55 research outputs found
Equilibrium structure of monatomic steps on vicinal Si(001)
The equilibrium structure of monatomic steps on vicinal Si(001) is described in terms of anisotropic nearest-neighbor and isotropic second-nearest-neighbor interactions between dimers. By comparing scanning-tunneling-microscopy data and this equilibrium structure, we obtained interaction energies of 0.38 eV between dimers in a row, 0.24 eV between sets of two dimers in adjacent rows, and -0.07 eV for the diagonal interaction between dimers in adjacent rows
Charge density waves and surface Mott insulators for adlayer structures on semiconductors: extended Hubbard modeling
Motivated by the recent experimental evidence of commensurate surface charge
density waves (CDW) in Pb/Ge(111) and Sn/Ge(111) sqrt{3}-adlayer structures, as
well as by the insulating states found on K/Si(111):B and SiC(0001), we have
investigated the role of electron-electron interactions, and also of
electron-phonon coupling, on the narrow surface state band originating from the
outer dangling bond orbitals of the surface. We model the sqrt{3} dangling bond
lattice by an extended two-dimensional Hubbard model at half-filling on a
triangular lattice. We include an on-site Hubbard repulsion U and a
nearest-neighbor Coulomb interaction V, plus a long-ranged Coulomb tail. The
electron-phonon interaction is treated in the deformation potential
approximation. We have explored the phase diagram of this model including the
possibility of commensurate 3x3 phases, using mainly the Hartree-Fock
approximation. For U larger than the bandwidth we find a non-collinear
antiferromagnetic SDW insulator, possibly corresponding to the situation on the
SiC and K/Si surfaces. For U comparable or smaller, a rich phase diagram
arises, with several phases involving combinations of charge and
spin-density-waves (SDW), with or without a net magnetization. We find that
insulating, or partly metallic 3x3 CDW phases can be stabilized by two
different physical mechanisms. One is the inter-site repulsion V, that together
with electron-phonon coupling can lower the energy of a charge modulation. The
other is a novel magnetically-induced Fermi surface nesting, stabilizing a net
cell magnetization of 1/3, plus a collinear SDW, plus an associated weak CDW.
Comparison with available experimental evidence, and also with first-principle
calculations is made.Comment: 11 pages, 9 figure
The impact of a pathologist's personality on the interobserver variability and diagnostic accuracy of predictive PD-L1 immunohistochemistry in lung cancer
OBJECTIVES: Programmed death-ligand 1 (PD-L1) is the only approved predictive biomarker for immunotherapy in non-small cell lung cancer (NSCLC). However, predictive PD-L1 immunohistochemistry is subject to interobserver variability. We hypothesized that a pathologist's personality influences the interobserver variability and diagnostic accuracy of PD-L1 immunoscoring. MATERIALS AND METHODS: Seventeen pathologists performed PD-L1 immunoscoring on 50 resected NSCLC tumors in three categories (<1%;1-49%;â„50%). Also, the pathologists completed a certified personality test (NEO-PI-r), assessing five personality traits: neuroticism, extraversion, openness, altruism and conscientiousness. RESULTS: The overall agreement among pathologists for a series of 47 tumors was substantial (kappa = 0.63). Of these, 23/47 (49%) tumors were entirely negative or largely positive, resulting in a kappa value of 0.93. The remaining 24/47 (51%) tumors had a PD-L1 score around the cutoff value, generating a kappa value of 0.32. Pathologists with high scores for conscientiousness (careful, diligent) had the least interobserver variability (r = 0.6, p = 0.009). Also, they showed a trend towards higher sensitivity (74% vs. 68%, p = 0.4), specificity (86% vs. 82%, p = 0.3) and percent agreement (83% vs. 79%, p = 0.3), although not significant. In contrast, pathologists with high scores for neuroticism (sensitive, anxious) had significantly lower specificity (80% vs. 87%, p = 0.03) and percent agreement (78% vs. 85%, p = 0.03). Also, a trend towards high interobserver variability (r = -0.3, p = 0.2) and lower sensitivity (68% vs. 74%, p = 0.3) was observed, although not significant. Pathologists with relatively high scores for conscientiousness scored fewer tumors PD-L1 positive at the â„ 1% cut-off (r = -0.5, p = 0.03). In contrast, pathologists with relatively high scores for neuroticism score more tumors PD-L1 positive at â„ 1% (r = 0.6, p = 0.017) and â„ 50% cut-offs (r = 0.6, p = 0.009). CONCLUSIONS: This study is the first to demonstrate the impact of a pathologist's personality on the interobserver variability and diagnostic accuracy of immunostaining, in the context of PD-L1 in NSCLC. Larger studies are needed for validation of these findings
