114 research outputs found
Estudio comparativo de los niveles de satisfacción de la formación universitaria en estudiantes del último semestre de la carrera de Educación Física de diferentes universidades chilenas
Tesis (Profesor de Educación Física para la Enseñanza Básica, Licenciado en Educación)El siguiente seminario de grado ha sido realizado con el objetivo de reunir información sobre el nivel de satisfacción formativa universitaria de estudiantes que cursan el último semestre de la carrera de Educación Física en la Universidad Andrés Bello, ubicada en la Región Metropolitana, Campus Casona de Las Condes; para luego comparar los resultados de la misma encuesta opinión de satisfacción con los de otras universidades. La comparación es crucial para que las universidades den cuenta de las falencias con las que están saliendo sus estudiantes, de la manera en que ellos abordan la información y saber cuáles son los puntos débiles con respecto al conocimiento proporcionado por la institución académica durante los años universitarios. La Universidad C fue la que presentó un nivel de satisfacción formativa mucho mayor que el resto de las Universidades
A comparison of Clinical Risk Index for babies (CRIB-II), Score for Neonatal Acute Physiology (SNAP-II) and SNAPPE-II in predicting parenteral nutrition necessity in low birth weight preterm neonates.
Advances in perinatal care have made it possible to improve survival of low birth weight neonates. Clinical risk index for babies (CRIB-II), score for neonatal acute physiology (SNAP-II), and SNAP-perinatal extension-II (SNAPPE-II) have been used as mortality predictors for preterm infants. Feeding intolerance is very frequent in preterm neonates, and the development of an early effective biomarker for its prediction could be useful for carrying out a proper feeding strategy. Our aim was to compare the ability of CRIB-II, SNAP-II and SNAPPE-II in predict the feeding intolerance and parenteral nutrition necessity in preterm neonates.
Methods: A retrospective cohort study on preterm neonates’ born at Jaen Hospital Complex with low birth weight and ≤ 36 weeks of gestation was done. Epidemiological, clinical and clinical scores CRIB II, SNAP-II and SNAPPE-II were recorded.
Results: 255 low birth weight preterm neonates, 131 males (51.4%), aged ≤32 weeks of gestation (71%), were enrolled at our hospital. Parenteral nutrition needed were significantly higher in preterm neonates weighed 2500-1500 g (73.3%) and ≤ 1000g (87%). CRIB-II, SNAP-II and SNAPPE-II mean values were higher in neonates group subjected to parenteral nutrition compared with oral nutrition (p<0.05). CRIB-II and SNAPPE-II scores significantly correlated with parenteral nutrition days (p<0.05). Overall mortality rate was 11%. The 78.6% of all deceased infants needed parenteral nutrition.
Conclusion: Clinical Risk Index for babies (CRIB-II) better than SNAPPE-II correlated with the feeding intolerance and thus the parenteral nutrition days in preterm neonates with low birth weight.Subvencionado: Ayuda del Plan Propio de Investigación de la UMA. Universidad de Málaga. Campus de Excelencia Internacional Andalucía Tech
A metabolite profile reveals the presence of neurodegenerative conditions according to severity of hydrocephalus
Introduction: In obstructive congenital hydrocephalus, cerebrospinal fluid accumulation is associated with high intracranial pressure (ICP), ischemia/hypoxia, metabolic impairment, neuronal damage and astrocytic reaction. The hyh mutant mice exhibit two different forms of hydrocephalus evolution: severe and moderate. A study was carried out in hyh mice to detect a metabolite profile that define the tissue response in each hydrocephalus form.
Methods: Metabolites levels in brain cortex were analyzed with 1H High Resolution Magic Angle Spinning Nuclear Magnetic Resonance (1H HR-MAS) spectroscopy. The study was complemented with ICP recording and histopathological analysis.
Results: Mice with severe hydrocephalus were found to have higher ICP and stronger astrocytic reaction. Several metabolites including glutamate and glutamine were found to correlate with the severity of hydrocephalus. The whole metabolite profile may be explained based in differential astrocyte reactions, neurodegenerative and ischemic conditions. The glutamate transporter EAAT2 and the metabolite taurine were found as key histopathological markers for the damaged parenchyma. Conclusions: Spectroscopy allowed the detection of a metabolite profile related to intracranial pressure and hydrocephalus severity, and therefore can be useful to monitor the efficacy of experimental therapies.
