12 research outputs found
Common Carp Disrupt Ecosystem Structure and Function Through Middle-out Effects
- Author
- Publication venue
- DigitalCommons@University of Nebraska - Lincoln
- Publication date
- 01/01/2017
- Field of study
Middle-out effects or a combination of top-down and bottom-up processes create many theoretical and empirical challenges in the realm of trophic ecology. We propose using specific autecology or species trait (i.e. behavioural) information to help explain and understand trophic dynamics that may involve complicated and nonunidirectional trophic interactions. The common carp (Cyprinus carpio) served as our model species for whole-lake observational and experimental studies; four trophic levels were measured to assess common carp-mediated middle-out effects across multiple lakes. We hypothesised that common carp could influence aquatic ecosystems through multiple pathways (i.e. abiotic and biotic foraging, early life feeding, nutrient). Both studies revealed most trophic levels were affected by common carp, highlighting strong middle-out effects likely caused by common carp foraging activities and abiotic influence (i.e. sediment resuspension). The loss of water transparency, submersed vegetation and a shift in zooplankton dynamics were the strongest effects. Trophic levels furthest from direct pathway effects were also affected (fish life history traits). The present study demonstrates that common carp can exert substantial effects on ecosystem structure and function. Species capable of middle-out effects can greatly modify communities through a variety of available pathways and are not confined to traditional top-down or bottom-up processes
pH-dependent structural transitions in cationic ionizable lipid mesophases are critical for lipid nanoparticle function
- Author
- Blanchet Clement E.
- Brummer Christiane
- Dabkowska Aleksandra
- Elvevold Kjetil
- Frank Kilian
- Henderson Neil
- Ibrahim Mohd
- Johansson Marie
- Johansson Svante
- Krzysztoń Rafał
- Lindfors Lennart
- Nickel Bert
- Philipp Julian
- Reiser Anita
- Rädler Joachim O.
- Schwierz Nadine
- Skantze Pia
- Skantze Urban
- Smedsrød Bård
- Sudarsan Akhil
- Östman Sofia
- Publication venue
- Publication date
- 01/01/2023
- Field of study
Lipid nanoparticles (LNPs) are advanced core-shell particles for messenger RNA (mRNA) based therapies that are made of polyethylene glycol (PEG) lipid, distearoylphosphatidylcholine (DSPC), cationic ionizable lipid (CIL), cholesterol (chol), and mRNA. Yet the mechanism of pH-dependent response that is believed to cause endosomal release of LNPs is not well understood. Here, we show that eGFP (enhanced green fluorescent protein) protein expression in the mouse liver mediated by the ionizable lipids DLin-MC3-DMA (MC3), DLin-KC2-DMA (KC2), and DLinDMA (DD) ranks MC3 ≥ KC2 > DD despite similar delivery of mRNA per cell in all cell fractions isolated. We hypothesize that the three CIL-LNPs react differently to pH changes and hence study the structure of CIL/chol bulk phases in water. Using synchrotron X-ray scattering a sequence of ordered CIL/chol mesophases with lowering pH values are observed. These phases show isotropic inverse micellar, cubic Fd3m inverse micellar, inverse hexagonal and bicontinuous cubic Pn3m symmetry. If polyadenylic acid, as mRNA surrogate, is added to CIL/chol, excess lipid coexists with a condensed nucleic acid lipid phase. The next-neighbor distance in the excess phase shows a discontinuity at the Fd3m inverse micellar to inverse hexagonal transition occurring at pH 6 with distinctly larger spacing and hydration for DD vs. MC3 and KC2. In mRNA LNPs, DD showed larger internal spacing, as well as retarded onset and reduced level of DD-LNP-mediated eGFP expression in vitro compared to MC3 and KC2. Our data suggest that the pH-driven Fd3m- transition in bulk phases is a hallmark of CIL-specific differences in mRNA LNP efficacy.publishedVersio
Evaluating the Value of the Internet for the Collection of Scientific Data (Use, Harvest, and Attitudes) From Anglers
- Author
- Publication venue
- Open PRAIRIE: Open Public Research Access Institutional Repository and Information Exchange
- Publication date
- 01/01/2014
- Field of study
Fisheries management is comprised of the biota, habitat, and human users. Appreciating the human user is critical for ensuring support for management practices (e.g., habitat alterations and fishing regulations), investigating angler effort on the landscape (e.g., site selection and consumptive choices), and to get vital political and economic support for conservation. Agencies have limited resources from which to collect stakeholder information. Entities perform surveys when data is needed from stakeholders similar to the biological surveys conducted when data is needed about fisheries. Both are necessary for limiting uncertainty during decision-making processes. Advances in survey methods provide opportunities for agencies to improve how they collect information from human users. South Dakota Game, Fish and Parks demonstrated its commitment to resource user research through eight mailed angler surveys over the last 19 years. However, internet surveys can also provide information relevant to fisheries management with lower costs and labor. Therefore, the agency has collected email addresses volunteered by a portion of license buyers for the purpose of online surveys. Email addresses allow agencies to send online survey invitations while controlling access to them. Internet survey data was compared to mail surveys of individuals not providing email addresses, and individuals not responding to the internet survey. Despite potential for bias due to incomplete email coverage and internet nonresponse, online survey data was comparable to both mail surveys. Agencies can consider appropriately conducted internet surveys as an effective stakeholder “sampling gear” when collecting information necessary for fisheries management. These results may also be applicable to other natural resource user populations including hunters, public land users, and land conservation enrollees
Common Carp Disrupt Ecosystem Structure and Function Through Middle-out Effects
- Author
- Publication venue
- DigitalCommons@University of Nebraska - Lincoln
- Publication date
- 01/01/2017
- Field of study
Middle-out effects or a combination of top-down and bottom-up processes create many theoretical and empirical challenges in the realm of trophic ecology. We propose using specific autecology or species trait (i.e. behavioural) information to help explain and understand trophic dynamics that may involve complicated and nonunidirectional trophic interactions. The common carp (Cyprinus carpio) served as our model species for whole-lake observational and experimental studies; four trophic levels were measured to assess common carp-mediated middle-out effects across multiple lakes. We hypothesised that common carp could influence aquatic ecosystems through multiple pathways (i.e. abiotic and biotic foraging, early life feeding, nutrient). Both studies revealed most trophic levels were affected by common carp, highlighting strong middle-out effects likely caused by common carp foraging activities and abiotic influence (i.e. sediment resuspension). The loss of water transparency, submersed vegetation and a shift in zooplankton dynamics were the strongest effects. Trophic levels furthest from direct pathway effects were also affected (fish life history traits). The present study demonstrates that common carp can exert substantial effects on ecosystem structure and function. Species capable of middle-out effects can greatly modify communities through a variety of available pathways and are not confined to traditional top-down or bottom-up processes
Common carp disrupt ecosystem structure and function through middle-out effects
- Author
- Allen
- Bajer
- Beal
- Borer
- Capon
- Carpenter
- Carpenter
- Craig P. Paukert
- Culver
- David W. Willis
- de Bello
- DeAngelis
- DeVries
- Duffy
- Dumont
- D�az
- Egertson
- Gabelhouse
- Glasby
- Greeney
- Greg A. Wanner
- Gulati
- Guy
- Harrison
- Jackson
- Jeffrey C. Jolley
- Jolley
- Jones
- Kaemingk
- Kaemingk
- Kjetil Henderson
- Krause
- Kufel
- Littell
- Louhi
- Mac Nally
- MacNeil
- Mapstone
- Mark A. Kaemingk
- Mark L. Lindvall
- Matsuzaki
- McDonald
- McQueen
- Meijer
- Melaas
- Miller
