302 research outputs found
Melanopsin-expressing retinal ganglion cells are resistant to cell injury, but not always
Melanopsin retinal ganglion cells (mRGCs) are intrinsically photosensitive RGCs deputed to non-image forming functions of the eye such as synchronization of circadian rhythms to light-dark cycle. These cells are characterized by unique electrophysiological, anatomical and biochemical properties and are usually more resistant than conventional RGCs to different insults, such as axotomy and different paradigms of stress. We also demonstrated that these cells are relatively spared compared to conventional RGCs in mitochondrial optic neuropathies (Leber's hereditary optic neuropathy and Dominant Optic Atrophy). However, these cells are affected in other neurodegenerative conditions, such as glaucoma and Alzheimer's disease. We here review the current evidences that may underlie this dichotomy. We also present our unpublished data on cell experiments demonstrating that melanopsin itself does not explain the robustness of these cells and some preliminary data on immunohistochemical assessment of mitochondria in mRGCs
Quantum Time and Spatial Localization: An Analysis of the Hegerfeldt Paradox
Two related problems in relativistic quantum mechanics, the apparent
superluminal propagation of initially localized particles and dependence of
spatial localization on the motion of the observer, are analyzed in the context
of Dirac's theory of constraints. A parametrization invariant formulation is
obtained by introducing time and energy operators for the relativistic particle
and then treating the Klein-Gordon equation as a constraint. The standard,
physical Hilbert space is recovered, via integration over proper time, from an
augmented Hilbert space wherein time and energy are dynamical variables. It is
shown that the Newton-Wigner position operator, being in this description a
constant of motion, acts on states in the augmented space. States with strictly
positive energy are non-local in time; consequently, position measurements
receive contributions from states representing the particle's position at many
times. Apparent superluminal propagation is explained by noting that, as the
particle is potentially in the past (or future) of the assumed initial place
and time of localization, it has time to propagate to distant regions without
exceeding the speed of light. An inequality is proven showing the Hegerfeldt
paradox to be completely accounted for by the hypotheses of subluminal
propagation from a set of initial space-time points determined by the quantum
time distribution arising from the positivity of the system's energy. Spatial
localization can nevertheless occur through quantum interference between states
representing the particle at different times. The non-locality of the same
system to a moving observer is due to Lorentz rotation of spatial axes out of
the interference minimum.Comment: This paper is identical to the version appearing in J. Math. Phys.
41; 6093 (Sept. 2000). The published version will be found at
http://ojps.aip.org/jmp/. The paper (40 page PDF file) has been completely
revised since the last posting to this archiv
Covariance properties and regularization of conserved currents in tetrad gravity
We discuss the properties of the gravitational energy-momentum 3-form within
the tetrad formulation of general relativity theory. We derive the covariance
properties of the quantities describing the energy-momentum content under
Lorentz transformations of the tetrad. As an application, we consider the
computation of the total energy (mass) of some exact solutions of Einstein's
general relativity theory which describe compact sources with asymptotically
flat spacetime geometry. As it is known, depending on the choice of tetrad
frame, the formal total integral for such configurations may diverge. We
propose a natural regularization method which yields finite values for the
total energy-momentum of the system and demonstrate how it works on a number of
explicit examples.Comment: 36 pages, Revtex, no figures; small changes, published versio
Toward a public service management: past, present, and future directions
Purpose: In providing a fine-grained analysis of public service management, the purpose of this paper is to make an important contribution to furthering research in service management, a body of literature that has tended to regard public services as homogenous or to neglect the context altogether.
Design/methodology/approach: Integrating public management and service management literatures, the past and present of public service management are discussed. Future directions for the field are outlined drawing on a service-dominant approach that has the potential to transform public services. Invited commentaries augment the review.
Findings: The review presents the Public Service Network Framework to capture the public value network in its abstraction and conceptualizes how value is created in public services. The study identifies current shortcomings in the field and offers a series of directions for future research where service management theory can contribute greatly.
Research limitations/implications: The review encourages service management research to examine the dynamic, diverse, and complex nature of public services and to recognize the importance of this context. The review calls for an interdisciplinary public service management community to develop, and to assist public managers in leveraging service logic.