Supported by Universidad de Málaga. Campus de Excelencia Internacional Andalucía Tech, and PI15/0619 (ISCIII/FEDER).Universidad de Málaga. Campus de Excelencia Internacional Andalucía Tech.
Supported by Universidad de Málaga. Campus de Excelencia Internacional Andalucía Tech, and PI15/0619 (ISCIII/FEDER)
Potential protective role of reactive astrocytes in the periventricular parenchyma in congenital hydrocephalus
Background
Cerebrospinal fluid accumulation in hydrocephalus produces an elevation of intraventricular pressure with pathological consequences on the periventricular brain parenchyma including ischemia, oedema, oxidative stress, and accumulation of metabolic waste products. Here we studied in the hyh mouse, an animal model of congenital hydrocephalus, the role of reactive astrocytes in this clinical degenerative condition.
Materials and Methods
Wild type and hydrocephalic hyh mice at 30 days of postnatal age were used. Three metabolites related to the oxidative and neurotoxic conditions were analysed in ex vivo samples (glutathione, glutamine and taurine) using High Resolution Magic Angle Spinning (HR-MAS). Glutathione synthetase and peroxidase, glutamine synthetase, kidney-type glutaminase (KGA), and taurine/taurine transporter were immunolocated in brain sections.
Results
Levels of the metabolites were remarkably higher in hydrocephalic conditions. Glutathione peroxidase and synthetase were both detected in the periventricular reactive astrocytes and neurons. Taurine was mostly found free in the periventricular parenchyma and in the reactive astrocytes, and the taurine transporter was mainly present in the neurons located in such regions. Glutamine synthetase was found in reactive astrocytes. Glutaminase was also detected in the reactive astrocytes and in periventricular neurons. These results suggest a possible protective response of reactive astrocytes against oxidative stress and neurotoxic conditions.
Conclusions
Astrocyte reaction seems to trigger an anti-oxidative and anti-neurotoxic response in order to ameliorate pathological damage in periventricular areas of the hydrocephalic mice.Universidad de Málaga. Campus de Excelencia Internacional Andalucía Tech. PI15-00619 to AJJ
Draft Genome Sequences of 29 Helicobacter pylori Strains Isolated from Colombia
Here, we present the draft genome sequences of 29 Colombian Helicobacter pylori strains. These strains were isolated in Bogotá, Colombia, from patients diagnosed with chronic gastritis. The genomic characterization of these strains will provide more information on the genetic composition of H. pylori strains from Colombia.We thank the entities that financially supported the development of this work. A.B.M. is a recipient of a scholarship from the Centro de Estudios Interdisciplinarios Básicos y Aplicados (CEIBA) Foundation, Colombia; and A.B.M., C.A., J.S., and A.A.T.-R. are recipients of a project grant (120380763025/2018) from MinCiencias, Colombia. The work is partially supported by Research Vice-Rectory, Pontificia Universidad Javeriana (PPTA_7676) and F.P.I.T. BanRepCultural (project 3956). F.F.V. is financed by national funds from the Fundação para a Ciência e a Tecnologia (FCT) through an assistant researcher grant (CEECIND/03023/2017), a project grant (PTDC/BTM-SAL/28978/2017), and projects UIDB/04138/2020 and UIDP/04138/2020; these funds partially supported this work. The funders had no role in study design, data collection and interpretation, or the decision to submit the work for publication.info:eu-repo/semantics/publishedVersio
Formación socioemocional: percepciones de académicos de la Universidad Católica de Temuco, Chile
Objective: Teacher education has been characterized by its focus on conceptual knowledge, however, current guidelines reveal the need to incorporate socio-emotional education in initial teacher training curricula. The objective of the study is to know the perceptions of trainers of trainers regarding the socio-emotional dimension in the university context.
