7,313 research outputs found
Fluid and Diffusion Limits for Bike Sharing Systems
Bike sharing systems have rapidly developed around the world, and they are
served as a promising strategy to improve urban traffic congestion and to
decrease polluting gas emissions. So far performance analysis of bike sharing
systems always exists many difficulties and challenges under some more general
factors. In this paper, a more general large-scale bike sharing system is
discussed by means of heavy traffic approximation of multiclass closed queueing
networks with non-exponential factors. Based on this, the fluid scaled
equations and the diffusion scaled equations are established by means of the
numbers of bikes both at the stations and on the roads, respectively.
Furthermore, the scaling processes for the numbers of bikes both at the
stations and on the roads are proved to converge in distribution to a
semimartingale reflecting Brownian motion (SRBM) in a -dimensional box,
and also the fluid and diffusion limit theorems are obtained. Furthermore,
performance analysis of the bike sharing system is provided. Thus the results
and methodology of this paper provide new highlight in the study of more
general large-scale bike sharing systems.Comment: 34 pages, 1 figure
The BAT AGN Spectroscopic Survey -- XVIII. Searching for Supermassive Black Hole Binaries in the X-rays
Theory predicts that a supermassive black hole binary (SMBHB) could be
observed as a luminous active galactic nucleus (AGN) that periodically varies
on the order of its orbital timescale. In X-rays, periodic variations could be
caused by mechanisms including relativistic Doppler boosting and shocks. Here
we present the first systematic search for periodic AGNs using hard X-ray
light curves (14-195 keV) from the first 105 months of the Swift Burst Alert
Telescope (BAT) survey (2004-2013). We do not find evidence for periodic AGNs
in Swift-BAT, including the previously reported SMBHB candidate
MCG+1111032. We find that the null detection is consistent with the
combination of the upper-limit binary population in AGNs in our adopted model,
their expected periodic variability amplitudes, and the BAT survey
characteristics. We have also investigated the detectability of SMBHBs against
normal AGN X-ray variability in the context of the eROSITA survey. Under our
assumptions of a binary population and the periodic signals they produce which
have long periods of hundreds of days, up to % true periodic binaries can
be robustly distinguished from normal variable AGNs with the ideal uniform
sampling. However, we demonstrate that realistic eROSITA sampling is likely to
be insensitive to long-period binaries because longer observing gaps reduce
their detectability. In contrast, large observing gaps do not diminish the
prospect of detecting binaries of short, few-day periods, as 19% can be
successfully recovered, the vast majority of which can be identified by the
first half of the survey.Comment: 17 pages, including 8 figures and 4 tables. Accepted for publication
in Ap
A Multiscale Approach to Determination of Thermal Properties and Changes in Free Energy: Application to Reconstruction of Dislocations in Silicon
We introduce an approach to exploit the existence of multiple levels of
description of a physical system to radically accelerate the determination of
thermodynamic quantities. We first give a proof of principle of the method
using two empirical interatomic potential functions. We then apply the
technique to feed information from an interatomic potential into otherwise
inaccessible quantum mechanical tight-binding calculations of the
reconstruction of partial dislocations in silicon at finite temperature. With
this approach, comprehensive ab initio studies at finite temperature will now
be possible.Comment: 5 pages, 3 figure
Achieving Acetylcholine Receptor Clustering in Tissue-Engineered Skeletal Muscle Constructs In vitro through a Materials-Directed Agrin Delivery Approach
Volumetric muscle loss (VML) can result from trauma, infection, congenital anomalies, or surgery, and produce permanent functional and cosmetic deficits. There are no effective treatment options for VML injuries, and recent advances toward development of muscle constructs lack the ability to achieve innervation necessary for long-term function. We sought to develop a proof-of-concept biomaterial construct that could achieve acetylcholine receptor (AChR) clustering on muscle-derived cells (MDCs) in vitro. The approach consisted of the presentation of neural (Z+) agrin from the surface of microspheres embedded with a fibrin hydrogel to muscle cells (C2C12 cell line or primary rat MDCs). AChR clustering was spatially restricted to areas of cell (C2C12)-microsphere contact when the microspheres were delivered in suspension or when they were incorporated into a thin (2D) fibrin hydrogel. AChR clusters were observed from 16 to 72 h after treatment when Z+ agrin was adsorbed to the microspheres, and for greater than 120 h when agrin was covalently coupled to the microspheres. Little to no AChR clustering was observed when agrin-coated microspheres were delivered from specially designed 3D fibrin constructs. However, cyclic stretch in combination with agrin-presenting microspheres led to dramatic enhancement of AChR clustering in cells cultured on these 3D fibrin constructs, suggesting a synergistic effect between mechanical strain and agrin stimulation of AChR clustering in vitro. These studies highlight a strategy for maintaining a physiological phenotype characterized by motor endplates of muscle cells used in tissue engineering strategies for muscle regeneration. As such, these observations may provide an important first step toward improving function of tissue-engineered constructs for treatment of VML injuries
Probabilistic classification of acute myocardial infarction from multiple cardiac markers
Logistic regression and Gaussian mixture model (GMM) classifiers have been trained to estimate the probability of acute myocardial infarction (AMI) in patients based upon the concentrations of a panel of cardiac markers. The panel consists of two new markers, fatty acid binding protein (FABP) and glycogen phosphorylase BB (GPBB), in addition to the traditional cardiac troponin I (cTnI), creatine kinase MB (CKMB) and myoglobin. The effect of using principal component analysis (PCA) and Fisher discriminant analysis (FDA) to preprocess the marker concentrations was also investigated. The need for classifiers to give an accurate estimate of the probability of AMI is argued and three categories of performance measure are described, namely discriminatory ability, sharpness, and reliability. Numerical performance measures for each category are given and applied. The optimum classifier, based solely upon the samples take on admission, was the logistic regression classifier using FDA preprocessing. This gave an accuracy of 0.85 (95% confidence interval: 0.78â0.91) and a normalised Brier score of 0.89. When samples at both admission and a further time, 1â6 h later, were included, the performance increased significantly, showing that logistic regression classifiers can indeed use the information from the five cardiac markers to accurately and reliably estimate the probability AMI
Peripheral killer cells do not differentiate between asthma patients with or without fixed airway obstruction
Objective: The three main types of killer cells â CD8+ T cells, NK cells and NKT cells â have been linked to asthma and chronic obstructive pulmonary disease (COPD). However, their role in a small subset of asthma patients displaying fixed airway obstruction (FAO), similar to that seen in COPD, has not been explored. The objective of the present study was to investigate killer cell numbers, phenotype and function in peripheral blood from asthma patients with FAO, asthma patients without FAO, and healthy individuals.
