PN fast winds: Temporal structure and stellar rotation

To diagnose the time-variable structure in the fast winds of central stars of planetary nebulae (CSPN), we present an analysis of P Cygni line profiles in FUSE satellite far-UV spectroscopic data. Archival spectra are retrieved to form time-series datasets for the H-rich CSPN NGC 6826, IC 418, IC 2149, IC 4593 and NGC 6543. Despite limitations due to the fragmented sampling of the time-series, we demonstrate that in all 5 CSPN the UV resonance lines are variable primarily due to the occurrence of blueward migrating discrete absorption components (DACs). Empirical (SEI) line-synthesis modelling is used to determine the range of fluctuations in radial optical depth, which are assigned to the temporal changes in large-scale wind structures. We argue that DACs are common in CSPN winds, and their empirical properties are akin to those of similar structures seen in the absorption troughs of massive OB stars. Constraints on PN central star rotation velocities are derived from Fast-Fourier Transform analysis of photospheric lines for our target stars. Favouring the causal role of co-rotating interaction regions, we explore connections between normalised DAC accelerations and rotation rates of PN central stars and O stars. The comparative properties suggest that the same physical mechanism is acting to generate large-scale structure in the line-driven winds in the two different settings.Comment: Accepted for publication in MNRAS; 10 pages, 5 figure

Stellar Populations Found in the Central kpc of Four Luminous Compact Blue Galaxies at Intermediate Redshift

We investigate the star formation history of the central regions of four Luminous Compact Blue Galaxies (LCBGs). LCBGs are blue (B-V<0.6), compact (MU_B<21.5 mag arcsec^-2) galaxies with absolute magnitudes M_B brighter than -17.5. The LCBGs analyzed here are located at 0.436<z<0.525. They are among the most luminous (M_B < -20.5), blue (B-V < 0.4) and high surface brightness (MU_B < 19.0 mag arcsec^-2) of this population. The observational data used were obtained with the HST/STIS spectrograph, the HST/WF/PC-2 camera and the HST/NICMOS first camera. We find evidence for multiple stellar populations. One of them is identified as the ionizing population, and the other one corresponds to the underlying stellar generation. The estimated masses of the inferred populations are compatible with the dynamical masses, which are typically 2--10x 10^9 M_sun. Our models also indicate that the first episodes of star formation the presented LCBGs underwent happened between 5 and 7 Gyr ago. We compare the stellar populations found in LCBGs with the stellar populations present in bright, local HII galaxies, nearby spheroidal systems and Blue Compact Dwarf Galaxies. It turns out that the underlying stellar populations of LCBGs are similar yet bluer to those of local HII galaxies. It is also the case that the passive color evolution of the LCBGs could convert them into local Spheroidal galaxies if no further episode of star formation takes place. Our results help to impose constraints on evolutionary scenarios for the population of LCBGs found commonly at intermediate redshifts.Comment: 35 pages, 10 Figures. Accepted for publication in AJ. Compile with pdflatex. Contains png figure

Caracterización tecnofuncional de harinas obtenidas de la cascara y semillas de pepino (Cucumis sativus) y su aplicación en un alimento funcional.

En la actualidad surge la idea de utilizar las frutas en forma de harina como una alternativa de ingrediente funcional. El objetivo del presente trabajo fue caracterizar las propiedades bromatológicas y funcionales harinas de cascara y semillas de pepino obtenidas como subproducto. En general se observan diferencias estadísticamente significativas entre ambas harinas de cascara y semillas obtenidas a partir de pepino, destacando el contenido proteico de 16.24 ± 0.320 y 20.42 ± 0.244% respectivamente y de fibra 17.29±0.990 y 27.91±0.088% respectivamente de ambas harinas por ende podrían utilizarse como ingrediente funcional en la realización de distintos alimentos, se realizaron galletas horneadas a partir de la harina de cascara de pepino debido al contenido de humedad de esta, y se obtuvieron características organolépticas aceptables

Features of dengue and chikungunya infections of colombian children under 24 months of age admitted to the emergency department

