857 research outputs found
The POINT-AGAPE survey II: An Unrestricted Search for Microlensing Events towards M31
An automated search is carried out for microlensing events using a catalogue
of 44554 variable superpixel lightcurves derived from our three-year monitoring
program of M31. Each step of our candidate selection is objective and
reproducible by a computer. Our search is unrestricted, in the sense that it
has no explicit timescale cut. So, it must overcome the awkward problem of
distinguishing long-timescale microlensing events from long-period stellar
variables. The basis of the selection algorithm is the fitting of the
superpixel lightcurves to two different theoretical models, using variable star
and blended microlensing templates. Only if microlensing is preferred is an
event retained as a possible candidate. Further cuts are made with regard to
(i) sampling, (ii) goodness of fit of the peak to a Paczynski curve, (iii)
consistency of the microlensing hypothesis with the absence of a resolved
source, (iv) achromaticity, (v) position in the colour-magnitude diagram and
(vi) signal-to-noise ratio. Our results are reported in terms of first-level
candidates, which are the most trustworthy, and second-level candidates, which
are possible microlensing but have lower signal-to-noise and are more
questionable. The pipeline leaves just 3 first-level candidates, all of which
have very short full-width half-maximum timescale (<5 days) and 3 second-level
candidates, which have timescales of 31, 36 and 51 days respectively. We also
show 16 third-level lightcurves, as an illustration of the events that just
fail the threshold for designation as microlensing candidates. They are almost
certainly mainly variable stars. Two of the 3 first-level candidates correspond
to known events (PA 00-S3 and PA 00-S4) already reported by the POINT-AGAPE
project. The remaining first-level candidate is new.Comment: 22 pages, 18 figures, MNRAS, to appea
Cell stemness is maintained upon concurrent expression of RB and the mitochondrial ribosomal protein S18-2
Stemness encompasses the capability of a cell for self-renewal and differentiation. The stem cell maintains a balance between proliferation, quiescence, and regeneration via interactions with the microenvironment. Previously, we showed that ectopic expression of the mitochondrial ribosomal protein S18-2 (MRPS18-2) led to immortalization of primary fibroblasts, accompanied by induction of an embryonic stem cell (ESC) phenotype. Moreover, we demonstrated interaction between S18-2 and the retinoblastoma-associated protein (RB) and hypothesized that the simultaneous expression of RB and S18-2 is essential for maintaining cell stemness. Here, we experimentally investigated the role of S18-2 in cell stemness and differentiation. Concurrent expression of RB and S18-2 resulted in immortalization of Rb1â/â primary mouse embryonic fibroblasts and in aggressive tumor growth in severe combined immunodeficiency mice. These cells, which express both RB and S18-2 at high levels, exhibited the potential to differentiate into various lineages in vitro, including osteogenic, chondrogenic, and adipogenic lineages. Mechanistically, S18-2 formed a multimeric protein complex with prohibitin and the ring finger protein 2 (RNF2). This molecular complex increased the monoubiquitination of histone H2ALys119, a characteristic trait of ESCs, by enhanced E3-ligase activity of RNF2. Furthermore, we found enrichment of KLF4 at the S18-2 promoter region and that the S18-2 expression is positively correlated with KLF4 levels. Importantly, knockdown of S18-2 in zebrafish larvae led to embryonic lethality. Collectively, our findings suggest an important role for S18-2 in cell stemness and differentiation and potentially also in cancerogenesis
International variation in the definition of âmain condition' in ICD-coded health data
Hospital-based medical records are abstracted to create International Classification of Disease (ICD) coded discharge health data in many countries. The âmain condition' is not defined in a consistent manner internationally. Some countries employ a âreason for admission' rule as the basis for the main condition, while other countries employ a âresource use' rule. A few countries have recently transitioned from one of these approaches to the other. The definition of âmain condition' in such ICD data matters when it is used to define a disease cohort to assign diagnosis-related groups and to perform risk adjustment. We propose a method of harmonizing the international definition to enable researchers and international organizations using ICD-coded health data to aggregate or compare hospital care and outcomes across countries in a consistent manner. Inter-observer reliability of alternative harmonization approaches should be evaluated before finalizing the definition and adopting it worldwid
Search for exoplanets in M31 with pixel-lensing and the PA-99-N2 event revisited
Several exoplanets have been detected towards the Galactic bulge with the
microlensing technique. We show that exoplanets in M31 may also be detected
with the pixel-lensing method, if telescopes making high cadence observations
of an ongoing microlensing event are used. Using a Monte Carlo approach we find
that the mean mass for detectable planetary systems is about .
However, even small mass exoplanets () can cause
significant deviations, which are observable with large telescopes. We
reanalysed the POINT-AGAPE microlensing event PA-99-N2. First, we test the
robustness of the binary lens conclusion for this light curve. Second, we show
that for such long duration and bright microlensing events, the efficiency for
finding planetary-like deviations is strongly enhanced with respect to that
evaluated for all planetary detectable events.Comment: 14 pages, 8 figures. Paper presented at the "II Italian-Pakistani
Workshop on Relativistic Astrophysics, Pescara, July 8-10, 2009. To be
published in a special issue of General Relativity and Gravitation (eds. F.
