Combined Cisplatinum and Laser Thermal Therapy for Palliation of Recurrent Head and Neck Tumors

In recent years endoscopically controlled laser-induced thermal therapy (LITT) has been increasingly accepted as a minimally invasive method for palliation of advanced or recurrent head and neck or gastrointestinal cancer. Previous studies have shown that adjuvant chemotherapy can potentiate endoscopic laser thermal ablation of obstructing tumors leading to improved palliation in advanced cancer patients. Eight patients with recurrent head and neck tumors volunteered to enroll as part of an ongoing phase II LITT clinical trial, and also elected to be treated with systemic chemotherapy (cisplatin, 80 mg/m2) followed 24 h later by palliative laser thermal ablation. Laser treatments were repeated in patients with residual disease or recurrence for a total of 27 LITT sessions. Four of the 8 patients treated with laser thermal chemotherapy remained alive after a median follow-up of 12 months. Of the 12 tumor sites treated, complete responses were located in the oral cavity (3), oropharynx (1), hypopharynx (1), maxillary sinus (1), and median survival for these patients was 9.5 months. This initial experience with cisplatinum-based laser chemotherapy indicates both safety and therapeutic potential for palliation of advanced head and neck cancer but this must be confirmed by longer follow-up in a larger cohort of patients

UJI AKTIVITAS PROTEASE DAN KARAKTERISASI PH ACTINOMYCETES ISOLAT ATH-03 ASAL TAHURA POCUT MEURAH INTAN KABUPATEN ACEH BESAR

ABSTRAKKata kunci: Aktivitas Protease, Karakterisasi pH, Actinomycetes.Penelitian Uji Aktivitas Protease dan Karakterisasi pH Actinomycetes Isolat ATH-03 Asal Tahura Pocut Meurah Intan Kabupaten Aceh Besar telah dilaksanakan sejak tanggal 3 September sampai dengan 27 Desember 2012. Penelitian ini bertujuan untuk mengukur aktivitas protease dan mengetahui pH optimum aktivitas protease dari isolat Actinomycetes ATH-03. Metode penelitian yang digunakan adalah metode Eksperimen dengan Rancangan Acak Lengkap Non Faktorial dengan 6 kali perlakuan, 2 kali ulangan. Data yang diperoleh dianalisis secara deskriptif yang terkait dengan nilai indeks proteolitik sebagai dasar seleksi isolat Actinomycetes. Isolat Actinomycetes berasal dari koleksi Laboratorium Mikrobiologi Jurusan Biologi FMIPA Universitas Syiah Kuala. Delapan belas isolat Actinomycetes menunjukkan aktivitas pada Media NA yang mengandung susu skim 1%. Isolat ATH-03 dipilih dalam penelitian ini karena memiliki zona bening yang lebar dengan indeks proteolitik (IP) tertinggi 8,537 setelah inkubasi selama 48 jam pada Media NAS. Protease ekstraseluler dikarakterisasi menggunakan media NB yang mengandung susu skim 1% sebagai media produksi. Waktu optimum pemanenan ekstrak kasar protease isolat ATH-03 pada hari ke-7 dengan aktivitas sebesar 0,083 U/ml, kadar protein 0,003 mg/ml dan aktivitas spesifik mencapai 23,72 U/mg. Hasil karakterisasi pH ekstrak kasar enzim isolat ATH-03 menunjukkan aktivitas optimum pada pH 8 yaitu 0,067 U/ml, protease yang dihasilkan oleh isolat ini aktif pada kisaran pH netral.Banda Ace

Faint High Latitude Carbon Stars Discovered by the Sloan Digital Sky Survey: Methods and Initial Results

We report the discovery of 39 Faint High Latitude Carbon Stars (FHLCs) from Sloan Digital Sky Survey commissioning data. The objects, each selected photometrically and verified spectroscopically, range over 16.6 < r* < 20.0, and show a diversity of temperatures as judged by both colors and NaD line strengths. At the completion of the Sloan Survey, there will be many hundred homogeneously selected and observed FHLCs in this sample. We present proper motion measures for each object, indicating that the sample is a mixture of extremely distant (>100 kpc) halo giant stars, useful for constraining halo dynamics, plus members of the recently-recognized exotic class of very nearby dwarf carbon (dC) stars. Motions, and thus dC classification, are inferred for 40-50 percent of the sample, depending on the level of statistical significance invoked. The new list of dC stars presented here, although selected from only a small fraction of the final SDSS, doubles the number of such objects found by all previous methods. (Abstract abridged).Comment: Accepted for publication in The Astronomical Journal, Vol. 124, Sep. 2002, 40 pages, 7 figures, AASTeX v5.

