88 research outputs found
Recommended from our members
Experimental investigation, CFD and theoretical modeling of two-phase heat transfer in a three-leg multi-channel heat pipe
Copyright © 2022 The Author(s). Muti-channel flat heat pipe is an innovative technology recently used at the rear of photovoltaic cells to absorb and reuse the wasted heat. To better understand the fundamentals of two-phase heat transfer (boiling and condensation) taking place inside multi-channel heat pipes, a unique three-leg heat pipe has been built. This one-of-a-kind heat pipe was used to develop both computational fluid dynamic (CFD) and theoretical models of a multi-channel heat pipe. To simulate the heat pipe operation with ANSYS Fluent, the Volume of Fluid (VOF) approach and Lee model were investigated. Different types of Lee models using user defined function (UDF) were compared and the influence of the condenser's boundary condition, saturation temperature, and mass transfer coefficient on the simulations was studied. For the first time, major limits of the Lee model for the simulation of heat pipes are identified. It is concluded that the available Lee model cannot predict the heat pipe temperature as it shows low physical meaning and can easily be manipulated to adjust the simulation's results. Based on the three-leg heat pipe experimental data, a new multi-channel theoretical model was developed that uses the thermal-electrical resistance analogy to predict the three-leg heat pipe thermal resistance. By selecting the optimum correlations for pool boiling and filmwise condensation, the developed iterative theoretical model was able to predict the three-leg heat pipe thermal resistance with an error of 8.2%.European Union's H2020 Programme ETEKINA and iWAYS under grant agreement numbers 768772 and 958274
Recommended from our members
Experimental and theoretical investigation of the influence of heat transfer rate on the thermal performance of a multi-channel flat heat pipe
Copyright © 2022 The Authors. Recently, flat heat pipes have been proposed for surface cooling applications to passively extract and recover thermal energy from hot surfaces. For instance, flat heat pipes have recently been proposed as thermal absorber for photovoltaic/thermal (PV/T) applications or for the thermal management of batteries. Following promising surface cooling results, increasing the fundamental knowledge of the two-phase heat transfer taking place inside such multi-channel flat heat pipes can participate to its widespread and lead to further improvement of the technology. Indeed, until now, the investigations have focused on the application only and not on the performance of the flat heat pipe itself. In this regard, this manuscript experimentally and theoretically investigates the thermal performance of a multi-channel flat heat pipe used for surface cooling applications. Heat transfer rates in the range 0â1500W are studied and their impact on the boiling, condensation, and total thermal resistance of the multi-channel flat heat pipe is measured. In order to predict the thermal performance of the multi-channel flat heat pipe at all heat transfer rates, a theoretical model is proposed, which considers the impact of the multi-channel geometry. This model uses a multi-channel thermal resistance network. Furthermore, an important number of two-phase correlations for pool boiling and condensation are compared with experimental data and the optimum equations are integrated into the multi-channel model. As a result, over the whole range of heat transfer rates investigated, the proposed multi-channel flat heat pipe model was able to predict the boiling, condensation, and total thermal resistances of the heat pipe with an average error of 17.2%, 14.4% and 13.1%, respectively. Finally, the impact of the tilt angle is also studied, and infrared imaging of the flat heat pipe surface is presented.UK Innovate project: âHigh-Power and High-Energy Battery Systems with Integrated Structural Thermal Management for Heavy-Duty Applicationsâ funded by Innovate UK. Project reference: 105302
A 1-D modelling of streaming potential dependence on water content during drainage experiment in sand
The understanding of electrokinetics for unsaturated conditions is crucial
for numerous of geophysical data interpretation. Nevertheless, the behaviour of
the streaming potential coefficient C as a function of the water saturation Sw
is still discussed. We propose here to model both the Richards' equation for
hydrodynamics and the Poisson's equation for electrical potential for
unsaturated conditions using 1-D finite element method. The equations are first
presented and the numerical scheme is then detailed for the Poisson's equation.
Then, computed streaming potentials (SPs) are compared to recently published SP
measurements carried out during drainage experiment in a sand column. We show
that the apparent measurement of DV / DP for the dipoles can provide the SP
coefficient in these conditions. Two tests have been performed using existing
models for the SP coefficient and a third one using a new relation. The results
show that existing models of unsaturated SP coefficients C(Sw) provide poor
results in terms of SP magnitude and behaviour. We demonstrate that the
unsaturated SP coefficient can be until one order of magnitude larger than
Csat, its value at saturation. We finally prove that the SP coefficient follows
a non-monotonous behaviour with respect to water saturation. Key words:
Electrical properties; Electromagnetic theory; Hydrogeophysics; Hydrology;
Permeability and porosity; electrokinetic; streaming potential; self-potential;
water content; water saturation; unsaturated condition; finite element modelin
Recommended from our members
Low-temperature heat transfer mediums for cryogenic applications
Copyright © 2023 The Author(s). Background:
Researchers and industrialists have grown interested in cryogenic technologies over the years. Cryogenic heat transfer has enabled new applications due to material properties and behaviour at very low temperatures. This domain is still underdeveloped and unfamiliar in various applications.
Methods:
This work discusses the recent progress on cryogenic mediums and their respective use in different heat transfer applications. After identifying what is commonly designated as a cryogenic medium, i.e., those with a boiling point below -150 °C, the different characteristics and features of such mediums are critically discussed.