- Morales-Castilla
- Murphy
- Nieoczym
- Noss
- Pabian
- Pace
- Parkos
- Paukert
- Paukert
- Paukert
- Peterson
- Poff
- Richard S. Holland
- Richardson
- Scheffer
- Schmitz
- Schmitz
- Schrage
- Simberloff
- Stein
- Strong
- van Donk
- van Veen
- Vander Zanden
- Vilizzi
- Wahl
- Weber
- Weier
- Wolfe
- Wood
- Publication venue
- 'CSIRO Publishing'
- Publication date
- 01/01/2017
- Field of study
The Genesis of the Modern Eritrean Struggle (1942-1961)
- Author
- A Schiller
- Abebe Zegeye
- Ambaye Zakarayas
- Araya Tseggai
- Asnake Ali
- Assafa Jalata
- Bereket Habteselassie
- Bereket Habteselassie
- Christopher Clapham
- Christopher Clapham
- Christopher Clapham
- Dan Connell
- David Pool
- David Pool
- E R J Hussey
- Edmond Keller
- G K N Trevaskis
- Guido Bimbi
- Haggai Erlich
- Haggai Erlich
- Haile Mariam
- Harold G Marcus
- Irma Taddia
- Irma Taddia
- John Markakis
- John Markakis
- John Markakis
- Jordan Gebre-Medhin
- K D D Henderson
- Kjetil Tronvoll
- Lloyd Elligson
- Mesfin Araya
- Michael Johnson
- Negussay Ayele
- Nikolaos Biziouras
- Okbazghi Yohannes
- Patrick Gilkes
- Paul B Henze
- Richard Leonard
- Richard Lobban
- Richard Sherman
- Roy Pateman
- Roy Pateman
- Ruth Iyob
- S F Nadel
- Sally Healy
- See Gilkes
- See Habteselassie
- See Hess
- See Marcus
- See Pool
- Shiferaw Jammo
- Shumet Sishagne
- Stephen H Longrigg
- Tekeste Negash
- Tekeste Negash
- Tekie Fessehatzion
- Tekie Fessehatzion
- Tesfatsion Medhanie
- Teshale Tibebu
- V Stitz
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2012
- Field of study
Global economic burden of unmet surgical need for appendicitis
- Author
- A A Essam
- Abd El-Rahman Hegazy Khedr
- Abd Elkhalek Sallam
- Abd Elrahman Elshafay
- Abdalla Gamal Saad
- Abdalla Gharib
- Abdalla Kenibar
- Abdallah Salah Elsherbiny
- Abdalrahman Adel
- Abdelaziz Abdelaal
- Abdelaziz Osman Abdelaziz Elhendawy
- Abdelfatah Hussein
- Abdelkader Belkouchi
- Abdelmalek Hrora
- Abdelrahman Adelshone
- Abdelrahman Alkammash
- Abdelrahman Assal
- Abdelrahman Geuoshy
- Abdelrahman Haroun
- Abdelrahman Mohammed
- Abdelrahman Sayed
- Abdelrahman Soliman
- Abdelrhman Essam Elnemr
- Abdelrhman Kz Darwish
- Abdelrhman Osama Elsebaaye
- Abdul Khalique
- Abdul Rehman Alvi
- Abdul Wahid Anwar
- Abdulaziz Altwijri
- Abdullah Al-Mallah
- Abdullah Almoflihi
- Abdullah Altamimi
- Abdullah Daqeeq
- Abdullah Dwydar
- Abdullah Gouda
- Abdullah Hashim
- Abdulmalik Altaf
- Abdulmalik Huwait
- Abdulrahman Abdel-Aty
- Abdulrahman M Altwigry
- Abdulrahman Sheshe
- Abdulrasheed A Nasir
- AbdulRazzaq Oluwagbemiga Lawal
- Abdulshafi Khaled Abdrabou
- Abdurrahaman Sheshe
- Abdussemiu Abdurrazzaaq
- Abebe Bekele Zerihun
- Abeer Al-Shammari
- Abeer El Gendy
- Abeer Esam
- Abeer Marey
- Abhishek Mittal
- Abiboye Yifieyeh
- Abid Bin Mahamood
- Abidemi Adesuyi
- Abouelatta Khairy Aly
- Abrar Nawawi
- Adam Gyedu
- Ade Waterman
- Adedapo Osinowo
- Adedeji Fatuga
- Adel Albiety
- Adel B Hassanein
- Adel Denewar
- Adeleke Adekoya
- Ademola Adebanjo
- Ademola Adeyeye
- Ademola Popoola
- Adesina Adedeji
- Adesoji O Ademuyiwa
- Adesoji Tade
- Adewale Adeniyi
- Adewale O Adisa
- Adham Tarek
- Adomas Ladukas
- Adrian F Palma
- Afifatun Hasanah
- Afizah Salleh
- Afnan Abdelfatah
- Afnan Altamimi
- Afnan Altamini
- Agazi Fitsum
- Agboola Taiwo
- Ahamed Hassan
- Ahed Ghaben
- Ahmad Abdel Fattah
- Ahmad Abdel Razaq Al Rafati
- Ahmad Aboelkassem Ibrahem
- Ahmad Aldalaq
- Ahmad Ali
- Ahmad Almallah
- Ahmad Alrifaie
- Ahmad Ashour
- Ahmad Bakr
- Ahmad Bani-Sadar
- Ahmad Bin Adnan
- Ahmad Elbatahgy
- Ahmad Faraz
- Ahmad Gudal
- Ahmad Hasan
- Ahmad Khaled Sabe
- Ahmad Khoja
- Ahmad Nashaat
- Ahmad Qaissieh
- Ahmad Sabe
- Ahmad Saber Sleem
- Ahmad Sakr
- Ahmad Shalabi
- Ahmad Uzair Qureshi
- Ahmed Aamer
- Ahmed Abd El Galeel
- Ahmed Abd Elmoen Elhusseiny
- Ahmed Abd Elsameea
- Ahmed Abdelkareem
- Ahmed Abdelmotaleb Ghazy
- Ahmed Abo El Magd
- Ahmed Abo Elazayem
- Ahmed Adamu
- Ahmed Adel
- Ahmed Afandy
- Ahmed Ahmed
- Ahmed Al-Khatib
- Ahmed Alghamdi
- Ahmed Ali
- Ahmed Altibi
- Ahmed Alzahrani
- Ahmed Ata
- Ahmed Badr
- Ahmed Dahy
- Ahmed Diab
- Ahmed El Kashash
- Ahmed El Kholy
- Ahmed El-Sehily
- Ahmed Elgaili Khalid Musa
- Ahmed Elgebaly
- Ahmed Elkelany
- Ahmed Elkholy
- Ahmed Essam
- Ahmed Fahiem
- Ahmed Farag
- Ahmed Fawzy
- Ahmed Fouad
- Ahmed Gad
- Ahmed Ghanem
- Ahmed Gheith
- Ahmed Gomaa
- Ahmed Hafez El-Badri Kotb
- Ahmed Hammad
- Ahmed Hassan
- Ahmed Hossam Eldin Fouad Rida
- Ahmed Ismail
- Ahmed Karim
- Ahmed Khyrallh
- Ahmed Lasheen
- Ahmed M Rashed
- Ahmed Magdy
- Ahmed Mahmoud Abdelraouf
- Ahmed Menshawy
- Ahmed Meshref
- Ahmed Mohamed Afifi
- Ahmed Mohamed Ibrahim
- Ahmed Mohameden
- Ahmed Mohammed
- Ahmed Mokhtar
- Ahmed Mosad
- Ahmed Moustafa
- Ahmed Moustafa Saeed
- Ahmed Negida
- Ahmed Rabeih Mohammed
- Ahmed Rabie Mohamed
- Ahmed Ragab Nayel
- Ahmed Ragab Soliman
- Ahmed Raslan
- Ahmed Raza
- Ahmed Refaat
- Ahmed Rslan
- Ahmed Sabry
- Ahmed Sabry El-Hamouly
- Ahmed Safwan Marey
- Ahmed Saidbadr
- Ahmed Sakr
- Ahmed Samir
- Ahmed Shahine
- Ahmed Sheta
- Ahmed Soliman
- Ahmed Tammam
- Ahmed Tarek Abdelbaset Hassan
- Ahmed W Shamsedine
- Ahmed Zaki
- Ahmed Zaki Eldeeb
- Ahmed Zohair
- Ahmedali M Kandil
- Ahmedglal Elnagar
- Ahsan Zil-E-Ali
- Aijaz Jabbar
- Ailsa Claire Snaith
- Ainhoa Costas-Chavarri
- Aiste Austraite
- Ajayesh Mistry
- Akin Olaolorun
- Akinlabi E Ajao
- Al Faifi Jubran
- Ala Shamasneh
- Alaa Abouelnasr
- Alaa Al-Buhaisi
- Alaa Bowabsak
- Alaa El Jamassi
- Alaa Elazab
- Alaa Elhadad
- Alaa Fergany
- Alaa Habeebullah
- Alaa Hassan
- Alaa Shabkah
- Alaa Shaheen
- Alaba Adesina
- Alan Baird
- Alan Grant
- Alasdair Ball
- Alban Cacurri
- Albert Mohale Mphatsoe
- Alberto Realis Luc
- Alejandro Matheu
- Alejandro Munera
- Alemayehu Ginbo Bedada
- Alessandro Favero
- Alessio Maniscalco
- Alexander Canta Calua
- Alexander J Fowler
- Alexandra Gerosa
- Alexandre Horobjowsky
- Alexandre Venancio De Sousa
- Alexia Farrugia
- Alexis Pierre Arnaud
- Alfio Alessandro Russo
- Alfredo Gulielmi
- Ali Ababneh
- Ali Abo El Dahab
- Ali Amin Ahmed Ata
- Ali Khan Niazi
- Ali Kiasat
- Ali Mohamed Hammad
- Ali Zardab
- Ali Zeynel Abidin Balkan
- Aliaa Gamal Toeema
- Aliaa Sadek
- Aliaksandr Filatau
- Aliang Latif
- Alibeth Andres Baquero Suarez
- Alice Faure
- Alice Niragire
- Alina Robledo-Rabanal
- Aline Broch
- Alireza Hasheminia
- Alisdair Macdonald
- Aliyu Ndajiwo
- Allan Novak
- Alphonse Zeta Mutabazi
- Alvaro Enrique Mendoza Beleño
- Alvin Ee Zhiun Cheah
- Aly Abd Elrazek
- Aly Nasr
- Aly Sanad
- Alyaa Halim Elgendy
- Alyne Daltri Lazzarini Cury
- Amal Ibrahim
- Amandine Martin
- Amani Althwainy
- Amany Abouzahra
- Amany Eldosouky Mohammed
- Amar Kourdouli
- Amel Hashish
- Amerdip Birring
- Amgad Al Meligy
- Amina Abdelhamid
- Aminah Hanum Haji Abdul Majid
- Aminu Mohammad
- Amir Ait Kaci
- Amira Atef Omar
- Amira Elsawy
- Amira Hassan Bekhet
- Amira Reda
- Amjad Abu Qumbos
- Amjad Elmashala
- Ammar Gado
- Amna Mamdouh Mohamed
- Amna Mohamed
- Amoudtha Rasendran
- Amr Ahmed Saleh
- Amr Fadel
- Amr Hasan
- Amr Hassaan
- Amr Hossameldin
- Amr Muhammad Elkorashy
- Amr Tarek Hafez
- Amreen Faruq
- Amro Aglan
- Ana Cecilia Manchego Bautista
- Ana Lucia Contreras-Vergara
- Ana Maria Sandoval Barrantes
- Ana Vega Carreiro De Freitas
- Ana Vega Freitas
- Anam Rashid
- Anan Rady Abdelazeam
- Anand Kirishnan
- Anass Majbar
- Anastasia Bamicha
- Anastasios Stefanopoulos
- Anders Thorell
- Andre Das
- Andre Dubois
- Andre L Mihaljevic
- Andre Navarro
- Andrea Allegri
- Andrea Armellini
- Andrea Belli
- Andrea Bondurri
- Andrea Echevarria Rosas Moran
- Andrea Natili
- Andrea Ruzzenente
- Andrea Simioni
- Andreass Haloho
- Andrei Tanase
- Andrej Kolosov
- Andrejus Subocius
- Andrew G N Robertson
- Andrew Kirby
- Andrew Mcguigan
- Andrew Spina
- Andrey Litvin
- Andrius Burmistrovas
- Andrius Strazdas
- Andy Arenas
- Aneel Bhangu
- Anele Rudzenskaite
- Angel David Pérez Rojas
- Angela Dell
- Angelica Genoveva Vergara Mejia
- Angeline Charles
- Angelo Antoniozzi
- Angelo Benevento
- Angelos Tselos
- Angham Solaiman El-Ma'doul
- Anjana Sreedharan
- Ankur Bhatnagar
- Ann Kjellin
- Anna Lasek
- Anna Maffioli
- Anna Powell
- Anna Rinaldi
- Anna Watts
- Annalisa Lo Conte
- Annamaria Bigaran
- Annelisse Ashton
- Annisa Dewi Fitriana Mukin
- Antanas Gulbinas
- Antanas Zadoroznas
- Anthonius Santoso Rulie
- Anthony Ajiboye
- Anthony Avoka
- Anthony Chuk-Him Lai
- Anthony Davor
