“The Other One”: An Unpublished Chapter of Sarah Orne Jewett’s \u3ci\u3eThe Country of the Pointed Firs\u3c/i\u3e

Sarah Orne Jewett’s The Country of the Pointed Firs (1896) has long been central to literary critical debates about the nature and character of American literary regionalism. In the early 1990s, some New Historicist critics aligned the emergence of the literary movement with the rise of tourism as two means by which urban elites defined themselves as a socially and racially privileged class in the postwar nation. In an influential analysis of the mutually reinforcing development of the literary marketplace and class and cultural hierarchies, Richard Brodhead describes regionalism in Cultures of Letters (1993) as evidencing “an elite need for the primitive made available as a leisure outlet.” In giving “exercise to a sophisticate-vacationer’s habits of mind,” Brodhead writes, regional fiction “rehearsed a habit of mental acquisitiveness strongly allied with genteel reading.” With a privileged urban vacationer as its narrator, Firs “builds the class logic of vacationing” into its very structure, Brodhead claims, pointing to the way that the unnamed narrator, who is also a publishing author, can arrive in the fictional community of Dunnet Landing, Maine, and “command someone else’s home as a second home for her leisure ... with a confident exercise of her rights.” Then, over the course of a summer, she turns the intimate life stories of the residents into her own “sympathetic possessions” that she abstracts and exports out of the place. Feminist critics, most notably Judith Fetterley and Marjorie Pryse in Writing out of Place: Regionalism, Women, and American Literary Culture, have vigorously contested such readings of women’s literary regionalism (including Jewett’s works), characterizing regionalism as “subvert[ing] . . . those assumptions the dominant discourse considers unassailable.” Jewett’s social and cultural position and her place in the field of cultural production as defined by the Atlantic Monthly and other highbrow literary magazines are central to readings of Firs aligned with Brodhead’s. In this context, the cultural politics and literary form of Firs appear to be nearly inevitable, even overdetermined, with Jewett uncritically reproducing her own position of social privilege in the figure of the narrator. Our contribution to these debates about the cultural politics of Firs is an edition of an unpublished manuscript chapter of Jewett’s book, in which she crafted an ending featuring an economically powerful rural heroine no longer subject to the tourist’s command. This manuscript has been available at Harvard University libraries since the 1930s but has not, until now, been properly identified. It provides persuasive evidence that Jewett thought critically about her representational practices as a cosmopolitan author depicting rural people for a national audience, as well as about the closely related issue of her book’s genre, another long-standing concern of Jewett criticism

Methods for estimating moment of inertia of cricket bats

Mass moment of inertia is a key inertial property of cricket bats and should be used in selection to optimise performance. Players currently rely on a subjective assessment of how the bat feels when swung supported only by a value for bat mass from the manufacturer. This reliance on a subjective assessment is because the moment of inertia of a bat typically requires a pendulum method to measure with sufficient accuracy. In this study, two methods for estimating moment of inertia were tested. The hypotheses were that (1) an acceptable estimate of moment of inertia could be calculated using a beam model approach, and (2) the inertial property first moment could act as a proxy measure for moment of inertia. Experimental values for moment of inertia were obtained using a pendulum method. The two-section beam model showed an error of 0.43–0.53% between model and experimental values based on a Root Mean Square Error of 0.0017 kg m2. First moment data were generated on 5005 bats spread across eight bat shapes. A correlation was shown between the measured value of first moment and the beam model value of moment of inertia, with an R2 value > 0.992 for all bat shapes. This study showed that a two-section beam model and first moment method for estimating cricket bat moment of inertia could be used to improve bat selection