Maternal psychological distress in primary care and association with child behavioural outcomes at age three

Observational studies indicate children whose mothers have poor mental health are at increased risk of socio-emotional behavioural difficulties, but it is unknown whether these outcomes vary by the mothers’ mental health recognition and treatment status. To examine this question, we analysed linked longitudinal primary care and research data from 1078 women enrolled in the Born in Bradford cohort. A latent class analysis of treatment status and self-reported distress broadly categorised women as (a) not having a common mental disorder (CMD) that persisted through pregnancy and the first 2 years after delivery (N = 756, 70.1 %), (b) treated for CMD (N = 67, 6.2 %), or (c) untreated (N = 255, 23.7 %). Compared to children of mothers without CMD, 3-year-old children with mothers classified as having untreated CMD had higher standardised factor scores on the Strengths and Difficulties Questionnaire (d = 0.32), as did children with mothers classified as having treated CMD (d = 0.27). Results were only slightly attenuated in adjusted analyses. Children of mothers with CMD may be at risk for socio-emotional and behavioural difficulties. The development of effective treatments for CMD needs to be balanced by greater attempts to identify and treat women. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1007/s00787-015-0777-2) contains supplementary material, which is available to authorized users

Non-destructive optical measurement of relative phase between two Bose condensates

We study the interaction of light with two Bose condensates as an open quantum system. The two overlapping condensates occupy two different Zeeman sublevels and two driving light beams induce a coherent quantum tunneling between the condensates. We derive the master equation for the system. It is shown that stochastic simulations of the measurements of spontaneously scattered photons establish the relative phase between two Bose condensates, even though the condensates are initially in pure number states. These measurements are non-destructive for the condensates, because only light is scattered, but no atoms are removed from the system. Due to the macroscopic quantum interference the detection rate of photons depends substantially on the relative phase between the condensates. This may provide a way to distinguish, whether the condensates are initially in number states or in coherent states.Comment: 26 pages, RevTex, 8 postscript figures, 1 MacBinary eps-figur

Dust Processing and Grain Growth in Protoplanetary Disks in the Taurus-Auriga Star-Forming Region

Mid-infrared spectra of 65 T Tauri stars (TTS) taken with the Infrared Spectrograph (IRS) on board the Spitzer Space Telescope are modeled using dust at two temperatures to probe the radial variation in dust composition in the uppermost layers of protoplanetary disks. Most spectra indicating crystalline silicates require Mg-rich minerals and silica, but a few suggest otherwise. Spectra indicating abundant enstatite at higher temperatures also require crystalline silicates at temperatures lower than those required for spectra showing high abundance of other crystalline silicates. A few spectra show 10 micron complexes of very small equivalent width. They are fit well using abundant crystalline silicates but very few large grains, inconsistent with the expectation that low peak-to-continuum ratio of the 10 micron complex always indicates grain growth. Most spectra in our sample are fit well without using the opacities of large crystalline silicate grains. If large grains grow by agglomeration of submicron grains of all dust types, the amorphous silicate components of these aggregates must typically be more abundant than the crystalline silicate components. Crystalline silicate abundances correlate positively with other such abundances, suggesting that crystalline silicates are processed directly from amorphous silicates and that neither forsterite, enstatite, nor silica are intermediate steps when producing either of the other two. Disks with more dust settling typically have greater crystalline abundances. Large-grain abundance is somewhat correlated with greater settling of disks. The lack of strong correlation is interpreted to mean that settling of large grains is sensitive to individual disk properties. Lower-mass stars have higher abundances of large grains in their inner regions.Comment: 84 pages, 27 figures, submitted to the Astrophysical Journal on 7 November, 200