Methods: The authoress rely on a qualitative approach, following a case study design. Ten academics from various majors from the Faculty of Education of the Catholic University of Temuco in Chile participated. Semi-structured interviews were applied.
Results: The findings show there are two categories. The first, the need to modify training programs to incorporate a socio-emotional approach. The second includes the tensions to consider when implementing a socio-emotional approach.
Conclusions: The authoress arrived at the conclusions that incorporating a socio-emotional approach in an explicit and transversal way would strengthen preservice teacher education. The lack of socio-emotional strategies makes the training of academics necessary. The incorporation of the approach will allow academics and future teachers to experience, value and strengthen socio-emotional education from their own educational practices. Resulting in a comprehensive training, as well as personal well-being and professional development.Objetivo: La formación del profesorado se ha caracterizado por un fuerte énfasis en saberes conceptuales, sin embargo, las actuales directrices revelan la necesidad de incorporar la educación socioemocional en los currículos de formación inicial docente. El objetivo del estudio es conocer las percepciones de formadores de formadores respecto de la dimensión socioemocional en el contexto universitario.
Método: Los autores asumieron un enfoque cualitativo, con diseño de estudio de caso. Participaron diez académicos de diversas carreras de la Facultad de Educación de la Universidad Católica de Temuco en Chile. Se aplicaron entrevistas semiestructuradas.
Resultados: La pesquisa produjo el hallazgo de dos categorías. La primera, la necesidad de modificar programas de formación para incorporar un enfoque socioemocional. La segunda, recoge las tensiones a considerar al implementar un enfoque socioemocional.
Conclusiones: Se concluye que incorporar un enfoque socioemocional de manera explícita y transversal, fortalecería la formación inicial del profesorado. La falta de estrategias socioemocionales hace necesario la formación de los académicos. La incorporación del enfoque permitirá a académicos y a futuros docentes vivenciar, valorar y fortalecer la educación socioemocional desde sus propias prácticas educativas. De esta manera, se responde a la formación integral, así como, al bienestar personal y al desarrollo profesional
Infective Endocarditis in Diabetic Patients: A Different Profile with Prognostic Consequences
Background. Infective Endocarditis (IE) is a severe condition. Diabetes mellitus (DM) has
been associated with a poor prognosis in other settings. Our aim was to describe the profile and
prognosis of IE with and without DM and to analyze the prognostic relevance of DM-related organ
damage. Methods. Retrospective analysis of the Spanish IE Registry (2008–2020). Results. The cohort
comprises 5590 IE patients with a mean age of 65.0 ± 15.5 years; 3764 (67.3%) were male. DM was
found in 1625 patients (29.1%) and 515 presented DM-related organ damage. DM prevalence during
the first half of the study period was 27.6% vs. 30.6% in the last half, p = 0.015. Patients with DM
presented higher in-hospital mortality than those without DM (521 [32.1%] vs. 924 [23.3%], p < 0.001)
and higher one-year mortality (640 [39.4%] vs. 1131 [28.5%], p < 0.001). Among DM patients, organ
damage was associated with higher in-hospital (200 [38.8%] vs. 321 [28.9%], p < 0.001) and one-year
mortality (247 [48.0%] vs. 393 [35.4%], p < 0.001). Multivariate analyses showed an independent
association of DM with in-hospital (odds ratio [OR] = 1.34, 95% confidence interval [CI]: 1.16–1.55,
p < 0.001) and one-year mortality (OR = 1.38, 95% CI: 1.21–1.59, p < 0.001). Among DM patients, organ
damage was independently associated with higher in-hospital (OR = 1.37, 95% CI: 1.06–1.76, p = 0.015)
and one-year mortality (OR = 1.59, 95% CI = 1.26–2.01, p < 0.001) Conclusions. The prevalence of DM
among patients with IE is increasing and is already above 30%. DM is independently associated with
a poor prognosis, particularly in the case of DM with organ damage
