1,014 research outputs found
1156-62 Economic outcomes of carotid stenting versus endarterectomy for high risk patients: Preliminary results from the SAPPHIRE trial
Combined Cisplatinum and Laser Thermal Therapy for Palliation of Recurrent Head and Neck Tumors
In recent years endoscopically controlled laser-induced thermal therapy (LITT) has been
increasingly accepted as a minimally invasive method for palliation of advanced or recurrent
head and neck or gastrointestinal cancer. Previous studies have shown that adjuvant
chemotherapy can potentiate endoscopic laser thermal ablation of obstructing tumors leading
to improved palliation in advanced cancer patients. Eight patients with recurrent head and
neck tumors volunteered to enroll as part of an ongoing phase II LITT clinical trial, and also
elected to be treated with systemic chemotherapy (cisplatin, 80 mg/m2) followed 24 h later by
palliative laser thermal ablation. Laser treatments were repeated in patients with residual
disease or recurrence for a total of 27 LITT sessions. Four of the 8 patients treated with laser
thermal chemotherapy remained alive after a median follow-up of 12 months. Of the 12 tumor
sites treated, complete responses were located in the oral cavity (3), oropharynx (1),
hypopharynx (1), maxillary sinus (1), and median survival for these patients was 9.5 months.
This initial experience with cisplatinum-based laser chemotherapy indicates both safety and
therapeutic potential for palliation of advanced head and neck cancer but this must be confirmed
by longer follow-up in a larger cohort of patients
UJI AKTIVITAS PROTEASE DAN KARAKTERISASI PH ACTINOMYCETES ISOLAT ATH-03 ASAL TAHURA POCUT MEURAH INTAN KABUPATEN ACEH BESAR
ABSTRAKKata kunci: Aktivitas Protease, Karakterisasi pH, Actinomycetes.Penelitian Uji Aktivitas Protease dan Karakterisasi pH Actinomycetes Isolat ATH-03 Asal Tahura Pocut Meurah Intan Kabupaten Aceh Besar telah dilaksanakan sejak tanggal 3 September sampai dengan 27 Desember 2012. Penelitian ini bertujuan untuk mengukur aktivitas protease dan mengetahui pH optimum aktivitas protease dari isolat Actinomycetes ATH-03. Metode penelitian yang digunakan adalah metode Eksperimen dengan Rancangan Acak Lengkap Non Faktorial dengan 6 kali perlakuan, 2 kali ulangan. Data yang diperoleh dianalisis secara deskriptif yang terkait dengan nilai indeks proteolitik sebagai dasar seleksi isolat Actinomycetes. Isolat Actinomycetes berasal dari koleksi Laboratorium Mikrobiologi Jurusan Biologi FMIPA Universitas Syiah Kuala. Delapan belas isolat Actinomycetes menunjukkan aktivitas pada Media NA yang mengandung susu skim 1%. Isolat ATH-03 dipilih dalam penelitian ini karena memiliki zona bening yang lebar dengan indeks proteolitik (IP) tertinggi 8,537 setelah inkubasi selama 48 jam pada Media NAS. Protease ekstraseluler dikarakterisasi menggunakan media NB yang mengandung susu skim 1% sebagai media produksi. Waktu optimum pemanenan ekstrak kasar protease isolat ATH-03 pada hari ke-7 dengan aktivitas sebesar 0,083 U/ml, kadar protein 0,003 mg/ml dan aktivitas spesifik mencapai 23,72 U/mg. Hasil karakterisasi pH ekstrak kasar enzim isolat ATH-03 menunjukkan aktivitas optimum pada pH 8 yaitu 0,067 U/ml, protease yang dihasilkan oleh isolat ini aktif pada kisaran pH netral.Banda Ace
Faint High Latitude Carbon Stars Discovered by the Sloan Digital Sky Survey: Methods and Initial Results
We report the discovery of 39 Faint High Latitude Carbon Stars (FHLCs) from
Sloan Digital Sky Survey commissioning data. The objects, each selected
photometrically and verified spectroscopically, range over 16.6 < r* < 20.0,
and show a diversity of temperatures as judged by both colors and NaD line
strengths. At the completion of the Sloan Survey, there will be many hundred
homogeneously selected and observed FHLCs in this sample. We present proper
motion measures for each object, indicating that the sample is a mixture of
extremely distant (>100 kpc) halo giant stars, useful for constraining halo
dynamics, plus members of the recently-recognized exotic class of very nearby
dwarf carbon (dC) stars. Motions, and thus dC classification, are inferred for
40-50 percent of the sample, depending on the level of statistical significance
invoked. The new list of dC stars presented here, although selected from only a
small fraction of the final SDSS, doubles the number of such objects found by
all previous methods. (Abstract abridged).Comment: Accepted for publication in The Astronomical Journal, Vol. 124, Sep.
