Associations between objectively measured and self‐reported sleep with academic and cognitive performance in adolescents: DADOS study

Adequate sleep has been positively related with health and school achievement out-comes during adolescence. The aim of this study was to investigate the associations ofobjectively measured and self‐reported sleep duration and quality with academic andcognitive performance in adolescents. This study was conducted with 257 adolescents(13.9 ± 0.3 years) from the DADOS study (Deporte, ADOlescencia y Salud). Objec-tively measured and self‐reported sleep duration and quality were obtained by a wrist‐worn GENEActiv accelerometer and the Spanish version of Pittsburgh Sleep QualityIndex questionnaire, respectively. Academic performance was analysed through schoolrecords using four indicators: math, language, science and grade point average score.Cognitive performance was measured using the Spanish version of the“SRA Test ofEducational Ability”. After Benjamini–Hochberg correction for the false discovery rate,objectively measured sleep duration was negatively associated with verbal ability (β=−0.179,p= .004), whilst self‐reported sleep quality was positively associated withacademic performance (βranging from 0.209 to 0.273; allp<.001). These associationsremained significant after further controlling for physical fitness and physical activity.Conversely, there were no associations between self‐reported sleep duration andobjective sleep quality with academic and cognitive performance. Our findings fit inline with previous research showing that sleep quality may play an important role onadolescents’academic performance. Further interventional research is needed to clar-ify the mechanisms by which sleep is related to academic performance in youth

Influence of bainite morphology on impact toughness of continuously cooled cementite free bainitic steels

The influence of bainite morphology on the impact toughness behaviour of continuously cooled cementite-free low carbon bainitic steels has been examined. In these steels, bainitic microstructures formed mainly by lath-like upper bainite, consisting of thin and long parallel ferrite laths, were shown to exhibit higher impact toughness values than those with a granular bainite, consisting of equiaxed ferrite structure and discrete island of marteniste/austenite (M/A) constituent. Results suggest that the mechanism of brittle fracture of cementite-free bainitic steels involves nucleation of microcracks in M/A islands but is controlled by the bainite packet sizeSpanish Ministry of Science and Innovation for financial support in the form of a PhD research grant (FPI grant under the project no. MAT2007-63873)Peer reviewe

A procedure for indirect and automatic measurement of prior austenite grain size in bainite/martensite microstructures

An alternative procedure for indirect and automatic measurement of the prior austenite grain size (PAGS) in bainite/martensite is proposed in this work. It consists in the determination of an effective grain size (EGS) by means of statistical post-processing of electron backscatter diffraction (EBSD) data. The algorithm developed for that purpose, which is available on-line, has been applied to simulated EBSD maps as well as to both a nanocrystalline bainitic steel and a commercial hot-rolled air-cooled steel with a granular bainitic microstructure. The new proposed method has been proven to be robust and results are in good agreement with conventional PAGS measurements. The added value of the procedure comes from its simplicity, as no parent reconstruction is involved during the process, and its suitability for low-magnification EBSD maps, thus allowing a large step-size and coverage of a substantially broader area of the sample than the previous methods reported.Spanish Ministry of Economy and Competitiveness for funding this research under the contract IPT-2012-0320-420000. L.M.-R. also acknowledges the Spanish Ministry of Economy and Competitiveness for financial support in the form of a PhD research grant (FPI-Ref. BES-2011-044186).Peer reviewe

Cytochrome P450 Epoxygenase-Derived Epoxyeicosatrienoic Acids Contribute to Insulin Sensitivity in Mice and in Humans

Aims/hypothesis: Insulin resistance is frequently associated with hypertension and type 2 diabetes. The P450 arachidonic acid epoxygenases (CYP2C, CYP2J) and their epoxyeicosatrienoic acid (EET) products lower blood pressure and may also improve glucose homeostasis. However, the direct contribution of endogenous EET production on insulin sensitivity has not been previously investigated. In this study we tested the hypothesis that endogenous CYP2C-derived EETs alter insulin sensitivity by analyzing mice lacking Cyp2c44, amajor EET producing enzyme, and by testing the association of plasma EETs with insulin sensitivity in humans.Methods: We assessed insulin sensitivity in wild-type (WT) and Cyp2c44(-/-) mice using hyperinsulinaemic-euglycaemic clamps and isolated skeletal muscles. Insulin secretory function was assessed using hyperglycaemic clamps and isolated islets. Vascular function was tested in isolated-perfused mesenteric vessels. Insulin sensitivity and secretion were assessed in humans using frequently sampled intravenous glucose tolerance tests and plasma EETs were measured by mass spectrometry.Results: Cyp2c44(-/-) mice showed decreased insulin sensitivity compared to WT controls. Although glucose uptake was diminished in Cyp2c44(-/-) mice in vivo, insulin-stimulated glucose uptake was unchanged ex vivo in isolated skeletal muscle. Capillary density was similar but vascular KATP-induced relaxation was impaired in isolated Cyp2c44(-/-) vessels, suggesting that impaired vascular reactivity produces impaired insulin sensitivity in vivo. Similarly, plasma EETs positively correlated with insulin sensitivity in human subjects. Conclusions/Interpretation: CYP2C-derived EETs contribute to insulin sensitivity in mice and in humans. Interventions to increase circulating EETs in humans could provide a novel approach to improve insulin sensitivity and treat hypertension