- Anthony Sander
- Antje Oosterkamp
- Antoinette Bediako-Bowan
- Antonella La Brocca
- Antonio Nocito
- Antonio Ramos-De La Medina
- Antonio Taddei
- Antônio Leal
- Anwar Atiyeh
- Anyomih Theophilus Teddy Kojo
- Aoife Driscoll
- Apar Shah
- Apostolos Vlachogiorgos
- April Camilla Roslani
- Aram Abdelhaq
- Arazzelly Del Pilar Paucar
- Arcangelo Picciariello
- Areej Tarek
- Arezo Kanani
- Ari Leppäniemi
- Arianna Birindelli
- Arij Ibrahim
- Arjun Nesaratnam
- Arlindawati Suyadi
- Armando José Román Velásquez
- Arnaud Bonnard
- Arnav Agarwal
- Aroub Alkaaki
- Arturas Vaicius
- Arvin Khamajeet
- Arvo Reinsoo
- Arwa Abouzaid
- Arwa Elfarargy
- Arwa Ibrahim
- Arwa Mohamed
- Asaf Kedar
- Asdaq Ahmed
- Ased Ali
- Aseel Alnusairat
- Aseel Hamarshi
- Aseel Musleh
- Ash Prabhudesai
- Ashraf A Maghrabi
- Ashraf Morsi
- Ashrarur Rahman Mitul
- Asmaa Abdel-Rahman Al-Aarag
- Asmaa Abdelgelil
- Asmaa Rezq
- Asmaa Salah
- Aspasia Papailia
- Assmaa Badwy
- Astrid Leusink
- Ata Khan
- Ataa Ahmed
- Athanasia Bamicha
- Athar Eysa
- Athirah Zulkifli
- Atif Mahdi
- Attia Attia
- Attia Mohamed Attia
- Audrey Clarissa
- Audrius Dulskas
- Audrius Parseliunas
- Augusto Zani
- Aung Kyaw Tun
- Aurel Mironescu
- Aurel Sandu Mironescu
- Aurelien Scalabre
- Aurora Mariani
- Aurore Haffreingue
- Aurore Thollot
- Ausrine Usaityte
- Austė Skardžiukaitė
- Awais Raza
- Aya Abdel Fatah Ibraheem
- Aya Aboarab
- Aya Adel Elsharkawy
- Aya El-Sawy
- Aya Elwaey
- Aya Firwana
- Aya Hagar
- Aya Hammad
- Aya Mohamed Fathy
- Aya Reda
- Aya Yehia Ata
- Ayah Hamdan
- Ayat Hassaan
- Ayman And Taher
- Ayman Elwan
- Ayman Nabawi
- Ayman Salman
- Ayman Shwky
- Ayokunle Ogunyemi
- Azher Herebat
- Azmina Verjee
- Babajide Adenekan
- Babatunde Odeyemi
- Badr Eldin Adel
- Badreldin Adel Tawfik
- Bahar Busra Ozkan
- Bakeer Mohamed
- Bakhtiar Nighat
- Bandar Albeladi
- Barbara Mijuskovic
- Barbara Pereira Silvestre
- Basant Kumar
- Basem Sieda
- Bashir Bello
- Basim Alghamdi
- Basma Magdy
- Basma Mahmoud
- Basmah Alhassan
- Bassant Mowafy
- Beatrice Brunoni
- Beatrix Weber
- Belen Sanchez
- Ben Thompson
- Benoît Parmentier
- Bernard Limoges
- Bernard Van Duren
- Bernhard Wolf
- Bertrand Dousset
- Besmir Grizhja
- Bettina Lieske
- Betty Maillot
- Billal Mansour
- Bjorn Frisk
- Bogdan Diaconescu
- Bogdan-Valeriu Martian
- Boris Marinkovic
- Brendan Skelly
- Brian Cameron
- Britta Dedekind
- Bruno Noukpozounkou
- Bryon Frankie Hon Khi Chong
- Bylapudi Seshu Kumar
- Bárbara Málaga
- Caio Vinícius Barroso de Lima
- Calogero Iacono
- Cameron Fairfield
- Camila Sanchez Samaniego
- Camilla Cona
- Camilo Lopez-Arevalo
- Caoimhe Normile
- Caranj Venugopal
- Carla Cecilia Ramã Rez Cabrera
- Carla Pierina García Torres
- Carlo Corbellini
- Carlos Alejandro Arroyo Basto
- Carlos Iván Pérez Velásquez
- Carlos Morales
- Carlos Nsengiyumva
- Carlos Paz Galvez
- Carmen Capito
- Carmen Fernández
- Carmina Diaz-Zorrilla
- Carolina Guzmán Dueñas
- Carolina Oliveira Felipe
- Caroline Clifford
- Caroluce K Musyoka
- Catherine A Shaw
- Cathy Magee
- Cecile Muller
- Cecilia Costa
- Cecilia Tolg
- Cecilia Wredberg
- Celeste Del Basso
- Cesar Augusto Azmitia Mendizabal
- Cesar Miranda
- Cesar Razuri
- Cezar Ciubotaru
- Chali Chibuye
- Challine Alexandre
- Charing Cheuk Ling Szeto
- Charles Dally
- Charlotte Jane Mcintyre
- Chaymae Benyaiche
- Chean Leung Chong
- Chee Siong Wong
- Cheewei Gan
- Chelise Currow
- Chelsea Deane
- Cheng Chun Goh
- Cherry Koh
- Cheryl Ou Yong
- Chetan Khatri
- Chi Chung Foo
- Chi Ying Jacquelyn Fok
- Chia Kong
- Chiara Ceriani
- Chimwemwe Kwatiwani
- Chingwan Yip
- Chintya Tedjaatmadja
- Choon Seng Chong
- Chouikh Taieb
- Choy Ling Tan
- Chris Bode
- Chris Lee
- Christel Leanne Almanon
- Christian Hinojosa
- Christian Lari Coompson
- Christin Schoewe
- Christina Neophytou
- Christina P Major
- Christina Panteli
- Christine Mizzi
- Christoforos Ferousis
- Christopher Bode
- Christos Agalianos
- Christos Anthoulakis
- Christos Barkolias
- Christos Dervenis
- Chu-Ann Chai
- Chui Yee Wong
- Ciara Fahy
- Cicilia Viany Evajelista
- Cirugia De Emergencia
- Ciskje Zarb
- Citra Dewi Mohd Ali
- Claire Sharpin
- Clara Milagros Herrera Puma
- Clare M Rees
- Clare Morgan
- Claudia Reali
- Claudio Arcudi
- Claudio Fermani
- Claudio Gabriel Fermani
- Clemens Nawara
- Clement Onuoha
- Clodagh Mangan
- Colleen Sampson
- Collins Nwokoro
- Colombani Jean-Francois
- Constantinos Marinos
- Cornelius Mukuzunga
- Corrado Bottini
- Craig Gouldthorpe
- Crislee Elizabeth Lopez
- Cristina Fernandes
- Crystal Yern Nee Chow
- Cutting Edge Manipal
- Céline Grosos
- D C Grobler
- D M Cocker
- Dale Vimalachandran
- Dalia Alkhabbaz
- Dalia Hemeda
- Damien Brown
- Damir Ljuhar
- Dan L Deckelbaum
- Dana Jaradat
- Danelo Du Plessis
- Daniel Ardian Soeselo
- Daniel Cox
- Daniel Dabessa
- Daniel Estuardo Marroquín Rodríguez
- Daniel Hamill
- Daniel Nel
- Daniel Youssef
- Daniela Magri
- Daniele Angelieri
- Daniele Gui
- Danilo Herrera Cruz
- Danjuma Sale
- Dansou Gaspard Gbessi
- Dario Andreotti
- Darius Kazanavicius
- Darragh McCullagh
- David Mcnish
- David Merlini
- David Monterroso Cohen
- Davide De Boni
- Davide Rossi
- Davies Justine
- Dayang Nita Abdul Aziz
- Debora Schivo
- Deborah Chiesa
- Deimante Mikuckyte
- Deividas Dragatas
- Demi Gray
- Diaa Eldin Abdelazeem Amin Elsorogy
- Diaa Moustafa Elbendary Elsawahly
- Diaaaldin Zahran
- Diana Duarte Cadogan
- Diana Sanchez
- Dickson Bandoh
- Diego Alonso Romani Pozo
- Diego Antezana
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- Mohamed Kelany
- Mohamed Mabrouk
- Mohamed Magdy
- Mohamed Mahmoud
- Mohamed Moamen Mohamed
- Mohamed Moaty
- Mohamed Mostafa
- Mohamed Mustafa
- Mohamed Nashat
- Mohamed Nazir
- Mohamed Reda Loaloa
- Mohamed Rezal Abdul Aziz
- Mohamed Sabry Ammar
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- Mohamed Salah Elhelbawy
- Mohamed Seisa
- Mohamed Shaalan
- Mohamed Sleem
- Mohamed Sobhi Jabal
- Mohamed Youssef
- Mohamed Zidan
- Mohamedraed Elshami
- Mohammad Abdulkhalek Habeeb
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- Mohammad Adawi
- Mohammad Alherz
- Mohammad Aliyu
- Mohammad Elsayed Omar
- Mohammad Ghannam
- Mohammad Ghassan Alwafai
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- Mohammadasim Amjad
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- Mohammed Mousa Salem
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- Mohammed Nasr
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- Mohammed Osman Dablouk
- Mohammed Saeed
- Mohammed Saleh A Alghamdi
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- Morgan Haines
- Morton Dion G
- Morvarid Ashtari
- Mostada Samy
- Mostafa Abdelkader
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- Mostafa Qenawy
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- Mostafa Shalaby
- Mousa Mustafa
- Moustafa Ibrahim Mahmoud
- Moustafa R Aboelsoud
- Msafiri Kimaro
- Muayad Ahmed Alfarsi
- Muhamed M H Farhan-Alanie
- Muhammad Adil
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- Muhammad Amsyar Auni Lokman
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- Sylvie Mochet
- Syrine Rekhis
- T Ariani Widiastini
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- Tewodros Worku
- Thamer Nouh
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- Thomas Tetens Moe
- Thuraya Alzayat
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- Tina Gaarder
- Tobias Schuetz
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- Tony Mak
- Toqa Khafagy
- Torhild Veen
- Trude Beate Wold
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- Tuan Nur'Azmah Tuan Mat
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- Tzu-Ling Chen
- Uday Muddebihal
- Ufuk Karabacak
- Ulf Gunnarsson
- Ulf Gustafsson
- Umar Muktar
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- Umme Salma
- Usama Hantour
- Uthman Alamoudi
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- Valentine Parent
- Vanessa Dina Palomino Castillo
- Vanessa Msosa
- Vania Guglielmo
- Vania Silvestri
- Vasileios Despotidis
- Vasileios Kalles
- Vasiliki Soulou
- Vassilis Kalles
- Veereanna Shatkar
- Venerand Barendegere
- Veronica Grassi
- Veronica Lazzari
- Vicky Jennings
- Victor Dassah
- Victor Etwire
- Victor Kong
- Victor Manuel Quintero Riaza
- Victor Nwinee
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- Vijaid Upadhyaya
- Vijay Gadhvi
- Viktorija Ambrozeviciute
- Viktorija Nevieraite
- Ville Sallinen
