Diffusion of IS in companies using renewable resources and its impact on uncertainty

The importance of sustainability is meanwhile well known in research as well as in practice. One way to produce moresustainable goods is the use of renewable resources. In this paper we present a two-staged study, consisting of a quantitativesurvey followed by qualitative interviews with companies which use renewable resources as an input for production. Thefocus of our study is on the diffusion of IS and supporting technologies and concepts in these special industrial sector. Due tothe natural growth and environmental influence factors it can be supposed that renewable resources are underlying a greateruncertainty regarding quantity, quality and time of availability. Therefore we also examine the influence of IS on uncertaintyin the companies surveyed

Mirror Symmetry in Generalized Calabi-Yau Compactifications

We discuss mirror symmetry in generalized Calabi-Yau compactifications of type II string theories with background NS fluxes. Starting from type IIB compactified on Calabi-Yau threefolds with NS three-form flux we show that the mirror type IIA theory arises from a purely geometrical compactification on a different class of six-manifolds. These mirror manifolds have SU(3) structure and are termed half-flat; they are neither complex nor Ricci-flat and their holonomy group is no longer SU(3). We show that type IIA appropriately compactified on such manifolds gives the correct mirror-symmetric low-energy effective action.Comment: 54 pages latex, references added, typos correcte

Flux compactifications in string theory: a comprehensive review

We present a pedagogical overview of flux compactifications in string theory, from the basic ideas to the most recent developments. We concentrate on closed string fluxes in type II theories. We start by reviewing the supersymmetric flux configurations with maximally symmetric four-dimensional spaces. We then discuss the no-go theorems (and their evasion) for compactifications with fluxes. We analyze the resulting four-dimensional effective theories, as well as some of its perturbative and non-perturbative corrections, focusing on moduli stabilization. Finally, we briefly review statistical studies of flux backgrounds.Comment: 85 pages, 2 figures. v2, v3: minor changes, references adde

Cumulative occupational lumbar load and lumbar disc disease – results of a German multi-center case-control study (EPILIFT)

Background The to date evidence for a dose-response relationship between physical workload and the development of lumbar disc diseases is limited. We therefore investigated the possible etiologic relevance of cumulative occupational lumbar load to lumbar disc diseases in a multi-center case-control study. Methods In four study regions in Germany (Frankfurt/Main, Freiburg, Halle/Saale, Regensburg), patients seeking medical care for pain associated with clinically and radiologically verified lumbar disc herniation (286 males, 278 females) or symptomatic lumbar disc narrowing (145 males, 206 females) were prospectively recruited. Population control subjects (453 males and 448 females) were drawn from the regional population registers. Cases and control subjects were between 25 and 70 years of age. In a structured personal interview, a complete occupational history was elicited to identify subjects with certain minimum workloads. On the basis of job task-specific supplementary surveys performed by technical experts, the situational lumbar load represented by the compressive force at the lumbosacral disc was determined via biomechanical model calculations for any working situation with object handling and load-intensive postures during the total working life. For this analysis, all manual handling of objects of about 5 kilograms or more and postures with trunk inclination of 20 degrees or more are included in the calculation of cumulative lumbar load. Confounder selection was based on biologic plausibility and on the change-in-estimate criterion. Odds ratios (OR) and 95% confidence intervals (CI) were calculated separately for men and women using unconditional logistic regression analysis, adjusted for age, region, and unemployment as major life event (in males) or psychosocial strain at work (in females), respectively. To further elucidate the contribution of past physical workload to the development of lumbar disc diseases, we performed lag-time analyses. Results We found a positive dose-response relationship between cumulative occupational lumbar load and lumbar disc herniation as well as lumbar disc narrowing among men and women. Even past lumbar load seems to contribute to the risk of lumbar disc disease. Conclusions According to our study, cumulative physical workload is related to lumbar disc diseases among men and women

Dairying, diseases and the evolution of lactase persistence in Europe

Update notice Author Correction: Dairying, diseases and the evolution of lactase persistence in Europe (Nature, (2022), 608, 7922, (336-345), 10.1038/s41586-022-05010-7) Nature, Volume 609, Issue 7927, Pages E9, 15 September 2022In European and many African, Middle Eastern and southern Asian populations, lactase persistence (LP) is the most strongly selected monogenic trait to have evolved over the past 10,000 years(1). Although the selection of LP and the consumption of prehistoric milk must be linked, considerable uncertainty remains concerning their spatiotemporal configuration and specific interactions(2,3). Here we provide detailed distributions of milk exploitation across Europe over the past 9,000 years using around 7,000 pottery fat residues from more than 550 archaeological sites. European milk use was widespread from the Neolithic period onwards but varied spatially and temporally in intensity. Notably, LP selection varying with levels of prehistoric milk exploitation is no better at explaining LP allele frequency trajectoriesthan uniform selection since the Neolithic period. In the UK Biobank(4,5) cohort of 500,000 contemporary Europeans, LP genotype was only weakly associated with milk consumption and did not show consistent associations with improved fitness or health indicators. This suggests that other reasons for the beneficial effects of LP should be considered for its rapid frequency increase. We propose that lactase non-persistent individuals consumed milk when it became available but, under conditions of famine and/or increased pathogen exposure, this was disadvantageous, driving LP selection in prehistoric Europe. Comparison of model likelihoods indicates that population fluctuations, settlement density and wild animal exploitation-proxies for these drivers-provide better explanations of LP selection than the extent of milk exploitation. These findings offer new perspectives on prehistoric milk exploitation and LP evolution.Peer reviewe