56 research outputs found

    Job Stability and Gender Perspectives: Application of a Logistic Regression Model

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    Several changes have been taking place in the labour market since the 1970s that have created the right climate to spur organisations and workers to demand greater flexibility in employment. In this context, temporary employment has been the focus of many research papers and temporary contracts have been used as a tool to achieve labour flexibility. In order to understand the situation in Andalusia (Spain), this paper aims to identify the decisive factors in permanent employment. To this end, starting hypotheses will be defined about the decisive factors in permanent employment and the positive or negative significance of their influence; the starting hypotheses will then be tested empirically using a logistic regression model on a sample population of wage earners in Andalusia. In the second stage, given that the ratio of temporary contracts is much higher among women, the variable ‘gender’ is likely to be decisive in the construction of the regression model, therefore the decisive factors for permanent employment in Andalusia will be evaluated separately for men and women, in order to calibrate the impact of gender on job stability. Finally, based on the estimated probabilities of having a permanent job depending on gender, the degree of labour discrimination faced by women in the Andalusian labour market will be analysed

    ¿Cómo ven la universidad privada los estudiantes preuniversitarios? Un estudio exploratorio mediante la combinación de redes semánticas naturales y despliegue multidimensional

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    This research studies the determinant attributes of the construction of the perception of private universities generically without referencing brands using a convenience sample of high school seniors in Andalusia. The methodology proposed is an exploratory research study combining two non-habitual techniques: natural semantic networks, a quantitative technique, and multidimensional unfolding, a scaling quantitative technique. The results point to the presence of two different dimensions: the associations with the expected results from private university (training, employment and language) and the required involvement of the student (effort and exchanges) and differences perceived according to sex and the nature of the student’s center of belonging. In addition, there is evidence of the advantages of combining techniques as a triangulation mechanism. Better comprehension of a research problem is verified by using different analysis procedures about the same phenomenon.Se presenta una investigación en la que se estudian los atributos determinantes en la construcción de imagen de la universidad privada, de forma genérica sin alusiones a marcas, recurriendo a una muestra de conveniencia de preuniversitarios en Andalucía. Como metodología se propone una investigación exploratoria con la combinación de dos técnicas poco habituales: la técnica Redes Semánticas Naturales, y una técnica cuantitativa de escalamiento denominada despliegue multidimensional. Los resultados apuntan hacia la presencia de dos dimensiones diferentes: asociados a los resultados esperados de la universidad privada (formación, empleo e idioma) y según la implicación requerida del discente (esfuerzo e intercambios) y se perciben diferencias según el sexo y la naturaleza del centro de pertenencia del alumnado. Además, se aportan evidencias de las ventajas de la combinación de técnicas como mecanismo de triangulación, pues utilizando procedimientos de análisis diferentes sobre el mismo fenómeno se constata una mejor comprensión del problema de investigación

    Estilbenos como una alternativa sostenible al anhídrido sulfuroso en vinos

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    Resumen El anhídrido sulfuroso (SO2) es el conservante más empleado en la industria agroalimentaria y enológica por sus propiedades antioxidantes y antimicrobianas. Sin embargo, también es un alérgeno que puede provocar problemas de salud en personas sensibles a él. Por otra parte, la madera de poda procedente de los viñedos es uno de los principales subproductos de la industria vitivinícola, con un volumen estimado entre 2 y 4 toneladas por hectárea y año. Este subproducto vitícola contiene polifenoles, entre otros estilbenos bioactivos con propiedades saludables. En el presente trabajo se ha elaborado y caracterizado un extracto puro de estilbenos obtenido a partir de madera de poda de la vid, para utilizarlo como alternativa sostenible al SO2 en la elaboración de vinos blancos y rosados. Se evaluó el impacto del extracto sobre la calidad de los vinos (parámetros enológicos, color, compuestos fenólicos y perfil sensorial) tanto en el embotellado y a los doce meses del embotellado. En paralelo se evaluó la posible toxicidad del extracto. Los resultados obtenidos concluyen que el extracto puro de estilbenos, obtenido a partir de madera de poda de la vid, puede proponerse como alternativa natural y sostenible al empleo de SO2 en la vinificación de vinos blancos y rosados. Además, el extracto no mostró toxicidad ni in vitro ni in vivo

    Clonal chromosomal mosaicism and loss of chromosome Y in elderly men increase vulnerability for SARS-CoV-2

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    The pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2, COVID-19) had an estimated overall case fatality ratio of 1.38% (pre-vaccination), being 53% higher in males and increasing exponentially with age. Among 9578 individuals diagnosed with COVID-19 in the SCOURGE study, we found 133 cases (1.42%) with detectable clonal mosaicism for chromosome alterations (mCA) and 226 males (5.08%) with acquired loss of chromosome Y (LOY). Individuals with clonal mosaic events (mCA and/or LOY) showed a 54% increase in the risk of COVID-19 lethality. LOY is associated with transcriptomic biomarkers of immune dysfunction, pro-coagulation activity and cardiovascular risk. Interferon-induced genes involved in the initial immune response to SARS-CoV-2 are also down-regulated in LOY. Thus, mCA and LOY underlie at least part of the sex-biased severity and mortality of COVID-19 in aging patients. Given its potential therapeutic and prognostic relevance, evaluation of clonal mosaicism should be implemented as biomarker of COVID-19 severity in elderly people. Among 9578 individuals diagnosed with COVID-19 in the SCOURGE study, individuals with clonal mosaic events (clonal mosaicism for chromosome alterations and/or loss of chromosome Y) showed an increased risk of COVID-19 lethality

    Treatment with tocilizumab or corticosteroids for COVID-19 patients with hyperinflammatory state: a multicentre cohort study (SAM-COVID-19)

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    Objectives: The objective of this study was to estimate the association between tocilizumab or corticosteroids and the risk of intubation or death in patients with coronavirus disease 19 (COVID-19) with a hyperinflammatory state according to clinical and laboratory parameters. Methods: A cohort study was performed in 60 Spanish hospitals including 778 patients with COVID-19 and clinical and laboratory data indicative of a hyperinflammatory state. Treatment was mainly with tocilizumab, an intermediate-high dose of corticosteroids (IHDC), a pulse dose of corticosteroids (PDC), combination therapy, or no treatment. Primary outcome was intubation or death; follow-up was 21 days. Propensity score-adjusted estimations using Cox regression (logistic regression if needed) were calculated. Propensity scores were used as confounders, matching variables and for the inverse probability of treatment weights (IPTWs). Results: In all, 88, 117, 78 and 151 patients treated with tocilizumab, IHDC, PDC, and combination therapy, respectively, were compared with 344 untreated patients. The primary endpoint occurred in 10 (11.4%), 27 (23.1%), 12 (15.4%), 40 (25.6%) and 69 (21.1%), respectively. The IPTW-based hazard ratios (odds ratio for combination therapy) for the primary endpoint were 0.32 (95%CI 0.22-0.47; p < 0.001) for tocilizumab, 0.82 (0.71-1.30; p 0.82) for IHDC, 0.61 (0.43-0.86; p 0.006) for PDC, and 1.17 (0.86-1.58; p 0.30) for combination therapy. Other applications of the propensity score provided similar results, but were not significant for PDC. Tocilizumab was also associated with lower hazard of death alone in IPTW analysis (0.07; 0.02-0.17; p < 0.001). Conclusions: Tocilizumab might be useful in COVID-19 patients with a hyperinflammatory state and should be prioritized for randomized trials in this situatio

    Eliminación de productos: ¿qué variables son determinantes en la identificación de productos poco rentables?

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