Mitigation of environmental hazards of sulfide mineral flotation with an insight into froth stability and flotation performance

Today\u27s major challenges facing the flotation of sulfide minerals involve constant variability in the ore composition; environmental concerns; water scarcity and inefficient plant performance. The present work addresses these challenges faced by the flotation process of complex sulfide ore of Mississippi Valley type with an insight into the froth stability and the flotation performance. The first project in this study was aimed at finding the optimum conditions for the bulk flotation of galena (PbS) and chalcopyrite (CuFeS₂) through Response Surface Methodology (RSM). In the second project, an attempt was made to replace toxic sodium cyanide (NaCN) with the biodegradable chitosan polymer as pyrite depressant. To achieve an optimum flotation performance and froth stability, the third project utilized two types of nanoparticles; silica (SiO₂) and alumina (Al₂O₃) as process aids. The fourth project investigated the impact of water chemistry on the process outcomes in an attempt to replace fresh water with sea water. In the last project, five artificial intelligence (AI) and machine learning (ML) models were employed to model the flotation performance of the ore which will allow the building of intelligent systems that can be used to predict the process outcomes of polymetallic sulfides. It was concluded that chitosan can be successfully used as a biodegradable depressant. Alumina nanoparticles successfully enhanced both froth stability and flotation performance while silica nanoparticles did not. Seawater had a negative effect on both the froth stability and the grade of lead (Pb) and copper (Cu) but it improved the recoveries of both Pb and Cu minerals. Hybrid Neural Fuzzy Interference System (HyFIS) ML model showed the best accuracy to be adopted for automated sulfide ore flotation process in the future --Abstract, page iii

Flotation Behavior of Complex Sulfide Ores in the Presence of Biodegradable Polymeric Depressants

In this study, chitosan polymer was tested as a potential selective green depressant of pyrite in the bulk flotation of galena (PbS) and chalcopyrite (CuFeS2) from sphalerite (ZnS) and pyrite (FeS2) using sodium isopropyl xanthate as a collector and 4-methyl-2-pentanol (MIBC) as a frother. Flotation tests were carried out in a D12-Denver flotation laboratory cell in the presence and absence of chitosan and/or sodium cyanide depressant which is commercially used as pyrite depressant in sulfide mineral flotation process. Flotation recoveries and concentrate grades (assay) were studied as a function of polymer concentration and flotation time. It was found that at 50 g/ton, chitosan depressed 5.6% more pyrite as compared to conventional depressant NaCN at its optimum dosage. Furthermore, the measured assay values of pyrite in concentrates dropped by ∼1.2% when NaCN depressant was replaced with chitosan polymer. Zeta potential measurements of galena, chalcopyrite, sphalerite, and pyrite suspensions before and after chitosan\u27s addition revealed that the polymer has preferential adsorption on pyrite minerals as compared to other sulfide minerals specially galena. Results obtained from this work show that chitosan polymer has a promising future as a biodegradable alternative to sodium cyanide for the purpose of depressing pyrite in sulfide minerals flotation

Flotation Behavior of Complex Sulfide Ores in the Presence of Biodegradable Polymeric Depressants

In this study, chitosan polymer was tested as a potential selective green depressant of pyrite in the bulk flotation of galena (PbS) and chalcopyrite (CuFeS2) from sphalerite (ZnS) and pyrite (FeS2) using sodium isopropyl xanthate as a collector and 4-methyl-2-pentanol (MIBC) as a frother. Flotation tests were carried out in a D12-Denver flotation laboratory cell in the presence and absence of chitosan and/or sodium cyanide depressant which is commercially used as pyrite depressant in sulfide mineral flotation process. Flotation recoveries and concentrate grades (assay) were studied as a function of polymer concentration and flotation time. It was found that at 50 g/ton, chitosan depressed 5.6% more pyrite as compared to conventional depressant NaCN at its optimum dosage. Furthermore, the measured assay values of pyrite in concentrates dropped by ~1.2% when NaCN depressant was replaced with chitosan polymer. Zeta potential measurements of galena, chalcopyrite, sphalerite, and pyrite suspensions before and after chitosan’s addition revealed that the polymer has preferential adsorption on pyrite minerals as compared to other sulfide minerals specially galena. Results obtained from this work show that chitosan polymer has a promising future as a biodegradable alternative to sodium cyanide for the purpose of depressing pyrite in sulfide minerals flotation

