659 research outputs found

    Identification of vortexes obstructing the dynamo mechanism in laboratory experiments

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    The magnetohydrodynamic dynamo effect explains the generation of self-sustained magnetic fields in electrically conducting flows, especially in geo- and astrophysical environments. Yet the details of this mechanism are still unknown, e.g., how and to which extent the geometry, the fluid topology, the forcing mechanism and the turbulence can have a negative effect on this process. We report on numerical simulations carried out in spherical geometry, analyzing the predicted velocity flow with the so-called Singular Value Decomposition, a powerful technique that allows us to precisely identify vortexes in the flow which would be difficult to characterize with conventional spectral methods. We then quantify the contribution of these vortexes to the growth rate of the magnetic energy in the system. We identify an axisymmetric vortex, whose rotational direction changes periodically in time, and whose dynamics are decoupled from those of the large scale background flow, is detrimental for the dynamo effect. A comparison with experiments is carried out, showing that similar dynamics were observed in cylindrical geometry. These previously unexpected eddies, which impede the dynamo effect, offer an explanation for the experimental difficulties in attaining a dynamo in spherical geometry.Comment: 25 pages, 12 figures, submitted to Physics of Fluid

    Transport Barriers in Magnetized Plasmas -- General Theory with Dynamical Constraints

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    A fundamental dynamical constraint -- that fluctuation induced charge-weighted particle flux must vanish -- can prevent instabilities from accessing the free energy in the strong gradients characteristic of Transport Barriers (TBs). Density gradients, when larger than a certain threshold, lead to a violation of the constraint and emerge as a stabilizing force. This mechanism, then, broadens the class of configurations (in magnetized plasmas) where these high confinement states can be formed and sustained. The need for velocity shear, the conventional agent for TB formation, is obviated. The most important ramifications of the constraint is to permit a charting out of the domains conducive to TB formation and hence to optimally confined fusion worthy states; the detailed investigation is conducted through new analytic methods and extensive gyrokinetic simulations

    Associations between childhood maltreatment and inflammatory markers.

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    BACKGROUND:Childhood maltreatment is one of the strongest predictors of adulthood depression and alterations to circulating levels of inflammatory markers is one putative mechanism mediating risk or resilience.AimsTo determine the effects of childhood maltreatment on circulating levels of 41 inflammatory markers in healthy individuals and those with a major depressive disorder (MDD) diagnosis. METHOD:We investigated the association of childhood maltreatment with levels of 41 inflammatory markers in two groups, 164 patients with MDD and 301 controls, using multiplex electrochemiluminescence methods applied to blood serum. RESULTS:Childhood maltreatment was not associated with altered inflammatory markers in either group after multiple testing correction. Body mass index (BMI) exerted strong effects on interleukin-6 and C-reactive protein levels in those with MDD. CONCLUSIONS:Childhood maltreatment did not exert effects on inflammatory marker levels in either the participants with MDD or the control group in our study. Our results instead highlight the more pertinent influence of BMI.Declaration of interestD.A.C. and H.W. work for Eli Lilly Inc. R.N. has received speaker fees from Sunovion, Jansen and Lundbeck. G.B. has received consultancy fees and funding from Eli Lilly. R.H.M.-W. has received consultancy fees or has a financial relationship with AstraZeneca, Bristol-Myers Squibb, Cyberonics, Eli Lilly, Ferrer, Janssen-Cilag, Lundbeck, MyTomorrows, Otsuka, Pfizer, Pulse, Roche, Servier, SPIMACO and Sunovian. I.M.A. has received consultancy fees or has a financial relationship with Alkermes, Lundbeck, Lundbeck/Otsuka, and Servier. S.W. has sat on an advisory board for Sunovion, Allergan and has received speaker fees from Astra Zeneca. A.H.Y. has received honoraria for speaking from Astra Zeneca, Lundbeck, Eli Lilly, Sunovion; honoraria for consulting from Allergan, Livanova and Lundbeck, Sunovion, Janssen; and research grant support from Janssen. A.J.C. has received honoraria for speaking from Astra Zeneca, honoraria for consulting with Allergan, Livanova and Lundbeck and research grant support from Lundbeck

