La "Transición" en femenino : rupturas y continuidades, mujeres represión y movimiento feminista

Incorporar la perspectiva de género a los estudios de memoria implica cuestionar las etapas históricas que han sido establecidas desde modelos androcéntricos. Atender a las experiencias de las mujeres durante la dictadura franquista y los primeros años de la democracia nos lleva a defender la necesidad de repensar el concepto hegemónico de "Transición". Al hacerlo, identificaremos una serie de rupturas y continuidades en el statu quo de género tras la muerte del dictador y la aprobación de la Constitución que nos llevan a plantear la necesidad de reconceptualizar la "Transición" desde una perspectiva crítica feminista que invite a pensar en este periodo como algo más que un remanso de paz y consenso

Tenemos cita con el arte: a pilot project of visits and workshops with people affected by Alzheimer's disease in the Prado Museum, the Centro de Arte Reina Sofía Museum and the Faculty of Fine Arts at the Complutense University of Madrid

GIMUPAI is a research group comprising teachers and researchers from the Faculty of Fine Arts (University Complutense of Madrid) and the Department of Social Psychology and Anthropology (Salamanca University) who have been working in art and health projects over the last thirteen years. Recently, we have carried out Tenemos cita con el arte, part of a national research project entitled "Art education in museums and other cultural institutions as a tool for increasing the wellbeing of people affected with Alzheimer" (Ministry of the Economy and Competitiveness-EDU2013-43253-R). The main objective of the program is to make the museum‘s artworks available to people with Alzheimer‘s and their caregivers, at the same time encouraging them to participate in artistic activities and artistic creation through art workshops. Tenemos cita con el arte has been designed as a program of visits of the Prado Museum and the Centro de Arte Reina Sofia Museum. The program also has included participation in workshops on visual arts and artistic creativity in the Faculty of Fine Arts. The program was undertaken between October and December 2015 with a group of 15 participants (Alzheimer‘s patients, caregivers, and other health and social workers)

A New Set of in Silico Tools to Support the Interpretation of ATM Missense Variants Using Graphical Analysis

Establishing the pathogenic nature of variants in ATM, a gene associated with breast cancer and other hereditary cancers, is crucial for providing patients with adequate care. Unfortunately, achieving good variant classification is still difficult. To address this challenge, we extended the range of in silico tools with a series of graphical tools devised for the analysis of computational evidence by health care professionals. We propose a family of fast and easy-to-use graphical representations in which the impact of a variant is considered relative to other pathogenic and benign variants. To illustrate their value, the representations are applied to three problems in variant interpretation. The assessment of computational pathogenicity predictions showed that the graphics provide an intuitive view of pre-diction reliability, complementing and extending conventional numerical reliability indexes. When applied to variant of unknown significance populations, the representations shed light on the nature of these variants and can be used to prioritize variants of unknown significance for further studies. In a third application, the graphics were used to compare the two versions of the ATM-adapted American College of Medical Genetics and Genomics and Association for Molecular Pathology guidelines, obtaining valuable information on their relative virtues and weaknesses. Finally, a server [ATMision (ATM missense in silico interpretation online)] was generated for users to apply these representations in their variant interpretation problems, to check the ATM-adapted guidelines' criteria for computational evidence on their variant(s) and access different sources of information. (J Mol Diagn 2024, 26: 17-28; https://doi.org/10.1016/j.jmoldx.2023.09.009

A Collaborative Effort to Define Classification Criteria for ATM Variants in Hereditary Cancer Patients

Background Gene panel testing by massive parallel sequencing has increased the diagnostic yield but also the number of variants of uncertain significance. Clinical interpretation of genomic data requires expertise for each gene and disease. Heterozygous ATM pathogenic variants increase the risk of cancer, particularly breast cancer. For this reason, ATM is included in most hereditary cancer panels. It is a large gene, showing a high number of variants, most of them of uncertain significance. Hence, we initiated a collaborative effort to improve and standardize variant classification for the ATM gene. Methods Six independent laboratories collected information from 766 ATM variant carriers harboring 283 different variants. Data were submitted in a consensus template form, variant nomenclature and clinical information were curated, and monthly team conferences were established to review and adapt American College of Medical Genetics and Genomics/Association for Molecular Pathology (ACMG/AMP) criteria to ATM, which were used to classify 50 representative variants. Results Amid 283 different variants, 99 appeared more than once, 35 had differences in classification among laboratories. Refinement of ACMG/AMP criteria to ATM involved specification for twenty-one criteria and adjustment of strength for fourteen others. Afterwards, 50 variants carried by 254 index cases were classified with the established framework resulting in a consensus classification for all of them and a reduction in the number of variants of uncertain significance from 58% to 42%. Conclusions Our results highlight the relevance of data sharing and data curation by multidisciplinary experts to achieve improved variant classification that will eventually improve clinical management.FEDER funds-a way to build Europe PI19/00553 PI16/00563 PI16/01898 SAF2015-68016-RGeneralitat de Catalunya 2017SGR1282 2017SGR496CERCA Program: Government of CataloniaXunta de GaliciaInstituto de Salud Carlos III. AES PI19/00340Spanish Government SAF2016-80255-REuropean Commission EFA086/15Instituto de Salud Carlos III European Commissio