Prospectus, May 5, 1975

MCCABE, MCMULLEN, REID….; StuGo Election May 7-8; PC News….In Brief: Art Exhibit To Be Held May 9th, Veterans Plan A Lake Of The Woods Cook-Out, Theta Epsilon Fair May 5, Recreation Society; Parkland Goes To Semester; StuGo Approves New Budget; Carnival A Tension Reliever ; editorials; \u27Next\u27; Vote! Vote!; letters; The Short Circuit; L.T.D.s Corner; Photography 35: Tips On Using An Exposure Meter, The Basic Elements Of Photography ; Candidate Platforms: McCabe, McMullen, Reid, Woodard, Eads, Hart, Weller, McQuinn, Weeks, Mandel, Miller; Skylines; Final Examination Schedule; Sports Views; Women\u27s Softball End With 5-1; Vets Scholarship Society; Cobras Eliminated From State Tourney; $44,000 Ripoff; Girl\u27s Volleyball Tournament May 5; sports; Wanted: Ace Reporters; Right To Life; Classified Ads; Parkland Events; Speeders....Beware!; New Communications 2yr. Program; Strike Freezes Construction; StuGo Minutes; The Parable, May 8 In C118; Band & Choir Scheduled Concerts; PC Hosts Teacher\u27s Aideshttps://spark.parkland.edu/prospectus_1975/1010/thumbnail.jp

Microscopic Investigation of Reversible Nanoscale Surface Size Dependent Protein Conjugation

Aβ1–40 coated 20 nm gold colloidal nanoparticles exhibit a reversible color change as pH is externally altered between pH 4 and 10. This reversible process may contain important information on the initial reversible step reported for the fibrillogenesis of Aβ (a hallmark of Alzheimer’s disease). We examined this reversible color change by microscopic investigations. AFM images on graphite surfaces revealed the morphology of Aβ aggregates with gold colloids. TEM images clearly demonstrate the correspondence between spectroscopic features and conformational changes of the gold colloid

nor-Mevaldic acid surrogates as selective antifungal agent leads against Botrytis cinerea. Enantioselective preparation of 4-hydroxy-6-(1-phenylethoxy)tetrahydro-2H-pyran-2-one

Solvent-free desymmetrisation of meso-dialdehyde 1 with chiral 1-phenylethan-1-ol, led to preparation of 4-silyloxy-6-alkyloxytetrahydro-2H-pyran-2-one (+)-3a with a 96:4 dr Deprotected lactone (+)-19a and the related racemic lactones 16a–18a present a lactone moiety resembling the natural substrate of HMG-CoA reductase and their antifungal properties have been evaluated against the phytopathogenic fungi Botrytis cinerea and Colletotrichum gloeosporioides. These compounds were selectively active against B. cinerea, while inactive against C. gloeosporioides

Transient reduction of tinnitus intensity is marked by concomitant reductions of delta band power

<p>Abstract</p> <p>Background</p> <p>Tinnitus is an auditory phantom phenomenon characterized by the sensation of sounds without objectively identifiable sound sources. To date, its causes are not well understood. Previous research found altered patterns of spontaneous brain activity in chronic tinnitus sufferers compared to healthy controls, yet it is unknown whether these abnormal oscillatory patterns are causally related to the tinnitus sensation. Partial support for this notion comes from a neurofeedback approach developed by our group, in which significant reductions in tinnitus loudness could be achieved in patients who successfully normalized their patterns of spontaneous brain activity. The current work attempts to complement these studies by scrutinizing how modulations of tinnitus intensity alter ongoing oscillatory activity.</p> <p>Results</p> <p>In the present study the relation between tinnitus sensation and spontaneous brain activity was investigated using residual inhibition (RI) to reduce tinnitus intensity and source-space projected magnetencephalographic (MEG) data to index brain activity. RI is the sustained reduction (criteria: 50% for at least 30 s) in tinnitus loudness after cessation of a tonal tinnitus masker. A pilot study (n = 38) identified 10 patients who showed RI. A significant reduction of power in the delta (1.3–4.0 Hz) frequency band was observed in temporal regions during RI (p ≤ 0.001).</p> <p>Conclusion</p> <p>The current results suggest that changes of tinnitus intensity induced by RI are mediated by alterations in the pathological patterns of spontaneous brain activity, specifically a reduction of delta activity. Delta activity is a characteristic oscillatory activity generated by deafferented/deprived neuronal networks. This implies that RI effects might reflect the transient reestablishment of balance between excitatory and inhibitory neuronal assemblies, via reafferentation, that have been perturbed (in most tinnitus individuals) by hearing damage. As enhancements have been reported in the delta frequency band for tinnitus at rest, this result conforms to our assumption that a normalization of oscillatory properties of cortical networks is a prerequisite for attenuating the tinnitus sensation. For RI to have therapeutic significance however, this normalization would have to be stabilized.</p