2002, 40 pages, 7 figures, AASTeX v5.
Maternal psychological distress in primary care and association with child behavioural outcomes at age three
Observational studies indicate children whose mothers have poor mental health are at increased risk of socio-emotional behavioural difficulties, but it is unknown whether these outcomes vary by the mothers’ mental health recognition and treatment status. To examine this question, we analysed linked longitudinal primary care and research data from 1078 women enrolled in the Born in Bradford cohort. A latent class analysis of treatment status and self-reported distress broadly categorised women as (a) not having a common mental disorder (CMD) that persisted through pregnancy and the first 2 years after delivery (N = 756, 70.1 %), (b) treated for CMD (N = 67, 6.2 %), or (c) untreated (N = 255, 23.7 %). Compared to children of mothers without CMD, 3-year-old children with mothers classified as having untreated CMD had higher standardised factor scores on the Strengths and Difficulties Questionnaire (d = 0.32), as did children with mothers classified as having treated CMD (d = 0.27). Results were only slightly attenuated in adjusted analyses. Children of mothers with CMD may be at risk for socio-emotional and behavioural difficulties. The development of effective treatments for CMD needs to be balanced by greater attempts to identify and treat women. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1007/s00787-015-0777-2) contains supplementary material, which is available to authorized users
Non-destructive optical measurement of relative phase between two Bose condensates
We study the interaction of light with two Bose condensates as an open
quantum system. The two overlapping condensates occupy two different Zeeman
sublevels and two driving light beams induce a coherent quantum tunneling
between the condensates. We derive the master equation for the system. It is
shown that stochastic simulations of the measurements of spontaneously
scattered photons establish the relative phase between two Bose condensates,
even though the condensates are initially in pure number states. These
measurements are non-destructive for the condensates, because only light is
scattered, but no atoms are removed from the system. Due to the macroscopic
quantum interference the detection rate of photons depends substantially on the
relative phase between the condensates. This may provide a way to distinguish,
whether the condensates are initially in number states or in coherent states.Comment: 26 pages, RevTex, 8 postscript figures, 1 MacBinary eps-figur
Dust Processing and Grain Growth in Protoplanetary Disks in the Taurus-Auriga Star-Forming Region
Mid-infrared spectra of 65 T Tauri stars (TTS) taken with the Infrared
Spectrograph (IRS) on board the Spitzer Space Telescope are modeled using dust
at two temperatures to probe the radial variation in dust composition in the
uppermost layers of protoplanetary disks. Most spectra indicating crystalline
silicates require Mg-rich minerals and silica, but a few suggest otherwise.
Spectra indicating abundant enstatite at higher temperatures also require
crystalline silicates at temperatures lower than those required for spectra
showing high abundance of other crystalline silicates. A few spectra show 10
micron complexes of very small equivalent width. They are fit well using
abundant crystalline silicates but very few large grains, inconsistent with the
expectation that low peak-to-continuum ratio of the 10 micron complex always
indicates grain growth. Most spectra in our sample are fit well without using
the opacities of large crystalline silicate grains. If large grains grow by
agglomeration of submicron grains of all dust types, the amorphous silicate
components of these aggregates must typically be more abundant than the
crystalline silicate components. Crystalline silicate abundances correlate
positively with other such abundances, suggesting that crystalline silicates
are processed directly from amorphous silicates and that neither forsterite,
enstatite, nor silica are intermediate steps when producing either of the other
two. Disks with more dust settling typically have greater crystalline
abundances. Large-grain abundance is somewhat correlated with greater settling
of disks. The lack of strong correlation is interpreted to mean that settling
of large grains is sensitive to individual disk properties. Lower-mass stars
have higher abundances of large grains in their inner regions.Comment: 84 pages, 27 figures, submitted to the Astrophysical Journal on 7
November, 200
Reimagining Heliophysics: A bold new vision for the next decade and beyond
The field of Heliophysics has a branding problem. We need an answer to the
question: ``What is Heliophysics\?'', the answer to which should clearly and
succinctly defines our science in a compelling way that simultaneously
introduces a sense of wonder and exploration into our science and our missions.