Effect of Cattle-Specific Diseases on Carcass Inspection and Meat Quality

There are severe cattle-specific viral (foot and mouth, vesicular stomatitis, rinderpest, rift valley fever, malignant catarrhal fever, lumpy skin, rabies, bovine leukosis, bovine viral diarrhea, and bovine spongiform encephalopathy), bacterial (tuberculosis, black quarter, botulism, malignant oedema, leptospirosis, brucellosis, anthrax, hemogenic septicemia, actinomycosis, actinobacillosis, mastitis, and metritis), parasitic (lungworm, fasciolosis, cysticercosis, hydatid disease, and onchocercosis), and protozoal (trypanosomiasis, theileriosis, anaplasmosis, babesiosis, and sarcosporidiosis) diseases that affect the carcass judgment and meat quality. These diseases adversely affect cattle health, welfare, and red meat production. This chapter aims to describe the etiology, mode of transmission, ante-mortem and post-mortem findings, carcass and meat quality judgment, and differential diagnosis of these diseases

The global, regional, and national burden of adult lip, oral, and pharyngeal cancer in 204 countries and territories:A systematic analysis for the Global Burden of Disease Study 2019

Importance Lip, oral, and pharyngeal cancers are important contributors to cancer burden worldwide, and a comprehensive evaluation of their burden globally, regionally, and nationally is crucial for effective policy planning.Objective To analyze the total and risk-attributable burden of lip and oral cavity cancer (LOC) and other pharyngeal cancer (OPC) for 204 countries and territories and by Socio-demographic Index (SDI) using 2019 Global Burden of Diseases, Injuries, and Risk Factors (GBD) Study estimates.Evidence Review The incidence, mortality, and disability-adjusted life years (DALYs) due to LOC and OPC from 1990 to 2019 were estimated using GBD 2019 methods. The GBD 2019 comparative risk assessment framework was used to estimate the proportion of deaths and DALYs for LOC and OPC attributable to smoking, tobacco, and alcohol consumption in 2019.Findings In 2019, 370 000 (95% uncertainty interval [UI], 338 000-401 000) cases and 199 000 (95% UI, 181 000-217 000) deaths for LOC and 167 000 (95% UI, 153 000-180 000) cases and 114 000 (95% UI, 103 000-126 000) deaths for OPC were estimated to occur globally, contributing 5.5 million (95% UI, 5.0-6.0 million) and 3.2 million (95% UI, 2.9-3.6 million) DALYs, respectively. From 1990 to 2019, low-middle and low SDI regions consistently showed the highest age-standardized mortality rates due to LOC and OPC, while the high SDI strata exhibited age-standardized incidence rates decreasing for LOC and increasing for OPC. Globally in 2019, smoking had the greatest contribution to risk-attributable OPC deaths for both sexes (55.8% [95% UI, 49.2%-62.0%] of all OPC deaths in male individuals and 17.4% [95% UI, 13.8%-21.2%] of all OPC deaths in female individuals). Smoking and alcohol both contributed to substantial LOC deaths globally among male individuals (42.3% [95% UI, 35.2%-48.6%] and 40.2% [95% UI, 33.3%-46.8%] of all risk-attributable cancer deaths, respectively), while chewing tobacco contributed to the greatest attributable LOC deaths among female individuals (27.6% [95% UI, 21.5%-33.8%]), driven by high risk-attributable burden in South and Southeast Asia.Conclusions and Relevance In this systematic analysis, disparities in LOC and OPC burden existed across the SDI spectrum, and a considerable percentage of burden was attributable to tobacco and alcohol use. These estimates can contribute to an understanding of the distribution and disparities in LOC and OPC burden globally and support cancer control planning efforts

The global burden of cancer attributable to risk factors, 2010-19 : a systematic analysis for the Global Burden of Disease Study 2019

