Prevention and early detection of prostate cancer

This Review was sponsored and funded by the International Society of Cancer Prevention (ISCaP), the European Association of Urology (EAU), the National Cancer Institute, USA (NCI) (grant number 1R13CA171707-01), Prostate Cancer UK, Cancer Research UK (CRUK) (grant number C569/A16477), and the Association for International Cancer Research (AICR

User evaluation of comfortable deceleration profiles for highly automated driving: Findings from a test track study

As automated vehicles advance and become more widespread, it is increasingly important to ensure optimal driving comfort for passengers. Recent research has focused on developing driving styles for automated vehicles that are perceived to be most comfortable. However, there is still little understanding of whether, and how, possible driving styles need to be adjusted for specific traffic scenarios. In this study, 36 participants experienced three different deceleration profiles (a linear deceleration profile ‘One-Step’, and two versions of stepwise deceleration profiles ‘Two-Step V1 and V2’) across different driving scenarios (deceleration before curves, approaching a speed-limit sign, and a stop sign). Deceleration profiles were rated by participants and the impact of non-driving related activities on driving comfort was investigated. Results showed a positive rating for all deceleration profiles in terms of comfort. For decelerations to a standstill at a Stop Sign, participants seemed to prefer the One-Step approach, in which there is a continuous, and constant deceleration. However, participants described the Two-Step V1 as a gentle and calmer approach and ranked it more frequently as a personal favourite than the One-Step profile or the Two-Step V2 profile. The visual distraction of the passenger through a non-driving activity had no impact on passenger comfort or profile preferences for the scenarios tested within this study. Nonetheless, participants reported perceiving a lower intensity of longitudinal vehicle movements when visually distracted during the drive. The results of the study provide insights into the design and implementation of comfortable deceleration profiles

Focal therapy for prostate cancer: revolution or evolution?

The face of prostate cancer has been dramatically changed since the late 1980s when PSA was introduced as a clinical screening tool. More men are diagnosed with small foci of cancers instead of the advanced disease evident prior to PSA screening. Treatment options for these smaller tumors consist of expectant management, radiation therapy (brachytherapy and external beam radiotherapy) and surgery (cryosurgical ablation and radical prostatectomy). In the highly select patient, cancer specific survival employing any of these treatment options is excellent, however morbidity from these interventions are significant. Thus, the idea of treating only the cancer within the prostate and sparing the non-cancerous tissue in the prostate is quite appealing, yet controversial. Moving forward if we are to embrace the focal treatment of prostate cancer we must: be able to accurately identify index lesions within the prostate, image cancers within the prostate and methodically study the litany of focal therapeutic options available