The minimum free-stream wind speed for initiating motion of surface material on Mars

Estimates of the minimum free-stream wind speed that is required for initiating the motion of surficial material on Mars have ranged from 30 to about 200 meters per second. Thus the best value for this quantity is not well established. Graphical comparison of much of the pertinent data taken in the laboratory and in the field on Earth provides a minimum value for the Bagnold coefficient of 0.08 and this in turn provides a minimum value for the threshold friction velocity of 1.3 meters per second for initiating motion of particulate matter on Mars at low elevations where the pressure is 7 millibars. The most appropriate value of the ratio of friction velocity to free-stream velocity for putative unstable condition appears to be 0.026. Thus the minimum free-stream wind speed for initiating motion is obtained as 50 meters per second. If the surface material on Mars, however, is less cohesive than that on earth, the minimum value may be smaller

Ages of White Dwarf-Red Subdwarf Systems

We provide the first age estimates for two recently discovered white dwarf-red subdwarf systems, LHS 193AB and LHS 300AB. These unusual systems provide a new opportunity for linking the reliable age estimates for the white dwarfs to the (measurable) metallicities of the red subdwarfs. We have obtained precise photometry in the $V_{J}R_{KC}I_{KC}JH$ bands and spectroscopy covering from 6000\AA to 9000\AA for the two new systems, as well as for a comparison white dwarf-main sequence red dwarf system, GJ 283 AB. Using model grids available in the literature, we estimate the cooling age as well as temperature, surface gravity, mass, progenitor mass and {\it total} lifetimes of the white dwarfs. The results indicate that the two new systems are probably ancient thick disk objects with ages of at least 6-9 Gyr. We also conduct searches of red dwarf and white dwarf compendia from SDSS data and the L{\'e}pine Shara Proper Motion (LSPM) catalog for additional common proper motion white dwarf-red subdwarf systems. Only seven new candidate systems are found, which indicates the rarity of these systems.Comment: accepted for publication in Ap

Functional Imaging of the Outer Retinal Complex using High Fidelity Imaging Retinal Densitometry

We describe a new technique, high fidelity Imaging Retinal Densitometry (IRD), which probes the functional integrity of the outer retinal complex. We demonstrate the ability of the technique to map visual pigment optical density and synthesis rates in eyes with and without macular disease. A multispectral retinal imaging device obtained precise measurements of retinal reflectance over space and time. Data obtained from healthy controls and 5 patients with intermediate AMD, before and after photopigment bleaching, were used to quantify visual pigment metrics. Heat maps were plotted to summarise the topography of rod and cone pigment kinetics and descriptive statistics conducted to highlight differences between those with and without AMD. Rod and cone visual pigment synthesis rates in those with AMD (v = 0.043 SD 0.019 min-1 and v = 0.119 SD 0.046 min-1, respectively) were approximately half those observed in healthy controls (v = 0.079 SD 0.024 min-1 for rods and v = 0.206 SD 0.069 min-1 for cones). By mapping visual pigment kinetics across the central retina, high fidelity IRD provides a unique insight into outer retinal complex function. This new technique will improve the phenotypic characterisation, diagnosis and treatment monitoring of various ocular pathologies, including AMD

Comparison of Interactions Between Control and Mutant Macrophages

This paper presents a preliminary study on macrophages migration in Drosophila embryos, comparing two types of cells. The study is carried out by a framework called macrosight which analyses the movement and interaction of migrating macrophages. The framework incorporates a segmentation and tracking algorithm into analysing motion characteristics of cells after contact. In this particular study, the interactions between cells is characterised in the case of control embryos and Shot3 mutants, where the cells have been altered to suppress a specific protein, looking to understand what drives the movement. Statistical significance between control and mutant cells was found when comparing the direction of motion after contact in specific conditions. Such discoveries provide insights for future developments in combining biological experiments to computational analysis

Effects of mechanically separated dairy cow slurry on grazing performance

Abstract Inorganic fertilisers are widely used to fertilise grasslands in dairy systems. Increasing the nutrient use efficiency of slurry applied as an alternative or supplementary fertiliser could reduce the volume of purchased fertiliser. This would reduce costs and improve security of future fertiliser supply since slurry is produced on farm. Slurry separation could increase the potential for fertilising grazed grassland with slurry. This experiment compared the effects on milk yields of fertilising grazing swards with the liquid fraction of separated slurry, whole slurry or inorganic fertiliser. Three groups of 12 core cows were grazed for two 24 day rotations on 2 day paddocks between 18 and 24 days after fertiliser treatment application in a put and take design. Nutrient use efficiency was significantly higher (P<0.05) from the liquid fraction of separated slurry (12.2 kg kgN -1 ) compared to whole slurry (8.0 kg kgN -1 ) application. This effect was most likely due to a combination of improved soil infiltration and reduced sward contamination

Galactic planetary nebulae with Wolf-Rayet nuclei. II. A consistent observational data set