Background Understanding the magnitude of cancer burden attributable to potentially modifiable risk factors is crucial for development of effective prevention and mitigation strategies. We analysed results from the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2019 to inform cancer control planning efforts globally. Methods The GBD 2019 comparative risk assessment framework was used to estimate cancer burden attributable to behavioural, environmental and occupational, and metabolic risk factors. A total of 82 risk-outcome pairs were included on the basis of the World Cancer Research Fund criteria. Estimated cancer deaths and disability-adjusted life-years (DALYs) in 2019 and change in these measures between 2010 and 2019 are presented. Findings Globally, in 2019, the risk factors included in this analysis accounted for 4.45 million (95% uncertainty interval 4.01-4.94) deaths and 105 million (95.0-116) DALYs for both sexes combined, representing 44.4% (41.3-48.4) of all cancer deaths and 42.0% (39.1-45.6) of all DALYs. There were 2.88 million (2.60-3.18) risk-attributable cancer deaths in males (50.6% [47.8-54.1] of all male cancer deaths) and 1.58 million (1.36-1.84) risk-attributable cancer deaths in females (36.3% [32.5-41.3] of all female cancer deaths). The leading risk factors at the most detailed level globally for risk-attributable cancer deaths and DALYs in 2019 for both sexes combined were smoking, followed by alcohol use and high BMI. Risk-attributable cancer burden varied by world region and Socio-demographic Index (SDI), with smoking, unsafe sex, and alcohol use being the three leading risk factors for risk-attributable cancer DALYs in low SDI locations in 2019, whereas DALYs in high SDI locations mirrored the top three global risk factor rankings. From 2010 to 2019, global risk-attributable cancer deaths increased by 20.4% (12.6-28.4) and DALYs by 16.8% (8.8-25.0), with the greatest percentage increase in metabolic risks (34.7% [27.9-42.8] and 33.3% [25.8-42.0]). Interpretation The leading risk factors contributing to global cancer burden in 2019 were behavioural, whereas metabolic risk factors saw the largest increases between 2010 and 2019. Reducing exposure to these modifiable risk factors would decrease cancer mortality and DALY rates worldwide, and policies should be tailored appropriately to local cancer risk factor burden. Copyright (C) 2022 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY 4.0 license.Peer reviewe

Global incidence, prevalence, years lived with disability (YLDs), disability-adjusted life-years (DALYs), and healthy life expectancy (HALE) for 371 diseases and injuries in 204 countries and territories and 811 subnational locations, 1990–2021: a systematic analysis for the Global Burden of Disease Study 2021