Originality/value: The review positions service research in the public sector, makes explicit the role of complex networks in value creation, argues for wider engagement with public service management, and offers future research directions to advance public service management research
A Systematic Review of Music Therapy Practice and Outcomes with Acute Adult Psychiatric In-Patients
PMCID: PMC3732280This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited
Migraine and the development of additional psychiatric and pain disorders in the transition from adolescence to adulthood
Introduction: The transition from childhood to adolescence and from adolescence to adulthood are vulnerable phases in life. In these phases, late or insufficient treatment of diseases may lead to chronification and favor development of additional disorders. In adolescents, migraine often has a highly negative impact on school performance and everyday life. The hypothesis of the present study was that adolescents with migraine have a higher risk for developing additional disorders such as psychiatric disorders or other pain syndromes in the course of the disease.
Materials and methods: In this study, we analyzed health insurance data of 56,597 German adolescents at the age of 15 years in the year 2006. By using the International Classification of Diseases (ICD 10), we determined a group with migraine diagnosis in the year 2006 and a control group without any headache diagnosis in 2006. We then compared both groups regarding the development of additional disorders (based on the ICD 10) during the following 10 years (2007 to 2016).
Results: Adolescents with migraine had a 2.1 fold higher risk than persons without migraine diagnosis to develop an additional affective or mood disorder, a 1.8 fold higher risk to obtain neurotic, stress-related and somatoform disorders, a 1.8 fold higher risk to subsequently suffer from behavioral syndromes, a 1.6 higher risk to get back pain and a 1.5 fold higher risk for irritable bowel syndrome during the next 10 years.
Conclusion: Adolescents with migraine are at risk for developing additional disorders later. Considering and addressing the patient’s risks and potential medical and psychosocial problems might improve the long-term outcome significantly
Field on Poincare group and quantum description of orientable objects
We propose an approach to the quantum-mechanical description of relativistic
orientable objects. It generalizes Wigner's ideas concerning the treatment of
nonrelativistic orientable objects (in particular, a nonrelativistic rotator)
with the help of two reference frames (space-fixed and body-fixed). A technical
realization of this generalization (for instance, in 3+1 dimensions) amounts to
introducing wave functions that depend on elements of the Poincare group . A
complete set of transformations that test the symmetries of an orientable
object and of the embedding space belongs to the group . All
such transformations can be studied by considering a generalized regular
representation of in the space of scalar functions on the group, ,
that depend on the Minkowski space points as well as on the
orientation variables given by the elements of a matrix .
In particular, the field is a generating function of usual spin-tensor
multicomponent fields. In the theory under consideration, there are four
different types of spinors, and an orientable object is characterized by ten
quantum numbers. We study the corresponding relativistic wave equations and
their symmetry properties.Comment: 46 page
Pituitary Adenylate Cyclase-Activating Polypeptide Stimulates Glucose Production via the Hepatic Sympathetic Innervation in Rats
OBJECTIVE-The unraveling of the elaborate brain networks that control glucose metabolism presents one of the current challenges in diabetes research. Within the central nervous system, the hypothalamus is regarded as the key brain area to regulate energy homeostasis. The aim of the present study was to investigate the hypothalamic mechanism involved in the hyperglycemic effects of the neuropeptide pituitary adenylyl cyclase-activating polypeptide (PACAP). RESEARCH DESIGN AND METHODS-Endogenous glucose production (EGP) was determined during intracerebroventricular infusions of PACAP-38, vasoactive intestinal peptide (VIP), or their receptor agonists. The specificity of their receptors was examined by coinfusions of receptor antagonists. The possible neuronal pathway involved was investigated by 1) local injections in hypothalamic nuclei, 2) retrograde neuronal tracing from the thoracic spinal cord to hypothalamic preautonomic neurons together with Fos immunoreactivity, and 3) specific hepatic sympathetic or parasympathetic denervation to block the autonomic neuronal input to liver. LTS-Intracerebroventiicular infusion of PACAP-38 increased EGP to a similar extent as a VIP/PACAP-2 (VPAC2) receptor agonist, and intracerebroventricular administration of VIP had significantly less influence on EGP. The PACAP-38 induced increase of EGP was significantly suppressed by preinfusion of a VPAC2 but not a PAC1 receptor antagonist, as well as by hepatic sympathetic but not parasympathetic denervation. In the hypothalamus, Fos immunoreactivity induced by PACAP-38 was colocalized within autonomic neurons in paraventricular nuclei projecting to preganglionic sympathetic neurons in the spinal cord. Local infusion of PACAP-38 directly into the PVN induced a significant increase of EGP. CONCLUSIONS-This study demonstrates that PACAP-38 signaling via sympathetic preautonomic neurons located in the paraventricular nucleus is an important component in the hypothalamic control of hepatic glucose production. Diabetes 59: 1591-1600, 201
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