- Vimalakanthan Thanusan
- Vincas Jonas Banaitis
- Virgilijus Beisa
- Viviana Sollazzo
- Vivien Graffieille
- Vizir Jean Paul Nsengimana
- Vladimir Khokha
- Vollmer Sebastian
- Vu Thanh Hien Le
- Vytautas Gaižauskas
- Vytautas Lipnickas
- Wahid Anwer
- Wai Cheong Soon
- Wai Him Lam
- Wairimu Ndegwa
- Waleed Thabet
- Walid Adham
- Walter Forno
- Walter Ruiz Panez
- Wan Nurul 'Ain Wan Mohd Nasir
- Wanigasekara Senanayake Mudiyanselage Kithsiri Janakantha Senanayake
- Ward Hamsho
- Wasim Dar
- Wedyan Alhazmi
- Wei Guo
- Weiguang Ho
- Weihei Dao
- Wendy Leslie Messa Aguilar
- Wennweoi Goh
- Wifanto Saditya Jeo
- Wilfredo Pino
- William Appeadu-Mensah
- William Beasley
- William Bonney
- William Hutch
- William J Lossius
- William Milligan
- Willy Alcca Ticona
- Wing Sum Li
- Witold Chachulski
- Xavier Delforge
- Xianelle Rodriguez
- Xinwei Low
- Xue Wei Chan
- Ya Theng Neo
- Yacoubou Imorou Souaibou
- Yahaya Ukwenya
- Yahya Salama
- Yaseen Rajjoub
- Yasmein Ibrahim
- Yasmin Abd-Elrasoul
- Yasmin Elfouly
- Yasmin Hegazy
- Yasmin Soliman
- Yasser Abd El Salam
- Yee Wen Tan
- Yehia Zakaria
- Yella Reddy
- Yi Koon Tan
- Yi Ting Mok
- Yih Jeng Cheong
- Yiing Yee Gan
- Yishan Der
- Yogendra Praveen Mogan
- Yomna Allam
- Yomna Hosny Asar
- Yong Yong Tew
- Yousef Abuowda
- Yousra El Shoura
- Ysabel Esthefany Alejos Bermúdez
- Yuk Hong Eric Cheung
- Yuksel Altinel
- Yung Kok Ng
- Yuri Macchitella
- Yves Aigrain
- Yücel Cengiz
- Zaher Mikwar
- Zahra Jaffry
- Zain Ali Khan
- Zainab Iftikhar
- Zaynab M Elsayed
- Zhongtao Zhang
- Zi Hao Sam
- Zigmantas Urniežius
- Zilvinas Dambrauskas
- Zineb Bentounsi
- Zygimantas Tverskis
- Publication venue
- 'Oxford University Press (OUP)'
- Publication date
- 01/01/2022
- Field of study
Background There is a substantial gap in provision of adequate surgical care in many low- and middle-income countries. This study aimed to identify the economic burden of unmet surgical need for the common condition of appendicitis. Methods Data on the incidence of appendicitis from 170 countries and two different approaches were used to estimate numbers of patients who do not receive surgery: as a fixed proportion of the total unmet surgical need per country (approach 1); and based on country income status (approach 2). Indirect costs with current levels of access and local quality, and those if quality were at the standards of high-income countries, were estimated. A human capital approach was applied, focusing on the economic burden resulting from premature death and absenteeism. Results Excess mortality was 4185 per 100 000 cases of appendicitis using approach 1 and 3448 per 100 000 using approach 2. The economic burden of continuing current levels of access and local quality was US 92492millionusingapproach1and73 141 million using approach 2. The economic burden of not providing surgical care to the standards of high-income countries was 95004millionusingapproach1and75 666 million using approach 2. The largest share of these costs resulted from premature death (97.7 per cent) and lack of access (97.0 per cent) in contrast to lack of quality. Conclusion For a comparatively non-complex emergency condition such as appendicitis, increasing access to care should be prioritized. Although improving quality of care should not be neglected, increasing provision of care at current standards could reduce societal costs substantially
Global economic burden of unmet surgical need for appendicitis
- Author
- Aahlin Eirik Kjus
- Aamer Ahmed
- Aaniana Kenneth
- Ababneh Ali
- Abaliksta Tomas
- Abantanga Francis
- Abbas Mohamed
- Abbasy Jibran
- Abbo Olivier
- Abbouch Meryem
- Abd-Elmawla Manar
- Abd-Elrasoul Yasmin
- Abdallah Emad
- Abdel-Aty Abdulrahman
- Abdel-Hameed Noran
- Abdel-Kader Sara Mahmoud
- Abdel-Wahab Nehal Yosri Elsayed
- Abdelaal Abdelaziz
- Abdelaty Mohamed
- Abdelazeam Anan Rady
- Abdelazim Galaleldin
- Abdelaziz Mohamed A
- Abdelbadeai Kholoud
- Abdelfatah Afnan
- AbdelFattah Ibrahim
- Abdelgelil Asmaa
- Abdelghany Sarah
- Abdelhady Samar
- Abdelhamed Rasha
- Abdelhamid Amina
- Abdelhaq Aram
- Abdelkader Mostafa
- Abdelkader Omar
- Abdelkareem Ahmed
- Abdelkhalek Mohamed
- Abdelmageed Eman
- Abdelmotaleb Ibrahem
- Abdelraheim Mohamed
- Abdelraouf Ahmed Mahmoud
- Abdelrouf Doaa Maher
- Abdelshafy Mahmoud
- Abdelshakour Mahmoud
- Abdrabou Abdulshafi Khaled
- Abdul-Latif Saiba
- Abdulaziz Hager
- Abdulbagi Omar
- Abdulgawad Mahmoud
- Abdulhakeem Eman Mahmoud
- Abdullah Mohamed Abozed
- Abdullah Nik Azim Nik
- Abdullah Noha
- Abdullahi Lawal
- Abdurrazzaaq Abdussemiu
- Abebe Nebiyou Seyoum
- Abebe Nebyou Seyoum
- Abem Owusu Emmanuel
- Abiola Olajide
- Aboarab Aya
- Aboelella Majed
- Aboelmagd Omnia
- Aboelsoud Moustafa R.
- Aboraya Metwally
- Aboraya Mohammad
- Abouelnasr Alaa
- Aboul-Naga Mariam Saad
- Abouzahra Amany
- Abouzaid Arwa
- Abozaid Mohamed
- Abozeid Khaled
- Abozyed Mahmoud Ahmed Fathi
- Abu-toyour Maram
- Abubakr Marwan
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- Elnemr Abdelrhman Essam
- Elrazek Aly Abd
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- Elsawy Amira
- Elsayed Makki
- Elsayed Mohammed
- Elsayed Nada Ahmed Reda
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- Farfan Erick Samuel Florez
- Farhad Mustafa
- Farhan-Alanie Muhamed M H
- Farinella Eriberto
- Farmakis Konstantinos
- Farouk Sara Amr Mohamed
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- Fergusson Stuart J
- Fermani Claudio
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- Fowler Alexander J
- Fozard Thomas
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- Furqan Muhammad Mohsin
- Gaafar Shireen
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- Gadelkarim Mohamed
- Gadhvi Vijay
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- Sacco Michele
- Sacco Rosario
- Sadek Aliaa
- Sadig Nawal
- Saeed Ahmed Moustafa
- Saeed Manar
- Saeed Mohammed
- Safa Hisham
- Sahel Sarah
- Saidbadr Ahmed
- Saied Ghiath Al
- Sakr Ahmad
- Sakr Ahmed
- Sakr Rokia
- Salah Asmaa
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- Salah Mohamed
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- Salah Osama Mohamed
- Salam Yasser Abd El
- Salama Mahmoud
- Salama Mai
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- Sale Danjuma
- Saleh Amr Ahmed
- Saleh Omar
- Salem Hosni Khairy
- Salem Menatalla
- Salem Mohammed Mousa
- Sallam Abd Elkhalek
- Salleh Afizah
- Sallinen Ville
- Salma Mahmoud
- Salma Umme
- Salman Ayman
- Salusso Paola
- Sam Zi Hao
- Samalavicius Narimantas E.
- Samaniego Camila Sanchez
- Samaraweera Dulan Irusha
- Samih Hisham
- Samir Ahmed
- Samison Luc Hervé
- Sammarco Giuseppe
- Sammut Keith
- Sampson Colleen
- Samson Garba
- Samuel Sani Ali
- Samy Mostada
- Samy Mostafa
- Samy Sarah
- Sanad Aly
- Sanchez Belen
- Sanchez Diana
- Sander Anthony
- Sandler Simone
- Santos Diogo Vinicius dos
- Saqlain Muhammad
- SAR Hong Kong
- Saravia Fridiz
- Sarmah Panchali
- Sarsik Sameh
- Sarwary Sayed
- Sasia Diego
- Satoskar Rajeev
- Satoskar Savni
- Sauvat Frederique
- Saverio Salomone Di
- Saw Jian Er
- Sayed Abdelrahman
- Sayed Farrag
- Sayed Gehad Samir El
- Sayed Islam Magdy El
- Sayed Marwa
- Sayma Eman Adel
- Scalabre Aurelien
- Schadde Erik
- Schiavone Roberto
- Schivo Debora
- Schmid Roger
- Schmitt Françoise
- Schoewe Christin
- Schuetz Tobias
- Schultz Johannes Kurt
- Scicluna Ruth
- Segundo Luiz Carlos Barros De Castro
- Seif Mostafa
- Seifelnasr Osama
- Seisa Mohamed
- Seisay Sam
- Selvaggi Francesco
- Selvaggi Lucio
- Semeda Nourhan
- Senanayake Wanigasekara Senanayake Mudiyanselage Kithsiri Janakantha
- Servin Gustavo Rodolfo Pertersen
- Setiawan Jonny
- Seto Djifid Morel
- Seyoum Nebyou
- Sfougaris Dimitrios
- Sgroi Giovanni
- Shaalan Mohamed
- Shabkah Alaa
- Shachykava Tatsiana
- Shah Apar
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- Shah Rohi
- Shaharuddin Shahadatul
- Shaheen Alaa
- Shahine Ahmed
- Shahzad Noman
- Shaikh Nihaal
- Shaker Heba
- Shaker Ramadan
- Shaker Ramdan
- Shakshouk Hend Adel Gawad
- Shalabi Ahmad
- Shalaby Mahmoud
- Shalaby Mostafa
- Shamasneh Ala
- Shamsedine Ahmed W.
- Shamsi Ghina Shamim
- Sharpin Claire
- Shatkar Veereanna
- Shaw Catherine A
- Shawki Marwan
- Shawky Martina Yusuf
- Shawqi Muhammad
- Sheehan Jacqueline
- Shehata Sherif
- Sherman Thomas
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- Sheshe Abdurrahaman
- Sheta Ahmed
- Shimy Gamal
- Shiwani Haaris A.
