Electron Symmetry Breaking during Attosecond Charge Migration Induced by Laser Pulses: Point Group Analyses for Quantum Dynamics

Quantum simulations of the electron dynamics of oriented benzene and Mg-porphyrin driven by short (<10 fs) laser pulses yield electron symmetry breaking during attosecond charge migration. Nuclear motions are negligible on this time domain, i.e., the point group symmetries G = D6h and D4h of the nuclear scaffolds are conserved. At the same time, the symmetries of the one-electron densities are broken, however, to specific subgroups of G for the excited superposition states. These subgroups depend on the polarization and on the electric fields of the laser pulses. They can be determined either by inspection of the symmetry elements of the one-electron density which represents charge migration after the laser pulse, or by a new and more efficient group-theoretical approach. The results agree perfectly with each other. They suggest laser control of symmetry breaking. The choice of the target subgroup is restricted, however, by a new theorem, i.e., it must contain the symmetry group of the time-dependent electronic Hamiltonian of the oriented molecule interacting with the laser pulse(s). This theorem can also be applied to confirm or to falsify complementary suggestions of electron symmetry breaking by laser pulses

The TeV Energy Spectrum of Mkn 501 Measured with the Stereoscopic Telescope System of HEGRA during 1998 and 1999

During 1997, the BL Lac object Mkn 501 went into an extraordinary state of high X-ray and TeV gamma-ray activity, lasting more than 6 months. In this paper we report on the TeV emission characteristics of the source in the subsequent years of 1998 and 1999 as measured with the Stereoscopic Cherenkov Telescope System of HEGRA (La Palma, Canary Islands). Our observations reveal a 1998-1999 mean emission level at 1 TeV of 1/3 of the flux of the Crab Nebula, a factor of 10 lower than during the year of 1997. A dataset of 122 observations hours with the HEGRA telescope system makes it possible to assess for the first time the Mkn 501 TeV energy spectrum for a mean flux level substantially below that of the Crab Nebula with reasonable statistical accuracy. Excluding the data of a strong flare, we find evidence that the 1998--1999 low-flux spectrum is substantially softer (by 0.44+-0.1(stat) in spectral index) than the 1997 time averaged spectrum. The 500 GeV to 10 TeV energy spectrum can well be described by a power law model with exponential cutoff: dN/dE ~ E^(-alpha) exp(-E/E0) with alpha=2.31+-0.22(stat), and E0=5.1 (-2.3+7.8)(stat) TeV. Within statistical accuracy, also a pure power law model gives an acceptable fit to the data: dN/dE ~ E^(-Gamma) with Gamma=2.76+-0.08(stat). After presenting the 1998-1999 TeV characteristics of the source we discuss the implications of the results.Comment: Accepted for publication in The Astrophysical Journal, Part 1, on August 4th, 200

Observations of H1426+428 with HEGRA -- Observations in 2002 and reanalysis of 1999&2000 data

The HEGRA system of imaging air Cherenkov telescopes has been used to observe the BL Lac object H1426+428 ($z=0.129$) for 217.5 hours in 2002. In this data set alone, the source is detected at a confidence level of $5.3~\sigma$, confirming this object as a TeV source. The overall flux level during the observations in 2002 is found to be a factor of $\approx 2.5$ lower than during the previous observations by HEGRA in 1999&2000. A new spectral analysis has been carried out, improving the signal-to-noise ratio at the expense of a slightly increased systematic uncertainty and reducing the relative energy resolution to $\Delta E/E\le 12$ over a wide range of energies. The new method has also been applied to the previously published data set taken in 1999 and 2000, confirming the earlier claim of a flattening of the energy spectrum between 1 and 5 TeV. The data set taken in 2002 shows again a signal at energies above 1 TeV. We combine the energy spectra as determined by the CAT and VERITAS groups with our reanalyzed result of the 1999&2000 data set and apply a correction to account for effects of absorption of high energy photons on extragalactic background light in the optical to mid infrared band. The shape of the inferred source spectrum is mostly sensitive to the characteristics of the extragalactic background light between wavelengths of 1 and 15~$\mu$mComment: 12 pages, 4 Figures, submitted to A&

DNA methylation-based classification of central nervous system tumours.

Accurate pathological diagnosis is crucial for optimal management of patients with cancer. For the approximately 100 known tumour types of the central nervous system, standardization of the diagnostic process has been shown to be particularly challenging-with substantial inter-observer variability in the histopathological diagnosis of many tumour types. Here we present a comprehensive approach for the DNA methylation-based classification of central nervous system tumours across all entities and age groups, and demonstrate its application in a routine diagnostic setting. We show that the availability of this method may have a substantial impact on diagnostic precision compared to standard methods, resulting in a change of diagnosis in up to 12% of prospective cases. For broader accessibility, we have designed a free online classifier tool, the use of which does not require any additional onsite data processing. Our results provide a blueprint for the generation of machine-learning-based tumour classifiers across other cancer entities, with the potential to fundamentally transform tumour pathology

Very high energy gamma rays from the direction of Sagittarius A*.

We report the detection of a point-like source of very high energy (VHE) -rays coincident within 1' of Sgr A *, obtained with the HESS array of Cherenkov telescopes. The -rays exhibit a power-law energy spectrum with a spectral index of and a flux above the 165 GeV threshold of m -2 s -1. The measured flux and spectrum differ substantially from recent results reported in particular by the CANGAROO collaboration

On the analysis of the vibrational Boson peak and low-energy excitations in glasses

Implications of reduction procedures applied to the low energy part of the vibrational density of states in glasses and supercooled liquids are considered by advancing a detailed comparison between the excess - over the Debye limit - vibrational density of states g(w) and the frequency-reduced representation g(w)/w^2 usually referred to as the Boson peak. Analyzing representative experimental data from inelastic neutron and Raman scattering we show that reduction procedures distort to a great extent the otherwise symmetric excess density of states. The frequency of the maximum and the intensity of the excess experience dramatic changes; the former is reduced while the latter increases. The frequency and the intensity of the Boson peak are also sensitive to the distribution of the excess. In the light of the critical appraisal between the two forms of the density of states (i.e. the excess and the frequency-reduced one) we discuss changes of the Boson peak spectral features that are induced under the presence of external stimuli such as temperature (quenching rate, annealing), pressure, and irradiation. The majority of the Boson peak changes induced by the presence of those stimuli can be reasonably traced back to simple and expected modifications of the excess density of states and can be quite satisfactorily accounted for the Euclidean random matrix theory. Parallels to the heat capacity Boson peak are also briefly discussed.Comment: To appear in J. Non-Cryst. Solids (Proceedings of the 5th IDMRCS, Lille, July 2005