De Paolis, G.F.R. Ellis, A. Qadir and R. Ruffini
Weak Lensing Mass Reconstruction of the Galaxy Cluster Abell 209
Weak lensing applied to deep optical images of clusters of galaxies provides
a powerful tool to reconstruct the distribution of the gravitating mass
associated to these structures. We use the shear signal extracted by an
analysis of deep exposures of a region centered around the galaxy cluster Abell
209, at redshift z=0.2, to derive both a map of the projected mass distribution
and an estimate of the total mass within a characteristic radius. We use a
series of deep archival R-band images from CFHT-12k, covering an area of 0.3
deg^2. We determine the shear of background galaxy images using a new
implementation of the modified Kaiser-Squires-Broadhurst pipeline for shear
determination, which we has been tested against the ``Shear TEsting Program 1
and 2'' simulations. We use mass aperture statistics to produce maps of the 2
dimensional density distribution, and parametric fits using both
Navarro-Frenk-White (NFW) and singular-isothermal-sphere profiles to constrain
the total mass. The projected mass distribution shows a pronounced asymmetry,
with an elongated structure extending from the SE to the NW. This is in general
agreement with the optical distribution previously found by other authors. A
similar elongation was previously detected in the X-ray emission map, and in
the distribution of galaxy colours. The circular NFW mass profile fit gives a
total mass of M_{200} = 7.7^{+4.3}_{-2.7} 10^{14} solar masses inside the
virial radius r_{200} = 1.8\pm 0.3 Mpc. The weak lensing profile reinforces the
evidence for an elongated structure of Abell 209, as previously suggested by
studies of the galaxy distribution and velocities.Comment: accepted by A&A, 15 pages, 11 figure
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Driving factors of aerosol properties over the foothills of central Himalayas based on 8.5 years continuous measurements
This study presents analysis of in situ measurements conducted over the period 2005â2014 in the Indian Himalayas to give a thorough overview of the factors and causes that drive aerosol properties. Aerosol extensive properties (namely, particle number concentration, scattering coefficient, equivalent black carbon, PM2.5, and PM10) have 1.5â2 times higher values in the early to late afternoon than during the night, and a strong seasonality. The interannual variability is ±20% for both PM2.5 and total particle number concentration. Analysis of the data shows statistically significant decreasing trends of â2.3 ÎŒg mâ3 yearâ1 and â2.7 ÎŒg mâ3 yearâ1 for PM2.5 and PM10, respectively, over the study period. The mountainous terrain site (Mukteshwar, MUK) is primarily under the influence of air from the plains. This is due to convective transport processes that are enhanced by local and mesoscale topography, leading to pronounced valley/mountain winds and consequently to atmospheric boundary layer air lifting from the plains below. The transport from plains is evident in seasonalâdiurnal patterns observed at MUK. The timing of the patterns corresponds with changes in turbulence and water vapor (q). According to our analysis, using these as proxies is a viable method for examining boundary layer influence in the absence of direct atmospheric boundary layer height measurements. Comparing the measurements with climate models shows that even regional climate models have problems capturing the orographic influence accurately at MUK, highlighting the importance of longâterm direct measurements at multiple points to understand aerosol behavior in mountainous areas
What are communities of practice? A comparative review of four seminal works
This paper is a comparative review of four seminal works on communities of practice. It is argued that the ambiguities of the terms community and practice are a source of the concept's reusability allowing it to be reappropriated for different purposes, academic and practical. However, it is potentially confusing that the works differ so markedly in their conceptualizations of community, learning, power and change, diversity and informality. The three earlier works are underpinned by a common epistemological view, but Lave and Wenger's 1991 short monograph is often read as primarily about the socialization of newcomers into knowledge by a form of apprenticeship, while the focus in Brown and Duguid's article of the same year is, in contrast, on improvising new knowledge in an interstitial group that forms in resistance to management. Wenger's 1998 book treats communities of practice as the informal relations and understandings that develop in mutual engagement on an appropriated joint enterprise, but his focus is the impact on individual identity. The applicability of the concept to the heavily individualized and tightly managed work of the twenty-first century is questionable. The most recent work by Wenger â this time with McDermott and Snyder as coauthors â marks a distinct shift towards a managerialist stance. The proposition that managers should foster informal horizontal groups across organizational boundaries is in fact a fundamental redefinition of the concept. However it does identify a plausible, if limited, knowledge management (KM) tool. This paper discusses different interpretations of the idea of 'co-ordinating' communities of practice as a management ideology of empowerment
The POINT-AGAPE survey â II. An unrestricted search for microlensing events towards M31
An automated search is carried out for microlensing events using a catalogue of 44 554 variable superpixel light curves derived from our 3-yr monitoring programme of M31. Each step of our candidate selection is objective and reproducible by a computer. Our search is unrestricted, in the sense that it has no explicit time-scale cut. So, it must overcome the awkward problem of distinguishing long time-scale microlensing events from long-period stellar variables. The basis of the selection algorithm is the fitting of the superpixel light curves to two different theoretical models, using variable star and blended microlensing templates. Only if microlensing is preferred is an event retained as a possible candidate. Further cuts are made with regard to: (i) sampling, (ii) goodness of fit of the peak to a PaczyĆski curve, (iii) consistency of the microlensing hypothesis with the absence of a resolved source, (iv) achromaticity, (v) position in the colour-magnitude diagram and (vi) signal-to-noise ratio. Our results are reported in terms of first-level candidates, which are the most trustworthy, and second-level candidates, which are possible microlensing events but have a lower signal-to-noise ratio and are more questionable. The pipeline leaves just three first-level candidates, all of which have very short full-width at half-maximum time-scales (t1/2 < 5 d) and three second-level candidates, which have time-scales of t1/2 = 31, 36 and 51 d. We also show 16 third-level light curves, as an illustration of the events that just fail the threshold for designation as microlensing candidates. They are almost certainly mainly variable stars. Two of the three first-level candidates correspond to known events (PA 00-S3 and 00-S4) already reported by the POINT-AGAPE project. The remaining first-level candidate is new. This algorithm does not find short time-scale events that are contaminated with flux from nearby variable stars (such as PA 99-N1
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