Methods: Peripheral CD8+ T cells (CD8+CD3+CD56â), NK cells (CD56+CD3â) and NKT-like cells (CD56+CD3+) of 14 asthma patients with FAO (post-bronchodilator FEV/FVC <0.7, despite clinician-optimised treatment), 7 asthma patients without FAO (post-bronchodilator FEV/FVC â„0.7), and 9 healthy individuals were studied.
Results: No significant differences were seen between the number, receptor expression, MAPK signalling molecule expression, cytotoxic mediator expression, and functional cytotoxicity of peripheral killer cells from asthma patients with FAO, asthma patients without FAO and healthy individuals.
Conclusions: Peripheral killer cell numbers or functions do not differentiate between asthma patients with or without fixed airway obstruction
Molecular Hydrogen and [FeII] in Active Galactic Nuclei
(Abridge) Near-infrared spectroscopy is used to study the kinematics and
excitation mechanisms of the H2 and [FeII] gas in a sample of AGN. The H2 lines
are unresolved in all objects in which they were detected while the [FeII]
lines have widths implying gas velocities of up to 650 km/s. This suggests
that, very likely, the H2 and [FeII] emission does not originate from the same
parcel of gas. Molecular H2 were detected in 90% of the sample, including PG
objects, indicating detectavel amounts of molecular material even in objects
with low levels of circumnuclear starburst activity. The data favors thermal
excitation for the H2 lines. Indeed, in NGC3227, Mrk766, NGC4051 and NGC4151,
the molecular emission is found to be purely thermal. This result is also
confirmed by the rather similar vibrational and rotational temperatures in the
objects for which they were derived. [FeII] lines are detected in all of the
AGN. The [FeII] 1.254mu/Pa-beta ratio is compatible with excitation of the
[FeII] by the active nucleus, but in Mrk 766 it implies a stellar origin. A
correlation between H2/Br-gamma and [FeII]/Pa-beta is found. We confirm that it
is a useful diagnostic tool in the NIR to separate emitting line objects by
their level of nuclear activity. X-ray excitation models are able to explain
the observed H2 and part of the [FeII] emission. Most likely, a combination of
X-ray heating, shocks driven by the radio jet, and circumnuclear star formation
contributes, in different proportions, to the H2 and [FeII] emission. In most
of our spectra, the [FeII] 1.257mu/1.644mu ratio is found to be 30% lower than
the intrinsic value based on current atomic data. This implies either than the
extinction towards the [FeII] emitting clouds is very similar in most objects
or there are possible inaccuracies in the A-values in the [FeII] transitions.Comment: 18 pages, 6 figures, Accepted for publication in Astronomy &
Astrophysic
The global oscillation network group site survey. II. Results
The Global Oscillation Network Group (GONG) Project will place a network of instruments around the world to observe solar oscillations as continuously as possible for three years. The Project has now chosen the six network sites based on analysis of survey data from fifteen sites around the world. The chosen sites are: Big Bear Solar Observatory, California; Mauna Loa Solar Observatory, Hawaii; Learmonth Solar Observatory, Australia; Udaipur Solar Observatory, India; Observatorio del Teide, Tenerife; and Cerro Tololo Interamerican Observatory, Chile.
Total solar intensity at each site yields information on local cloud cover, extinction coefficient, and transparency fluctuations. In addition, the performance of 192 reasonable components analysis. An accompanying paper describes the analysis methods in detail; here we present the results of both the network and individual site analyses.
The selected network has a duty cycle of 93.3%, in good agreement with numerical simulations. The power spectrum of the network observing window shows a first diurnal sidelobe height of 3 Ă 10â»âŽ with respect to the central component, an improvement of a factor of 1300 over a single site. The background level of the network spectrum is lower by a factor of 50 compared to a single-site spectrum
- âŠ