- Shiwani Hunain
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- Siguantay Miguel
- Sii Samuel S. Y.
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- Sila George Manrique
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- Silvani Paolo
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- Silvestri Vania
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- Sleem Mohamed
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- Snyder Elizabeth
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- Soeselo Daniel Ardian
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- Soley Rafael
- Soliman Abdelrahman
- Soliman Ahmed
- Soliman Ahmed Ragab
- Soliman Noha Abdullah
- Soliman Nourhan
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- Soliman Yasmin
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- Sollazzo Viviana
- Song Jiheon
- Soon Wai Cheong
- Souaibou Yacoubou Imorou
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- Spence Richard
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- Sroor Fathy
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- Staerkle Ralph F
- Starr Nichole
- Steccanella Francesca
- Stefanopoulos Anastasios
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- Strupas Kestutis
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- Styles Kristian
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- Subocius Andrejus
- Suleiman Siyaka Itopa
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- Swann Joanna
- Syibrah Khuzaimah Zahid
- Sykes Mark
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- Szeto Kylie Joan-yi
- Søreide Jon Arne
- Søreide Kjetil
- Tabiri Stephen
- Tackie Enoch
- Taddei Antonio
- Tade Adesoji
- Taha Emad Mohamed Saeed
- Tahboub Haya
- Taher Ayman And
- Taher Mustafa Mohammed
- Taieb Chouikh
- Taiwo Agboola
- Taiwo Ogechukwu
- Talaat Muhammed
- Tale Fernando
- Tale Luis
- Talukder Shagorika
- Talving Peep
- Tammam Ahmed
- Tan Choy Ling
- Tan Jessica Juliana
- Tan Joel Kin
- Tan Keith Say Kwang
- Tan Ryan Choon Kiat
- Tan Yee Wen
- Tan Yi Koon
- Tanase Andrei
- Tarek Adham
- Tarek Areej
- Tarek Dina
- Targa Simone
- Tariq Sherif
- Tata Mahadevan Deva
- Tatagiba Luiza Sarmento
- Tawfik Badreldin Adel
- Tawfik Gehad
- Teasdale Ella
- Tedeschi Umberto
- Tedjaatmadja Chintya
- Telfah Muwaffaq Mezeil
- Tembo Thelma
- Temoche Edilberto
- Teo Shuang Yi
- Tessera Gaetano
- Teufelberger Gerfried
- Tew Yong Yong
- Tewari Shirish
- Thabet Waleed
- Thanusan Vimalakanthan
- Tharmalingam Shivanee
- Theodosopoulos Theodosios
- Thollot Aurore
- Thomas Efeson
- Thomas Hannah S
- Thompson Ben
- Thorarinsdottir Hildur
- Thorell Anders
- Thorsen Kenneth
- Ticona Willy Alcca
- Timothy Oyediran Kehinde
- Ting Jesse Ron Swire
- Toeema Aliaa Gamal
- Toit Frederick Du
- Tolba Hager
- Tolg Cecilia
- Tolonen Matti
- Tolotra Todisoa Emmanuella Christina
- Tori Sayeeda Aktar
- Torres Carla Pierina García
- Torres Shalon Guevara
- Trompetto Mario
- Tselos Angelos
- Tshisola Serge Kapenda
- Tugnoli Gregorio
- Tun Aung Kyaw
- Tun Myint
- Turati Luca
- Turkustani Sondos
- Turner Megan
- Tutino Roberta
- Tverskis Zygimantas
- Tyler Robert
- Tze R. Goh Ern
- Tze Reuben Goh Ern
- Tzikos Georgios
- Ubiali Paolo
- Ugalde Paul
- Ukwenya Yahaya
- Uluşahin Mehmet
- Upadhyaya Vijaid
- Upchurch Emma
- Urbanavicius Linas
- Urniežius Zigmantas
- Urquizu Mario Contreras
- Usaityte Ausrine
- Uščinas Laimonas
- Utter Maria
- Uzabumwana Norbert
- Vaicius Arturas
- Valcarcel-Saldaña María
- Valioulis Ioannis
- Vargas Marvin
- Varkalys Karolis
- Vartic Mihaela
- Vasquez Giorgio
- Vasquez Idelso
- Veen Torhild
- Vega Gustavo Miguel Machain
- Velasquez Ricardo
- Velásquez Armando José Román
- Velásquez Carlos Iván Pérez
- Vella-Baldacchino Martinique
- Venclauskas Linas
- Vendramin Elena
- Venskutonis Donatas
- Venugopal Caranj
- Verjee Azmina
- Vermaas Maarten
- Veronese Ezio
- Vianna Julia Guasti Pinto
- Vicario Erika
- Vida Lucian Corneliu
- Vilčinskas Mantas
- Villa Roberta
- Villalobos Santiago
- Vimalachandran Dale
- Vincent Joe
- Violi Paola
- Višinskas Petras
- Vivekanantham Sayinthen
- Vlachogiorgos Apostolos
- Vollmer Sebastian
- Voulgaris Evangelos
- Wael Noha
- Wagener Mark
- Waleed Hamza
- Walędziak Maciej
- Walsh Michael
- Waqar Muhammad
- Warda Mahmoud
- Warren Oliver
- Waterman Ade
- Watts Anna
- Weber Beatrix
- Weber Per
- Weiser Thomas G
- Wheeler James
- Whitaker John
- White Timothy
- Whitehurst Katharine
- Wiborg Joachim
- Widiastini T Ariani
- Wild Jonathan R L
- Williams Omolara
- Wilson Ling
- Wilson Michael
- Witherspoon Paul
- Wogensen Fredrik
- Woin Evelina
- Wold Trude Beate
- Wolf Bernhard
- Wondimu Sahlu
- Wondoh Paul
- Wong Chee Siong
- Wong Chui Yee
- Wong Hong Yee
- Wood Greta
- Woodward Helen
- Worku Mengistu
- Worku Tewodros
- Wredberg Cecilia
- Wright Naomi J
- Xerri Thelma
- Yahaya Muhammad Taqiyuddin
- Yakubu Musah
- Yam Sir Young
- Yang James
- Yaseen Tahir
- Yaseen Tahir Muhammad
- Yavuz Mehmet Ali
- Ye Joselyn
- Yeang Li Jing
- Yeo Lee Shi
- Yeung Man Hon Andrew
- Yifieyeh Abiboye
- Yip Chingwan
- Yip Sebastian Bernardo Shu
- Ymeri Shpetim
- Yoganathan Pigeneswaren
- Yong Cheryl Ou
- Yong Guo Liang
- Youssef Daniel
- Youssef Haney
- Youssef Mohamed
- Youssif Jehad Hassan
- Yuksek Mahmut Arif
- Yusufali Taha
- Zaa'treh Rula
- Zachariades Dimitris-Christos
- Zadoroznas Antanas
- Zahran Diaaaldin
- Zakaria Esraay
- Zakaria Mahmoud
- Zakaria Yehia
- Zaki Ahmed
- Zalabia Mohamed F
- Zamarin Kresimir
- Zammit Stefan
- Zampitis Nikolaos
- Zani Augusto
- Zanini Nicola
- Zapata Felipe
- Zarb Ciskje
- Zardab Ali
- Zegarra Sergio
- Zerihun Abebe Bekele
- Zhang Zhongtao
- Zheng Fei
- Zidan Hagar
- Zidan Mohamed
- Ziff Oliver
- Zil-E-Ali Ahsan
- Zohair Ahmed
- Zuber Markus
- Zulkifli Athirah
- Žilinskas Justas
- Žilinskienė Reda
- Žiubrytė Greta
- Publication venue
- Publication date
- 01/01/2022
- Field of study
Background There is a substantial gap in provision of adequate surgical care in many low- and middle-income countries. This study aimed to identify the economic burden of unmet surgical need for the common condition of appendicitis. Methods Data on the incidence of appendicitis from 170 countries and two different approaches were used to estimate numbers of patients who do not receive surgery: as a fixed proportion of the total unmet surgical need per country (approach 1); and based on country income status (approach 2). Indirect costs with current levels of access and local quality, and those if quality were at the standards of high-income countries, were estimated. A human capital approach was applied, focusing on the economic burden resulting from premature death and absenteeism. Results Excess mortality was 4185 per 100 000 cases of appendicitis using approach 1 and 3448 per 100 000 using approach 2. The economic burden of continuing current levels of access and local quality was US 92492millionusingapproach1and73 141 million using approach 2. The economic burden of not providing surgical care to the standards of high-income countries was 95004millionusingapproach1and75 666 million using approach 2. The largest share of these costs resulted from premature death (97.7 per cent) and lack of access (97.0 per cent) in contrast to lack of quality. Conclusion For a comparatively non-complex emergency condition such as appendicitis, increasing access to care should be prioritized. Although improving quality of care should not be neglected, increasing provision of care at current standards could reduce societal costs substantially
Global variation in postoperative mortality and complications after cancer surgery: a multicentre, prospective cohort study in 82 countries
- Author
- A Yacoub Mina
- A. Adam Mohammed
- A. Nassar Mahmoud
- A.Nemer Ayoob
- Aahlin Eirik Kjus
- Ab Rahim Mohd Fadliyazid
- Abad Gurumeta Alfredo
- Abad-Motos Ane
- Abang Jamari Dyg Zahratul Hamrak
- Abantanga Francis
- Abarca Sol
- Abazid Eias
- Abbas Abbas
- Abbas Khalid
- Abbas Mohammad Monir
- Abbasy Jibran
- Abbosh Ali
- Abd Karim Muhammad Fairuz Shah
- Abd Wahab Haidar Hadri
- Abd Barook
- Abdalei Abdulwahab
- Abdalla Ahmed Elkamel Ahmed
- Abdallah Aya
- AbdAllah Mostafa Salim Mohamed
- Abdel Malik Abu Baker
- Abdelhady Mousa Heba
- Abdelhady Samar
- Abdelhakim Ahmed
- Abdelkader Muhammad
- Abdelkawy Shaza
- Abdelkhalek Mohamed
- Abdellatif Esraa
- Abdelmaksoud Tawakel Noura
- Abdelmohsen Naglaa
- Abdelmotaleb Ibrahem
- Abdelrazek Aly
- Abdelsalam Israa
- Abdelshakour Mahmoud
- Abdelwahed Ahmed Mohamed
- Abdou Abdulrahman Osama
- Abdou Alrawy
- Abdou Hossam
- Abdul Aziz Mohamed Rezal
- Abdul Aziz Nora
- Abdulgawad Almogy Mariam
- Abdulla Mazin A.
