Sustainability assessment of organic dairy farms in mountainous areas of Austria

Dairy farming plays a major role in mountainous regions of Austria, mostly due to high proportion of grasslands. In general, Austria’s dairy farming faces challenges regarding sustainability, e.g. environmental impacts, but specifically for alpine areas low productivity and dependency on direct payments are lowering sustainability. Organic farming is considered as a strategy to overcome these challenges. Considering this general background, we analysed the sustainability performance and its main drivers of organic dairy farms in mountainous regions of Austria

Identification of novel genetic risk factors of dilated cardiomyopathy: from canine to human

BACKGROUND: Dilated cardiomyopathy (DCM) is a life-threatening heart disease and a common cause of heart failure due to systolic dysfunction and subsequent left or biventricular dilatation. A significant number of cases have a genetic etiology; however, as a complex disease, the exact genetic risk factors are largely unknown, and many patients remain without a molecular diagnosis. METHODS: We performed GWAS followed by whole-genome, transcriptome, and immunohistochemical analyses in a spontaneously occurring canine model of DCM. Canine gene discovery was followed up in three human DCM cohorts. RESULTS: Our results revealed two independent additive loci associated with the typical DCM phenotype comprising left ventricular systolic dysfunction and dilatation. We highlight two novel candidate genes, RNF207 and PRKAA2, known for their involvement in cardiac action potentials, energy homeostasis, and morphology. We further illustrate the distinct genetic etiologies underlying the typical DCM phenotype and ventricular premature contractions. Finally, we followed up on the canine discoveries in human DCM patients and discovered candidate variants in our two novel genes. CONCLUSIONS: Collectively, our study yields insight into the molecular pathophysiology of DCM and provides a large animal model for preclinical studies

Integrated annotation and analysis of genomic features reveal new types of functional elements and large-scale epigenetic phenomena in the developing zebrafish

Zebrafish, a popular model for embryonic development and for modelling human diseases, has so far lacked a systematic functional annotation programme akin to those in other animal models. To address this, we formed the international DANIO-CODE consortium and created the first central repository to store and process zebrafish developmental functional genomic data. Our Data Coordination Center (https://danio-code.zfin.org) combines a total of 1,802 sets of unpublished and reanalysed published genomics data, which we used to improve existing annotations and show its utility in experimental design. We identified over 140,000 cis-regulatory elements in development, including novel classes with distinct features dependent on their activity in time and space. We delineated the distinction between regulatory elements active during zygotic genome activation and those active during organogenesis, identifying new aspects of how they relate to each other. Finally, we matched regulatory elements and epigenomic landscapes between zebrafish and mouse and predict functional relationships between them beyond sequence similarity, extending the utility of zebrafish developmental genomics to mammals

The value of manure - Manure as co-product in life cycle assessment

Research ArticleLivestock production is important for food security, nutrition, and landscape maintenance, but it is associated with several environmental impacts. To assess the risk and benefits arising from livestock production, transparent and robust indicators are required, such as those offered by life cycle assessment. A central question in such approaches is how environmental burden is allocated to livestock products and to manure that is re-used for agricultural production. To incentivize sustainable use of manure, it should be considered as a co-product as long as it is not disposed of, or wasted, or applied in excess of crop nutrient needs, in which case it should be treated as a waste. This paper proposes a theoretical approach to define nutrient requirements based on nutrient response curves to economic and physical optima and a pragmatic approach based on crop nutrient yield adjusted for nutrient losses to atmosphere and water. Allocation of environmental burden to manure and other livestock products is then based on the nutrient value from manure for crop production using the price of fertilizer nutrients. We illustrate and discuss the proposed method with two case studiesinfo:eu-repo/semantics/publishedVersio

Farm- and product-level biodiversity assessment of conventional and organic dairy production in Austria

The novel method developed for this study evaluates the impact of farming practices on farmland biodiversity, allowing for the assessment of the biodiversity potential of dairy farms at farm and product levels. We linked farming practices as pressure indicators to the species number and abundance of 11 indicator species groups (ISGs), evaluated semi-quantitatively by expert judgements. We calculated biodiversity potential based on food–web relationships between the ISGs, using Monte Carlo simulations for the analysis of uncertainty of expert assessments. We applied the assessment model to 8925 dairy farms from seven different Austrian regions, using official statistical data sets at farm level and interviews with farmers and experts. The results show that the approach can be used to identify differences in the biodiversity potential of farms and milk. Milk from organic farms received 4–79% higher biodiversity scores than milk from conventional farms in all regions. The application showed that in the case of Austrian dairy production, the approach can be used for assessments of both farms and products. However, the approach needs validation and, for product-level assessment, further development to cope with longer supply chains or compound products from different bio-geographic regions