Afghanistan, Britain and Russia, 1905-21

This thesis attempts to present the story of Afghanistan's relations with the outside world during the first two decades of this century, and her achievement of complete independence in l9l9-2l. In l905 the Government of India signed with the Afghan government a treaty reinforcing an earlier Anglo-Afghan agreement which forbad the Amir to maintain diplomatic relations with any third power. Amir Habibullah (l90l-l9) accepted this arrangement readily, but subsequent developments changed the attitudes of both parties. The Amir was anxious to endow his country with the trappings of modernity - with motor roads, schools and hospitals - and created in the process a small Afghan j.ntelligensia who chafed at their country<s backwardness, and resented her inferior international status. The British also began to doubt the wisdom of their earlier policy, They had sought to exercise influence in Kabul because they feared that if they failed to do so Afghanistan would fall into Russian hands, and that the British position in India would then be seriously endangered. They believed further that a firm understanding with the Amir would help to keep the peace among the unruly tribesmen of India's north-west frontier. Continued tribal rebellions forced them to reconsider their optimism. Developments in the diplomatic world of London and St. Petersburg impelled those who were not directl-y concerned with these local problems towards similar conclusions. Between l90l and l907 the London cabinet considered the possibilit-y of an agreement with Russia defining British and Russian "spheres of influence" in central Asia. These approaches resulted in the signature of an Anglo-Russian "Convention concerning Afghanistan" in August l907. The first crac.k had appeared in the previously solid structure of Anglo-Afghan relations. The Anglo-Russian convention failed to right many of the grievances of both signatories, but when a revision of the convention was undertaken just before the first world war, the British tentatively discussed a plan for the partition of Afghanistan with Russia which undermined the basis of their previous policy. The Amir was disturbed by the Anglo-Russian entente, for the Anglo-Russian agreement depreciated the value of his friendship with the British, and demonstrated that the Indian government were ready to sacrifice Afghan interests if the needs of great power politics dictated it. The involvement of both his neighbours into the first world war, and "he visit to Kabul of a Turko-German mission anxious to draw Afghanistan into the struggle against the allies, presented the Amir with an opportunity to demand the complete independence of his country in the event of a German victory

On Pole Assignment and Stabilizability of Neutral Type Systems

In this note we present a systematic approach to the stabilizability problem of linear infinite-dimensional dynamical systems whose infinitesimal generator has an infinite number of instable eigenvalues. We are interested in strong non-exponential stabilizability by a linear feed-back control. The study is based on our recent results on the Riesz basis property and a careful selection of the control laws which preserve this property. The investigation may be applied to wave equations and neutral type delay equations

Strand bond performance in prestressed concrete accounting for bondslip

This paper presents the results of an experimental research program addressing the bond behavior of prestressing strands in pretensioned prestressed concrete members after anchorage failure has occurred. A test methodology based on measuring the prestressing strand force and strand end slip at the specimens free end was employed. Transmission- and anchorage-length tests were performed on several series of prestressed specimens with different embedment lengths using twelve concrete mixes. Average bond stresses along the transmission length and the anchorage length were obtained for specimens with release strengths ranging from 24 MPa to 55 MPa. For the anchorage analysis, a parameter was developed that includes strand slip to be used in determining anchorage length. Based on the test results, an analysis to experimentally substantiate the Stress Waves Theory of Janney has been proposed. Additionally, the potential bond performance of prestressing strands after anchorage failure at the end regions has been suggested.The content of the present paper is based on tests which were conducted in the Institute of Concrete Science and Technology (ICITECH), at Universitat Politecnica of Valencia (Spain), in collaboration with the companies PREVALESA and ISOCRON. Funding for this experimental research work was provided by the Spanish Ministry of Education and Science/Science and Innovation and ERDF (Project BIA2006-05521 and Project BIA2009-12722). The authors wish to thank the above companies as well as the concrete structures laboratory technicians at the Universitat Politecnica of Valencia for their cooperation. Finally, the authors also wish to pay their respects to C.A. Arbelaez.Martí Vargas, JR.; Serna Ros, P.; Hale, WM. (2013). Strand bond performance in prestressed concrete accounting for bondslip. Engineering Structures. 51:236-244. doi:10.1016/j.engstruct.2013.01.023S2362445

An Integrated TCGA Pan-Cancer Clinical Data Resource to Drive High-Quality Survival Outcome Analytics

