The Chuacús Metamorphic Complex, central Guatemala : geochronological and geochemical constraints on its Paleozoic - Mesozoic evolution

The Chuacús Metamorphic Complex is located in Central Guatemala, between the Polochic and Motagua fault zones. It is made up of complexly intercalated, mafic and felsic high-grade gneisses, amphibolites, pelitic and quartzofeldsphatic metasediments and subordinate marbles. Mafic dikes and lenses metamorphosed to amphibolite and eclogite facies are tholeiitic and similar to mid-ocean ridge basalts. In contrast, metamorphosed intrusives (gabbro, diorite and granite) are calc-alkaline and have the geochemical signature of arc magmas. Laser Ablation Inductively Coupled Plasma Mass Spectrometry U-Pb zircon geochronology allows the recognition of three episodes of metamorphism. The first eclogite facies metamorphism (M1) is bracketed between Ordovician magmatism in the northern Chuacús Metamorphic Complex and the neighboring Rabinal granitic suite; the second corresponds to an Upper Triassic period of arc magmatism and migmatization (M2); the third high-grade metamorphic event (M3) occurred during the Late Cretaceous. The tectonic evolution of the Chuacús Metamorphic Complex began during the Early Paleozoic as a basin in the Rheic Ocean that received detrital material from the Maya Block, Acatlán and southeastern México. The Chuacús Metamorphic Complex evolved to an active margin that subducted to HP conditions during the Mid- Late Paleozoic, and then was exhumed and involved in two tectonothermal events during the Upper Triassic and Late Cretaceous. The Chuacús Metamorphic Complex was accreted to the southern Maya Block during the Late Cretaceous, as a result of the convergent tectonics between the latter and either the Greater Antillean arc or the Chortís Block

Shoulder pain prevalence in competitive swimmers: A pilot study

Objetivos: conocer la prevalencia de dolor de hombro en nadadores de competición, sus características y su relación con factores antropométricos y deportivos. Métodos: estudio de prevalencia. Ciento cuarenta nadadores/as entre 12 y 24 años cumplimentaron un cuestionario durante una fase de entrenamiento específico. Resultados: el 25,7% revelaron padecer dolor de hombro. Se hallaron relaciones estadísticamente significativas entre el dolor de hombro y episodios previos de dolor (p<0,001), experiencia superior a tres años (p=0,014), Índice de Masa Corporal (p=0,015) y la especialidad estilo (p=0,008) y distancia (p=0,011). El dolor fue significativamente más intenso durante la actividad que en reposo (p<0,001). Conclusiones: el dolor de hombro en nadadores de competición entre 12 y 24 años parece ser un problema frecuente mayor Índice de Masa Corporal y a la especialidad del nadadorObjectives: to investigate the prevalence of shoulder pain in competitive swimmers and find out the characteristics of pain as well as its relation to anthropometric and sports factors. Methods: prevalence study. A hundred and forty competitive swimmers between 12 and 24 years old completed a questionnaire in a high intensity training phase. Results: 25.7% swimmers reported shoulder pain. There were significant statistical correlations between shoulder pain and previous episodes of pain (p<0.001), more than three years of experience (p=0.014), Body Mass Index (p=0.015) and stroke (p=0.008) and distance (p=0.011) specialty. Pain was statistically correlated with activity (p<0.001). Conclusions: shoulder pain seems to be a frequent and repetitive problem in competitive swimmers between 12 and 24 years old, which increases with years of practice. Furthermore, it seems to be associated with the activity, a higher Body Mass Index and the swimmers’ specialty

Vertebral compression fractures managed with brace: risk factors for progression

The aim of this study is to identify risk factors for vertebral compression fracture (VCF) progression in patients treated conservatively with a brace. Then, a case–control study was designed. All patients over 50 years old with diagnosis of thoracic or lumbar VCF (T5 to L5) in absence of underlying oncological process, treated conservatively with brace, and consecutively attended at our department from January 2017 to June 2021 were retrospectively selected for analysis. Patients missed for follow-up or dead during the frst 3 months of follow-up were excluded. Five hundred and eighty-two consecutive patients were recorded. Incomplete follow-up excluded 74 patients and other 19 died in the frst three months after diagnosis, so 489 cases were fnally analyzed. Median follow-up was 21 (IQR 13;30) weeks. Increased collapse of the vertebral body was found in 29.9% of VCFs with a median time to progression of 9 (IQR 7;13) weeks. Male gender (OR 1.6), type A3 fracture of the AOSpine classifcation (OR 2.7), thoracolumbar junction location (OR 1.7), and incorrect use of the brace (OR 3.5) were identifed as independent risk factors for progression after multivariable analysis. Male gender, type A3 fracture of the AOSpine classifcation, thoracolumbar junction location, and incorrect use of the brace were identifed as independent risk factors for VCF progression, which resulted in worse pain control, when treated with brace. Thus, other treatments such as percutaneous vertebral augmentation could be considered to avoid progression in selected cases, since collapse rate has been demonstrated lower with these procedure

