Emerg Infect Dis

27869609PMC518915

Risk-taking and fairness among cocaine-dependent patients in dual diagnoses: Schizophrenia and Anti-Social Personality Disorder

This study reports experimental results from a clinical sample of patients with a cocaine-related disorder and dual diagnosis: Schizophrenia and Anti-Social Personality Disorder. Both types of patients as well as a non-clinical group of students performed two incentivized decision-making tasks. In the first part of the experiment, they performed a lottery-choice task in order to elicit their degree of risk aversion. In the second part, they decided in two modified dictator games aimed at eliciting their aversion to advantageous and disadvantageous inequality. It is found that the Anti-Social Personality Disorder group exhibits no significant differences from the non-clinical sample in either task. However, compared with the students’ sample, subjects from the group with schizophrenia show more risk aversion and exhibit more aversion towards disadvantageous inequality

Escenarios de guerra: paseando por Madrid a través de su memoria

La actividad "Escenarios de Guerra. Paseando por Madrid a través de su memoria" se organiza en el marco de la XV Semana de la Ciencia (2015) con el objetivo de difundir los resultados de las investigaciones llevadas a cabo por los proyectos de investigación de I+D+i "50 años de arte en el Siglo de Plata español (1931-1981)" (HAR2014-53871-P) y "Madrid 1936-1939: capital, frente, retaguardia y ciudad en guerra" (HAR2014-52065-P). En ella se proponen tres itinerarios por los lugares más significativos del impacto de la Guerra Civil española en Madrid: el centro de la ciudad (Cibeles-Museo Nacional Centro de Arte Reina Sofía), el norte (Ciudad Universitaria) y el oeste (Plaza de Oriente-Arco de la Victoria). A lo largo de estos recorridos guiados, los miembros de los mencionados proyectos comentarán aspectos de la historia, el arte, el patrimonio, la memoria y la vida cotidiana, apoyándose en las fuentes directas de quienes vivieron el conflicto, recogidas en la publicación que tiene entre sus manos.Proyectos de I+D+i: "50 años de arte en el Siglo de Plata español (1931-1981)" (HAR2014-53871-P) y "Madrid 1936-1939: capital, frente, retaguardia y ciudad en guerra" (HAR2014-52065-P).Peer reviewe

ABCG2 transporter plays a key role in the biodistribution of melatonin and its main metabolites

[EN] The ATP-binding cassette G2 (ABCG2) is an efflux transporter expressed in the apical membrane of cells from a large number of tissues, directly affecting bioavailability, tissue accumulation, and secretion into milk of both xenobiotics and endogenous compounds. The aim of this work was to characterize the role of ABCG2 in the systemic distribution and secretion into milk of melatonin and its main metabolites, 6-hydroxymelatonin, and 6-sulfatoxymelatonin. For this purpose, we first showed that these three molecules are transported by this transporter using in vitro transepithelial assays with MDCK-II polarized cells transduced with different species variants of ABCG2. Second, we tested the in vivo effect of murine Abcg2 in the systemic distribution of melatonin and its metabolites using wild-type and Abcg2−/− mice. Our results show that after oral administration of melatonin, the plasma concentration of melatonin metabolites in Abcg2−/− mice was between 1.5 and 6-fold higher compared to the wild-type mice. We also evaluated in these animals differences in tissue accumulation of melatonin metabolites. The most relevant differences between both types of mice were found for small intestine and kidney (>sixfold increase for 6-sulfatoxymelatonin in Abcg2−/− mice). Finally, melatonin secretion into milk was also affected by the murine Abcg2 transporter, with a twofold higher milk concentration in wild-type compared with Abcg2−/− lactating female mice. In addition, melatonin metabolites showed a higher milk-to-plasma ratio in wild-type mice. Overall, our results show that the ABCG2 transporter plays a critical role in the biodistribution of melatonin and its main metabolites, thereby potentially affecting their biological and therapeutic activity.SIPublicación en abierto financiada por el Consorcio de Bibliotecas Universitarias de Castilla y León (BUCLE), con cargo al Programa Operativo 2014ES16RFOP009 FEDER 2014-2020 DE CASTILLA Y LEÓN, Actuación:20007-CL - Apoyo Consorcio BUCL

Estudio descriptivo-inferencial de la situación económica y financiera de las empresas del municipio Ibagué

Objetivo: analizar la situación económica de las empresas de Ibagué pertenecientes al departamento de Tolima en un escenario previo y en pandemia Covid-19 mediante valoraciones financieras y estadísticas. Metodología: el estudio se llevó a cabo en 186 empresas en Ibagué durante 2019-2020, utilizando regresión múltiple, efectos marginales y prueba t de muestras emparejadas. Resultados: En 2019, había una oportunidad de mejorar la solvencia interna y aumentar la capacidad productiva sin afectar la rentabilidad. En 2020, la solvencia interna se considera esencial para mantener una rentabilidad estable debido a un entorno más limitado. Conclusión: enfatizando en lo antes mencionado, la adherencia al riesgo antes del Covid-19 era factible ante un entorno sin tanta restricción

A comprehensive survey on reinforcement-learning-based computation offloading techniques in Edge Computing Systems