Permanent Genetic Resources added to Molecular Ecology Resources Database 1 February 2013-31 March 2013

This article documents the addition of 142 microsatellite marker loci to the Molecular Ecology Resources database. Loci were developed for the following species: Agriophyllum squarrosum, Amazilia cyanocephala, Batillaria attramentaria, Fungal strain CTeY1 (Ascomycota), Gadopsis marmoratus, Juniperus phoenicea subsp. turbinata, Liriomyza sativae, Lupinus polyphyllus, Metschnikowia reukaufii, Puccinia striiformis and Xylocopa grisescens. These loci were cross-tested on the following species: Amazilia beryllina, Amazilia candida, Amazilia rutila, Amazilia tzacatl, Amazilia violiceps, Amazilia yucatanensis, Campylopterus curvipennis, Cynanthus sordidus, Hylocharis leucotis, Juniperus brevifolia, Juniperus cedrus, Juniperus osteosperma, Juniperus oxycedrus, Juniperus thurifera, Liriomyza bryoniae, Liriomyza chinensis, Liriomyza huidobrensis and Liriomyza trifolii. © 2013 John Wiley & Sons Ltd.Peer Reviewe

Manuales y textos de enseñanza en la universidad liberal : VII congreso internacional sobre la historia de las universidades hispánicas

Congreso Internacional de Historia de las Universidades Hispánicas (VII, 2004: Universidad Carlos III de Madrid)El libro edita las actas del VII Congreso internacional sobre la historia de las universidades hispánicas celebrado los días 16-18 de noviembre de 2000 en el campus de Colmenarejo de la Universidad Carlos III de Madrid. Fue una reunión científica monográfica sobre los manuales y textos de enseñanza en la universidad liberal. Contó con un conjunto de ponencias que se adentraron en los ámbitos de la economía, el derecho público, el derecho privado, la filosofía y la medicina. Otras muchas cuestiones fueron analizadas en las comunicaciones.Presentación / Manuel Ángel Bermejo Castrillo. -- Una ciencia peligrosa: la enseñanza de la economía en la Universidad española / Pedro Fraile Balbín. -- La enseñanza del derecho público en España. Un ensayo critico / Alfredo Gallego Anabitarte. -- La enseñanza del derecho privado en la Universidad liberal /Ángel M. López y López y Cecilia Gómez-Salvago Sánchez. -- La enseñanza de la filosofía en la Universidad decimonónica (Asignaturas y textos oficiales) / Antonio Jiménez García. -- Manuales y textos de enseñanza médica en la Universidad liberal: la España del siglo XIX / José M. López Piñero. -- ¿Política o Academia? La disputa en torno al texto de lógica en la escuela nacional preparatoria / María de Lourdes Alvarado. -- La enseñanza del derecho natural y de gentes: el libro de Heineccio / Antonio Álvarez de Morales. -- Manuales y libros de texto utilizados en las escuelas industriales españolas durante la época isabelina / José Manuel Cano Pavón. -- Las bibliotecas universitarias en España durante la revolución liberal / Genaro Luis García López. -- Il magistero di Corrado Segre a Torino. I quaderni manoscritti delle lezioni universitarie (1888-1924) / Livia Giacardi. -- Los manuales de literatura en la facultad de Filosofía (1846-1867) / Jean-Louis Guereña. -- Los asertos de conclusiones públicas de Filosofía en el Colegio del Rosario durante la época de la Universidad Central (1826-1842) / María Clara Guillén de Iriarte. -- Vattel larva detracta. Reflexiones sobre la recepción del Ius Publicum Europaeum en la Universidad preliberal española / Pablo Gutiérrez Vega. -- La enseñanza del derecho en la Argentina por dos pequeños grandes libros: el Álvarez y el prontuario de Castro / Alberto David Leiva. -- Los libros útiles o la utilidad de los libros. Manuales de derecho entre 1841 y 1845 / Manuel Martínez Neira. -- L’insegnamento della storia nell’università italiana dopo l’unità / Mauro Moretti e Ilaria Porciani. -- Manuales de historia de filosofía en España (s. XIX) / Laureano Robles. -- L’insegnamento della matematica all’università di Torino (1848-1948). Aspetti storici, istituzionali e scientifici / Clara Silvia Roero. -- La enseñanza del derecho natural en el último tercio del siglo XIX / Salvador Rus Rufino. -- Un español republicano en Argentina: Juan Bialet Massé. Sus textos de anatomía y manual de medicina legal / María Cristina Vera de Flachs. -- La docenza del giansenista Pietro Tamburini a Pavia nel periodo francese. Un esperimento di sintesi tra etica teologica e diritti dell’uomo all’ombra dell’albero della libertà /Emauela Verzella Pettiti. -- El sentido humanista de la Universidad. Comentario a un texto de 1930: Misión de la Universidad, de José Ortega y Gasset / Javier Zamora Bonill