We present high resolution spectrophotometric data for 34 galactic planetary nebulae with [WC] nuclei (WRPNe).The sample includes PNe with early and late [WC] stars and some WELS. Physical conditions and chemical abundances have been derived and expansion velocities were estimated for most objects of the sample. A statistical study was developed to find fundamental relationships between the nebular and central star parameters.We found evidence for a strong unexpected electron temperature gradient in WRPNe which is related to nebular excitation. Abundance ratios indicate that there seems to be no preferential stellar mass for the WR phenomenon to occur in the nucleus of a planetary nebula. The PNe M 1-25 and M 1-32 were found to have very small Ne/O ratios.Our data confirm the trend of the electron density decreasing with decreasing spectral type, which was interpreted as evidence that [WC] stars evolve from late to early [WC] types. On the other hand, the expansion velocities do not show the increase with decreasing spectral type, that one might expect in such a scenario. Two objects with very late [WC] central stars, K 2-16 and PM 1-188, do not follow the general density sequence, being of very low density for their spectral types. We suggest that the stars either underwent a late helium flash (the ``born again'' scenario) or that they have had a particularly slow evolution from the AGB. The 6 WELS of our sample follow the same density vs. [WC]-type relation as the bona fide WRPNe, but they tend to have smaller expansion velocities. The comparison between the WRPNe in the Magellanic Clouds and in the Galaxy indicates that metallicity affects the [WR] phenomenon in central stars of planetary nebulae.Comment: 20 pages, including 2 figures and 3 tables. Paper accepted in Astronomy and Astrophysics, 200

A randomised trial of the effect of omega-3 polyunsaturated fatty acid supplements on the human intestinal microbiota

Objective; Omega-3 polyunsaturated fatty acids (PUFAs) have anticolorectal cancer (CRC) activity. The intestinal microbiota has been implicated in colorectal carcinogenesis. Dietary omega-3 PUFAs alter the mouse intestinal microbiome compatible with antineoplastic activity. Therefore, we investigated the effect of omega-3 PUFA supplements on the faecal microbiome in middle-aged, healthy volunteers (n=22). Design A randomised, open-label, cross-over trial of 8 weeks’ treatment with 4 g mixed eicosapentaenoic acid/docosahexaenoic acid in two formulations (soft-gel capsules and Smartfish drinks), separated by a 12-week ‘washout’ period. Faecal samples were collected at five time-points for microbiome analysis by 16S ribosomal RNA PCR and Illumina MiSeq sequencing. Red blood cell (RBC) fatty acid analysis was performed by liquid chromatography tandem mass spectrometry. Results; Both omega-3 PUFA formulations induced similar changes in RBC fatty acid content, except that drinks were associated with a larger, and more prolonged, decrease in omega-6 PUFA arachidonic acid than the capsule intervention (p=0.02). There were no significant changes in α or β diversity, or phyla composition, associated with omega-3 PUFA supplementation. However, a reversible increased abundance of several genera, including Bifidobacterium, Roseburia and Lactobacillus was observed with one or both omega-3 PUFA interventions. Microbiome changes did not correlate with RBC omega-3 PUFA incorporation or development of omega-3 PUFA-induced diarrhoea. There were no treatment order effects. Conclusion; Omega-3 PUFA supplementation induces a reversible increase in several short-chain fatty acid-producing bacteria, independently of the method of administration. There is no simple relationship between the intestinal microbiome and systemic omega-3 PUFA exposure. Trial registration number; ISRCTN18662143

Electrophysiologic actions of high plasma concentrations of propranolol in human subjects

The authors have previously shown that 40% of patients whose ventricular arrhythmias respond to propranolol require plasma concentrations in excess of those producing substantial beta-receptor blockade (> 150 ng/ml). However, the electrophysiologic actions of propranolol have only been examined in human beings after small intravenous doses achieving concentrations of less than 100 ng/ml. In this study, the electrophysiologic effects of a wider concentration range of propranolol was examined in nine patients. Using a series of loading and maintenance infusions, measurements were made at baseline, at low mean plasma propranolol concentrations (104 ± 17 ng/ml) and at high concentrations (472 ± 68 ng/ml). Significant (p < 0.05) increases in AH interval and sinus cycle length were seen at low concentrations of propranolol, with no further prolongation at the high concentrations; these effects are typical of those produced by beta-blockade. However, progressive shortening of the endocardial monophasic action potential duration and QTc interval were seen over the entire concentration range tested (p < 0.05). At high concentrations, there was significant (p < 0.05) further shortening of both the QTc and monophasic action potential duration beyond that seen at low propranolol concentrations, along with a progressive increase in the ratio of the ventricular effective refractory period to monophasic action potential duration. No significant changes were seen in HV interval, QRS duration or ventricular effective refractory period.In summary, the concentration-response relations for atrioventricular conductivity and sinus node automat-icity were flat above concentrations of 150 ng/ml. On the other hand, the durations of the monophasic action potential and the QTc interval shortened at high concentrations. It is concluded that propranolol, in addition to blocking beta-receptors, produces other beta-receptor independent electrophysiologic effects in human beings

Do Children\u27s Advocacy Centers improve families’ experiences of child sexual abuse investigations?

Abstract Objective The Children\u27s Advocacy Center (CAC) model of child abuse investigation is designed to be more child and family-friendly than traditional methods, but there have been no rigorous studies of their effect on children\u27s and caregivers’ experience. Data collected as part of the Multi-Site Evaluation of Children\u27s Advocacy Centers were used to examine whether CACs improve caregivers’ and children\u27s satisfaction with investigations. Methods Nonoffending caregiver and child satisfaction were assessed during research interviews, including the administration of a 14-item Investigation Satisfaction Scale (ISS) for caregivers. Two hundred and twenty-nine sexual abuse cases investigated through a CAC were compared to 55 cases investigated in communities with no CAC. Results Hierarchical linear regression results indicated that caregivers in CAC cases were more satisfied with the investigation than those from comparison sites, even after controlling for a number of relevant variables. There were few differences between CAC and comparison samples on children\u27s satisfaction. Children described moderate to high satisfaction with the investigation, while a minority expressed concerns about their experience. Conclusions The CAC model shows promise for improving families’ experiences, but to build upon this promise, agencies will need to systematize procedures for refining and adapting the model as new research becomes available