Background: Detailed, comprehensive, and timely reporting on population health by underlying causes of disability and premature death is crucial to understanding and responding to complex patterns of disease and injury burden over time and across age groups, sexes, and locations. The availability of disease burden estimates can promote evidence-based interventions that enable public health researchers, policy makers, and other professionals to implement strategies that can mitigate diseases. It can also facilitate more rigorous monitoring of progress towards national and international health targets, such as the Sustainable Development Goals. For three decades, the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) has filled that need. A global network of collaborators contributed to the production of GBD 2021 by providing, reviewing, and analysing all available data. GBD estimates are updated routinely with additional data and refined analytical methods. GBD 2021 presents, for the first time, estimates of health loss due to the COVID-19 pandemic. Methods: The GBD 2021 disease and injury burden analysis estimated years lived with disability (YLDs), years of life lost (YLLs), disability-adjusted life-years (DALYs), and healthy life expectancy (HALE) for 371 diseases and injuries using 100 983 data sources. Data were extracted from vital registration systems, verbal autopsies, censuses, household surveys, disease-specific registries, health service contact data, and other sources. YLDs were calculated by multiplying cause-age-sex-location-year-specific prevalence of sequelae by their respective disability weights, for each disease and injury. YLLs were calculated by multiplying cause-age-sex-location-year-specific deaths by the standard life expectancy at the age that death occurred. DALYs were calculated by summing YLDs and YLLs. HALE estimates were produced using YLDs per capita and age-specific mortality rates by location, age, sex, year, and cause. 95% uncertainty intervals (UIs) were generated for all final estimates as the 2·5th and 97·5th percentiles values of 500 draws. Uncertainty was propagated at each step of the estimation process. Counts and age-standardised rates were calculated globally, for seven super-regions, 21 regions, 204 countries and territories (including 21 countries with subnational locations), and 811 subnational locations, from 1990 to 2021. Here we report data for 2010 to 2021 to highlight trends in disease burden over the past decade and through the first 2 years of the COVID-19 pandemic. Findings: Global DALYs increased from 2·63 billion (95% UI 2·44–2·85) in 2010 to 2·88 billion (2·64–3·15) in 2021 for all causes combined. Much of this increase in the number of DALYs was due to population growth and ageing, as indicated by a decrease in global age-standardised all-cause DALY rates of 14·2% (95% UI 10·7–17·3) between 2010 and 2019. Notably, however, this decrease in rates reversed during the first 2 years of the COVID-19 pandemic, with increases in global age-standardised all-cause DALY rates since 2019 of 4·1% (1·8–6·3) in 2020 and 7·2% (4·7–10·0) in 2021. In 2021, COVID-19 was the leading cause of DALYs globally (212·0 million [198·0–234·5] DALYs), followed by ischaemic heart disease (188·3 million [176·7–198·3]), neonatal disorders (186·3 million [162·3–214·9]), and stroke (160·4 million [148·0–171·7]). However, notable health gains were seen among other leading communicable, maternal, neonatal, and nutritional (CMNN) diseases. Globally between 2010 and 2021, the age-standardised DALY rates for HIV/AIDS decreased by 47·8% (43·3–51·7) and for diarrhoeal diseases decreased by 47·0% (39·9–52·9). Non-communicable diseases contributed 1·73 billion (95% UI 1·54–1·94) DALYs in 2021, with a decrease in age-standardised DALY rates since 2010 of 6·4% (95% UI 3·5–9·5). Between 2010 and 2021, among the 25 leading Level 3 causes, age-standardised DALY rates increased most substantially for anxiety disorders (16·7% [14·0–19·8]), depressive disorders (16·4% [11·9–21·3]), and diabetes (14·0% [10·0–17·4]). Age-standardised DALY rates due to injuries decreased globally by 24·0% (20·7–27·2) between 2010 and 2021, although improvements were not uniform across locations, ages, and sexes. Globally, HALE at birth improved slightly, from 61·3 years (58·6–63·6) in 2010 to 62·2 years (59·4–64·7) in 2021. However, despite this overall increase, HALE decreased by 2·2% (1·6–2·9) between 2019 and 2021. Interpretation: Putting the COVID-19 pandemic in the context of a mutually exclusive and collectively exhaustive list of causes of health loss is crucial to understanding its impact and ensuring that health funding and policy address needs at both local and global levels through cost-effective and evidence-based interventions. A global epidemiological transition remains underway. Our findings suggest that prioritising non-communicable disease prevention and treatment policies, as well as strengthening health systems, continues to be crucially important. The progress on reducing the burden of CMNN diseases must not stall; although global trends are improving, the burden of CMNN diseases remains unacceptably high. Evidence-based interventions will help save the lives of young children and mothers and improve the overall health and economic conditions of societies across the world. Governments and multilateral organisations should prioritise pandemic preparedness planning alongside efforts to reduce the burden of diseases and injuries that will strain resources in the coming decades. Funding: Bill & Melinda Gates Foundation

Global, regional, and national burden of disorders affecting the nervous system, 1990–2021: a systematic analysis for the Global Burden of Disease Study 2021

BackgroundDisorders affecting the nervous system are diverse and include neurodevelopmental disorders, late-life neurodegeneration, and newly emergent conditions, such as cognitive impairment following COVID-19. Previous publications from the Global Burden of Disease, Injuries, and Risk Factor Study estimated the burden of 15 neurological conditions in 2015 and 2016, but these analyses did not include neurodevelopmental disorders, as defined by the International Classification of Diseases (ICD)-11, or a subset of cases of congenital, neonatal, and infectious conditions that cause neurological damage. Here, we estimate nervous system health loss caused by 37 unique conditions and their associated risk factors globally, regionally, and nationally from 1990 to 2021.MethodsWe estimated mortality, prevalence, years lived with disability (YLDs), years of life lost (YLLs), and disability-adjusted life-years (DALYs), with corresponding 95% uncertainty intervals (UIs), by age and sex in 204 countries and territories, from 1990 to 2021. We included morbidity and deaths due to neurological conditions, for which health loss is directly due to damage to the CNS or peripheral nervous system. We also isolated neurological health loss from conditions for which nervous system morbidity is a consequence, but not the primary feature, including a subset of congenital conditions (ie, chromosomal anomalies and congenital birth defects), neonatal conditions (ie, jaundice, preterm birth, and sepsis), infectious diseases (ie, COVID-19, cystic echinococcosis, malaria, syphilis, and Zika virus disease), and diabetic neuropathy. By conducting a sequela-level analysis of the health outcomes for these conditions, only cases where nervous system damage occurred were included, and YLDs were recalculated to isolate the non-fatal burden directly attributable to nervous system health loss. A comorbidity correction was used to calculate total prevalence of all conditions that affect the nervous system combined.FindingsGlobally, the 37 conditions affecting the nervous system were collectively ranked as the leading group cause of DALYs in 2021 (443 million, 95% UI 378–521), affecting 3·40 billion (3·20–3·62) individuals (43·1%, 40·5–45·9 of the global population); global DALY counts attributed to these conditions increased by 18·2% (8·7–26·7) between 1990 and 2021. Age-standardised rates of deaths per 100 000 people attributed to these conditions decreased from 1990 to 2021 by 33·6% (27·6–38·8), and age-standardised rates of DALYs attributed to these conditions decreased by 27·0% (21·5–32·4). Age-standardised prevalence was almost stable, with a change of 1·5% (0·7–2·4). The ten conditions with the highest age-standardised DALYs in 2021 were stroke, neonatal encephalopathy, migraine, Alzheimer's disease and other dementias, diabetic neuropathy, meningitis, epilepsy, neurological complications due to preterm birth, autism spectrum disorder, and nervous system cancer.InterpretationAs the leading cause of overall disease burden in the world, with increasing global DALY counts, effective prevention, treatment, and rehabilitation strategies for disorders affecting the nervous system are needed

