Functional regulation of FEN1 nuclease and its link to cancer

Flap endonuclease-1 (FEN1) is a member of the Rad2 structure-specific nuclease family. FEN1 possesses FEN, 5′-exonuclease and gap-endonuclease activities. The multiple nuclease activities of FEN1 allow it to participate in numerous DNA metabolic pathways, including Okazaki fragment maturation, stalled replication fork rescue, telomere maintenance, long-patch base excision repair and apoptotic DNA fragmentation. Here, we summarize the distinct roles of the different nuclease activities of FEN1 in these pathways. Recent biochemical and genetic studies indicate that FEN1 interacts with more than 30 proteins and undergoes post-translational modifications. We discuss how FEN1 is regulated via these mechanisms. Moreover, FEN1 interacts with five distinct groups of DNA metabolic proteins, allowing the nuclease to be recruited to a specific DNA metabolic complex, such as the DNA replication machinery for RNA primer removal or the DNA degradosome for apoptotic DNA fragmentation. Some FEN1 interaction partners also stimulate FEN1 nuclease activities to further ensure efficient action in processing of different DNA structures. Post-translational modifications, on the other hand, may be critical to regulate protein–protein interactions and cellular localizations of FEN1. Lastly, we also review the biological significance of FEN1 as a tumor suppressor, with an emphasis on studies of human mutations and mouse models

Hamiltonian Formalism of the de-Sitter Invariant Special Relativity

Lagrangian of the Einstein's special relativity with universal parameter $c$ ($\mathcal{SR}_c$) is invariant under Poincar\'e transformation which preserves Lorentz metric $\eta_{\mu\nu}$. The $\mathcal{SR}_c$ has been extended to be one which is invariant under de Sitter transformation that preserves so called Beltrami metric $B_{\mu\nu}$. There are two universal parameters $c$ and $R$ in this Special Relativity (denote it as $\mathcal{SR}_{cR}$). The Lagrangian-Hamiltonian formulism of $\mathcal{SR}_{cR}$ is formulated in this paper. The canonic energy, canonic momenta, and 10 Noether charges corresponding to the space-time's de Sitter symmetry are derived. The canonical quantization of the mechanics for $\mathcal{SR}_{cR}$-free particle is performed. The physics related to it is discussed.Comment: 24 pages, no figur

Quantum Griffiths effects and smeared phase transitions in metals: theory and experiment

In this paper, we review theoretical and experimental research on rare region effects at quantum phase transitions in disordered itinerant electron systems. After summarizing a few basic concepts about phase transitions in the presence of quenched randomness, we introduce the idea of rare regions and discuss their importance. We then analyze in detail the different phenomena that can arise at magnetic quantum phase transitions in disordered metals, including quantum Griffiths singularities, smeared phase transitions, and cluster-glass formation. For each scenario, we discuss the resulting phase diagram and summarize the behavior of various observables. We then review several recent experiments that provide examples of these rare region phenomena. We conclude by discussing limitations of current approaches and open questions.Comment: 31 pages, 7 eps figures included, v2: discussion of the dissipative Ising chain fixed, references added, v3: final version as publishe

Fermi-liquid ground state in n-type copper-oxide superconductor Pr0.91Ce0.09LaCuO4-y

We report nuclear magnetic resonance studies on the low-doped n-type copper-oxide Pr_{0.91}LaCe_{0.09}CuO_{4-y} (T_c=24 K) in the superconducting state and in the normal state uncovered by the application of a strong magnetic field. We find that when the superconductivity is removed, the underlying ground state is the Fermi liquid state. This result is at variance with that inferred from previous thermal conductivity measurement and contrast with that in p-type copper-oxides with a similar doping level where high-T_c superconductivity sets in within the pseudogap phase. The data in the superconducting state are consistent with the line-nodes gap model.Comment: version to appear in Phys. Rev. Let

Nuclear effects in the Drell-Yan process at very high energies

We study Drell-Yan (DY) dilepton production in proton(deuterium)-nucleus and in nucleus-nucleus collisions within the light-cone color dipole formalism. This approach is especially suitable for predicting nuclear effects in the DY cross section for heavy ion collisions, as it provides the impact parameter dependence of nuclear shadowing and transverse momentum broadening, quantities that are not available from the standard parton model. For p(D)+A collisions we calculate nuclear shadowing and investigate nuclear modification of the DY transverse momentum distribution at RHIC and LHC for kinematics corresponding to coherence length much longer than the nuclear size. Calculations are performed separately for transversely and longitudinally polarized DY photons, and predictions are presented for the dilepton angular distribution. Furthermore, we calculate nuclear broadening of the mean transverse momentum squared of DY dileptons as function of the nuclear mass number and energy. We also predict nuclear effects for the cross section of the DY process in heavy ion collisions. We found a substantial nuclear shadowing for valence quarks, stronger than for the sea.Comment: 46 pages, 18 figures, title changed and some discussion added, accepted for publication in PR