What lies beneath: exploring links between asylum policy and hate crime in the UK

This paper explores the link between increasing incidents of hate crime and the asylum policy of successive British governments with its central emphasis on deterrence. The constant problematisation of asylum seekers in the media and political discourse ensures that 'anti-immigrant' prejudice becomes mainstr earned as a common-sense response. The victims are not only the asylum seekers hoping for a better life but democratic society itself with its inherent values of pluralism and tolerance debased and destabilised

PPARα Ligands as Antitumorigenic and Antiangiogenic Agents

Peroxisome proliferator-activated receptors (PPARs) belong to the nuclear receptor family of ligand-activated transcription factors. This subfamily is composed of three members—PPARα, PPARδ, and PPARγ—that differ in their cell and tissue distribution as well as in their target genes. PPARα is abundantly expressed in liver, brown adipose tissue, kidney, intestine, heart, and skeletal muscle; and its ligands have been used to treat diseases such as obesity and diabetes. The recent finding that members of the PPAR family, including the PPARα, are expressed by tumor and endothelial cells together with the observation that PPAR ligands regulate cell growth, survival, migration, and invasion, suggested that PPARs also play a role in cancer. In this review, we focus on the contribution of PPARα to tumor and endothelial cell functions and provide compelling evidence that PPARα can be viewed as a new class of ligand activated tumor “suppressor” gene with antiangiogenic and antitumorigenic activities. Given that PPAR ligands are currently used in medicine as hypolipidemic drugs with excellent tolerance and limited toxicity, PPARα activation might offer a novel and potentially low-toxic approach for the treatment of tumor-associated angiogenesis and cancer

Dynamic Interpretation of Hedgehog Signaling in the Drosophila Wing Disc

Morphogens are classically defined as molecules that control patterning by acting at a distance to regulate gene expression in a concentration-dependent manner. In the Drosophila wing imaginal disc, secreted Hedgehog (Hh) forms an extracellular gradient that organizes patterning along the anterior–posterior axis and specifies at least three different domains of gene expression. Although the prevailing view is that Hh functions in the Drosophila wing disc as a classical morphogen, a direct correspondence between the borders of these patterns and Hh concentration thresholds has not been demonstrated. Here, we provide evidence that the interpretation of Hh signaling depends on the history of exposure to Hh and propose that a single concentration threshold is sufficient to support multiple outputs. Using mathematical modeling, we predict that at steady state, only two domains can be defined in response to Hh, suggesting that the boundaries of two or more gene expression patterns cannot be specified by a static Hh gradient. Computer simulations suggest that a spatial “overshoot” of the Hh gradient occurs, i.e., a transient state in which the Hh profile is expanded compared to the Hh steady-state gradient. Through a temporal examination of Hh target gene expression, we observe that the patterns initially expand anteriorly and then refine, providing in vivo evidence for the overshoot. The Hh gene network architecture suggests this overshoot results from the Hh-dependent up-regulation of the receptor, Patched (Ptc). In fact, when the network structure was altered such that the ptc gene is no longer up-regulated in response to Hh-signaling activation, we found that the patterns of gene expression, which have distinct borders in wild-type discs, now overlap. Our results support a model in which Hh gradient dynamics, resulting from Ptc up-regulation, play an instructional role in the establishment of patterns of gene expression

Euclid preparation: XXVI The Euclid Morphology Challenge: Towards structural parameters for billions of galaxies