Irrigation efficiency and water-policy implications for river basin resilience

Rising demand for food, fiber, and biofuels drives expanding irrigation withdrawals from surface water and groundwater. Irrigation efficiency and water savings have become watchwords in response to climate-induced hydrological variability, increasing freshwater demand for other uses including ecosystem water needs, and low economic productivity of irrigation compared to most other uses. We identify three classes of unintended consequences, presented here as paradoxes. Ever-tighter cycling of water has been shown to increase resource use, an example of the <i>efficiency paradox</i>. In the absence of effective policy to constrain irrigated-area expansion using "saved water", efficiency can aggravate scarcity, deteriorate resource quality, and impair river basin resilience through loss of flexibility and redundancy. Water scarcity and salinity effects in the lower reaches of basins (symptomatic of the <i>scale paradox</i>) may partly be offset over the short-term through groundwater pumping or increasing surface water storage capacity. However, declining ecological flows and increasing salinity have important implications for riparian and estuarine ecosystems and for non-irrigation human uses of water including urban supply and energy generation, examples of the <i>sectoral paradox</i>. This paper briefly considers three regional contexts with broadly similar climatic and water-resource conditions – central Chile, southwestern US, and south-central Spain – where irrigation efficiency directly influences basin resilience. The comparison leads to more generic insights on water policy in relation to irrigation efficiency and emerging or overdue needs for environmental protection

Evaluating animal-based foods and plant-based alternatives using multi-criteria and SWOT analyses

Open Access Article; Published online: 29 Oct 2020Global diets have transitioned in recent decades with animal and processed products increasing. Promoting a reversal in these trends towards plant-based diets could reduce the environmental impacts of food systems and reduce the prevalence of non-communicable diseases and malnutrition. In Spain, a reference point for the Mediterranean diet (predominantly plant-source based), plant-based alternatives to traditional animal-based products are receiving increased attention. However, limited focus has been given to the opinions of stakeholder groups on the potential of these novel products. We evaluate the opinions of stakeholders within the Spanish agri-food sector, using multicriteria and SWOT analyses, on traditional and novel food products. Stakeholders involved in the supply chain of food products (producers, processors, and distributors) were critical of novel plant-based foods, highlighting problems with their taste, processing technology, and high prices. These results contrast with the perspectives of policymakers, researchers, environmental NGOs, and consumers who see novel products more positively - healthier, more sustainable, and highly profitable. These results illustrate the more traditional mindset seen in Spanish production systems, contrasting with the rapidly shifting tastes and demands of consumers and the potential legislative orientation of policymakers. This study calls for improved understanding and collaboration between stakeholders to better manage complex choices that affect the future of food systems during their needed transformation

In vivo activity of plant-based interleukin-12 in the lung of Balb/c mouse

<p>Abstract</p> <p>Background</p> <p>In the last years, plants are being used for the production of a wide variety of biopharmaceuticals, including cytokines, and have the potential to serve as vehicles for mucosal administration of these molecules. We had previously reported the expression of a cytokine, interleukin-12 (IL-12), in transgenic tomato plants and had demonstrated that it retained its biologic activity <it>in vitro</it>.</p> <p>Findings</p> <p>In this work, we administered crude extracts of IL-12-containing tomato fruits to mice through the intratracheal route, measuring endogenous IL-12 and determining biologic activity by quantification of interferon-gamma (IFN-γ) in lungs and by histological analysis. IFN-γ expression in lungs, as well as histological analysis, indicate that tomato-expressed IL-12 retains its biologic activity and, most importantly, its effects are restricted to the site of administration.</p> <p>Conclusion</p> <p>Our results indicate that the functional activity of tomato-expressed IL-12 is comparable to that of commercial recombinant IL-12 when given via the mucosal route. This opens the possibility of using crude extracts prepared from tomatoes expressing IL-12 for certain immunotherapies.</p