We aimed to assess clinical and laboratory differences between dengue and chikungunya in children <24 months of age in a comparative study. We collected retrospective clinical and laboratory data confirmed by NS1/IgM for dengue for 19 months (1 January 2013 to 17 August 2014). Prospective data for chikungunya confirmed by real-time polymerase chain reaction were collected for 4 months (22 September 2014-14 December 2014). Sensitivity and specificity [with 95% confidence interval (CI)] were reported for each disease diagnosis. A platelet count <150 000 cells/ml at emergency admission best characterized dengue, with a sensitivity of 67% (95% CI, 53-79) and specificity of 95% (95% CI, 82-99). The algorithm developed with classification and regression tree analysis showed a sensitivity of 93% (95% CI, 68-100) and specificity of 38% (95% CI, 9-76) to diagnose dengue. Our study provides potential differential characteristics between chikungunya and dengue in young children, especially low platelet counts. © The Author [2017].Universidad Nacional de Colombia, UN Johns Hopkins University1Departamento de Epidemiologia, Hospital Infantil Napoleón Franco Pareja—La Casa del Niño, Cartagena, Colombia 2Facultad de Medicina, Universidad Nacional de Colombia, Bogotá, Colombia 3Departamento de Epidemiologia, Faculdade de Saúde Publica, Universidade de São Paulo, São Paulo, Brazil 4Facultad de Ingenería, Universidad Tecnológica de Bolívar, Cartagena, Colombia 5Facultad Ciencias Básicas y Biomédicas, Universidad Simón Bolívar, Barranquilla, Colombia 6Facultad de Medicina, Universidad de Cartagena, Cartagena, Colombia 7Instituto de Investigaciones Biologicas del Tropico, Universidad de Córdoba, Montería, Colombia 8Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD, USA Correspondence: Angel Paternina-Caicedo, Hospital Infantil Napoleón Franco Pareja—La Casa del Niño, Bruselas Transversal 36 N. 36-33, Cartagena, Bolívar, Colombia. Tel: +1-412-3267809. E-mail or

Sublittoral soft bottom communities and diversity of Mejillones Bay in northern Chile (Humboldt Current upwelling system)

The macrozoobenthos of Mejillones Bay (23°S; Humboldt Current) was quantitatively investigated over a 7-year period from austral summer 1995/1996 to winter 2002. About 78 van Veen grab samples taken at six stations (5, 10, 20 m depth) provided the basis for the analysis of the distribution of 60 species and 28 families of benthic invertebrates, as well as of their abundance and biomass. Mean abundance (2,119 individuals m-2) was in the same order compared to a previous investigation; mean biomass (966 g formalin wet mass m-2), however, exceeded prior estimations mainly due to the dominance of the bivalve Aulacomya ater. About 43% of the taxa inhabited the complete depth range. Mean taxonomic Shannon diversity (H', Log e) was 1.54 ± 0.58 with a maximum at 20 m (1.95 ± 0.33); evenness increased with depth. The fauna was numerically dominated by carnivorous gastropods, polychaetes and crustaceans (48%). About 15% of the species were suspensivorous, 13% sedimentivorous, 11% detritivorous, 7% omnivorous and 6% herbivorous. Cluster analyses showed a significant difference between the shallow and the deeper stations. Gammarid amphipods and the polychaete family Nephtyidae characterized the 5-mzone, the molluscs Aulacomya ater, Mitrella unifasciata and gammarids the intermediate zone, while the gastropod Nassarius gayi and the polychaete family Nereidae were most prominent at the deeper stations. The communities of the three depth zones did not appear to be limited by hypoxia during non-El Niño conditions. Therefore, no typical change in community structure occurred during El Niño 1997–1998, in contrast to what was observed for deeper faunal assemblages and hypoxic bays elsewhere in the coastal Humboldt Current system

Desarrollo de bebidas funcionales adicionadas con α-tocoferol y aceites esenciales de limón y toronja por medio de una nanoemulsión múltiple (w1/o/w2).

