ECG analysis

Tématem diplomové práce je analýza EKG signálu s využitím vlnkové transformace. V úvodních kapitolách je stručně popsána anatomie srdce, vznik a šíření potenciálů, které jsou evokovány činností myokardu. Následuje přehled svodů, využívaných u snímání EKG signálů a vysvětlení diagnostického významu vln EKG křivky. Dále je vysvětlen obecný postup analýzy EKG signálů a stručný přehled růžných přístupů. Hlavní částí práce je samotný program na detekci významných intervalů v EKG signálu, vytvořený v prostředí Matlab. V několika kapitolách je podrobně vysvětlen postup detekce spolu se zdůvodněním právě zvolené metody. V posledních kapitolách je již zobrazení několika rozměřených vzorových signálů spolu s vyhodnocením testů provedených na databázi CSE. Senzitivita detektoru byla vyčíslena na 99,10 %.The topic of this master's thesis is the analysis of ECG signals using wavelet transform. In the introductory chapters there is a brief description of heart anatomy, the emergence and spread of potentials, which evocating activities of myocardium. There is an overview of techniques used for ECG signals analysis and explanation of ECG curve diagnostic importance. Work also containts an ECG signal analysis common procedure explanation and different approaches brief overview. The main part of this work is an application detecting significant intervals in the ECG signal, developed in Matlab. In several chapters the detection procedure is described in more details and gave reasons for chosen methods. In the last chapter there is a preview of several signals as a result of developed application, together with evaluation of the tests carried out at the CSE database. Detector sensitivity was quantified over 99,10%.

Pressure-assisted solvent- and catalyst-free production of well-defined poly(1-vinyl-2-pyrrolidone) for biomedical applications

In this work, we developed a fast, highly efficient, and environmentally friendly catalytic systemfor classical freeradical polymerization (FRP) utilizing a high-pressure (HP) approach. The application of HP for thermallyinduced, bulk FRP of 1-vinyl-2-pyrrolidone (VP) allowed to eliminate the current limitation of ambientpressure polymerization of ‘less-activated’ monomer (LAM), characterized by the lack of temporal control yielding polymers of unacceptably large disperisites and poor result reproducibility. By a simple manipulation of thermodynamic conditions (p ¼ 125–500 MPa, T ¼ 323–333 K) and reaction composition (twocomponent system: monomer and low content of thermoinitiator) well-defined poly(1-vinyl-2-pyrrolidone)s (PVP) in a wide range of molecular weights and low/moderate dispersities (Mn ¼ 16.2–280.5 kg mol 1, Đ ¼ 1.27–1.45) have been produced. We have found that HP can act as an ‘external’ controlling factor that warrants the first-order polymerization kinetics for classical FRP, something that was possible so far only for reversible deactivation radical polymerization (RDRP) systems. Importantly, our synthetic strategy adopted for VP FRP enabled us to obtain polymers of very high Mn in a very short time-frame (0.5 h). It has also been confirmed that VP bulk polymerization yields polymers with significantly lower glass transition temperatures (Tg) and different solubility properties in comparison to macromolecules obtained during the solvent-assisted reaction

Long‐term overall survival and toxicities of ABVD vs BEACOPP in advanced Hodgkin lymphoma: A pooled analysis of four randomized trials

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The Effect of Various Poly (N-vinylpyrrolidone) (PVP) Polymers on the Crystallization of Flutamide

In this study, several experimental techniques were applied to probe thermal properties, molecular dynamics, crystallization kinetics and intermolecular interactions in binary mixtures (BMs) composed of flutamide (FL) and various poly(N-vinylpyrrolidone) (PVP) polymers, including a commercial product and, importantly, samples obtained from high-pressure syntheses, which differ in microstructure (defined by the tacticity of the macromolecule) from the commercial PVP. Differential Scanning Calorimetry (DSC) studies revealed a particularly large difference between the glass transition temperature (Tg) of FL+PVPsynth. mixtures with 10 and 30 wt% of the excipient. In the case of the FL+PVPcomm. system, this effect was significantly lower. Such unexpected findings for the former mixtures were strictly connected to the variation of the microstructure of the polymer. Moreover, combined DSC and dielectric measurements showed that the onset of FL crystallization is significantly suppressed in the BM composed of the synthesized polymers. Further non-isothermal DSC investigations carried out on various FL+10 wt% PVP mixtures revealed a slowing down of FL crystallization in all FL-based systems (the best inhibitor of this process was PVP Mn = 190 kg/mol). Our research indicated a significant contribution of the microstructure of the polymer on the physical stability of the pharmaceutical—an issue completely overlooked in the literature

Intrathecal liposomal cytarabine (lipoCIT) administration in patients with leukemic or lymphomatous meningitis: efficacy and long-term safety in a single institution.

International audienceBACKGROUND: There is limited information regarding the efficacy and long term safety of intrathecal injection of liposomal cytarabine in leukemic or lymphomatous meningitis. DESIGN AND METHODS: We studied 20 consecutive HIV-negative patients with leukemic or lymphomatous meningitis who were treated with intrathecal liposomal cytarabine between 2004 and 2007. We focused on efficacy and on any late effects of the drug. RESULTS: Twenty patients who received intrathecal liposomal cytarabine injection as part of their treatment; of these, 9 were alive and in complete remission at the end of the study. Median survival from the time of the first injection was 22.7 months (range, 0.5 to 64 months). Short-term toxicity related to intrathecal of liposomal cytarabine was observed in 2 cases; headache in 1 case and regressive facial palsy and diplopy in 1 case. Long-term toxicity was seen in 2 cases; clinical symptoms were urinary and fecal dysfunction with confusion in 1 case, and urinary dysfunction in 1 case. Both patients had been heavily pre-treated with neurotoxic drugs and neuraxis irradiation. CONCLUSION: In our experience, intrathecal liposomal cytarabine injections were convenient in the management of leukemic and lymphomatous meningitis, and can lead to long-term survival. Although neurotoxicity was rare, clinicians should exercise caution when retreatment is required in relapsing patients