An Evaluation of Machine Learning and Artificial Intelligence Models for Predicting the Flotation Behavior of Fine High-Ash Coal

In this study, five different machine learning (ML) and artificial intelligence (AI) models: random forest (RF), artificial neural networks (ANN), the adaptive neuro-fuzzy inference system (ANFIS), Mamdani fuzzy logic (MFL) and a hybrid neural fuzzy inference system (HyFIS) were employed to predict the flotation behavior of fine high ash coal in the presence of a novel hybrid ash depressant consisting of polyacrylamide chains grafted onto aluminium hydroxide nanoparticles: Al(OH)3-PAM (Al-PAM). A total of 51 flotation tests were conducted on coal samples with 38% ash-content and a P80 of approximately 49 μm. Different influencing variables of coal flotation including polymer dosage, pH, polymer conditioning time, sodium metasilicate dosage (commercial dispersant), and the impeller speed were used as inputs for the models. The combustible recovery and ash content of coal reported to the concentrate were used as response variables (outputs). For AI model development, 80% of the total data was used for training phase and 20% was used for testing phase. Coefficient of determination (R2) and root-mean-square error (RMSE) were used as performance indicators of the models. The MFL model showed the best accuracy for the prediction of the combustible recoveries and the froth ash contents for this specific feed. However, in case of any significant change in the characteristics of the feed, these models would have to be re-trained using the data obtained through further physical experimentation and/or process model simulations. Moreover as these models are trained on laboratory scale data, these are only good for the predictions at laboratory scale

Solar Energy -- A Look into Power Generation, Challenges, and a Solar-Powered Future

Sun is an inexhaustible source of energy capable of fulfilling all the energy needs of humankind. The energy from the sun can be converted into electricity or used directly. Electricity can be generated from solar energy either directly using photovoltaic (PV) cells or indirectly using concentrated solar power (CSP) technology. Progress has been made to raise the efficiency of the PV solar cells that can now reach up to approximately 34.1% in multi-junction PV cells. Electricity generation from concentrated solar technologies has a promising future as well, especially the CSP, because of its high capacity, efficiency, and energy storage capability. Solar energy also has direct application in agriculture primarily for water treatment and irrigation. Solar energy is being used to power the vehicles and for domestic purposes such as space heating and cooking. The most exciting possibility for solar energy is satellite power station that will be transmitting electrical energy from the solar panels in space to Earth via microwave beams. Solar energy has a bright future because of the technological advancement in this field and its environment-friendly nature. The biggest challenge however facing the solar energy future is its unavailability all-round the year, coupled with its high capital cost and scarcity of the materials for PV cells. These challenges can be met by developing an efficient energy storage system and developing cheap, efficient, and abundant PV solar cells. This article discusses the solar energy system as a whole and provides a comprehensive review on the direct and the indirect ways to produce electricity from solar energy and the direct uses of solar energy. The state-of-the-art procedures being employed for PV characterization and performance rating have been summarized. Moreover, the technical, economic, environmental, and storage-related challenges are discussed with possible solutions. Furthermore, a comprehensive list of future potential research directions in the field of direct and indirect electricity generation from solar energy is proposed