of life, work productivity), safety and predictive factors for relapse. The required sample size is 194 patients. In addition to the main analysis (discontinuation versus continuation), subanalyses will include stratification by type of inflammatory bowel disease, phenotype and previous treatment. Biological samples will be obtained to identify factors predictive of relapse after treatment withdrawal. Results: Enrolment began in 2016, and the study is expected to end in 2020. Conclusions: This study will contribute prospective, controlled data on outcomes and predictors of relapse in patients with inflammatory bowel disease after withdrawal of anti-TNF agents following achievement of clinical remission. Clinical trial reference number: EudraCT 2015-001410-1