- Abdullah Muhammad Tariq
- Abdullahi Lawal
- Abdullayev Seymur
- Abed Saeed
- Abelló David
- Abiola Olajide
- Abo mahadi Asmaa'
- Abo-khammash Areej
- Abou Chaar Mohamad K.
- Abou El.soud Moustafa Ramadan
- Abouelsoad Nervana
- Abraham Joyner
- Abreu da Silva Alberto
- Abu Ahammala Ayman B.
- Abu Al Amrain Mahmoud
- Abu Al-saleem Hasan
- Abu Alamrain Abdulwhhab
- Abu Alqumboz Amjad
- Abu Ataya Ahmed
- Abu hallalah Muad fathi khalleefah
- Abu Jamie Najlaa
- Abu Jayyab Israa
- Abu shua'ib Rana
- Abu Zainah Baraa
- Abu-Nimeh Samar
- Abu-Rous Mohammed R.
- Abu-srour Abrar
- Abuelhatal Hasan
- Abuelqomboz Ayham
- Abuhilal Baseel
- Abuhlaiga Ma'aly
- Abujamra Saleh
- Abukhalaf Sadi A.
- Abusalem Lana
- AbuSirrees Mahmoud
- Acevedo Veronica
- Acharya Rajgopal
- Achkasov Sergey
- Acosta Eric
- Adamo Karin
- Adamou Harissou
- Adams Jamie
- Adams Lawrence
- Adawi Samer
- Adebanjo Ademola
- Adel Marina
- Adel Sawsan
- Ademuyiwa Adesoji
- Ademuyiwa Adesoji
- Adenuga Adedire
- Aderounmu Adewale
- Adesanya Opeoluwa
- Adesina Alaba
- Adesunkanmi Abdul-Rashid
- Adeyeye Ademola
- Adidharma Peter
- Adisa Adewale O
- Adnan Nour
- Afifi Amr Abdelghani
- Afifi Eman
- Afolayan Michael Olatunji
- Afzal Asma
- Agarwal Arnav
- Agarwal Raksheeth
- Agbakwuru Augustine
- Agbeko Anita Eseenam
- Aguilar Martinez Maria Del Mar
- Aguilera Maria Lorena
- Aguilera-Arevalo Maria-Lorena
- Ahlqvist Sandra
- Ahmad Izzuddin Ahmad Imran
- Ahmad Kasim
- Ahmad Sarwat
- Ahmed Ahmedgaber
- Ahmed Hazem Abdelkarem
- Ahmed Mariam
- Ahmed Nabila
- Ahmed Zahra
- Ainoa Eppu
- Aithie Joanna M S
- Ajani Costanza
- Ajao Akinlabi
- Ajiboye Anthony
- Ajmera Ankit
- Akande Oluwatosin
- Akaydin Elif
- Akbaba Ata Cem
- Akbar Sana Amir
- Akeel Nouf
- Akeem Aderogba Adeleke
- Akin Alp
- Akinkuolie Akinbolaji
- Akisheva Aygulya
- Akitikori Mabel Temisanren
- Akrida Ioanna
- Aktas Melik Kagan
- Al basos Iyad
- Al Farsi Maryam
- Al Nassrallah Majdi
- Al Sagheir Eman
- Al Saqqa Sara
- Al Saqqa Sara
- Al-Allaf Omar
- Al-Busaidi Ibrahim S.
- Al-Dhufri Ali
- Al-Himyari Hamza S.
- Al-Masri Mahmoud
- Al-Najjar Hani
- Al-Sabbagh Yusra
- Al-Shwaikh Samar
- Al-Slaibi Ibrahim
- Al-Taher Raed
- Al-Tammam Hiba
- Alabuzidi Aya
- Alagha Othman
- Alammarin Mohammad
- Alapatt John
- Alasttal Mohammed
- Alatise Olusegun Isaac
- Albaggar Marwa
- Albahnasawi Moath A.
- Albati Naif
- Alberga Anna
- Alberts Justin
- AlBsoul Ahmad
- Albsoul Nader
- Alcorta Rodrigo
- Alejandre Villalobos Cristina
- Alemdag Gökçe nur
- Alexander Philip
- Alfarra Nada
- Alfitory Asma
- Alhabil Belal
- Alhaj Ahmad
- Alherz Mohammad
- Alhimyar Maryam
- Ali Ahmad Syed Mustafa
- Ali SANI Samuel
- Ali Amr
- Ali Asmaa
- Ali Mahmoud
- Ali Shabina
- Alimi Marjan
- Aliosin Oleg
- Aliyu Halima
- Aljaafreh Almoutuz
- Aljaber Dana
- Aljaberi Loay
- Aljanfi Asma
- Aljiffry Murad
- Aljohmani Lylas
- Alkhaledi Ahmad
- Alkhatib Ala'a Aldeen
- Alkhatib Haya
- Alkhatib Mo'min
- Allen Ingabire J.C.
- Almasri Murad
- Almeida Braga Sara
- Almeida Filipe
- Almigheerbi Alabas
- Almoqayyad Abdelrahman
- Almuzghi Fakhruddin
- Alnoury Mostafa
- Alonso Batanero Ester
- Alqadi Mohammad
- Alsaid Bayan
- Alsalameh Barah
- Alsallaq Osama
- Alser Osaid
- Alshaar Muhammad
- Alsharef Tagwa
- Alsharqawi Nourah
- Alswerki Mohammad
- Altaf Amna
- Altaf Rabiya
- AlTaweel Mohammed
- Althini Abdulmunem Ahmed Mustafa
- Altibi Ahmed M.
- Altinel Yuksel
- Altiner Saygin
- Altomare Donato Francesco
- Altumei Zohoor
- Alvarez Rivera Alvaro Eduardo
- Alvarez-Cano Alethia
- Alves do Canto Brum Homero
- Alves Daniela Macedo
- Alves Magda
- Alvi Abdul
- Alwaheidi Malak
- Alwali Abdallah
- Alwerfally AbdulMawlay
- Alwhaidi Noor
- Alyafi Amr
- Alzabti Fatima
- Alzahaf Ahmed
- AlZohour Mohammad
- Amadou Magagi Ibrahim
- Amandito Radhian
- Amarin Justin Z.
- Amaro Margarida
- Ambrazevicius Marijus
- Amendola Alfonso
- Amin Leila
- Amine Souadka
- Amjad Talal
- Amorim Edgar
- Amro Adham
- Anandan Premkumar
- Anas khalifa Rawda
- Anastasio Lorenzo
- Andersson Yvette
- Andreotti Dario
- Andrew David
- André Benoît
- Ang Sue Ean
- Angel Miguel
- Anggita Gultom Phebe
- Annapureddy Naga
- Anokhin Evgeny
- Ansaloni Luca
- Ansarei Dhirar
- Ansari Abdul Basit
- Antaky Marco
- Anthony Natasha
- Anthoulakis Christos
- Antonopoulou Maria Ioanna
- Anwar Mohamed
- Anwer Abdul Wahid
- Anyanwu Chikamuche
- Anyanwu Lofty-John
- Anyanwu Mercy Chinemerem
- Anyomih Theophilus Teddy Kojo
- Appukuttan Akhila
- Aquilino Fabrizio
- Archibald Jess
- Arciénega Yañez María del pilar
- Argentou Maria-Ioanna
- Argudo Nuria
- Argyriou Eleftherios Orestis
- Arias Madrid Natalia
- Aribi Sarra
- Arifin Ghafur Rasyid
- Arizpe Daniel
- Arnaud Alexis P
- Arora Bharti
- Arora Deeksha
- Arowolo Olukayode
- Arrangoiz Rodrigo
- Arslan Ekin
- Artigau Eva
- Ashfaq Ahsan
- Ashour Dina
- Ashour Firas
- Ashoushan Hana
- Ashraf Ahmed
- Ashraf Alaa
- Asif Ashar
- Asnel Dorisme
- Asok Anjitha
- Assa Rawan
- Assalhi Mohamed
- Asta Martina
- Asti Emanuele Luigi Giuseppe
- Atakul Onur
- Atallah Khalid
- Atanasov Boyko
- Atawneh Mohammad
- Athamneh Sarah
- Ather Muaaz
- Athisayaraj Thomas
- Atkociunas Aivaras
- Attia Mohamed
- Au Angela
- Awad Israa
- Awadallah Haneen
- Awaji Kholoud
- Awesat Eman
- Awolowo Ajibola
- Ayandipo Omobolaji
- Ayash Mohammad
- Ayau Fernanda
- Ayesh Kholoud
- Ayman El-sawy Esraa
- Ayoub Rami
- Aytac Erman
- Ayub Bushra
- Ayub Saima
- Ayyad Rawan
- Azevedo José
- Azodo Ijeoma
- Azzubia Joma
- B L Ashika
- Ba Mouhamadou Bachir
- Babaa Basheer
- Babirye Lilian
- Bacic Ivan
- Badr Esraa Tarek
- Badr Helmy
- Badran Abdul
- Badwe Rajendra
- Bafford Andrea Chao M.D.
- Baggaley Caitlin
- Bahroun Sumayyah Ghayth
- Baiao José Miguel
- Baiocchi Daniella
- Bairos Menezes Maria
- Baiu Ioana
- Bajilan Mohammad
- Bajomo Oreoluwa
- Bake Jacques
- Baki Bahadir Emre
- Bakoleas Panagiotis
- Balaawi Reem
- Balalis Dimitrios
- Balata Mohamed
- Balkarov Artem
- Ballouhey Quentin
- Balogun Olanrewaju
- Baloyiannis Ioannis
- Baltaci Ege
- Bamaca Ixcajoc Elvis Benjamin
- Banaz Tuba
- Banda Bitiel
- Banglani Muntaha
- Bani Hani Farah
- Bani hani Mohammad
- Bani hani Zeina
- Baniowda Muath
- Banks Alexander
- Bannister Sharon
- Baranyai Zsolt
- Barati Nastaran
- Barbosa Camacho Francisco José
- Barbosa José
- Bardos David
- Barendegere Venerand
- Barghuthi Lutfi
- Barhoush Ola
- Barnes Nicole
- Baronio Gianluca
- Barreda Zelaya Lilian Elizabeth
- Barrera López Francisco Javier
- Barsic Neven
- Barter Charlotte
- Bartosiak Katarzyna
- Basarab Maksym
- Basso Stefano Maria Massimiliano.
