Stellar Content from high resolution galactic spectra via Maximum A Posteriori

This paper describes STECMAP (STEllar Content via Maximum A Posteriori), a flexible, non-parametric inversion method for the interpretation of the integrated light spectra of galaxies, based on synthetic spectra of single stellar populations (SSPs). We focus on the recovery of a galaxy's star formation history and stellar age-metallicity relation. We use the high resolution SSPs produced by PEGASE-HR to quantify the informational content of the wavelength range 4000 - 6800 Angstroms. A detailed investigation of the properties of the corresponding simplified linear problem is performed using singular value decomposition. It turns out to be a powerful tool for explaining and predicting the behaviour of the inversion. We provide means of quantifying the fundamental limitations of the problem considering the intrinsic properties of the SSPs in the spectral range of interest, as well as the noise in these models and in the data. We performed a systematic simulation campaign and found that, when the time elapsed between two bursts of star formation is larger than 0.8 dex, the properties of each episode can be constrained with a precision of 0.04 dex in age and 0.02 dex in metallicity from high quality data (R=10 000, signal-to-noise ratio SNR=100 per pixel), not taking model errors into account. The described methods and error estimates will be useful in the design and in the analysis of extragalactic spectroscopic surveys.Comment: 31 pages, 23 figures, accepted for publication in MNRA

A comprehensive evaluation of colonic mucosal isolates of Sutterella wadsworthensis from inflammatory bowel disease

Peer reviewedPublisher PD

A Chandra X-ray Observatory Study of PSR J1740--5340 and Candidate Millisecond Pulsars in the Globular Cluster NGC 6397

We present a deep Chandra X-ray Observatory study of the peculiar binary radio millisecond pulsar PSR J1740--5340 and candidate millisecond pulsars (MSPs) in the globular cluster NGC 6397. The X-rays from PSR J1740--5340 appear to be non-thermal and exhibit variability at the binary period. These properties suggest the presence of a relativistic intrabinary shock formed due to interaction of a relativistic rotation-powered pulsar wind and outflow from the unusual "red-straggler/sub-subgiant" companion. We find the X-ray source U18 to show similar X-ray and optical properties to those of PSR J1740--5340, making it a strong MSP candidate. It exhibits variability on timescales from hours to years, also consistent with an intrabinary shock origin of its X-ray emission. The unprecedented depth of the X-ray data allows us to conduct a complete census of MSPs in NGC 6397. Based on the properties of the present sample of X-ray--detected MSPs in the Galaxy we find that NGC 6397 probably hosts no more than 6 MSPs.Comment: 10 pages, 6 figures, 3 tables; accepted for publication in The Astrophysical Journa

Changes in anthropometry and performance, and their inter-relationships, across three seasons in elite youth rugby league players

This is a non-final version of an article published in final form in Journal of Strength and Conditioning Research, 2014, 28(11), pp. 3128-3136.This study investigated changes in anthropometry and performance, and their inter-relationships, across three consecutive seasons (under-15 to under-17 age group) in elite youth rugby league players. Each player took part in annual anthropometrical and performance assessments, comprising measurements of stature; body mass; limb lengths and circumference; skinfolds, predicted muscle cross-sectional area (CSA); 20 m speed, counter-movement jump height, vertical power and aerobic power. Lean body mass % changed (P < 0.05) between the under-15 (70.9 ± 5.9 %), under-16 (72.0 ± 5.8 %) and the under-17 age groups (74.1 ± 5.7 %). Likewise, predicted quadriceps muscle cross-sectional area (CSA) also changed (P < 0.05) between each age group (under-15 = 120.9 ± 37.8 cm2; under-16 = 133.2 ± 36.0 cm2; under-17 = 154.8 ± 28.3 cm2). Concomitant changes between the under-15 and under-16 group were found for 20 m speed (3.5 ± 0.1 cf. 3.4 ± 0.2 s; P = 0.008) and predicted jumping power (3611.3 ± 327.3 W cf. 4081.5 ± 453.9 W; P = 0.003). Both lean body mass and quadriceps muscle CSA consistently, related to both 20 m sprint time and jumping power, with r-values ranging between -0.39 to –0.63 (20 m sprint time) and 0.55 to 0.75 (jumping power). Our findings demonstrate the importance of gains in lean body mass across later-adolescence that support the ability to generate horizontal speed and predicted vertical power. This information should inform the expectations and subsequent training programs of elite rugby league practitioners

Global report on preterm birth and stillbirth (3 of 7): evidence for effectiveness of interventions.

