Handmade tales : sustainable fashion through craft connections : a thesis submitted in partial fulfilment for the degree of Master of Design, Massey University, Wellington, New Zealand

India is a country with an ancient history. The crafts of this country are diverse and are a reflection of the country’s cultural heritage. According to Dasra (2013), the craft industry provides millions of artisans with employment and is one of the largest small scale or cottage industries. For centuries, these craft communities have specialized in traditions that are specific to the regions and respective skills, which have been handed down from generations of artisans. Yet in recent years, as Wood (2011) notes, this sector faces a major threat as a result of growing preference for mass produced designs that are cheap and easy to afford. This has contributed to the steady decline of craft based products. This, alongside a lack of knowledge of new innovative ways to design, and decreasing demand for their products have left the craftspeople very vulnerable and has posed a big threat to their sustainable livelihoods. Integrating fashion design with artisan textiles can help regenerate the community and village culture while enhancing the value of products. This practice led research project offers a framework to meet the emerging challenges associated with ethical and environmental principles linked with fashion by incorporating sustainable processes used in traditional craft production. Importantly, it can also offer one strategy to support economic sustainability issues linked to the livelihood of craftspeople at the village level. The project develops an example of a sustainable fashion design process by drawing from the rich heritage of Indian crafts and focuses on developing a fashion collection that integrates artisan craft textiles into the design process. This reaches out to a market that is sensitive towards sustainability issues linked to artisan livelihood and fashion and values the handmade and organic as an alternative approach. This exploration of issues related to sustainability both for fashion design and craft is an attempt to uncover why developing a relationship between the two is significantly more relevant today than it ever has been

AI Quantification of Language Puzzle to Language Learning Generalization

Online language learning applications provide users multiple ways/games to learn a new language. Some of the ways include rearranging words in the foreign language sentences, filling in the blanks, providing flashcards, and many more. Primarily this research focused on quantifying the effectiveness of these games in learning a new language. Secondarily my goal for this project was to measure the effectiveness of exercises for transfer learning in machine translation. Currently, very little research has been done in this field except for the research conducted by the online platforms to provide assurance to their users [12]. Machine learning has been used in this research to achieve the goals mentioned earlier. Specifically, deep learning models with Recurrent Neural Network (RNN) were employed to process the data. Models were designed on popular exercises from these platforms using sequence-to-sequence learning. Our research discovered that most of the models had cross-validation accuracy in the range of 70%- 80%. This result shows that knowledge learned from one model is transferrable to the other

Investigating Staphylococcus aureus Intracellular Tactics and Nanomedicine Solutions

The rapid spread of antimicrobial resistance (AMR) jeopardizes the effectiveness of modern medicine in treating infections. This thesis describes the use of nanomedicine in addressing the clinical challenges posed by multi-drug resistant Staphylococcus aureus bacteria. Nanoparticles possess unique properties that can be engineered for various biomedical applications, including the potential bypass of antibiotic resistance mechanisms. Two central aims of the presented research are to gain a better understanding of S. aureus interactions with human host cells, and to investigate a nanomedicine-based solution for targeting intracellular S. aureus infections.The thesis begins by introducing S. aureus and the epidemiology of S. aureus infections, detailing this bacterium’s ability to develop AMR, to invade different tissues and to form biofilms. Several intracellular infection models are presented, along with potential methods to identify infected cells, thereby providing a better understanding of how S. aureus interacts with and persists inside host cells. The results support the identification of potential nanomedicinal strategies to treat intracellular S. aureus infections. The second part of the thesis describes the feasibility of using gold nanoparticles as carriers for antibiotic delivery to target intracellular S. aureus bacteria, as well as planktonic or biofilm-resident bacteria. Altogether, the results presented in this thesis show that a multi-pronged approach is needed to combat AMR. It is concluded that knowledge gained from further fundamental research into the biology of microbes and their interactions with host cells will be instrumental for developing new strategies to combat AMR and to ensure the continued effectiveness of antimicrobial treatments

Pyruvate kinase M2 (PKM2), a glycolytic enzyme, is required to maintain vascular barrier function

RATIONALE - Metabolic enzymes, like pyruvate kinase M2 (PKM2), play an essential role in altering endothelial cell (EC) phenotypes and behavior. Extensive research has elucidated the function of PKM2, a rate-limiting glycolytic enzyme, in the context of cancer cells and in activated immune cells, but its role in EC biology is only newly emerging. Recent findings show PKM2 acts as a key regulator of angiogenesis. Where exogenous circulating PKM2 induces EC cell proliferation leading to increased tumor angiogenesis and growth. Also, PKM2 deficient ECs exhibit decreased proliferation and migration. The relevance of PKM2 in modulating vascular barrier function is yet to be defined. OBJECTIVE -This study attempts to elucidate the role of PKM2 in regulating vascular barrier function. METHODS AND RESULTS - In vivo, EC specific deletion of PKM2 promotes increased vascular permeability in pulmonary capillary vessels and increased VEGF-induced acute vessel permeability in mouse dermal vessels. Similarly, in vitro, PKM2 deficient ECs exhibit decreased electrical resistance, disrupted VE-cadherin junctions and gap formations (illustrated via florescent VE-cadherin staining and phosphorylation of VE- cadherin protein at tyrosine residue Y658). Mechanistically, the deletion of PKM2 in ECs leads to increased angiopoietin-2 (Ang-2) expression, a well-known modulator of vascular permeability. Also, deletion of Ang-2 was sufficient to attenuate vascular leakage in PKM2 deficient endothelium, indicating that vascular leaky phenotype observed in PKM2 deficient endothelium is mediated by increased Ang-2 expression. CONCLUSIONS - PKM2, by modulating Ang-2 expression, plays a vital role in maintaining vascular barrier function.2019-07-11T00:00:00