Unfortunately, recent over-reliance on space weather to define our field, as
opposed to simply using it as a practical and relatable example of applied
Heliophysics science, narrows the scope of what solar and space physics is and
diminishes its fundamental importance. Moving forward, our community needs to
be bold and unabashed in our definition of Heliophysics and its big questions.
We should emphasize the general and fundamental importance and excitement of
our science with a new mindset that generalizes and expands the definition of
Heliophysics to include new ``frontiers'' of increasing interest to the
community. Heliophysics should be unbound from its current confinement to the
Sun-Earth connection and expanded to studies of the fundamental nature of space
plasma physics across the solar system and greater cosmos. Finally, we need to
come together as a community to advance our science by envisioning,
prioritizing, and supporting -- with a unified voice -- a set of bold new
missions that target compelling science questions - even if they do not explore
the traditional Sun- and Earth-centric aspects of Heliophysics science. Such
new, large missions to expand the frontiers and scope of Heliophysics science
large missions can be the key to galvanizing the public and policymakers to
support the overall Heliophysics program
Training of Instrumentalists and Development of New Technologies on SOFIA
This white paper is submitted to the Astronomy and Astrophysics 2010 Decadal
Survey (Astro2010)1 Committee on the State of the Profession to emphasize the
potential of the Stratospheric Observatory for Infrared Astronomy (SOFIA) to
contribute to the training of instrumentalists and observers, and to related
technology developments. This potential goes beyond the primary mission of
SOFIA, which is to carry out unique, high priority astronomical research.
SOFIA is a Boeing 747SP aircraft with a 2.5 meter telescope. It will enable
astronomical observations anywhere, any time, and at most wavelengths between
0.3 microns and 1.6 mm not accessible from ground-based observatories. These
attributes, accruing from the mobility and flight altitude of SOFIA, guarantee
a wealth of scientific return. Its instrument teams (nine in the first
generation) and guest investigators will do suborbital astronomy in a
shirt-sleeve environment. The project will invest $10M per year in science
instrument development over a lifetime of 20 years. This, frequent flight
opportunities, and operation that enables rapid changes of science instruments
and hands-on in-flight access to the instruments, assure a unique and extensive
potential - both for training young instrumentalists and for encouraging and
deploying nascent technologies. Novel instruments covering optical, infrared,
and submillimeter bands can be developed for and tested on SOFIA by their
developers (including apprentices) for their own observations and for those of
guest observers, to validate technologies and maximize observational
effectiveness.Comment: 10 pages, no figures, White Paper for Astro 2010 Survey Committee on
State of the Professio
A Spitzer IRS Survey of NGC 1333: Insights into disk evolution from a very young cluster
We report on the {\lambda} = 5-36{\mu}m Spitzer Infrared Spectrograph spectra
of 79 young stellar objects in the very young nearby cluster NGC 1333. NGC
1333's youth enables the study of early protoplanetary disk properties, such as
the degree of settling as well as the formation of gaps and clearings. We
construct spectral energy distributions (SEDs) using our IRS data as well as
published photometry and classify our sample into SED classes. Using
"extinction-free" spectral indices, we determine whether the disk, envelope, or
photosphere dominates the spectrum. We analyze the dereddened spectra of
objects which show disk dominated emission using spectral indices and
properties of silicate features in order to study the vertical and radial
structure of protoplanetary disks in NGC 1333. At least nine objects in our
sample of NGC 1333 show signs of large (several AU) radial gaps or clearings in
their inner disk. Disks with radial gaps in NGC 1333 show more-nearly pristine
silicate dust than their radially continuous counterparts. We compare
properties of disks in NGC 1333 to those in three other well studied regions,
Taurus-Auriga, Ophiuchus and Chamaeleon I, and find no difference in their
degree of sedimentation and dust processing.Comment: 67 pages, 20 figures, accepted to The Astrophysical Journal
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