120 research outputs found
Absorption enhancement in InGaN-based photonic crystal-implemented solar cells
Cataloged from PDF version of article.We investigate the absorption characteristics of InGaN solar cells with high indium (0.8) content and a one-dimensional periodic nano-scale pattern (implemented) in the InGaN layer theoretically. The short-circuit current of our InGaN-based solar cell structure is calculated for different lattice constant, etch depth, and fill factor values. A substantial increase in the absorption (17.5% increase in short-circuit current) is achieved when the photonic crystal pattern is thoroughly optimized. (c) 2012 Society of Photo-Optical Instrumentation Engineers (SPIE). [DOI: 10.1117/1.JNP.6.061603
Scheduling of grid tied battery energy storage system participating in frequency response services and energy arbitrage
Battery energy storage
systems
(BESS)
are
widely used to smooth
power
fluctuations
and maintain the voltage and
frequency of the power feeder at a desired level.
T
he National Grid Electricity Transmission (NGET), the primary electricity
transmission network operator in the UK, has introduced various frequency response servic
es that are
designed
to provide a
real
-
time response to deviations in the grid frequency.
In this study
,
a
control
algorithm is
developed
which generates a
charge/discharge power output with respect to deviations in
the grid frequency and the requisite
service
specifications. Using
historical
UK electricity prices, a new
balancing
service scheduling approach
has
also been
developed to
maximize
energy
arbitrage
revenue
by layering
different types of balancing services
throughout the day
. Simulation result
s show that the
proposed algorithm delivers both dynamic and non
-
dynamic firm frequency response (FFR) and also enhanced frequency
response (EFR) to
NGET
specifications while
generating arbitrage revenue
as well as service availability payment
s
in the
balancing market. A comparative study is also presented to compare the yearly arbitrage revenue
obtained
from
the work
presented in this
paper and
a
previous
reference study
.
Finall
y, exper
imental results of
a
grid
-
tied
2MW
/1MWh
BESS
have
been used
for verification purposes
A missense mutation in the catalytic domain of O-GlcNAc transferase links perturbations in protein O-GlcNAcylation to X-linked intellectual disability
Mutations in <i>N</i>-acetylglucosamine (<i>O</i>-GlcNAc) transferase in patients with X-linked intellectual disability
Contains fulltext :
177227.pdf (publisher's version ) (Open Access)N-Acetylglucosamine (O-GlcNAc) transferase (OGT) regulates protein O-GlcNAcylation, an essential and dynamic post-translational modification. The O-GlcNAc modification is present on numerous nuclear and cytosolic proteins and has been implicated in essential cellular functions such as signaling and gene expression. Accordingly, altered levels of protein O-GlcNAcylation have been associated with developmental defects and neurodegeneration. However, mutations in the OGT gene have not yet been functionally confirmed in humans. Here, we report on two hemizygous mutations in OGT in individuals with X-linked intellectual disability (XLID) and dysmorphic features: one missense mutation (p.Arg284Pro) and one mutation leading to a splicing defect (c.463-6T>G). Both mutations reside in the tetratricopeptide repeats of OGT that are essential for substrate recognition. We observed slightly reduced levels of OGT protein and reduced levels of its opposing enzyme O-GlcNAcase in both patient-derived fibroblasts, but global O-GlcNAc levels appeared to be unaffected. Our data suggest that mutant cells attempt to maintain global O-GlcNAcylation by down-regulating O-GlcNAcase expression. We also found that the c.463-6T>G mutation leads to aberrant mRNA splicing, but no stable truncated protein was detected in the corresponding patient-derived fibroblasts. Recombinant OGT bearing the p.Arg284Pro mutation was prone to unfolding and exhibited reduced glycosylation activity against a complex array of glycosylation substrates and proteolytic processing of the transcription factor host cell factor 1, which is also encoded by an XLID-associated gene. We conclude that defects in O-GlcNAc homeostasis and host cell factor 1 proteolysis may play roles in mediation of XLID in individuals with OGT mutations
The effect of particle size on the core losses of soft magnetic composites
In the field of electrical machines, the actual research activities mainly focus on improving the energetic aspects; for this reason, new magnetic materials are currently investigated and proposed, supporting the design and production of magnetic cores. The innovative aspects are related to both hard and soft magnetic materials. In the case of permanent magnets, the use of NdFeB bonded magnets represents a good solution in place of ferrites. For what concerns the soft magnetic materials, the adoption of Soft Magnetic Composites (SMCs) cores permits significant advantages compared to the laminated sheets, such as complex geometries and reduced eddy currents losses. SMC materials are ferromagnetic grains covered with an insulating layer that can be of an organic or inorganic type. The proposed study focuses on the impact of the particle size and distribution on the final material properties. The original powder was cut into three different fractions, and different combinations have been prepared, varying the fractions percentages. The magnetic and energetic properties have been evaluated in different frequency ranges, thus ranking the best combinations. The best specimens were then tested to evaluate the mechanical performances. The preliminary results are promising, but deeper analysis and tests are required to refine the selection and evaluate the improvements against the original composition taken as a reference.In the field of electrical machines, the actual research activities mainly focus on improving the energetic aspects; for this reason, new magnetic materials are currently investigated and proposed, supporting the design and production of magnetic cores. The innovative aspects are related to both hard and soft magnetic materials. In the case of permanent magnets, the use of NdFeB bonded magnets represents a good solution in place of ferrites. For what concerns the soft magnetic materials, the adoption of Soft Magnetic Composites (SMCs) cores permits significant advantages compared to the laminated sheets, such as complex geometries and reduced eddy currents losses. SMC materials are ferromagnetic grains covered with an insulating layer that can be of an organic or inorganic type. The proposed study focuses on the impact of the particle size and distribution on the final material properties. The original powder was cut into three different fractions, and different combinations have been prepared, varying th..