PRARANCANGAN PABRIK ETHANOLAMINE DENGAN KAPASITAS 30.000 TON / TAHUN

ABSTRAKPrarancangan pabrik ethanolamine ini menggunakan bahan baku berupa amonia dan etilen oksida. Kapasitas bahan baku pabrik etilen oksida ini adalah 30.000 Ton/Tahun dengan hari kerja 330 hari/tahun. Bentuk perusahaan yang direncanakan adalah Perseroan Terbatas (PT) dengan menggunakan metode struktur garis dan staf. Kebutuhan tenaga kerja untuk menjalankan perusahaan ini berjumlah 160 orang. Lokasi pabrik direncanakan didirikan di Jalan Raya Merak, Cilegon, Banten, dengan luas tanah 30000 m2. Hasil analisa ekonomi yang diperoleh adalah sebagai berikut : a.Total modal investasi: Rp. 514.031.633.593,-b.Biaya produksi per tahun: Rp. 332.571.429.008,-c.Hasil penjualan per tahun: Rp. 784.892.653.589,-d.Laba bersih per tahun: Rp. 115.245.130.198,-e.Internal Rate of Return (IRR): 23 %f.Pay Out Time (POT): 2 tahun 7 bulang.Break Even Point (BEP): 43

PENGARUH REBUSAN DAUN SELEDRI TERHADAP PENURUNAN TEKANAN DARAH PADA LANSIA HIPERTENSI DI DESA BACANG KECAMATAN BLANGKEJEREN KABUPATEN GAYO LUES

Hipertensi adalah tekanan darah tinggi yang bersifat abnormal dan dapat diukur paling tidak pada tiga kesempatan yang berbeda. Secara umum, seseorang dianggap mengalami hipertensi apabila tekanan darahnya lebih dari 140/90 mmHg.Word Health Organization (WHO) menyebut bahwa hipertensi menyerang 22% dari total penduduk dunia. Tujuan penelitian ini untuk mengetahui pengaruh rebusan daun seledri terhadap penurunan tekanan darah pada lansia hipertensi di Desa Bacang tahun 2021. Penelitian ini dilakukan dengan desain pendekatan Pre-Experimental design dengan bentuk One Group Pre-test dan Post-test. Populasi dalam penelitian ini adalah lansia yang mengalami hipertensi sebanyak 15 lansia. Teknik pengambilan sampel dalam penelitian ini adalah non probability sampling dengan teknik purposive sampling yaitu pengambilan sampel berdasarkan pada suatu pertimbangan tertentu yang dibuat oleh peneliti sendiri sebanyak 16 responden. Uji statistik yang digunakan adalah uji wilxocon. Hasil penelitian dapat diketahui bahwa dari hasil Uji wilcoxon diperoleh nilai Z hitung untuk tekanan darah sistole sebesar dengan p-value sebesar 0.001. oleh karena p-value 0.001< α (0.05), dan Z hitung untuk tekanan darah diastole sebesar dengan p-value 0.000. Oleh karena kedua p-value tersebut <α (0.05) maka Ho di tolak. Kesimpulan dari penelitian ini adalah ada pengaruh rebusan daun seledri terhadap penurunan tekanan darah pada lansia hipertensi di Desa Bacang tahun 2021. Bagi Desa Bacang, disarankan pada petugas kesehatan lebih meningkatkan pelayanan untuk memberikan informasi kesehatan khususnya pada lansia hipertensi

PENGARUH MODEL INKUIRI TERBIMBING DIPADU KOOPERATIF JIGSAW TERHADAP KETERAMPILAN PROSES SAINS DITINJAU DARI KEMAMPUAN AKADEMIK

The purposes of this research are to ascertain: 1) the influence of Guided Inquiry combined Cooperative Jigsaw model toward science process skills, 2) the influence of academic ability toward science process skills, 3) the interaction between Guided Inquiry combined Cooperative Jigsaw model and academic ability toward science process skills. The research was quasi experiment research. The research was designed using pretest posttest nonequivalent control group design. Experimental group applied Guided Inquiry combined Cooperative Jigsaw model. Control group applied Conventional model. The populations of this research were all of 10th degree students at SMA Negeri 2 Surakarta in academic year 2011/2012. The samples of this research were the students of X-1 as experiment group and X-3 as control group. The sample of this research was established by cluster random sampling. The data was collected essay test, observation form, and document. The hypotheses analyzed by Anacova. The research concluded that 1) application of Guided Inquiry combined Cooperative Jigsaw model had significant effect toward science process skill, 2) the academic ability didn’t has significant effect toward science process skill, 3) there was not interaction between Guided Inquiry combined Cooperative Jigsaw model and academic ability toward science process skills

PERANCANGAN SISTEM INFORMASI PENGELOLAAN DANA DESA

The purpose of this final project is to create an information system application for reporting Hilindrasoniha village funds in order to facilitate the Village Government in managing village funds by using a computer-based system application in an effective, efficient, and structured manner so that it can help the work of the village head and reduce fraudulent actions. In making the application of the Hilindrasoniha village fund reporting information system, what is done is to analyze the village funds associated with the above processes and then design the village fund report. The design method used is to design a Flowchart, DVD and screen display. The results of the research are poured into the village fund reporting system which is expected to provide convenience in processing data and making reports that can help Hilindrasoniha Village in analyzing and making decisions. With the use of the village fund reporting system, which is designed to be a useful facility for the company and can overcome the problems that have been faced so far