Artículo escrito por un elevado número de autores, solo se referencian el que aparece en primer lugar, el nombre del grupo de colaboración, si le hubiere, y los autores pertenecientes a la UAMThe various Euclid imaging surveys will become a reference for studies of galaxy morphology by delivering imaging over an unprecedented area of 15 000 square degrees with high spatial resolution. In order to understand the capabilities of measuring morphologies from Euclid-detected galaxies and to help implement measurements in the pipeline of the Organisational Unit MER of the Euclid Science Ground Segment, we have conducted the Euclid Morphology Challenge, which we present in two papers. While the companion paper focusses on the analysis of photometry, this paper assesses the accuracy of the parametric galaxy morphology measurements in imaging predicted from within the Euclid Wide Survey. We evaluate the performance of five state-of-the-art surface-brightness-fitting codes, DeepLeGATo, Galapagos-2, Morfometryka, ProFit and SourceXtractor++, on a sample of about 1.5 million simulated galaxies (350 000 above 5s) resembling reduced observations with the Euclid VIS and NIR instruments. The simulations include analytic Sérsic profiles with one and two components, as well as more realistic galaxies generated with neural networks. We find that, despite some code-specific differences, all methods tend to achieve reliable structural measurements (< 10% scatter on ideal Sérsic simulations) down to an apparent magnitude of about IE = 23 in one component and IE = 21 in two components, which correspond to a signal-to-noise ratio of approximately 1 and 5, respectively. We also show that when tested on non-analytic profiles, the results are typically degraded by a factor of 3, driven by systematics. We conclude that the official Euclid Data Releases will deliver robust structural parameters for at least 400 million galaxies in the Euclid Wide Survey by the end of the mission. We find that a key factor for explaining the different behaviour of the codes at the faint end is the set of adopted priors for the various structural parameter

The sunburn response in human skin is characterized by sequential eicosanoid profiles that may mediate its early and late phases.

yesSunburn is a commonly occurring acute inflammatory process, with dermal vasodilatation and leukocyte infiltration as central features. Ultraviolet (UV) B-induced hydrolysis of membrane phospholipids releases polyunsaturated fatty acids and their subsequent metabolism by cyclooxygenases (COX) and lipoxygenases (LOX) may produce potent eicosanoid mediators modulating different stages of the inflammation. Our objective was to identify candidate eicosanoids formed during the sunburn reaction in relation to its clinical and histological course. We exposed skin of healthy humans (n=32) to UVB and for 72h examined (i) expression of pro- and anti-inflammatory eicosanoids using LC/ESI-MS/MS and (ii) immunohistochemical expression of COX-2, 12-LOX, 15-LOX and leucocyte markers, while (iii) quantifying clinical erythema. We show that vasodilatory prostaglandins (PG)E2, PGF2¿ and PGE3 accompany the erythema in the first 24-48h, associated with increased COX-2 expression at 24h. Novel, potent leukocyte chemoattractants 11-, 12- and 8-monohydroxy-eicosatetraenoic acid (-HETE) are elevated from 4-72h, in association with peak dermal neutrophil influx at 24h, and increased dermal CD3+ lymphocytes and 12- and 15-LOX expression from 24-72h. Anti-inflammatory metabolite 15-HETE shows later expression, peaking at 72h. Sunburn is characterized by overlapping phases of increases in COX products followed by LOX products that may regulate subsequent events and ultimately its resolution.The Wellcome Trus

The Dark Energy Survey Bright Arcs Survey: Candidate strongly lensed galaxy systems from the dark energy survey 5000 square degree footprint

Artículo escrito por un elevado número de autores, solo se referencian el que aparece en primer lugar, el nombre del grupo de colaboración, si le hubiere, y los autores pertenecientes a la UAMWe report the combined results of eight searches for strong gravitational lens systems in the full 5000 square degrees of Dark Energy Survey (DES) observations. The observations accumulated by the end of the third observing season fully covered the DES footprint in five filters (grizY), with an i-band limiting magnitude (at 10σ) of 23.44. In four searches, a list of potential candidates was identified using a color and magnitude selection from the object catalogs created from the first three observing seasons. Three other searches were conducted at the locations of previously identified galaxy clusters. Cutout images of potential candidates were then visually scanned using an object viewer. An additional set of candidates came from a data-quality check of a subset of the color-coadd tiles created from the full DES six-season data set. A short list of the most promising strong-lens candidates was then numerically ranked according to whether or not we judged them to be bona fide strong gravitational lens systems. These searches discovered a diverse set of 247 strong-lens candidate systems, of which 81 are identified for the first time. We provide the coordinates, magnitudes, and photometric properties of the lens and source objects, and an estimate of the Einstein radius for 81 new systems and 166 previously reported systems. This catalog will be of use for selecting interesting systems for detailed follow up, studies of galaxy cluster and group mass profiles, as well as a training/validation set for automated strong-lens searche