"No one likes that judgmental look like you are a terrorist." Sensorial encounters with the Muslim Other in Amsterdam

Often framed in the public discourse as Europe's ultimate Other, Muslims have been heftily debated and vastly problematised by politicians, pundits, and public intellectuals as unwanted immigrants, part of a bad diversity, problematic, violent, refusals of modernity, secularism, and freedom. Thinking through the body as a phenomenal lived body, we explore Othering as a set of visual, auditory, olfactory, and haptic encounters. Employing an urban ethnography on everyday lived experiences of young Muslims in Amsterdam, the paper investigates multiple modes through which Othering is sensed, lived, and felt through the body

Building the e-science grid in the UK: middleware, applications and tools deployed at level 2

Over the period September 2002-April 2003 the UK Grid Engineering Task Force and staff at Regional e-Science Centres and CCLRC deployed the Globus Toolkit GT2 at 14 sites and on approximately 80 compute resources to set up the first production-quality e-Science Grid for the UK. This work is proving to be exemplary of what can be achieved using heterogeneous resources on a national scale and is feeding discussions on how to link Grids with multiple virtual organisations across Europe. This paper therefore reports on experiences of this deployment exercise, compares with other efforts worldwide and suggests further work to be done

Proteomic and Mutant Analysis of the CO2 Concentrating Mechanism of Hydrothermal Vent Chemolithoautotroph Thiomicrospira crunogena.

Many autotrophic microorganisms are likely to adapt to scarcity in dissolved inorganic carbon (DIC; CO(2) + HCO(3)(−) + CO(3)(2−)) with CO(2) concentrating mechanisms (CCM) that actively transport DIC across the cell membrane to facilitate carbon fixation. Surprisingly, DIC transport has been well studied among cyanobacteria and microalgae only. The deep-sea vent gammaproteobacterial chemolithoautotroph Thiomicrospira crunogena has a low-DIC inducible CCM, though the mechanism for uptake is unclear, as homologs to cyanobacterial transporters are absent. To identify the components of this CCM, proteomes of T. crunogena cultivated under low- and high-DIC conditions were compared. Fourteen proteins, including those comprising carboxysomes, were at least 4-fold more abundant under low-DIC conditions. One of these proteins was encoded by Tcr_0854; strains carrying mutated copies of this gene, as well as the adjacent Tcr_0853, required elevated DIC for growth. Strains carrying mutated copies of Tcr_0853 and Tcr_0854 overexpressed carboxysomes and had diminished ability to accumulate intracellular DIC. Based on reverse transcription (RT)-PCR, Tcr_0853 and Tcr_0854 were cotranscribed and upregulated under low-DIC conditions. The Tcr_0853-encoded protein was predicted to have 13 transmembrane helices. Given the mutant phenotypes described above, Tcr_0853 and Tcr_0854 may encode a two-subunit DIC transporter that belongs to a previously undescribed transporter family, though it is widespread among autotrophs from multiple phyla. IMPORTANCE DIC uptake and fixation by autotrophs are the primary input of inorganic carbon into the biosphere. The mechanism for dissolved inorganic carbon uptake has been characterized only for cyanobacteria despite the importance of DIC uptake by autotrophic microorganisms from many phyla among the Bacteria and Archaea. In this work, proteins necessary for dissolved inorganic carbon utilization in the deep-sea vent chemolithoautotroph T. crunogena were identified, and two of these may be able to form a novel transporter. Homologs of these proteins are present in 14 phyla in Bacteria and also in one phylum of Archaea, the Euryarchaeota. Many organisms carrying these homologs are autotrophs, suggesting a role in facilitating dissolved inorganic carbon uptake and fixation well beyond the genus Thiomicrospira

Postmortem Genetic Testing for Cardiac Ion Channelopathies in Stillbirths.

BACKGROUND: Although stillbirth is a significant health problem worldwide, the definitive cause of death remains elusive in many cases, despite detailed autopsy. In this study of partly explained and unexplained stillbirths, we used next-generation sequencing to examine an extended panel of 35 candidate genes known to be associated with ion channel disorders and sudden cardiac death. METHODS AND RESULTS: We examined tissue from 242 stillbirths (≥22 weeks), including those where no definite cause of death could be confirmed after a full autopsy. We obtained high-quality DNA from 70 cases, which were then sequenced for a custom panel of 35 genes, 12 for inherited long- and short-QT syndrome genes (LQT1-LQT12 and SQT1-3), and 23 additional candidate genes derived from genome-wide association studies. We examined the functional significance of a selected variant by patch-clamp electrophysiological recording. No predicted damaging variants were identified in KCNQ1 (LQT1) or KCNH2 (LQT2). A rare putative pathogenic variant was found in KCNJ2(LQT7) in 1 case, and several novel variants of uncertain significance were observed. The KCNJ2 variant (p. R40Q), when assessed by whole-cell patch clamp, affected the function of the channel. There was no significant evidence of enrichment of rare predicted damaging variants within any of the candidate genes. CONCLUSIONS: Although a causative link is unclear, 1 putative pathogenic and variants of uncertain significance variant resulting in cardiac channelopathies was identified in some cases of otherwise unexplained stillbirth, and these variants may have a role in fetal demise. CLINICAL TRIAL REGISTRATION: URL: https://www.clinicaltrials.gov. Unique identifier: NCT01120886

Moving forward with dignity: Exploring health awareness in an isolated Deaf community of Australia

Background Those within the Deaf community are disadvantaged in a number of aspects of day-to-day life including their access to health care. At times, they may encounter barriers to health care even before they reach the consultation room. As a consequence, they may receive insufficient and inappropriate health care which may lead to poorer health outcomes. Objective A study was conducted to explore health awareness and access to health information and services of Deaf people living in Tasmania, Australia and identify ways of enhancing the interaction between the Deaf and the wider community. Methods A questionnaire was administered, including a number of demographic, health awareness and health service usage questions. In addition, semi-structured interviews and focus groups were conducted with service providers and the Deaf community between March and August 2014. An interpreter was present to translate the questions into Auslan and who then translated the Deaf participant's discussion into English for the researcher. Data were then analyzed using research software SPSS v20.0 and NVivo 10.0. Results Health as a concept was poorly understood, including mental health, sexual health and health concerning alcohol and drug abuse. Regarding health care resources, due to a sense of security, trust and confidence, the family physician or general practitioner was the single most important health care provider among the Deaf. Conclusions The Deaf remain underserved by the current health care system; however, through resourcefulness and life experiences, the Deaf have developed coping and management strategies to move forward with dignity in education, meaningful employment and health access. © 2016 Elsevier Inc. All rights reserved

Humanitarian assistance

Humanitarian assistance is a key part of the global security policy toolkit. This chapter examines how the definition of humanitarianism, as humanitarian assistance in response to conflict-related insecurity, has been broadened from the alleviation of insecurity to the actual provision of security through concepts such as military humanitarian intervention and the Responsibility to Protect, prompting claims that it risks becoming a driver of insecurity in its own right. The chapter also explores the contested notion of humanitarian space, arguing that debates about the extent and protection of humanitarian space have become the foci for key discussions about the security of professional humanitarians and those they aspire to serve. It then argues that what is omitted from discussions of humanitarian space is often the sense of such spaces as sites of governance, in which humanitarianism's consequences for the security and insecurity of intended beneficiaries needs to be examined more closely