Design of a modular Autonomous Underwater Vehicle for archaeological investigations
MARTA (MARine Tool for Archaeology) is a modular AUV (Autonomous Underwater Vehicle) designed and developed by the University of Florence in the framework of the ARROWS (ARchaeological RObot systems for the World's Seas) FP7 European project. The ARROWS project challenge is to provide the underwater archaeologists with technological tools for cost affordable campaigns: i.e. ARROWS adapts and develops low cost AUV technologies to significantly reduce the cost of archaeological operations, covering the full extent of an archaeological campaign (underwater mapping, diagnosis and cleaning tasks). The tools and methodologies developed within ARROWS comply with the "Annex" of the 2001 UNESCO Convention for the protection of Underwater Cultural Heritage (UCH). The system effectiveness and MARTA performance will be demonstrated in two scenarios, different as regards the environment and the historical context, the Mediterranean Sea (Egadi Islands) and the Baltic Sea
The ARROWS project: Adapting and developing robotics technologies for underwater archaeology
ARchaeological RObot systems for the World's Seas (ARROWS) EU Project proposes to adapt and develop low-cost Autonomous Underwater Vehicle (AUV) technologies to significantly reduce the cost of archaeological operations, covering the full extent of archaeological campaign. ARROWS methodology is to identify the archaeologists requirements in all phases of the campaign and to propose related technological solutions. Starting from the necessities identified by archaeological project partners in collaboration with the Archaeology Advisory Group, a board composed of European archaeologists from outside ARROWS, the aim is the development of a heterogeneous team of cooperating AUVs capable of comply with a complete archaeological autonomous mission. Three new different AUVs have been designed in the framework of the project according to the archaeologists' indications: MARTA, characterized by a strong hardware modularity for ease of payload and propulsion systems configuration change; U-C AT, a turtle inspired bio-mimetic robot devoted to shipwreck penetration and A-Size AUV, a vehicle of small dimensions and weight easily deployable even by a single person. These three vehicles will cooperate within the project with AUVs already owned by ARROWS partners exploiting a distributed high-level control software based on the World Model Service (WMS), a storage system for the environment knowledge, updated in real-time through online payload data process, in the form of an ontology. The project includes also the development of a cleaning tool for well-known artifacts maintenance operations. The paper presents the current stage of the project that will lead to overall system final demonstrations, during Summer 2015, in two different scenarios, Sicily (Italy) and Baltic Sea (Estonia
Polygenic burden in focal and generalized epilepsies
Rare genetic variants can cause epilepsy, and genetic testing has been widely adopted for severe, paediatric-onset epilepsies. The phenotypic consequences of common genetic risk burden for epilepsies and their potential future clinical applications have not yet been determined. Using polygenic risk scores (PRS) from a European-ancestry genome-wide association study in generalized and focal epilepsy, we quantified common genetic burden in patients with generalized epilepsy (GE-PRS) or focal epilepsy (FE-PRS) from two independent non-Finnish European cohorts (Epi25 Consortium, n = 5705; Cleveland Clinic Epilepsy Center, n = 620; both compared to 20 435 controls). One Finnish-ancestry population isolate (Finnish-ancestry Epi25, n = 449; compared to 1559 controls), two European-ancestry biobanks (UK Biobank, n = 383 656; Vanderbilt biorepository, n = 49 494), and one Japaneseancestry biobank (BioBank Japan, n = 168 680) were used for additional replications. Across 8386 patients with epilepsy and 622 212 population controls, we found and replicated significantly higher GE-PRS in patients with generalized epilepsy of European-ancestry compared to patients with focal epilepsy (Epi25: P = 1.64
710-15; Cleveland: P = 2.85
710-4; Finnish-ancestry Epi25: P = 1.80
710-4) or population controls (Epi25: P = 2.35
710-70; Cleveland: P = 1.43
710-7; Finnish-ancestry Epi25: P = 3.11
710-4; UK Biobank and Vanderbilt biorepository meta-analysis: P = 7.99
710-4). FE-PRS were significantly higher in patients with focal epilepsy compared to controls in the non-Finnish, non-biobank cohorts (Epi25: P = 5.74
710-19; Cleveland: P = 1.69
710-6). European ancestry-derived PRS did not predict generalized epilepsy or focal epilepsy in Japanese-ancestry individuals. Finally, we observed a significant 4.6-fold and a 4.5-fold enrichment of patients with generalized epilepsy compared to controls in the top 0.5% highest GE-PRS of the two non-Finnish European cohorts (Epi25: P = 2.60
710-15; Cleveland: P = 1.39
710-2). We conclude that common variant risk associated with epilepsy is significantly enriched in multiple cohorts of patients with epilepsy compared to controls-in particular for generalized epilepsy. As sample sizes and PRS accuracy continue to increase with further common variant discovery, PRS could complement established clinical biomarkers and augment genetic testing for patient classification, comorbidity research, and potentially targeted treatment
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