Kidney Transplantation Outcomes in Temporarily Protected Syrian Patients With End-Stage Renal Failure in Turkey

Background: Approximately 6.3 million Syrian people migrated to other countries due to war since 2011. There are more than 3.5 million Syrian people living in Turkey under temporary protection. Syrian people receive free health care in Turkey, including kidney transplantation. Our institution started a kidney transplantation program about 3 years ago. It is the first institution performing living, related kidney transplantation for Syrian patients with end-stage renal failure. Methods: All living, related kidney transplantations to Turkish and Syrian patients from the beginning of our transplantation program until September 2018 were enrolled in this study. Donor and recipient characteristics, induction and maintenance immunosuppression, length of hospital stay, creatinine values at first week and first month, treatment incompatibility, and graft survival were evaluated. Results: Of the 25 living, related kidney transplantations 20% were Syrian. Three of 5 Syrian recipients were in the pediatric age group. None of the Syrian transplantations were preemptive, while half of the Turkish transplantations were preemptive (P = .005). Immunosuppression protocols, creatinine values, length of hospital stay, and graft survival rates were similar between groups. None of the Syrian recipients had treatment incompatibility (0%), unlike the Turkish recipients (15%). Conclusion: Outcomes of kidney transplantation for Syrian recipients are similar to those of Turkish recipients. Having this no-cost facility is great for Syrian kidney failure patients. The number of transplantations for Syrian patients under temporary protection in Turkey is expected to increase in the future, with these favorable results and easy to access, free health care facilities. © 2019 Elsevier Inc

AUTOLOGOUS STEM CELL COLLECTION IN LYMPHOMA AND MYELOMA PATIENTS: SINGLE CENTER ANALYSIS WITH INTENT TO SUCCESSFULLY MOBILIZE AND TRANSPLANT

40th Annual Meeting of the European-Group-for-Blood-and-Marrow-Transplantation -- MAR 30-APR 02, 2014 -- Milan, ITALYWOS: 000359941901255…European Grp Blood & Marrow Transplanta

ALLOGENEIC RELATED DONOR STEM CELL TRANSPLANTATION IN AML CR1: ANY RISK FACTOR FOR BETTER SURVIVAL?

40th Annual Meeting of the European-Group-for-Blood-and-Marrow-Transplantation -- MAR 30-APR 02, 2014 -- Milan, ITALYWOS: 000359941901036…European Grp Blood & Marrow Transplanta

Polymorphisms of interferon-γ, interleukin-10, and interleukin-12 genes in myasthenia gravis

To assess the involvement of polymorphisms in genetic susceptibility to myasthenia gravis (MG), this study analyzed four polymorphisms of interferon (IFN)-γ, interleukin (IL)-10, and IL-12 genes in 115 patients and 204 healthy controls (HC). IFNG +874T carriers were less frequent in MG, in patients with anti-acetylcholine receptor (AChR) (63%) and anti-titin (56.2%) antibodies compared with HC (p = 0.01 for all, OR: 0.5, 0.5, and 0.4, respectively). The presence of thymoma was also associated with lower frequency of IFNG +874T allele (p = 0.018, OR = 0.34). At IL10, -2763A allele was found to be slightly more frequent in MG and in patients with anti-AChR than in HC group (p = 0.05, OR = 1.7, p = 0.036, OR = 1.83). However, these associations did not remain significant after correction for multiple comparisons. IL12B allele distribution was not different among groups. These data suggest that some cytokine gene polymorphisms may contribute to susceptibility to or antibody production in MG. These findings need to be replicated in further studies. © 2007 American Society for Histocompatibility and Immunogenetics