INTRODUCTION: Interventions directed toward mothers before and during pregnancy and childbirth may help reduce preterm births and stillbirths. Survival of preterm newborns may also be improved with interventions given during these times or soon after birth. This comprehensive review assesses existing interventions for low- and middle-income countries (LMICs). METHODS: Approximately 2,000 intervention studies were systematically evaluated through December 31, 2008. They addressed preterm birth or low birth weight; stillbirth or perinatal mortality; and management of preterm newborns. Out of 82 identified interventions, 49 were relevant to LMICs and had reasonable amounts of evidence, and therefore selected for in-depth reviews. Each was classified and assessed by the quality of available evidence and its potential to treat or prevent preterm birth and stillbirth. Impacts on other maternal, fetal, newborn or child health outcomes were also considered. Assessments were based on an adaptation of the Grades of Recommendation Assessment, Development and Evaluation criteria. RESULTS: Most interventions require additional research to improve the quality of evidence. Others had little evidence of benefit and should be discontinued. The following are supported by moderate- to high-quality evidence and strongly recommended for LMICs: Two interventions prevent preterm births--smoking cessation and progesterone. Eight interventions prevent stillbirths--balanced protein energy supplementation, screening and treatment of syphilis, intermittant presumptive treatment for malaria during pregnancy, insecticide-treated mosquito nets, birth preparedness, emergency obstetric care, cesarean section for breech presentation, and elective induction for post-term delivery. Eleven interventions improve survival of preterm newborns--prophylactic steroids in preterm labor, antibiotics for PROM, vitamin K supplementation at delivery, case management of neonatal sepsis and pneumonia, delayed cord clamping, room air (vs. 100% oxygen) for resuscitation, hospital-based kangaroo mother care, early breastfeeding, thermal care, and surfactant therapy and application of continued distending pressure to the lungs for respiratory distress syndrome CONCLUSION: The research paradigm for discovery science and intervention development must be balanced to address prevention as well as improve morbidity and mortality in all settings. This review also reveals significant gaps in current knowledge of interventions spanning the continuum of maternal and fetal outcomes, and the critical need to generate further high-quality evidence for promising interventions

Developing a digital intervention for cancer survivors: an evidence-, theory- and person-based approach

This paper illustrates a rigorous approach to developing digital interventions using an evidence-, theory- and person-based approach. Intervention planning included a rapid scoping review which identified cancer survivors’ needs, including barriers and facilitators to intervention success. Review evidence (N=49 papers) informed the intervention’s Guiding Principles, theory-based behavioural analysis and logic model. The intervention was optimised based on feedback on a prototype intervention through interviews (N=96) with cancer survivors and focus groups with NHS staff and cancer charity workers (N=31). Interviews with cancer survivors highlighted barriers to engagement, such as concerns about physical activity worsening fatigue. Focus groups highlighted concerns about support appointment length and how to support distressed participants. Feedback informed intervention modifications, to maximise acceptability, feasibility and likelihood of behaviour change. Our systematic method for understanding user views enabled us to anticipate and address important barriers to engagement. This methodology may be useful to others developing digital interventions

An epigenetic clock for gestational age at birth based on blood methylation data

Background: Gestational age is often used as a proxy for developmental maturity by clinicians and researchers alike. DNA methylation has previously been shown to be associated with age and has been used to accurately estimate chronological age in children and adults. In the current study, we examine whether DNA methylation in cord blood can be used to estimate gestational age at birth. Results: We find that gestational age can be accurately estimated from DNA methylation of neonatal cord blood and blood spot samples. We calculate a DNA methylation gestational age using 148 CpG sites selected through elastic net regression in six training datasets. We evaluate predictive accuracy in nine testing datasets and find that the accuracy of the DNA methylation gestational age is consistent with that of gestational age estimates based on established methods, such as ultrasound. We also find that an increased DNA methylation gestational age relative to clinical gestational age is associated with birthweight independent of gestational age, sex, and ancestry. Conclusions: DNA methylation can be used to accurately estimate gestational age at or near birth and may provide additional information relevant to developmental stage. Further studies of this predictor are warranted to determine its utility in clinical settings and for research purposes. When clinical estimates are available this measure may increase accuracy in the testing of hypotheses related to developmental age and other early life circumstances

The ethics of digital well-being: a multidisciplinary perspective

This chapter serves as an introduction to the edited collection of the same name, which includes chapters that explore digital well-being from a range of disciplinary perspectives, including philosophy, psychology, economics, health care, and education. The purpose of this introductory chapter is to provide a short primer on the different disciplinary approaches to the study of well-being. To supplement this primer, we also invited key experts from several disciplines—philosophy, psychology, public policy, and health care—to share their thoughts on what they believe are the most important open questions and ethical issues for the multi-disciplinary study of digital well-being. We also introduce and discuss several themes that we believe will be fundamental to the ongoing study of digital well-being: digital gratitude, automated interventions, and sustainable co-well-being