Occurrence of Hepatitis E Virus in Pigs and Pork Cuts and Organs at the Time of Slaughter, Spain, 2017
Zoonotic hepatitis E, mainly caused by hepatitis E virus (HEV) genotype (gt) 3, is a foodborne disease that has emerged in Europe in recent decades. The main animal reservoir for genotype 3 is domestic pigs. Pig liver and liver derivates are considered the major risk products, and studies focused on the presence of HEV in pig muscles are scarce. The objective of the present study was to evaluate the presence of HEV in different organs and tissues of 45 apparently healthy pigs from nine Spanish slaughterhouses (50% national production) that could enter into the food supply chain. Anti-HEV antibodies were evaluated in serum by an ELISA test. Ten samples from each animal were analyzed for the presence of HEV RNA by reverse transcription real-time PCR (RT-qPCR). The overall seroprevalence obtained was 73.3% (33/45). From the 450 samples analyzed, a total of 26 RT-qPCR positive samples were identified in the liver (7/45), feces (6/45), kidney (5/45), heart (4/45), serum (3/45), and diaphragm (1/45). This is the first report on detection of HEV RNA in kidney and heart samples of naturally infected pigs. HEV RNA detection was negative for rib, bacon, lean ham, and loin samples. These findings indicate that pig meat could be considered as a low risk material for foodborne HEV infection.This study was partially supported by the RTA2014-00024-C04 from the Spanish Ministry of Economy and Innovation. NG and DR-L received a research grant by INTERPORC.S
Occurrence of Hepatitis E Virus in Pigs and Pork Cuts and Organs at the Time of Slaughter, Spain, 2017
Zoonotic hepatitis E, mainly caused by hepatitis E virus (HEV) genotype (gt) 3, is a foodborne disease that has emerged in Europe in recent decades. The main animal reservoir for genotype 3 is domestic pigs. Pig liver and liver derivates are considered the major risk products, and studies focused on the presence of HEV in pig muscles are scarce. The objective of the present study was to evaluate the presence of HEV in different organs and tissues of 45 apparently healthy pigs from nine Spanish slaughterhouses (50% national production) that could enter into the food supply chain. Anti-HEV antibodies were evaluated in serum by an ELISA test. Ten samples from each animal were analyzed for the presence of HEV RNA by reverse transcription realtime PCR (RT-qPCR). The overall seroprevalence obtained was 73.3% (33/45). From the 450 samples analyzed, a total of 26 RT-qPCR positive samples were identified in the liver (7/45), feces (6/45), kidney (5/45), heart (4/45), serum (3/45), and diaphragm (1/45). This is the first report on detection of HEV RNA in kidney and heart samples of naturally infected pigs. HEV RNA detection was negative for rib, bacon, lean ham, and loin samples. These findings indicate that pig meat could be considered as a low risk material for foodborne HEV infection.Fil: García, Nerea. Universidad Complutense de Madrid; EspañaFil: Hernández, Marta. Universidad de Burgos; EspañaFil: Gutierrez Boada, Maialen. Universidad de Burgos; EspañaFil: Valero, Antonio. Universidad de Córdoba; EspañaFil: Navarro, Alejandro. Universidad Complutense de Madrid; EspañaFil: Muñoz Chimeno, Milagros. Universidad Carlos III de Madrid. Instituto de Salud; EspañaFil: Fernández Manzano, Alvaro. Universidad Complutense de Madrid; EspañaFil: Escobar, Franco Matias. Universidad Nacional de Río Cuarto. Facultad de Ciencias Exactas, Fisicoquímicas y Naturales. Departamento de Microbiología e Inmunología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba; ArgentinaFil: Martínez, Irene. Universidad Complutense de Madrid; EspañaFil: Bárcena, Carmen. Universidad Complutense de Madrid; EspañaFil: González, Sergio. Universidad Complutense de Madrid; EspañaFil: Avellón, Ana. Universidad Carlos III de Madrid. Instituto de Salud; EspañaFil: Eiros, Jose M.. Hospital Universitario Rio Hortega; EspañaFil: Fongaro, Gislaine. Universidade Federal de Santa Catarina; BrasilFil: Domínguez, Lucas. Universidad Complutense de Madrid; EspañaFil: Goyache, Joaquín. Universidad Complutense de Madrid; EspañaFil: Rodríguez Lázaro, David. Universidad de Burgos; Españ
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