Investigación joven con perspectiva de género III

Actas del III Congreso Internacional de Estudios de Género, Perspectivas y Retos de Futuro: Jóvenes Investigadores (Getafe, 13 - 15 de junio de 2018) organizado por el Instituto Universitario de Estudios de Género de la Universidad Carlos III de Madrid

Treatment with tocilizumab or corticosteroids for COVID-19 patients with hyperinflammatory state: a multicentre cohort study (SAM-COVID-19)

Objectives: The objective of this study was to estimate the association between tocilizumab or corticosteroids and the risk of intubation or death in patients with coronavirus disease 19 (COVID-19) with a hyperinflammatory state according to clinical and laboratory parameters. Methods: A cohort study was performed in 60 Spanish hospitals including 778 patients with COVID-19 and clinical and laboratory data indicative of a hyperinflammatory state. Treatment was mainly with tocilizumab, an intermediate-high dose of corticosteroids (IHDC), a pulse dose of corticosteroids (PDC), combination therapy, or no treatment. Primary outcome was intubation or death; follow-up was 21 days. Propensity score-adjusted estimations using Cox regression (logistic regression if needed) were calculated. Propensity scores were used as confounders, matching variables and for the inverse probability of treatment weights (IPTWs). Results: In all, 88, 117, 78 and 151 patients treated with tocilizumab, IHDC, PDC, and combination therapy, respectively, were compared with 344 untreated patients. The primary endpoint occurred in 10 (11.4%), 27 (23.1%), 12 (15.4%), 40 (25.6%) and 69 (21.1%), respectively. The IPTW-based hazard ratios (odds ratio for combination therapy) for the primary endpoint were 0.32 (95%CI 0.22-0.47; p < 0.001) for tocilizumab, 0.82 (0.71-1.30; p 0.82) for IHDC, 0.61 (0.43-0.86; p 0.006) for PDC, and 1.17 (0.86-1.58; p 0.30) for combination therapy. Other applications of the propensity score provided similar results, but were not significant for PDC. Tocilizumab was also associated with lower hazard of death alone in IPTW analysis (0.07; 0.02-0.17; p < 0.001). Conclusions: Tocilizumab might be useful in COVID-19 patients with a hyperinflammatory state and should be prioritized for randomized trials in this situatio

Clonal chromosomal mosaicism and loss of chromosome Y in elderly men increase vulnerability for SARS-CoV-2

The pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2, COVID-19) had an estimated overall case fatality ratio of 1.38% (pre-vaccination), being 53% higher in males and increasing exponentially with age. Among 9578 individuals diagnosed with COVID-19 in the SCOURGE study, we found 133 cases (1.42%) with detectable clonal mosaicism for chromosome alterations (mCA) and 226 males (5.08%) with acquired loss of chromosome Y (LOY). Individuals with clonal mosaic events (mCA and/or LOY) showed a 54% increase in the risk of COVID-19 lethality. LOY is associated with transcriptomic biomarkers of immune dysfunction, pro-coagulation activity and cardiovascular risk. Interferon-induced genes involved in the initial immune response to SARS-CoV-2 are also down-regulated in LOY. Thus, mCA and LOY underlie at least part of the sex-biased severity and mortality of COVID-19 in aging patients. Given its potential therapeutic and prognostic relevance, evaluation of clonal mosaicism should be implemented as biomarker of COVID-19 severity in elderly people. Among 9578 individuals diagnosed with COVID-19 in the SCOURGE study, individuals with clonal mosaic events (clonal mosaicism for chromosome alterations and/or loss of chromosome Y) showed an increased risk of COVID-19 lethality