Computer mouse movement patterns: A potential marker of mild cognitive impairment

AbstractIntroductionSubtle changes in cognitively demanding activities occur in mild cognitive impairment (MCI) but are difficult to assess with conventional methods. In an exploratory study, we examined whether patterns of computer mouse movements obtained from routine home computer use discriminated between older adults with and without MCI.MethodsParticipants were 42 cognitively intact and 20 older adults with MCI enrolled in a longitudinal study of in-home monitoring technologies. Mouse pointer movement variables were computed during one week of routine home computer use using algorithms that identified and characterized mouse movements within each computer use session.ResultsMCI was associated with making significantly fewer total mouse moves (P < .01) and making mouse movements that were more variable, less efficient, and with longer pauses between movements (P < .05). Mouse movement measures were significantly associated with several cognitive domains (P values <.01–.05).DiscussionRemotely monitored computer mouse movement patterns are a potential early marker of real-world cognitive changes in MCI

Quark transverse charge densities in the Δ(1232)\Delta(1232) from lattice QCD

We extend the formalism relating electromagnetic form factors to transverse quark charge densities in the light-front frame to the case of a spin-3/2 baryon and calculate these transverse densities for the $\Delta(1232)$ isobar using lattice QCD. The transverse charge densities for a transversely polarized spin-3/2 particle are characterized by monopole, dipole, quadrupole, and octupole patterns representing the structure beyond that of a pure point-like spin-3/2 particle. We present lattice QCD results for the $\Delta$-isobar electromagnetic form factors for pion masses down to approximatively 350 MeV for three cases: quenched QCD, two-degenerate flavors of dynamical Wilson quarks, and three flavors of quarks using a mixed action that combines domain wall valence quarks and dynamical staggered sea quarks. We extract transverse quark charge densities from these lattice results and find that the $\Delta$ is prolately deformed, as indicated by the fact that the quadrupole moment $G_{E2}(0$) is larger than the value -3 characterizing a point particle and the fact that the transverse charge density in a $\Delta^+$ of maximal transverse spin projection is elongated along the axis of the spin.Comment: 35 pages, 10 figure

Mixed-species aggregations in arthropods

This review offers the first synthesis of the research on mixed-species groupings of arthropods and highlights the behavioural and evolutionary questions raised by such behaviour. Mixed-species groups are commonly found in mammals and birds. Such groups are also observed in a large range of arthropod taxa independent of their level of sociality. Several examples are presented to highlight the mechanisms underlying such groupings, particularly the evidence for phylogenetic proximity between members that promotes cross-species recognition. The advantages offered by such aggregates are described and discussed. These advantages can be attributed to the increase in group size and could be identical to those of non-mixed groupings, but competition-cooperation dynamics might also be involved, and such effects may differ between homo- and heterospecific groups. We discuss three extreme cases of interspecific recognition that are likely involved in mixed-species groups as vectors for cross-species aggregation: tolerance behaviour between two social species, one-way mechanism in which one species is attractive to others and two-way mechanism of mutual attraction. As shown in this review, the study of mixed-species groups offers biologists an interesting way to explore the frontiers of cooperation-competition, including the process of sympatric speciation.PostprintPeer reviewe

Screening for Mild Cognitive Impairment through Digital Biomarkers of Cognitive Performance in Games

status: publishe