La industria de bebidas en México, experimenta una creciente demanda de nuevos productos con propiedadesfuncionales. El objetivo de este trabajo fue desarrollar una nanoemulsion múltiple w1/o/w2 con propiedades antioxidantes otorgadas por el α-Tocoferol y los aceites esenciales de toronja y limón e incorporarla a una bebida natural a base de frutas e incorporación de una fibra soluble. En este caso inulina destaca por sus propiedades prebióticas. Se lograron obtener nanoemulsiones estables debido a la adición de una proteína en la fase acuosa externa, ya que se disminuye el tamaño de partícula que contribuyó a mejorar la estabilidad de la nanoemulsión doble esto concuerda con los valores obtenidos de tasa de coalescencia, mayores a 1x10-6, así mismo las nanoemulsión presentó alta actividad antioxidante. La densidad y el pH no variaron respecto al tiempo. Se logró la estabilidad de la nanoemulsión en la bebida, gracias a que la densidad fue muy cercana a la del agua. Los resultados obtenidos sugieren que es factible la adición de nanoemulsiones para incorporarse en bebidas con antioxidantes encapsulados, contribuyendo en el sabor y aroma en bebidas, usando aceites esenciales

Caracterización inmunológica de un grupo familiar colombiano con infección por SARS-CoV-2

Introduction: Immunological markers have been described during COVID-19 and persist after recovery. These immune markers are associated with clinical features among SARSCoV-2 infected individuals. Nevertheless, studies reporting a comprehensive analysis of the immune changes occurring during SARS-CoV-2 infection are still limited.Objective: To evaluate the production of proinflammatory cytokines, the antibody response, and the phenotype and function of NK cells and T cells in a Colombian family cluster with SARS-CoV-2 infection.Materials and methods: Proinflammatory cytokines were evaluated by RT-PCR and ELISA. The frequency, phenotype, and function of NK cells (cocultures with K562 cells) and T-cells (stimulated with spike/RdRp peptides) were assessed by flow cytometry. Anti-SARS-CoV-2 antibodies were determined using indirect immunofluorescence and plaque reduction neutralization assay.Results: During COVID-19, we observed a high proinflammatory-cytokine production and a reduced CD56bright-NK cell and cytotoxic response. Compared with healthy controls, infected individuals had a higher frequency of dysfunctional CD8+ T cells CD38+HLA-DR-. During the acute phase, CD8+ T cells stimulated with viral peptides exhibited a monofunctional response characterized by high IL-10 production. However, during recovery, we observed a bifunctional response characterized by the co-expression of CD107a and granzyme B or perforin.Conclusion: Although the proinflammatory response is a hallmark of SARS-CoV-2 infection, other phenotypic and functional alterations in NK cells and CD8+ T cells couldbe associated with the outcome of COVID-19. However, additional studies are required to understand these alterations and to guide future immunotherapy strategies.Introducción. Se han descrito diferentes marcadores inmunológicos durante la COVID-19, los cuales persisten incluso después de la convalecencia y se asocian con los estadios clínicos de la infección. Sin embargo, aún son pocos los estudios orientados al análisis exhaustivo de las alteraciones del sistema inmunológico en el curso de la infección.Objetivo. Evaluar la producción de citocinas proinflamatorias, la reacción de anticuerpos, y el fenotipo y la función de las células NK y los linfocitos T en una familia colombiana con infección por SARS-CoV-2.Materiales y métodos. Se evaluaron las citocinas proinflamatorias mediante RT-PCR y ELISA; la frecuencia, el fenotipo y la función de las células NK (en cocultivos con células K562) y linfocitos T CD8+ (estimulados con péptidos spike/RdRp) mediante citometría de flujo, y los anticuerpos anti-SARS-CoV-2, mediante inmunofluorescencia indirecta y prueba de neutralización por reducción de placa.Resultados. Durante la COVID-19 hubo una producción elevada de citocinas proinflamatorias, con disminución de las células NK CD56bright y reacción citotóxica. Comparados con los controles sanos, los individuos infectados presentaron con gran frecuencia linfocitos T CD8+ disfuncionales CD38+HLA-DR-. Además, en los linfocitos T CD8+ estimulados con péptidos virales, predominó una reacción monofuncional con gran producción de IL-10 durante la fase aguda y una reacción bifuncional caracterizada por la coexpresión de CD107a y granzima B o perforina durante la convalecencia.Conclusión. Aunque la reacción inflamatoria caracteriza la infección por SARS-CoV-2, hay otras alteraciones fenotípicas y funcionales en células NK y linfocitos T CD8+ que podrían asociarse con la progresión de la infección. Se requieren estudios adicionales para entender estas alteraciones y guiar futuras estrategias de inmunoterapia