Thermodynamics of Modified Chaplygin Gas and Tachyonic Field

Here we generalize the results of the work of ref. [10] in modified Chaplygin gas model and tachyonic field model. Here we have studied the thermodynamical behaviour and the equation of state in terms of volume and temperature for both models. We have used the solution and the corresponding equation of state of our previous work [12] for tachyonic field model. We have also studied the thermodynamical stability using thermal equation of state for the tachyonic field model and have shown that there is no critical points during thermodynamical expansion. The determination of $T_{*}$ due to expansion for the tachyonic field have been discussed by assuming some initial conditions. Here, the thermal quantities have been investigated using some reduced parameters.Comment: 10 page

From particle systems to the Landau equation: a consistency result

We consider a system of N classical particles, interacting via a smooth, short- range potential, in a weak-coupling regime. This means that N tends to infinity when the interaction is suitably rescaled. The j-particle marginals, which obey to the usual BBGKY hierarchy, are decomposed into two contributions: one small but strongly oscillating, the other hopefully smooth. Eliminating the first, we arrive to establish the dynamical problem in term of a new hierarchy (for the smooth part) involving a memory term. We show that the first order correction to the free flow converges, as N \rightarrow \infty, to the corresponding term associated to the Landau equation. We also show the related propagation of chaos.Comment: 21 page

Effect of screening of the electron-phonon interaction on the temperature of Bose-Einstein condensation of intersite bipolarons

Here we consider an interacting electron-phonon system within the framework of extended Holstein-Hubbard model at strong enough electron-phonon interaction limit in which (bi)polarons are the essential quasiparticles of the system. It is assumed that the electron-phonon interaction is screened and its potential has Yukawa-type analytical form. An effect of screening of the electron-phonon interaction on the temperature of Bose-Einstein condensation of the intersite bipolarons is studied for the first time. It is revealed that the temperature of Bose-Einstein condensation of intersite bipolarons is higher in the system with the more screened electron-phonon interaction.Comment: 6 pages, 4 figure

Thorium speciation in seawater

Author Posting. © The Authors, 2006. This is the author's version of the work. It is posted here by permission of Elsevier B.V. for personal use, not for redistribution. The definitive version was published in Marine Chemistry 100 (2006): 250-268, doi:10.1016/j.marchem.2005.10.024.Since the 1960’s, thorium isotopes occupy a special place in the oceanographer’s toolbox as tracers for determining rates and mechanisms of oceanic scavenging, particle dynamics, and carbon fluxes. Due to their unique and constant production rates from soluble parent nuclides of uranium and radium, their disequilibrium can be used to calculate rates and time scales of sinking particles. In addition, by ratio-ing particulate 234Th (as well, in principle, other Thnuclides) to carbon (and other elements), and linking this ratio to the parent-daughter disequilibrium in the water column, it is possible to calculate fluxes of carbon and other elements. Most of these applications are possible with little knowledge of the dissolved chemical properties of thorium, other than its oxidation state (IV) and tendency to strongly sorb to surfaces, i.e., its “particle- or surface-activity”. However, the use of any tracer is hindered by a lack of knowledge of its chemical properties. Recent observations in the variability of carbon to 234Th ratios in different particle types, as well as of associations of Th(IV) with various marine organic biomolecules has led to the need for a review of current knowledge and what future endeavors should be taken to understand the marine chemistry of thorium.The writing of this paper was supported, in parts by NSF (OCE-0351559; OCE-0350758, and OCE 0354757)

Interacting new agegraphic viscous dark energy with varying GG

We consider the new agegraphic model of dark energy with a varying gravitational constant, $G$, in a non-flat universe. We obtain the equation of state and the deceleration parameters for both interacting and noninteracting new agegraphic dark energy. We also present the equation of motion determining the evolution behavior of the dark energy density with a time variable gravitational constant. Finally, we generalize our study to the case of viscous new agegraphic dark energy in the presence of an interaction term between both dark components.Comment: 12 pages, accepted for publication in IJTP (2010