The Bankart repair versus the Putti-Platt procedure: A randomized study with WOSI score at 10-year follow-up in 62 patients

Background and purpose This randomized study compared clinical results after surgery for posttraumatic shoulder instability with either an anatomical repair or an older, less anatomical but commonly used method. The less anatomical procedure has been considered quicker and less demanding, but it has been questioned regarding the clinical result. We therefore wanted to compare the clinical outcome of the two different procedures. Our hypothesis was that the anatomical repair would give less residual impairment postoperatively

IL-4 AND INTERFERON GAMMA IN RECENTLY DIAGNOSED TYPE I DIABETES, A CASE-CONTROL STUDY

&nbsp; Abstract INTRODUCTION: The aim of this study was to measure serum levels of interferon-gamma (IFN-&gamma;) and interleukin-4 (IL-4), the two major cytokines secreted by Th-1 and Th-2 cells, in islet cell autoantibody (ICA)-positive, newly-diagnosed type I diabetic patients. methods: The study was conducted on 30 newly diagnosed, ICA-positive type I diabetics and 30 age- and sex-matched healthy controls. Cytokine levels in serum were quantified by indirect sandwich ELISA in pg/ml. results: We observed no significant difference in concentration of IL-4 in ICA-positive diabetics (median=126.535) compared with healthy controls (median=136.440) (P&gt;0.05). IFN-&gamma; levels were significantly higher in patients (median=11.305) compared with healthy controls (median=8.200) (P&lt;0.05). CONCLUSIONS: Increased levels of IFN-&gamma; in patients may be suggestive of its destructive role in the pathophysiology of type I autoimmune diabetes. &nbsp; &nbsp; Keywords: Type I diabetes mellitus, interleukin-4 (IL-4), interferon-gamma (IFN-&gamma;), islet cell autoantibody (ICA), T-helper 1 (Th-1) response, T-helper 2 (Th-2</div

Synthesis, docking and evaluation of in vitro anti-inflammatory activity of novel morpholine capped β-lactam derivatives

International audienceThis study reports the synthesis and biological investigation of three series of novel β-lactams bearing a morpholine substituent of the nitrogen center. These products were synthesized via Staudinger's [2+2]-ketene-imine cycloaddition reaction. The cycloadducts were fully characterized by spectral data, including 1 H-NMR, 13 C-NMR, IR, mass spectroscopy and elemental analyses, and then evaluated for anti-inflammatory activity. A number of the derivatives demonstrated higher therapeutic ratios than dexamethasone and corticosteroid medication. In silico molecular docking experiments showed a good correlation between the experimental activity and the calculated binding affinity to human inducible nitric oxide synthase, the enzymatic target for the anti-inflammatory response