VAMOS: a Pathfinder for the HAWC Gamma-Ray Observatory

VAMOS was a prototype detector built in 2011 at an altitude of 4100m a.s.l. in the state of Puebla, Mexico. The aim of VAMOS was to finalize the design, construction techniques and data acquisition system of the HAWC observatory. HAWC is an air-shower array currently under construction at the same site of VAMOS with the purpose to study the TeV sky. The VAMOS setup included six water Cherenkov detectors and two different data acquisition systems. It was in operation between October 2011 and May 2012 with an average live time of 30%. Besides the scientific verification purposes, the eight months of data were used to obtain the results presented in this paper: the detector response to the Forbush decrease of March 2012, and the analysis of possible emission, at energies above 30 GeV, for long gamma-ray bursts GRB111016B and GRB120328B.Comment: Accepted for pubblication in Astroparticle Physics Journal (20 pages, 10 figures). Corresponding authors: A.Marinelli and D.Zaboro

Caribbean Corals in Crisis: Record Thermal Stress, Bleaching, and Mortality in 2005

BACKGROUND The rising temperature of the world's oceans has become a major threat to coral reefs globally as the severity and frequency of mass coral bleaching and mortality events increase. In 2005, high ocean temperatures in the tropical Atlantic and Caribbean resulted in the most severe bleaching event ever recorded in the basin. METHODOLOGY/PRINCIPAL FINDINGS Satellite-based tools provided warnings for coral reef managers and scientists, guiding both the timing and location of researchers' field observations as anomalously warm conditions developed and spread across the greater Caribbean region from June to October 2005. Field surveys of bleaching and mortality exceeded prior efforts in detail and extent, and provided a new standard for documenting the effects of bleaching and for testing nowcast and forecast products. Collaborators from 22 countries undertook the most comprehensive documentation of basin-scale bleaching to date and found that over 80% of corals bleached and over 40% died at many sites. The most severe bleaching coincided with waters nearest a western Atlantic warm pool that was centered off the northern end of the Lesser Antilles. CONCLUSIONS/SIGNIFICANCE Thermal stress during the 2005 event exceeded any observed from the Caribbean in the prior 20 years, and regionally-averaged temperatures were the warmest in over 150 years. Comparison of satellite data against field surveys demonstrated a significant predictive relationship between accumulated heat stress (measured using NOAA Coral Reef Watch's Degree Heating Weeks) and bleaching intensity. This severe, widespread bleaching and mortality will undoubtedly have long-term consequences for reef ecosystems and suggests a troubled future for tropical marine ecosystems under a warming climate.This work was partially supported by salaries from the NOAA Coral Reef Conservation Program to the NOAA Coral Reef Conservation Program authors. NOAA provided funding to Caribbean ReefCheck investigators to undertake surveys of bleaching and mortality. Otherwise, no funding from outside authors' institutions was necessary for the undertaking of this study. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript

Patient-reported outcomes in a phase III, randomized study of sunitinib versus interferon-α as first-line systemic therapy for patients with metastatic renal cell carcinoma in a European population

Background: The purpose of this study is to evaluate the impact on the health-related quality of life (HRQoL) of sunitinib versus interferon-alpha (IFN-α) treatment in patients with metastatic renal cell carcinoma (mRCC)