- Bastiaenen Vivian
- Batashki Ilia
- Bath Michael
- Beattie Miriam
- Bedada Alemayehu Ginbo
- Belais Fanny
- Belal qadomi Asef
- Belev Nikolay
- Belli Andrea
- Beltrán de Heredia Juan
- Belvedere Angela
- Ben Dallah Najah
- Ben Saoud Abdulsalam Ali
- Bengur Fuat Baris
- Benkabbou Amine
- Benke Marton
- Benyaiche Chaymae
- Bergeat Damien
- Bernstein Mitchell
- Beshtawi Doha
- Besli Sevval
- Beuran Mircea
- Bhandare Manish
- Bhangu Aneel
- Bhatti Muhammad Iqbal
- Bianchini Stefania
- Bianco Francesco
- Bibas Fatma
- Biccard Bruce M
- Bielosludtsev Oleksii
- Bienfait Mumbere
- Billy Matthew
- Bin Mohamad Sithik Muhammad Navid
- Binetti Margherita
- Bingham Janne
- Bird Jonathan
- Birindelli Arianna
- Birks Sarah
- Birutis Justas
- Björklund Ida
- Blackman Brighid
- Blackwell James
- Blanco-Colino Ruth
- Blok Robin
- Blomme Nina
- Blomqvist Malin
- Blunnie Eimear
- Bnhameida Sondos
- Boddy Alex
- Bodur Muhammed Selim
- Boereboom Catherine
- Bogusevicius Algirdas
- Bolzonaro Elisa
- Bonavina Luigi
- Bondurri Andrea
- Bonghaseh Divine Tim
- Bono Lorenzo
- Borda-Luque Giuliano
- Borg Elaine
- Borghi Felice
- Borham Hala
- Borowski David W
- Bortolasi Luca
- Bosch Marina
- Bosire Fridah
- Bossi Daniela
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- Wondoh Paul M.
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- Zaffaroni Gloria
- Zahra Baryab
- Zahran Diaaaldin
- Zakaria Andee Dzulkarnaen
- Zakaria Mai
- Zakaria Omar
- Zakaria Zaidi
- Zambrana Campos Vanesa
- Zammit Matthew
- Zanini Nicola
- Zara Vlu Jean
- Zara Vlu Jean
- Zarti Heba
- Zarzycki Piotr
- Zattoni Davide
- Zavala Gabriela
- Zawahrah Hassan
- Zeiton Asaid
- Zeko Amanda
- Zeng Zhi
- Zeromskas Paulius
- Zhang Geoffrey
- Zhivkov Evgeni
- Zid Esraa
- Zidan Ahmed Mohy
- Zielasek Christian
- Zilinskas Justas
- Zimmermann Bernd
- Ziprin Paul
- Zizzo Maurizio
- Zografos George
- Zoikas Athanasios
- Zorrilla Matilla Laura Patricia
- Zoulamoglou Menelaos
- Zreeg Dafer
- Zub-Pokrowiecka Anna
- Zubiaurre Vanessa
- Zuhdy Mohammed
- Zuikyte Diana
- Zuloaga Fernandez del Valle Carlos Jose
- Zulu Stanley
- Ângelo Miguel
- Älgå Andreas
- Çolak Elif
- Ümarik Toomas
- Šatkauskas Mindaugas
- Škimelyte Monika
- Šlenfuktas Vygintas
- Šuman Oliver
- Žatecký Jan
- Žumbakys Žygimantas
- Župan Domagoj
- Publication venue
- 'Elsevier BV'
- Publication date
- 30/01/2021
- Field of study
© 2021 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY-NC-ND 4.0 licenseBackground: 80% of individuals with cancer will require a surgical procedure, yet little comparative data exist on early outcomes in low-income and middle-income countries (LMICs). We compared postoperative outcomes in breast, colorectal, and gastric cancer surgery in hospitals worldwide, focusing on the effect of disease stage and complications on postoperative mortality. Methods: This was a multicentre, international prospective cohort study of consecutive adult patients undergoing surgery for primary breast, colorectal, or gastric cancer requiring a skin incision done under general or neuraxial anaesthesia. The primary outcome was death or major complication within 30 days of surgery. Multilevel logistic regression determined relationships within three-level nested models of patients within hospitals and countries. Hospital-level infrastructure effects were explored with three-way mediation analyses. This study was registered with ClinicalTrials.gov, NCT03471494. Findings: Between April 1, 2018, and Jan 31, 2019, we enrolled 15 958 patients from 428 hospitals in 82 countries (high income 9106 patients, 31 countries; upper-middle income 2721 patients, 23 countries; or lower-middle income 4131 patients, 28 countries). Patients in LMICs presented with more advanced disease compared with patients in high-income countries. 30-day mortality was higher for gastric cancer in low-income or lower-middle-income countries (adjusted odds ratio 3·72, 95% CI 1·70–8·16) and for colorectal cancer in low-income or lower-middle-income countries (4·59, 2·39–8·80) and upper-middle-income countries (2·06, 1·11–3·83). No difference in 30-day mortality was seen in breast cancer. The proportion of patients who died after a major complication was greatest in low-income or lower-middle-income countries (6·15, 3·26–11·59) and upper-middle-income countries (3·89, 2·08–7·29). Postoperative death after complications was partly explained by patient factors (60%) and partly by hospital or country (40%). The absence of consistently available postoperative care facilities was associated with seven to 10 more deaths per 100 major complications in LMICs. Cancer stage alone explained little of the early variation in mortality or postoperative complications. Interpretation: Higher levels of mortality after cancer surgery in LMICs was not fully explained by later presentation of disease. The capacity to rescue patients from surgical complications is a tangible opportunity for meaningful intervention. Early death after cancer surgery might be reduced by policies focusing on strengthening perioperative care systems to detect and intervene in common complications. Funding: National Institute for Health Research Global Health Research Unit
Effects of hospital facilities on patient outcomes after cancer surgery: an international, prospective, observational study
- Author
- A Yacoub Mina
- A. Adam Mohammed
- A. Nassar Mahmoud
- A.Nemer Ayoob
- Aahlin Eirik Kjus
- Ab Rahim Mohd Fadliyazid
- Abad Gurumeta Alfredo
- Abad-Motos Ane
- Abang Jamari Dyg Zahratul Hamrak
- Abantanga Francis
- Abarca Sol
- Abazid Eias
- Abbas Abbas
- Abbas Khalid
- Abbas Mohammad Monir
- Abbasy Jibran
- Abbosh Ali
- Abd Karim Muhammad Fairuz Shah
- Abd Wahab Haidar Hadri
- Abd Barook
- Abdalei Abdulwahab
- Abdalla Ahmed Elkamel Ahmed
- Abdallah Aya
- AbdAllah Mostafa Salim Mohamed
- Abdel Malik Abu Baker
- Abdelhady Mousa Heba
- Abdelhady Samar
- Abdelhakim Ahmed
- Abdelkader Muhammad
- Abdelkawy Shaza
- Abdelkhalek Mohamed
- Abdellatif Esraa
- Abdelmaksoud Tawakel Noura
- Abdelmohsen Naglaa
- Abdelmotaleb Ibrahem
- Abdelrazek Aly
- Abdelsalam Israa
- Abdelshakour Mahmoud
- Abdelwahed Ahmed Mohamed
- Abdou Abdulrahman Osama
- Abdou Alrawy
- Abdou Hossam
- Abdul Aziz Mohamed Rezal
- Abdul Aziz Nora
- Abdulgawad Almogy Mariam
- Abdulla Mazin A.
- Abdullah Muhammad Tariq
- Abdullahi Lawal
- Abdullayev Seymur
- Abed Saeed
- Abelló David
- Abiola Olajide
- Abo mahadi Asmaa'
- Abo-khammash Areej
- Abou Chaar Mohamad K.
- Abou El.soud Moustafa Ramadan
- Abouelsoad Nervana
- Abraham Joyner
- Abreu da Silva Alberto
- Abu Ahammala Ayman B.
- Abu Al Amrain Mahmoud
- Abu Al-saleem Hasan
- Abu Alamrain Abdulwhhab
- Abu Alqumboz Amjad
- Abu Ataya Ahmed
- Abu hallalah Muad fathi khalleefah
- Abu Jamie Najlaa
- Abu Jayyab Israa
- Abu shua'ib Rana
- Abu Zainah Baraa
- Abu-Nimeh Samar
- Abu-Rous Mohammed R.
- Abu-srour Abrar
- Abuelhatal Hasan
- Abuelqomboz Ayham
- Abuhilal Baseel
- Abuhlaiga Ma'aly
- Abujamra Saleh
- Abukhalaf Sadi A.
- Abusalem Lana
- AbuSirrees Mahmoud
- Acevedo Veronica
- Acharya Rajgopal
- Achkasov Sergey
- Acosta Eric
- Adamo Karin
- Adamou Harissou
- Adams Jamie
- Adams Lawrence
- Adawi Samer
- Adebanjo Ademola
- Adel Marina
- Adel Sawsan
- Ademuyiwa Adesoji
- Ademuyiwa Adesoji O
- Adenuga Adedire
- Aderounmu Adewale
- Adesanya Opeoluwa
- Adesina Alaba
- Adesunkanmi Abdul-Rashid
- Adeyeye Ademola
- Adidharma Peter
- Adisa Adewale
- Adisa Adewale O
- Adnan Nour
- Afifi Amr Abdelghani
- Afifi Eman
- Afolayan Michael Olatunji
- Afzal Asma
- Agarwal Arnav
- Agarwal Raksheeth
- Agbakwuru Augustine
- Agbeko Anita Eseenam
- Aguilar Martinez Maria Del Mar
- Aguilera Maria Lorena
- Aguilera-Arevalo Maria-Lorena
- Ahlqvist Sandra
- Ahmad Izzuddin Ahmad Imran
- Ahmad Kasim
- Ahmad Sarwat
- Ahmed Ahmedgaber
- Ahmed Hazem Abdelkarem
- Ahmed Mariam
- Ahmed Nabila
- Ahmed Zahra
- Ainoa Eppu
- Aithie Joanna M S
- Ajani Costanza
- Ajao Akinlabi
- Ajiboye Anthony
- Ajmera Ankit
- Akande Oluwatosin
- Akaydin Elif
- Akbaba Ata Cem
- Akbar Sana Amir
- Akeel Nouf
- Akeem Aderogba Adeleke
- Akin Alp
- Akinkuolie Akinbolaji
- Akisheva Aygulya
- Akitikori Mabel Temisanren
- Akrida Ioanna
- Aktas Melik Kagan
- Al basos Iyad
- Al Farsi Maryam
- Al Nassrallah Majdi
- Al Sagheir Eman
- Al Saqqa Sara
- Al Saqqa Sara
- Al-Allaf Omar
- Al-Busaidi Ibrahim S.
- Al-Dhufri Ali
- Al-Himyari Hamza S.
- Al-Masri Mahmoud
- Al-Najjar Hani
- Al-Sabbagh Yusra
- Al-Shwaikh Samar
- Al-Slaibi Ibrahim
- Al-Taher Raed
- Al-Tammam Hiba
- Alabuzidi Aya
- Alagha Othman
- Alammarin Mohammad
- Alapatt John
- Alasttal Mohammed
- Alatise Olusegun Isaac
- Albaggar Marwa
- Albahnasawi Moath A.