Producción CientíficaIn recent years, the number of embedded computing devices connected to the Internet has exponentially increased. At the same time, new applications are becoming more complex and computationally demanding, which can be a problem for devices, especially when they are battery powered. In this context, the concepts of computation offloading and edge computing, which allow applications to be fully or partially offloaded and executed on servers close to the devices in the network, have arisen and received increasing attention. Then, the design of algorithms to make the decision of which applications or tasks should be offloaded, and where to execute them, is crucial. One of the options that has been gaining momentum lately is the use of Reinforcement Learning (RL) and, in particular, Deep Reinforcement Learning (DRL), which enables learning optimal or near-optimal offloading policies adapted to each particular scenario. Although the use of RL techniques to solve the computation offloading problem in edge systems has been covered by some surveys, it has been done in a limited way. For example, some surveys have analysed the use of RL to solve various networking problems, with computation offloading being one of them, but not the primary focus. Other surveys, on the other hand, have reviewed techniques to solve the computation offloading problem, being RL just one of the approaches considered. To the best of our knowledge, this is the first survey that specifically focuses on the use of RL and DRL techniques for computation offloading in edge computing system. We present a comprehensive and detailed survey, where we analyse and classify the research papers in terms of use cases, network and edge computing architectures, objectives, RL algorithms, decision-making approaches, and time-varying characteristics considered in the analysed scenarios. In particular, we include a series of tables to help researchers identify relevant papers based on specific features, and analyse which scenarios and techniques are most frequently considered in the literature. Finally, this survey identifies a number of research challenges, future directions and areas for further study.Consejería de Educación de la Junta de Castilla y León y FEDER (VA231P20)Ministerio de Ciencia e Innovación y Agencia Estatal de Investigación (Proyecto PID2020-112675RB-C42, PID2021-124463OBI00 y RED2018-102585-T, financiados por MCIN/AEI/10.13039/501100011033

Metabolic Signatures Associated with Severity in Hospitalized COVID-19 Patients

The clinical evolution of COVID-19 pneumonia is poorly understood. Identifying the metabolic pathways that are altered early with viral infection and their association with disease severity is crucial to understand COVID-19 pathophysiology, and guide clinical decisions. This study aimed at assessing the critical metabolic pathways altered with disease severity in hospitalized COVID-19 patients. Forty-nine hospitalized patients with COVID-19 pneumonia were enrolled in a prospective, observational, single-center study in Barcelona, Spain. Demographic, clinical, and analytical data at admission were registered. Plasma samples were collected within the first 48 h following hospitalization. Patients were stratified based on the severity of their evolution as moderate (N = 13), severe (N = 10), or critical (N = 26). A panel of 221 biomarkers was measured by targeted metabolomics in order to evaluate metabolic changes associated with subsequent disease severity. Our results show that obesity, respiratory rate, blood pressure, and oxygen saturation, as well as some analytical parameters and radiological findings, were all associated with disease severity. Additionally, ceramide metabolism, tryptophan degradation, and reductions in several metabolic reactions involving nicotinamide adenine nucleotide (NAD) at inclusion were significantly associated with respiratory severity and correlated with inflammation. In summary, assessment of the metabolomic profile of COVID-19 patients could assist in disease severity stratification and even in guiding clinical decisions

Negociación y Solución de Conflictos - PS199 201702

Negociación y Conflictos es un curso de especialidad en el área Organizacional en la carrera de Psicología, de naturaleza teórico práctico, dirigido a los estudiantes del décimo ciclo, que busca desarrollar la competencia general de pensamiento crítico y ciudadanía y en cuanto a la competencia específica es la de intervención y evaluación. En la actualidad, dentro de las organizaciones, se vive en un mundo competitivo que genera conflictos, Aquellos, muchas veces, fragmentan las relaciones humanas y crean un clima negativo dentro de ellas, haciéndose necesario comprender la naturaleza del conflicto y generar estrategias de negociación para la solución de las mismas. Por ende, a través del curso, el alumno desarrollará la habilidad de analizar los factores que intervienen en un proceso de negociación, considerando los diversos intereses y puntos de vista de las partes involucradas. Además de poder mejorar sus habilidades en materia de negociación, comunicación, toma de decisiones, diagnóstico y solución de conflictos; para que cuando intervenga en el ámbito laboral pueda comprender, diagnosticar y proponer alternativas en un proceso de negociación

Liderazgo y Negociación - PS92 - 201302

El taller de Liderazgo y negociación se crea en base al perfil de competencias que el estudiante de ingeniería requiere desarrollar a lo largo de su carrera y brinda al alumno la posibilidad de fortalecer competencias tales como: aprendizaje para toda la vida, responsabilidad y ética profesional, comunicación y trabajo en equipo. Este taller está orientado a que el estudiante de ingeniería en su cuarto año de carrera y a puertas de egresar tenga la oportunidad de autoevaluarse y se proponga metas de mejora y transformación personal, así como experimentar situaciones que le permitan explorar los procesos de comunicación y negociación, relaciones interpersonales, y la orientación hacia el logro desde la perspectiva de su dinámica individual y como parte de un equipo