Dinámicas socioecológicas y ecoturismo comunitario: Un análisis comparativo en el eje fluvial Guayabero-Guaviare

The effects of the ecotourism in the relationships between inhabitants and their environment are complex and multidimensional. To explore these effects, two community ecotourism initiatives in the Guaviare Province were comparatively analyzed. This territory has been historically affected by the armed conflict and today is given priority as a scenery for the peace construction. The analysis herein articulates approaches both from the political ecology and the socio-ecological systems and considers how important it is to understand the power relations emerging in community ecotourism contexts that, in turn, help to measure how this kind of tourism impacts the socio-ecological dynamics and the strategies by the peasant families who try to diversify their economies to made them sustainable. © 2018, Pontificia Universidad Javeriana. All rights reserved

Methodology to improve the model of series inductance in CMOS integrated inductors

This paper presents a systematic optimization methodology to achieve an accurate estimation of series inductance of inductors implemented in standard CMOS technologies. Proposed method is based on an optimization procedure which aims to obtain adjustment factors associated to main physical inductor characteristics, allowing to estimate more accurate series inductance values that can be used in design stage. Experimental measurements of diverse square inductor geometries are shown and compared with previous approaches in order to demonstrate and validate presented approach.National Council of Science and Technology of México (CONACYT) TEC2013-45638-C3-3-RSpanish Ministry of Economy and Competitiveness TEC2013-45638-C3-3-REuropean Regional Development Fund TEC2013-45638-C3-3-RConsejería de Economía, Innovación, Ciencia y Empleo de la Junta de Andalucía P12-TIC-148

Isolation and genetic characterization of Toxoplasma gondii in Spanish sheep flocks

© The Author(s) 2020.[Background]: Toxoplasma gondii is a major cause of abortion in small ruminants and presents a zoonotic risk when undercooked meat containing cysts is consumed. The aim of the present study was to investigate the genetic diversity among the T. gondii strains circulating in ovine livestock in Spain.[Methods]: Selected samples collected from abortion outbreaks due to toxoplasmosis (n = 31) and from chronically infected adult sheep at slaughterhouses (n = 50) in different Spanish regions were bioassayed in mice, aiming at parasite isolation. In addition, all original clinical samples and the resulting isolates were genotyped by multi-nested PCR-RFLP analysis of 11 molecular markers and by PCR-DNA sequencing of portions of the SAG3, GRA6 and GRA7 genes.[Results]: As a result, 30 isolates were obtained from 9 Spanish regions: 10 isolates from abortion-derived samples and 20 isolates from adult myocardial tissues. Overall, 3 genotypes were found: ToxoDB#3 (type II PRU variant) in 90% (27/30) of isolates, ToxoDB#2 (clonal type III) in 6.7% (2/30), and ToxoDB#1 (clonal type II) in 3.3% (1/30). When T. gondii-positive tissue samples (n = 151) were directly subjected to RFLP genotyping, complete restriction profiles were obtained for 33% of samples, and up to 98% of the specimens belonged to the type II PRU variant. A foetal brain showed a clonal type II pattern, and four specimens showed unexpected type I alleles at the SAG3 marker, including two foetal brains that showed I + II alleles as co-infection events. Amplicons of SAG3, GRA6 and GRA7 obtained from isolates and clinical samples were subjected to sequencing, allowing us to confirm RFLP results and to detect different single-nucleotide polymorphisms.[Conclusions]: The present study informed the existence of a predominant type II PRU variant genotype (ToxoDB#3) infecting domestic sheep in Spain, in both abortion cases and chronic infections in adults, coexisting with other clonal (ToxoDB#1 and ToxoDB#2), much less frequent genotypes, as well as polymorphic strains as revealed by clinical sample genotyping. The use of multilocus sequence typing aided in accurately estimating T. gondii intragenotype diversity.This research was supported by projects funded by the Spanish Ministry of Science and Innovation (AGL2016-75935-C2-R) and the Community of Madrid (PLATESA2-CM-P2018/BAA-4370). MF and RC were funded by UCM-Santander/2017 pre-doctoral grants, and PLATESA2 post-doctoral grants, respectively. CG was funded by DGAPA, National Autonomous University of Mexico (UNAM). RC, EC and LO are part of the TOXOSOURCES consortium, supported by funding from the European Union’s Horizon 2020 Research and Innovation programme under grant agreement No. 773830: One Health European Joint Programme.Peer reviewe