- Albati Naif
- Alberga Anna
- Alberts Justin
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- Alhabil Belal
- Alhaj Ahmad
- Alherz Mohammad
- Alhimyar Maryam
- Ali Ahmad Syed Mustafa
- Ali SANI Samuel
- Ali Amr
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- Ali Mahmoud
- Ali Shabina
- Alimi Marjan
- Aliosin Oleg
- Aliyu Halima
- Aljaafreh Almoutuz
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- Aljohmani Lylas
- Alkhaledi Ahmad
- Alkhatib Ala'a Aldeen
- Alkhatib Haya
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- Allen Ingabire J.C.
- Almasri Murad
- Almeida Braga Sara
- Almeida Filipe
- Almigheerbi Alabas
- Almoqayyad Abdelrahman
- Almuzghi Fakhruddin
- Alnoury Mostafa
- Alonso Batanero Ester
- Alqadi Mohammad
- Alsaid Bayan
- Alsalameh Barah
- Alsallaq Osama
- Alser Osaid
- Alshaar Muhammad
- Alsharef Tagwa
- Alsharqawi Nourah
- Alswerki Mohammad
- Altaf Amna
- Altaf Rabiya
- AlTaweel Mohammed
- Althini Abdulmunem Ahmed Mustafa
- Altibi Ahmed M.
- Altinel Yuksel
- Altiner Saygin
- Altomare Donato Francesco
- Altumei Zohoor
- Alvarez Rivera Alvaro Eduardo
- Alvarez-Cano Alethia
- Alves do Canto Brum Homero
- Alves Daniela Macedo
- Alves Magda
- Alvi Abdul
- Alwaheidi Malak
- Alwali Abdallah
- Alwerfally AbdulMawlay
- Alwhaidi Noor
- Alyafi Amr
- Alzabti Fatima
- Alzahaf Ahmed
- AlZohour Mohammad
- Amadou Magagi Ibrahim
- Amandito Radhian
- Amarin Justin Z.
- Amaro Margarida
- Ambrazevicius Marijus
- Amendola Alfonso
- Amin Leila
- Amine Souadka
- Amjad Talal
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- Anandan Premkumar
- Anas khalifa Rawda
- Anastasio Lorenzo
- Andersson Yvette
- Andreotti Dario
- Andrew David
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- Anggita Gultom Phebe
- Annapureddy Naga
- Anokhin Evgeny
- Ansaloni Luca
- Ansarei Dhirar
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- Antaky Marco
- Anthony Natasha
- Anthoulakis Christos
- Antonopoulou Maria Ioanna
- Anwar Mohamed
- Anwer Abdul Wahid
- Anyanwu Chikamuche
- Anyanwu Lofty-John
- Anyanwu Mercy Chinemerem
- Anyomih Theophilus Teddy Kojo
- Appukuttan Akhila
- Aquilino Fabrizio
- Archibald Jess
- Arciénega Yañez María del pilar
- Argentou Maria-Ioanna
- Argudo Nuria
- Argyriou Eleftherios Orestis
- Arias Madrid Natalia
- Aribi Sarra
- Arifin Ghafur Rasyid
- Arizpe Daniel
- Arnaud Alexis P
- Arora Bharti
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- Asnel Dorisme
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- Assalhi Mohamed
- Asta Martina
- Asti Emanuele Luigi Giuseppe
- Atakul Onur
- Atallah Khalid
- Atanasov Boyko
- Atawneh Mohammad
- Athamneh Sarah
- Ather Muaaz
- Athisayaraj Thomas
- Atkociunas Aivaras
- Attia Mohamed
- Au Angela
- Awad Israa
- Awadallah Haneen
- Awaji Kholoud
- Awesat Eman
- Awolowo Ajibola
- Ayandipo Omobolaji
- Ayash Mohammad
- Ayau Fernanda
- Ayesh Kholoud
- Ayman El-sawy Esraa
- Ayoub Rami
- Aytac Erman
- Ayub Bushra
- Ayub Saima
- Ayyad Rawan
- Azevedo José
- Azodo Ijeoma
- Azzubia Joma
- B L Ashika
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- Babaa Basheer
- Babirye Lilian
- Bacic Ivan
- Badr Esraa Tarek
- Badr Helmy
- Badran Abdul
- Badwe Rajendra
- Bafford Andrea Chao M.D.
- Baggaley Caitlin
- Bahroun Sumayyah Ghayth
- Baiao José Miguel
- Baiocchi Daniella
- Bairos Menezes Maria
- Baiu Ioana
- Bajilan Mohammad
- Bajomo Oreoluwa
- Bake Jacques
- Baki Bahadir Emre
- Bakoleas Panagiotis
- Balaawi Reem
- Balalis Dimitrios
- Balata Mohamed
- Balkarov Artem
- Ballouhey Quentin
- Balogun Olanrewaju
- Baloyiannis Ioannis
- Baltaci Ege
- Bamaca Ixcajoc Elvis Benjamin
- Banaz Tuba
- Banda Bitiel
- Banglani Muntaha
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- Bani hani Mohammad
- Bani hani Zeina
- Baniowda Muath
- Banks Alexander
- Bannister Sharon
- Baranyai Zsolt
- Barati Nastaran
- Barbosa Camacho Francisco José
- Barbosa José
- Bardos David
- Barendegere Venerand
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- Barhoush Ola
- Barnes Nicole
- Baronio Gianluca
- Barreda Zelaya Lilian Elizabeth
- Barrera López Francisco Javier
- Barsic Neven
- Barter Charlotte
- Bartosiak Katarzyna
- Basarab Maksym
- Basso Stefano Maria Massimiliano.
- Bastiaenen Vivian
- Batashki Ilia
- Bath Michael
- Beattie Miriam
- Bedada Alemayehu Ginbo
- Belais Fanny
- Belal qadomi Asef
- Belev Nikolay
- Belli Andrea
- Beltrán de Heredia Juan
- Belvedere Angela
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- Bhatti Muhammad Iqbal
- Bianchini Stefania
- Bianco Francesco
- Bibas Fatma
- Biccard Bruce M
- Bielosludtsev Oleksii
- Bienfait Mumbere
- Billy Matthew
- Bin Mohamad Sithik Muhammad Navid
- Binetti Margherita
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- Yeen Chin Leow
- Yemez Kürşat
- Yenidünya Nilüfer
- Yenli Edwin
- Yeo Jeremy
- Yeoh Andrea
- Yepez Raul
- Yeşilsancak Merve
- Yildirim Reyyan
- Yildiz Alp
- Yilmaz Duygu
- Yip Ching Wan
- Ylatoma Díaz Edgar Alcides
- Yong Shun Qi
- Yoong Andrel
- Yorke Joseph
- Yotsov Tsanko
- You Lucia
- Younes Eman
- Younes Maha
- Yousry Basant
- Yozgatli Tahir Koray
- Yu Kristin
- Yue Sum Yu Pansy
- Yunes Asmaa
- Yusuf Baasil
- Yüksel Osman
- Zabiyaka Mikhail
- Zachariah Sanoop Koshy
- Zafar Syed Nabeel
- Zaffaroni Gloria
- Zahra Baryab
- Zahran Diaaaldin
- Zakaria Andee Dzulkarnaen
- Zakaria Mai
- Zakaria Omar
- Zakaria Zaidi
- Zambrana Campos Vanesa
- Zammit Matthew
- Zanini Nicola
- Zara Vlu Jean
- Zarti Heba
- Zarzycki Piotr
- Zattoni Davide
- Zavala Gabriela
- Zawahrah Hassan
- Zeiton Asaid
- Zeko Amanda
- Zeng Zhi
- Zeromskas Paulius
- Zhang Geoffrey
- Zhivkov Evgeni
- Zid Esraa
- Zidan Ahmed Mohy
- Zielasek Christian
- Zilinskas Justas
- Zimmermann Bernd
- Ziprin Paul
- Zizzo Maurizio
- Zografos George
- Zoikas Athanasios
- Zorrilla Matilla Laura Patricia
- Zoulamoglou Menelaos
- Zreeg Dafer
- Zub-Pokrowiecka Anna
- Zubiaurre Vanessa
- Zuhdy Mohammed
- Zuikyte Diana
- Zuloaga Fernandez del Valle Carlos Jose
- Zulu Stanley
- Ângelo Miguel
- Älgå Andreas
- Çolak Elif
- Ümarik Toomas
- Čepuliené Daiva
- Şahin Can
- Šatkauskas Mindaugas
- Škimelytè Monika
- Šlenfuktas Vygintas
- Šuman Oliver
- Žatecký Jan
- Žumbakys Žygimantas
- Župan Domagoj
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/07/2022
- Field of study
© 2022 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY 4.0 licenseBackground: Early death after cancer surgery is higher in low-income and middle-income countries (LMICs) compared with in high-income countries, yet the impact of facility characteristics on early postoperative outcomes is unknown. The aim of this study was to examine the association between hospital infrastructure, resource availability, and processes on early outcomes after cancer surgery worldwide. Methods: A multimethods analysis was performed as part of the GlobalSurg 3 study—a multicentre, international, prospective cohort study of patients who had surgery for breast, colorectal, or gastric cancer. The primary outcomes were 30-day mortality and 30-day major complication rates. Potentially beneficial hospital facilities were identified by variable selection to select those associated with 30-day mortality. Adjusted outcomes were determined using generalised estimating equations to account for patient characteristics and country-income group, with population stratification by hospital. Findings: Between April 1, 2018, and April 23, 2019, facility-level data were collected for 9685 patients across 238 hospitals in 66 countries (91 hospitals in 20 high-income countries; 57 hospitals in 19 upper-middle-income countries; and 90 hospitals in 27 low-income to lower-middle-income countries). The availability of five hospital facilities was inversely associated with mortality: ultrasound, CT scanner, critical care unit, opioid analgesia, and oncologist. After adjustment for case-mix and country income group, hospitals with three or fewer of these facilities (62 hospitals, 1294 patients) had higher mortality compared with those with four or five (adjusted odds ratio [OR] 3·85 [95% CI 2·58–5·75]; p<0·0001), with excess mortality predominantly explained by a limited capacity to rescue following the development of major complications (63·0% vs 82·7%; OR 0·35 [0·23–0·53]; p<0·0001). Across LMICs, improvements in hospital facilities would prevent one to three deaths for every 100 patients undergoing surgery for cancer. Interpretation: Hospitals with higher levels of infrastructure and resources have better outcomes after cancer surgery, independent of country income. Without urgent strengthening of hospital infrastructure and resources, the reductions in cancer-associated mortality associated with improved access will not be realised. Funding: National Institute for Health and Care Research