264 research outputs found
Attitude Estimation and Control Using Linear-Like Complementary Filters: Theory and Experiment
This paper proposes new algorithms for attitude estimation and control based
on fused inertial vector measurements using linear complementary filters
principle. First, n-order direct and passive complementary filters combined
with TRIAD algorithm are proposed to give attitude estimation solutions. These
solutions which are efficient with respect to noise include the gyro bias
estimation. Thereafter, the same principle of data fusion is used to address
the problem of attitude tracking based on inertial vector measurements. Thus,
instead of using noisy raw measurements in the control law a new solution of
control that includes a linear-like complementary filter to deal with the noise
is proposed. The stability analysis of the tracking error dynamics based on
LaSalle's invariance theorem proved that almost all trajectories converge
asymptotically to the desired equilibrium. Experimental results, obtained with
DIY Quad equipped with the APM2.6 auto-pilot, show the effectiveness and the
performance of the proposed solutions.Comment: Submitted for Journal publication on March 09, 2015. Partial results
related to this work have been presented in IEEE-ROBIO-201
Determinan Electronic Loyalty (E-Loyalty) Pada Website
The purpose of this research was to investigate the factors influencing consumer’s loyalty toward e-commerce website. The samples were those who used and interacted to the website. We applied accidental sampling and the questionnaires were distributed manually and through on line. Returned and processed questionnaires were from 175 respondents. Ten of 14 hypotheses in our research were supported by the data. Those hypotheses are the relationship among the factors of perceived ease of use, perceived usefulness, trust, social presence, enjoyment and value, patronage intent and e- loyalty towards the website
Polarimetry of 16Ngs produced in mu --capture on 16O nuclei
A polarimetry technique based on stack targets and /3-'/-coincidences
has been applied to the 16N nuclei produced in the ground state capture
of negative muons on lb0 nuclei. The performance of the polarimeter and
the first measurements of /3-asymmetry due to the longitudinal nuclear
polarization are discussed
Impact of ion irradiation-induced interface intermixing on the magnetic and electrical properties of magnetic tunnel junctions
The impact of 400 keV Ar+ irradiation on the magnetic and electrical properties of in-plane magnetized magnetic tunnel junction (MTJ) stacks was investigated by ferromagnetic resonance, vibrating sample magnetometry and current-in-plane tunneling techniques. The ion fluences ranged from 10^12 cm−2 to 5 × 10^15 cm−2. Below 10^14 cm−2, the anisotropy of the Ta-capped FeCoB free layer was weakly modulated, following a decrease in the saturation magnetization. The tunnel magnetoresistance (TMR), along with the exchange-bias and the interlayer exchange coupling providing a stable magnetic configuration to the reference layer, decreased continuously. Above 10^14 cm−2, a strong decrease in the saturation magnetization was accompanied by a loss of the magnetic coupling and of the TMR. We show there is an ion-fluence window where the modulation of magnetic anisotropy can occur while preserving a large TMR and stable magnetic configuration of the MTJ, and demonstrate that the layers surrounding the free layer play a decisive role in determining the trend of the magnetic anisotropy modulation resulting from the irradiation. Our results provide guidance for the tailoring of MTJ parameters via ion irradiation, which we propose as a potentially suitable technique for setting the magnetic easy-cone state in MTJ for attaining field-free, fast, and non-stochastic magnetization switching.publishe
The synthetic antimicrobial peptide 19-2.5 attenuates septic cardiomyopathy and prevents down-regulation of SERCA2 in polymicrobial sepsis
LM has received grants by the Faculty of Medicine at the RWTH Aachen University (START 15/14 and
START 46/16) and the Deutsche Forschungsgemeinschaft (DFG, MA 7082/1–1). This work was supported by
the Immunohistochemistry and Confocal Microscopy Unit, a core facility of the Interdisciplinary Centre for
Clinical Research (IZKF) Aachen, within the Faculty of Medicine at the RWTH Aachen University and the
RWTH centralized Biomaterial Database (RWTH cBMB) of the University Hospital RWTH Aachen. We are
very grateful to Antons Martincuks M.Sc. and Professor Gerhard Müller-Newen for live-cell imaging. This work
was supported, in part, by the University of Turin (ex-60% 2015A and B) and by the William Harvey Research
Foundation and forms part of the research themes contributing to the translational research portfolio of Barts
and the London Cardiovascular Biomedical Research Unit that is supported and funded by the National Institute
for Health Research. This work also contributes to the Organ Protection research theme of the Barts Centre for
Trauma Sciences supported by the Barts and The London Charity (Award 753/1722)
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Combination Therapy with STAT3 Inhibitor Enhances SERCA2a-Induced BMPR2 Expression and Inhibits Pulmonary Arterial Hypertension.
Pulmonary arterial hypertension (PAH) is a devastating lung disease characterized by the progressive obstruction of the distal pulmonary arteries (PA). Structural and functional alteration of pulmonary artery smooth muscle cells (PASMC) and endothelial cells (PAEC) contributes to PA wall remodeling and vascular resistance, which may lead to maladaptive right ventricular (RV) failure and, ultimately, death. Here, we found that decreased expression of sarcoplasmic/endoplasmic reticulum Ca2+ ATPase 2a (SERCA2a) in the lung samples of PAH patients was associated with the down-regulation of bone morphogenetic protein receptor type 2 (BMPR2) and the activation of signal transducer and activator of transcription 3 (STAT3). Our results showed that the antiproliferative properties of SERCA2a are mediated through the STAT3/BMPR2 pathway. At the molecular level, transcriptome analysis of PASMCs co-overexpressing SERCA2a and BMPR2 identified STAT3 amongst the most highly regulated transcription factors. Using a specific siRNA and a potent pharmacological STAT3 inhibitor (STAT3i, HJC0152), we found that SERCA2a potentiated BMPR2 expression by repressing STAT3 activity in PASMCs and PAECs. In vivo, we used a validated and efficient model of severe PAH induced by unilateral left pneumonectomy combined with monocrotaline (PNT/MCT) to further evaluate the therapeutic potential of single and combination therapies using adeno-associated virus (AAV) technology and a STAT3i. We found that intratracheal delivery of AAV1 encoding SERCA2 or BMPR2 alone or STAT3i was sufficient to reduce the mean PA pressure and vascular remodeling while improving RV systolic pressures, RV ejection fraction, and cardiac remodeling. Interestingly, we found that combined therapy of AAV1.hSERCA2a with AAV1.hBMPR2 or STAT3i enhanced the beneficial effects of SERCA2a. Finally, we used cardiac magnetic resonance imaging to measure RV function and found that therapies using AAV1.hSERCA2a alone or combined with STAT3i significantly inhibited RV structural and functional changes in PNT/MCT-induced PAH. In conclusion, our study demonstrated that combination therapies using SERCA2a gene transfer with a STAT3 inhibitor could represent a new promising therapeutic alternative to inhibit PAH and to restore BMPR2 expression by limiting STAT3 activity
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