An overview of the mid-infrared spectro-interferometer MATISSE: science, concept, and current status
MATISSE is the second-generation mid-infrared spectrograph and imager for the
Very Large Telescope Interferometer (VLTI) at Paranal. This new interferometric
instrument will allow significant advances by opening new avenues in various
fundamental research fields: studying the planet-forming region of disks around
young stellar objects, understanding the surface structures and mass loss
phenomena affecting evolved stars, and probing the environments of black holes
in active galactic nuclei. As a first breakthrough, MATISSE will enlarge the
spectral domain of current optical interferometers by offering the L and M
bands in addition to the N band. This will open a wide wavelength domain,
ranging from 2.8 to 13 um, exploring angular scales as small as 3 mas (L band)
/ 10 mas (N band). As a second breakthrough, MATISSE will allow mid-infrared
imaging - closure-phase aperture-synthesis imaging - with up to four Unit
Telescopes (UT) or Auxiliary Telescopes (AT) of the VLTI. Moreover, MATISSE
will offer a spectral resolution range from R ~ 30 to R ~ 5000. Here, we
present one of the main science objectives, the study of protoplanetary disks,
that has driven the instrument design and motivated several VLTI upgrades
(GRA4MAT and NAOMI). We introduce the physical concept of MATISSE including a
description of the signal on the detectors and an evaluation of the expected
performances. We also discuss the current status of the MATISSE instrument,
which is entering its testing phase, and the foreseen schedule for the next two
years that will lead to the first light at Paranal.Comment: SPIE Astronomical Telescopes and Instrumentation conference, June
2016, 11 pages, 6 Figure
X-shooter, the new wide band intermediate resolution spectrograph at the ESO Very Large Telescope
X-shooter is the first 2nd generation instrument of the ESO Very Large
Telescope(VLT). It is a very efficient, single-target, intermediate-resolution
spectrograph that was installed at the Cassegrain focus of UT2 in 2009. The
instrument covers, in a single exposure, the spectral range from 300 to 2500
nm. It is designed to maximize the sensitivity in this spectral range through
dichroic splitting in three arms with optimized optics, coatings, dispersive
elements and detectors. It operates at intermediate spectral resolution
(R~4,000 - 17,000, depending on wavelength and slit width) with fixed echelle
spectral format (prism cross-dispersers) in the three arms. It includes a
1.8"x4" Integral Field Unit as an alternative to the 11" long slits. A
dedicated data reduction package delivers fully calibrated two-dimensional and
extracted spectra over the full wavelength range. We describe the main
characteristics of the instrument and present its performance as measured
during commissioning, science verification and the first months of science
operations.Comment: accepted for publication in A&
Mid-infrared circumstellar emission of the long-period Cepheid l Carinae resolved with VLTI/MATISSE
Stars and planetary system
Field Ion Microscope, Imaging Atom Probe Study of Metallic Glasses
The application of a field ion microscope and imaging atom probe to the problem of atomic structure of metallic glasses has been investigated in two systems, Ni40Pd40P20, an amorphous alloy of the type transition metal-metalloid, and FeZr, an alloy system of two transition metals, of which two compositions are studied. The spatial resolution of both techniques does not permit to probe local atomic configurations, but homogeneity on a nm scale and the presence of microcrystallites can be establishe
The Atomic-Structure of the Icosahedral Phase Probed by Field-Ion Microscopy Compared with Computer-Simulations
Field ion images have been simulated of fifteen different decorations of the rhombohedral cells of the three dimensional Penrose packing in order to achieve a best fit with FIM experiment. The decorations having the correct number of atoms per unit cell result in strong fivefold poles in the FIM image. In contrast, the experimental images show two- and threefold poles stronger than fivefold one
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