Southeastern Association of Law Libraries Annual Meeting

The 2009 SEAALL Annual Meeting was held in Athens Georgia, April 16-18, 2009

Requirement of argininosuccinate lyase for systemic nitric oxide production

Nitric oxide (NO) is crucial in diverse physiological and pathological processes. We show that a hypomorphic mouse model of argininosuccinate lyase (encoded by Asl) deficiency has a distinct phenotype of multiorgan dysfunction and NO deficiency. Loss of Asl in both humans and mice leads to reduced NO synthesis, owing to both decreased endogenous arginine synthesis and an impaired ability to use extracellular arginine for NO production. Administration of nitrite, which can be converted into NO in vivo, rescued the manifestations of NO deficiency in hypomorphic Asl mice, and a nitric oxide synthase (NOS)-independent NO donor restored NO-dependent vascular reactivity in humans with ASL deficiency. Mechanistic studies showed that ASL has a structural function in addition to its catalytic activity, by which it contributes to the formation of a multiprotein complex required for NO production. Our data demonstrate a previously unappreciated role for ASL in NOS function and NO homeostasis. Hence, ASL may serve as a target for manipulating NO production in experimental models, as well as for the treatment of NO-related diseases

Weaning practices in phenylketonuria vary between health professionals in Europe

Background: In phenylketonuria (PKU), weaning is considered more challenging when compared to feeding healthy infants. The primary aim of weaning is to gradually replace natural protein from breast milk or standard infant formula with solids containing equivalent phenylalanine (Phe). In addition, a Phe-free second stage L-amino acid supplement is usually recommended from around 6 months to replace Phe-free infant formula. Our aim was to assess different weaning approaches used by health professionals across Europe. Methods: A cross sectional questionnaire (survey monkey (R)) composed of 31 multiple and single choice questions was sent to European colleagues caring for inherited metabolic disorders (IMD). Centres were grouped into geographical regions for analysis. Results: Weaning started at 17-26 weeks in 85% (n=81/95) of centres, > 26 weeks in 12% (n=11/95) and 26 weeks. First solids were mainly low Phe vegetables (59%, n=56/95) and fruit (34%, n=32/95). A Phe exchange system to allocate dietary Phe was used by 52% (n=49/95) of centres predominantly from Northern and Southern Europe and 48% (n=46/95) calculated most Phe containing food sources (all centres in Eastern Europe and the majority from Germany and Austria). Some centres used a combination of both methods. A second stage Phe-free L-amino acid supplement containing a higher protein equivalent was introduced by 41% (n=39/95) of centres at infant age 26-36 weeks (mainly from Germany, Austria, Northern and Eastern Europe) and 37% (n=35/95) at infant age > 1y mainly from Southern Europe. 53% (n=50/95) of centres recommended a second stage Phe-free L-amino acid supplement in a spoonable or semi-solid form. Conclusions: Weaning strategies vary throughout European PKU centres. There is evidence to suggest that different infant weaning strategies may influence longer term adherence to the PKU diet or acceptance of Phe-free L-amino acid supplements; rendering prospective long-term studies important. It is essential to identify an effective weaning strategy that reduces caregiver burden but is associated with acceptable dietary adherence and optimal infant feeding development.Peer reviewe