Play Behaviors of Young Children with and without Expressive Language Delay: An Exploratory Study

The association between language and play development during the early years of children’s lives is important as tremendous growth in development occurs in both at this time. Literature has suggested that if children have less developed language abilities, they may also have less developed play skills. The aim of the current exploratory study was to observe and categorize children’s play behavior using a comprehensive play assessment tool. This tool, the Play in Early Childhood Evaluation System (PIECES) coding scheme developed by Kelly-Vance and Ryalls (2005, 2014), provides information on differences in percentage of time in exploratory, simple pretend, and complex pretend play, highest levels of play behavior observed, and dimensions of social play. For the present exploratory study, six young children, three with and three without language delay, were matched in dyads. The six children ranging in age from 24-31 months. Using videotaped 40-minute play observations of each child during free play with a parent, researchers coded the play behaviors of each child using the PIECES coding scheme and interpreted findings accordingly. In two of the three participant dyads, participants with language delay spent more time in exploratory play and less time in pretend play compared to their counterparts without language delay. However, two out of the three participants had the same highest level of play as their matched peer. Participants with language delay demonstrated a lower percentage of play initiation than participants with no language delay. These results, although limited in generalization to only the participants of the study, suggest support of the positive association between play and language of young children and warrant further investigation. Additionally, this study offers a description of a play assessment approach that could be utilized with a larger participant cohort to extend this line of research as researchers continue to determine the appropriate role of play in assessment and intervention for young children with language delay

Le Forum, Vol. 45 #4

https://digitalcommons.library.umaine.edu/francoamericain_forum/1109/thumbnail.jp

The complete genome sequence of Corynebacterium pseudotuberculosis FRC41 isolated from a 12-year-old girl with necrotizing lymphadenitis reveals insights into gene-regulatory networks contributing to virulence

Trost E, Ott L, Schneider J, et al. The complete genome sequence of Corynebacterium pseudotuberculosis FRC41 isolated from a 12-year-old girl with necrotizing lymphadenitis reveals insights into gene-regulatory networks contributing to virulence. BMC Genomics. 2010;11(1): 728

Genomic Variability of Monkeypox Virus among Humans, Democratic Republic of the Congo

Monkeypox virus is a zoonotic virus endemic to Central Africa. Although active disease surveillance has assessed monkeypox disease prevalence and geographic range, information about virus diversity is lacking. We therefore assessed genome diversity of viruses in 60 samples obtained from humans with primary and secondary cases of infection from 2005 through 2007. We detected 4 distinct lineages and a deletion that resulted in gene loss in 10 (16.7%) samples and that seemed to correlate with human-to-human transmission (p = 0.0544). The data suggest a high frequency of spillover events from the pool of viruses in nonhuman animals, active selection through genomic destabilization and gene loss, and increased disease transmissibility and severity. The potential for accelerated adaptation to humans should be monitored through improved surveillance

Vaccine breakthrough hypoxemic COVID-19 pneumonia in patients with auto-Abs neutralizing type I IFNs

Life-threatening `breakthrough' cases of critical COVID-19 are attributed to poor or waning antibody response to the SARS- CoV-2 vaccine in individuals already at risk. Pre-existing autoantibodies (auto-Abs) neutralizing type I IFNs underlie at least 15% of critical COVID-19 pneumonia cases in unvaccinated individuals; however, their contribution to hypoxemic breakthrough cases in vaccinated people remains unknown. Here, we studied a cohort of 48 individuals ( age 20-86 years) who received 2 doses of an mRNA vaccine and developed a breakthrough infection with hypoxemic COVID-19 pneumonia 2 weeks to 4 months later. Antibody levels to the vaccine, neutralization of the virus, and auto- Abs to type I IFNs were measured in the plasma. Forty-two individuals had no known deficiency of B cell immunity and a normal antibody response to the vaccine. Among them, ten (24%) had auto-Abs neutralizing type I IFNs (aged 43-86 years). Eight of these ten patients had auto-Abs neutralizing both IFN-a2 and IFN-., while two neutralized IFN-omega only. No patient neutralized IFN-ss. Seven neutralized 10 ng/mL of type I IFNs, and three 100 pg/mL only. Seven patients neutralized SARS-CoV-2 D614G and the Delta variant (B.1.617.2) efficiently, while one patient neutralized Delta slightly less efficiently. Two of the three patients neutralizing only 100 pg/mL of type I IFNs neutralized both D61G and Delta less efficiently. Despite two mRNA vaccine inoculations and the presence of circulating antibodies capable of neutralizing SARS-CoV-2, auto-Abs neutralizing type I IFNs may underlie a significant proportion of hypoxemic COVID-19 pneumonia cases, highlighting the importance of this particularly vulnerable population

Stock assessment and management of cephalopods: advances and challenges for short-lived fishery resources

17 pages, 1 tableCephalopods have become an important global food source, but their sustainable management is challenged by unique life history characteristics associated with short lifespans and semelparous reproduction, high natural mortality rates, rapid and often nonasymptotic growth, and complex population structures. Weak stock-recruitment relationships together with the time-consuming work required for age validation and high-volume annual age determinations make traditional age-based modelling impractical. We propose that the best method for cephalopod assessment involves innovative depletion models, fitted with in-season data on catch numbers and fishing effort, to produce realistic estimates of stock biomass. A “fast lane” assessment approach is suggested that includes high-frequency data collection for separate, in-season stock assessments of each cohort to ensure sustainable exploitation of these short-lived resources. However, most cephalopod fisheries are data-poor and/or lack the infrastructure and resources needed to apply depletion methods; therefore, we also present alternative assessment methods that have been recently applied worldwide. We also offer suggestions for further research on the remaining challenges of cephalopod stock assessment and managementGJP and J-PR acknowledge support from the Cephs & Cephs INTERREG project (EAPA_282/2016). IP acknowledges the Agency ANID of the Government of Chile for a fellowship that partially financed his participation in this reviewPeer reviewe