306 research outputs found

    The Feast

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    The Seventh Night

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    The Lesley Lee Francis Award

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    Stepwise transition from deglacial/Early Holocene to modern-like conditions in the eastern Fram Strait, sub-Arctic north, inferred from planktic foraminifer fauna and sea surface temperatures

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    EGU2012-4750 The heat content of the Arctic Ocean is mainly controlled by the inflow of north-heading warm and saline Atlantic Water through eastern Fram Strait. The eastern Fram Strait is therefore ice-free all year, opposite to its perennially ice-covered western part where large amounts of Arctic sea ice are exported year-round to the Nordic Seas. The Early and Mid-Holocene phases (ca 12 to 5 cal ka BP) in the (sub-)Arctic have been especially marked not only by high summer insolation but also by rising sea level and the final disintegration of large ice sheets that had been established during the preceding glacial phase. Two sediment cores with multidecadal resolution from the Western Svalbard margin have been investigated for its planktic foraminiferal distribution, sea surface temperatures, planktic and benthic stable isotope ratios, and lithological parameters to derive information on the Holocene variability of the heat transport to the Arctic Ocean and related fluctuations of the marginal ice zone in the eastern Fram Strait. Planktic foraminifer fauna and a summer sea surface temperature reconstruction based on the modern analogue technique imply a stepwise transition from deglacial/Early Holocene to modern-like conditions in the eastern Fram Strait. Repeated short-term advances of the sea ice margin accompanied the generally strong heat transport to the Arctic Ocean during the Early to Mid-Holocene. Consistent with the decreasing solar insolation, cooler (sub-)surface conditions established after ca 5 cal ka BP most likely related to both a weakening of the Atlantic Water inflow and strong export of Arctic sea ice through Fram Strait. The Late Holocene Neoglacial phase was characterized by high contents of ice-rafted material and dominance of the cold water-indicating planktic foraminifer species Neogloboquadrina pachyderma. Cool Late Holocene conditions are reversed by a strong warming event likely caused by a significant strengthening of Atlantic heat advection to the Arctic during the present, anthropogenically influenced period

    Specific Rab GTPase-activating proteins define the Shiga toxin and epidermal growth factor uptake pathways

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    Rab family guanosine triphosphatases (GTPases) together with their regulators define specific pathways of membrane traffic within eukaryotic cells. In this study, we have investigated which Rab GTPase-activating proteins (GAPs) can interfere with the trafficking of Shiga toxin from the cell surface to the Golgi apparatus and studied transport of the epidermal growth factor (EGF) from the cell surface to endosomes. This screen identifies 6 (EVI5, RN-tre/USP6NL, TBC1D10A–C, and TBC1D17) of 39 predicted human Rab GAPs as specific regulators of Shiga toxin but not EGF uptake. We show that Rab43 is the target of RN-tre and is required for Shiga toxin uptake. In contrast, RabGAP-5, a Rab5 GAP, was unique among the GAPs tested and reduced the uptake of EGF but not Shiga toxin. These results suggest that Shiga toxin trafficking to the Golgi is a multistep process controlled by several Rab GAPs and their target Rabs and that this process is discrete from ligand-induced EGF receptor trafficking

    WELL-TO-WHEELS Report version 4.a : JEC WELL-TO-WHEELS ANALYSIS

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    The JEC research partners [Joint Research Centre of the European Commission, EUCAR and CONCAWE] have updated their joint evaluation of the well-to-wheels energy use and greenhouse gas emissions for a wide range of potential future fuel and powertrain options. This document reports on the fourth release of this study replacing Version 3c published in July 2011. The original version was published in December 2003.JRC.F.8-Sustainable Transpor

    Unifying prospective and retrospective interval-time estimation: a fading-gaussian activation-based model of interval-timing

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    Hass and Hermann (2012) have shown that only variance-based processes will lead to the scalar growth of error that is characteristic of human time judgments. Secondly, a major meta-review of over one hundred studies (Block et al., 2010) reveals a striking interaction between the way in which temporal judgments are queried and cognitive load on participants’ judgments of interval duration. For retrospective time judgments, estimates under high cognitive load are longer than under low cognitive load. For prospective judgments, the reverse pattern holds, with increased cognitive load leading to shorter estimates. We describe GAMIT, a Gaussian spreading-activation model, in which the sampling rate of an activation trace is differentially affected by cognitive load. The model unifies prospective and retrospective time estimation, normally considered separately, by relating them to the same underlying process. The scalar property of time estimation arises naturally from the model dynamics and the model shows the appropriate interaction between mode of query and cognitive load

    TANK-to-WHEELS Report Version 4.0

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    The Tank-to-Wheel study described in this report includes several different fuel–powertrain configurations for conventional1 (i.e. “ICE-only”) as well as electrified (i.e. “xEV”) vehicles. These variants are considered for 2010 (including technologies in the market in the years 2008 up to 2012) to represent the current state-of-the-art in automotive industry and for 2020+JRC.F.8-Sustainable Transpor

    Fatigue Life of a NiCr-Coated Powder Metallurgy Disk Superalloy After Varied Processing and Exposures

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    A protective ductile NiCr coating has shown promise to mitigate oxidation and corrosion attack on superalloy disk alloys. The effects of this coating on fatigue life and failure modes of the disk superalloy are an important concern. The objective of this study was to investigate the fatigue life and failure modes of disk superalloy specimens protected by this coating, using varied pre-coating and post-coating processes. Cylindrical gage fatigue specimens of a powder metallurgy-processed disk superalloy were grit blast or wet blast before being coated with a ductile NiCrY coating, then shot peened at low or medium levels after coating. All were then heat treated, some exposed, and finally all were subjected to fatigue at high temperature. The effects of varied pre-coating treatment, post-coating shot peening, and oxidation plus hot corrosion exposures on fatigue life with the coating were compared

    Andreev Reflection and Spin Injection into ss- and dd-wave Superconductors

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    We study the effect of spin injection into ss- and dd-wave superconductors, with an emphasis on the interplay between boundary and bulk spin transport properties. The quantities of interest include the amount of non-equilibrium magnetization (mm), as well as the induced spin-dependent current (IsI_s) and boundary voltage (VsV_s). In general, the Andreev reflection makes each of the three quantities depend on a different combination of the boundary and bulk contributions. The situation simplifies either for half-metallic ferromagnets or in the strong barrier limit, where both VsV_s and mm depend solely on the bulk spin transport/relaxation properties. The implications of our results for the on-going spin injection experiments in high TcT_c cuprates are discussed.Comment: 4 pages, REVTEX, 1 figure included; typos correcte
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