Reimagining Heliophysics: A bold new vision for the next decade and beyond

The field of Heliophysics has a branding problem. We need an answer to the question: ``What is Heliophysics\?'', the answer to which should clearly and succinctly defines our science in a compelling way that simultaneously introduces a sense of wonder and exploration into our science and our missions. Unfortunately, recent over-reliance on space weather to define our field, as opposed to simply using it as a practical and relatable example of applied Heliophysics science, narrows the scope of what solar and space physics is and diminishes its fundamental importance. Moving forward, our community needs to be bold and unabashed in our definition of Heliophysics and its big questions. We should emphasize the general and fundamental importance and excitement of our science with a new mindset that generalizes and expands the definition of Heliophysics to include new ``frontiers'' of increasing interest to the community. Heliophysics should be unbound from its current confinement to the Sun-Earth connection and expanded to studies of the fundamental nature of space plasma physics across the solar system and greater cosmos. Finally, we need to come together as a community to advance our science by envisioning, prioritizing, and supporting -- with a unified voice -- a set of bold new missions that target compelling science questions - even if they do not explore the traditional Sun- and Earth-centric aspects of Heliophysics science. Such new, large missions to expand the frontiers and scope of Heliophysics science large missions can be the key to galvanizing the public and policymakers to support the overall Heliophysics program

Training of Instrumentalists and Development of New Technologies on SOFIA

This white paper is submitted to the Astronomy and Astrophysics 2010 Decadal Survey (Astro2010)1 Committee on the State of the Profession to emphasize the potential of the Stratospheric Observatory for Infrared Astronomy (SOFIA) to contribute to the training of instrumentalists and observers, and to related technology developments. This potential goes beyond the primary mission of SOFIA, which is to carry out unique, high priority astronomical research. SOFIA is a Boeing 747SP aircraft with a 2.5 meter telescope. It will enable astronomical observations anywhere, any time, and at most wavelengths between 0.3 microns and 1.6 mm not accessible from ground-based observatories. These attributes, accruing from the mobility and flight altitude of SOFIA, guarantee a wealth of scientific return. Its instrument teams (nine in the first generation) and guest investigators will do suborbital astronomy in a shirt-sleeve environment. The project will invest $10M per year in science instrument development over a lifetime of 20 years. This, frequent flight opportunities, and operation that enables rapid changes of science instruments and hands-on in-flight access to the instruments, assure a unique and extensive potential - both for training young instrumentalists and for encouraging and deploying nascent technologies. Novel instruments covering optical, infrared, and submillimeter bands can be developed for and tested on SOFIA by their developers (including apprentices) for their own observations and for those of guest observers, to validate technologies and maximize observational effectiveness.Comment: 10 pages, no figures, White Paper for Astro 2010 Survey Committee on State of the Professio

A Spitzer IRS Survey of NGC 1333: Insights into disk evolution from a very young cluster

We report on the {\lambda} = 5-36{\mu}m Spitzer Infrared Spectrograph spectra of 79 young stellar objects in the very young nearby cluster NGC 1333. NGC 1333's youth enables the study of early protoplanetary disk properties, such as the degree of settling as well as the formation of gaps and clearings. We construct spectral energy distributions (SEDs) using our IRS data as well as published photometry and classify our sample into SED classes. Using "extinction-free" spectral indices, we determine whether the disk, envelope, or photosphere dominates the spectrum. We analyze the dereddened spectra of objects which show disk dominated emission using spectral indices and properties of silicate features in order to study the vertical and radial structure of protoplanetary disks in NGC 1333. At least nine objects in our sample of NGC 1333 show signs of large (several AU) radial gaps or clearings in their inner disk. Disks with radial gaps in NGC 1333 show more-nearly pristine silicate dust than their radially continuous counterparts. We compare properties of disks in NGC 1333 to those in three other well studied regions, Taurus-Auriga, Ophiuchus and Chamaeleon I, and find no difference in their degree of sedimentation and dust processing.Comment: 67 pages, 20 figures, accepted to The Astrophysical Journal Supplement Serie