    Skin-impedance in Fabry Disease: A prospective, controlled, non-randomized clinical study

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    <p>Abstract</p> <p>Background</p> <p>We previously demonstrated improved sweating after enzyme replacement therapy (ERT) in Fabry disease using the thermo-regularity sweat and quantitative sudomotor axon reflex tests. Skin-impedance, a measure skin-moisture (sweating), has been used in the clinical evaluation of burns and pressure ulcers using the portable dynamic dermal impedance monitor (DDIM) system.</p> <p>Methods</p> <p>We compared skin impedance measurements in hemizygous patients with Fabry disease (22 post 3-years of bi-weekly ERT and 5 ERT naive) and 22 healthy controls. Force compensated skin-moisture values were used for statistical analysis. Outcome measures included 1) moisture reading of the 100<sup>th </sup>repetitive reading, 2) rate of change, 3) average of 60–110<sup>th </sup>reading and 4) overall average of all readings.</p> <p>Results</p> <p>All outcome measures showed a significant difference in skin-moisture between Fabry patients and control subjects (p < 0.0001). There was no difference between Fabry patients on ERT and patients naïve to ERT. Increased skin-impedance values for the four skin-impedance outcome measures were found in a small number of dermatome test-sites two days post-enzyme infusions.</p> <p>Conclusion</p> <p>The instrument portability, ease of its use, a relatively short time required for the assessment, and the fact that DDIM system was able to detect the difference in skin-moisture renders the instrument a useful clinical tool.</p

    Microtearding mode study in NSTX using machine learning enhanced reduced model

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    This article presents a survey of NSTX cases to study the microtearing mode (MTM) stabilities using the newly developed global reduced model for Slab-Like Microtearing modes (SLiM). A trained neutral network version of SLiM enables rapid assessment (0.05s/mode) of MTM with 98%98\% accuracy providing an opportunity for systemic equilibrium reconstructions based on the matching of experimentally observed frequency bands and SLiM prediction across a wide range of parameters. Such a method finds some success in the NSTX discharges, the frequency observed in the experiment matches with what SLiM predicted. Based on the experience with SLiM analysis, a workflow to estimate the potential MTM frequency for a quick assessment based on experimental observation has been established

    A Giant Metrewave Radio Telescope/Chandra view of IRAS 09104+4109: A type 2 QSO in a cooling flow

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    IRAS 09104+4109 is a rare example of a dust enshrouded type 2 QSO in the centre of a cool-core galaxy cluster. Previous observations of this z=0.44 system showed that as well as powering the hyper-luminous infrared emission of the cluster-central galaxy, the QSO is associated with a double-lobed radio source. However, the steep radio spectral index and misalignment between the jets and ionised optical emission suggested that the orientation of the QSO had recently changed. We use a combination of new, multi-band Giant Metrewave Radio Telescope observations and archival radio data to confirm that the jets are no longer powered by the QSO, and estimate their age to be 120-160 Myr. This is in agreement with the ~70-200 Myr age previously estimated for star-formation in the galaxy. Previously unpublished Very Long Baseline Array data reveal a 200 pc scale double radio source in the galaxy core which is more closely aligned with the current QSO axis and may represent a more recent period of jet activity. These results suggest that the realignment of the QSO, the cessation of jet activity, and the onset of rapid star-formation may have been caused by a gas-rich galaxy merger. A Chandra X-ray observation confirms the presence of cavities associated with the radio jets, and we estimate the energy required to inflate them to be ~7.7x10^60 erg. The mechanical power of the jets is sufficient to balance radiative cooling in the cluster, provided they are efficiently coupled to the intra-cluster medium (ICM). We find no evidence of direct radiative heating and conclude that the QSO either lacks the radiative luminosity to heat the ICM, or that it requires longer than 100-200 Myr to significantly impact its environment. [Abridged]Comment: 23 pages, 18 figures and 7 tables. Accepted for publication in MNRA
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