For a decade, The Cancer Genome Atlas (TCGA) program collected clinicopathologic annotation data along with multi-platform molecular profiles of more than 11,000 human tumors across 33 different cancer types. TCGA clinical data contain key features representing the democratized nature of the data collection process. To ensure proper use of this large clinical dataset associated with genomic features, we developed a standardized dataset named the TCGA Pan-Cancer Clinical Data Resource (TCGA-CDR), which includes four major clinical outcome endpoints. In addition to detailing major challenges and statistical limitations encountered during the effort of integrating the acquired clinical data, we present a summary that includes endpoint usage recommendations for each cancer type. These TCGA-CDR findings appear to be consistent with cancer genomics studies independent of the TCGA effort and provide opportunities for investigating cancer biology using clinical correlates at an unprecedented scale. Analysis of clinicopathologic annotations for over 11,000 cancer patients in the TCGA program leads to the generation of TCGA Clinical Data Resource, which provides recommendations of clinical outcome endpoint usage for 33 cancer types

Constraining the electric charges of some astronomical bodies in Reissner-Nordstrom spacetimes and generic r^-2-type power-law potentials from orbital motions

We put model-independent, dynamical constraints on the net electric charge Q of some astronomical and astrophysical objects by assuming that their exterior spacetimes are described by the Reissner-Nordstroem metric, which induces an additional potential U_RN \propto Q^2 r^-2. Our results extend to other hypothetical power-law interactions inducing extra-potentials U_pert = r^-2 as well (abridged).Comment: LaTex2e, 16 pages, 3 figures, no tables, 128 references. Version matching the one at press in General Relativity and Gravitation (GRG). arXiv admin note: substantial text overlap with arXiv:1112.351

The Origin, Early Evolution and Predictability of Solar Eruptions

Coronal mass ejections (CMEs) were discovered in the early 1970s when space-borne coronagraphs revealed that eruptions of plasma are ejected from the Sun. Today, it is known that the Sun produces eruptive flares, filament eruptions, coronal mass ejections and failed eruptions; all thought to be due to a release of energy stored in the coronal magnetic field during its drastic reconfiguration. This review discusses the observations and physical mechanisms behind this eruptive activity, with a view to making an assessment of the current capability of forecasting these events for space weather risk and impact mitigation. Whilst a wealth of observations exist, and detailed models have been developed, there still exists a need to draw these approaches together. In particular more realistic models are encouraged in order to asses the full range of complexity of the solar atmosphere and the criteria for which an eruption is formed. From the observational side, a more detailed understanding of the role of photospheric flows and reconnection is needed in order to identify the evolutionary path that ultimately means a magnetic structure will erupt

Integrating sequence and array data to create an improved 1000 Genomes Project haplotype reference panel

A major use of the 1000 Genomes Project (1000GP) data is genotype imputation in genome-wide association studies (GWAS). Here we develop a method to estimate haplotypes from low-coverage sequencing data that can take advantage of single-nucleotide polymorphism (SNP) microarray genotypes on the same samples. First the SNP array data are phased to build a backbone (or 'scaffold') of haplotypes across each chromosome. We then phase the sequence data 'onto' this haplotype scaffold. This approach can take advantage of relatedness between sequenced and non-sequenced samples to improve accuracy. We use this method to create a new 1000GP haplotype reference set for use by the human genetic community. Using a set of validation genotypes at SNP and bi-allelic indels we show that these haplotypes have lower genotype discordance and improved imputation performance into downstream GWAS samples, especially at low-frequency variants. © 2014 Macmillan Publishers Limited. All rights reserved

Driver Fusions and Their Implications in the Development and Treatment of Human Cancers.

Gene fusions represent an important class of somatic alterations in cancer. We systematically investigated fusions in 9,624 tumors across 33 cancer types using multiple fusion calling tools. We identified a total of 25,664 fusions, with a 63% validation rate. Integration of gene expression, copy number, and fusion annotation data revealed that fusions involving oncogenes tend to exhibit increased expression, whereas fusions involving tumor suppressors have the opposite effect. For fusions involving kinases, we found 1,275 with an intact kinase domain, the proportion of which varied significantly across cancer types. Our study suggests that fusions drive the development of 16.5% of cancer cases and function as the sole driver in more than 1% of them. Finally, we identified druggable fusions involving genes such as TMPRSS2, RET, FGFR3, ALK, and ESR1 in 6.0% of cases, and we predicted immunogenic peptides, suggesting that fusions may provide leads for targeted drug and immune therapy