Significant findings:
Liquid He and N2 were found to be the most used cryogenic mediums, mainly due to the very low temperature attained by liquid He, as the closest to the absolute zero, along with the low cost and high availability of liquid N2. The use of liquid-phase cryogenic in a single-phase state was found to be the most common application method. Two-phase applications of the cryogenic medium are mainly for use in a heat pipe, in which both latent and sensible heat is utilized. Cryogenic mediums are essential for critical and niche applications such as in aerospace, superconductivity, advanced machining and manufacturing methods, and more critically in many healthcare applications and advanced scientific research.Air Products PLC under grant agreement: 216-206-P-F
Recommended from our members
Experimental and theoretical investigation of the performance of an air to water multi-pass heat pipe-based heat exchanger
Innovate UK- Erva Mate Dryin
Biodiversity, Species Protection, and Animal Welfare Under International Law
The chapter explores the influence of the concept of animal welfare on international biodiversity law. A close examination of the recent evolution of this branch of international law shows that animal welfare has an ambivalent place in biodiversity-related agreements. Indeed, while welfare is only a faint consideration in the development of international regimes dealing with biodiversity as a whole, the concept has become an essential element for agreements dealing with the conservation of specific endangered species. Despite its role in these agreements, the place of animal welfare in international biodiversity law highlights that this corpus of rules is currently insufficient to be an effective tool for the protection of wildlife welfare. The last section of this study suggests that the adoption of international rules aiming at ensuring the protection of wild animalsâ welfare could serve the double purpose of strengthening the conservation purpose of biodiversity regimes while also filling the welfare gap of international biodiversity law
TCEAL1 Loss-of-Function Results in an X-Linked Dominant Neurodevelopmental Syndrome and Drives the Neurological Disease Trait in Xq222 Deletions
An Xq22.2 region upstream of PLP1 has been proposed to underly a neurological disease trait when deleted in 46,XX females. Deletion mapping revealed that heterozygous deletions encompassing the smallest region of overlap (SRO) spanning six Xq22.2 genes (BEX3, RAB40A, TCEAL4, TCEAL3, TCEAL1, and MORF4L2) associate with an early-onset neurological disease trait (EONDT) consisting of hypotonia, intellectual disability, neurobehavioral abnormalities, and dysmorphic facial features. None of the genes within the SRO have been associated with monogenic disease in OMIM. Through local and international collaborations facilitated by GeneMatcher and Matchmaker Exchange, we have identified and herein report seven de novo variants involving TCEAL1 in seven unrelated families: three hemizygous truncating alleles; one hemizygous missense allele; one heterozygous TCEAL1 full gene deletion; one heterozygous contiguous deletion of TCEAL1, TCEAL3, and TCEAL4; and one heterozygous frameshift variant allele. Variants were identified through exome or genome sequencing with trio analysis or through chromosomal microarray. Comparison with previously reported Xq22 deletions encompassing TCEAL1 identified a more-defined syndrome consisting of hypotonia, abnormal gait, developmental delay/intellectual disability especially affecting expressive language, autistic-like behavior, and mildly dysmorphic facial features. Additional features include strabismus, refractive errors, variable nystagmus, gastroesophageal reflux, constipation, dysmotility, recurrent infections, seizures, and structural brain anomalies. An additional maternally inherited hemizygous missense allele of uncertain significance was identified in a male with hypertonia and spasticity without syndromic features. These data provide evidence that TCEAL1 loss of function causes a neurological rare disease trait involving significant neurological impairment with features overlapping the EONDT phenotype in females with the Xq22 deletion
Loss-of-Function Mutations in WDR73 Are Responsible for Microcephaly and Steroid-Resistant Nephrotic Syndrome: Galloway-Mowat Syndrome
Galloway-Mowat syndrome is a rare autosomal-recessive condition characterized by nephrotic syndrome associated with microcephaly and neurological impairment. Through a combination of autozygosity mapping and whole-exome sequencing, we identified WDR73 as a gene in which mutations cause Galloway-Mowat syndrome in two unrelated families. WDR73 encodes a WD40-repeat-containing protein of unknown function. Here, we show that WDR73 was present in the brain and kidney and was located diffusely in the cytoplasm during interphase but relocalized to spindle poles and astral microtubules during mitosis. Fibroblasts from one affected child and WDR73-depleted podocytes displayed abnormal nuclear morphology, low cell viability, and alterations of the microtubule network. These data suggest that WDR73 plays a crucial role in the maintenance of cell architecture and cell survival. Altogether, WDR73 mutations cause Galloway-Mowat syndrome in a particular subset of individuals presenting with late-onset nephrotic syndrome, postnatal microcephaly, severe intellectual disability, and homogenous brain MRI features. WDR73 is another example of a gene involved in a disease affecting both the kidney glomerulus and the CNS
Genetic and Chemical Modifiers of a CUG Toxicity Model in Drosophila
Non-coding CUG repeat expansions interfere with the activity of human Muscleblind-like (MBNL) proteins contributing to myotonic dystrophy 1 (DM1). To understand this toxic RNA gain-of-function mechanism we developed a Drosophila model expressing 60 pure and 480 interrupted CUG repeats in the context of a non-translatable RNA. These flies reproduced aspects of the DM1 pathology, most notably nuclear accumulation of CUG transcripts, muscle degeneration, splicing misregulation, and diminished Muscleblind function in vivo. Reduced Muscleblind activity was evident from the sensitivity of CUG-induced phenotypes to a decrease in muscleblind genetic dosage and rescue by MBNL1 expression, and further supported by the co-localization of Muscleblind and CUG repeat RNA in ribonuclear foci. Targeted expression of CUG repeats to the developing eye and brain mushroom bodies was toxic leading to rough eyes and semilethality, respectively. These phenotypes were utilized to identify genetic and chemical modifiers of the CUG-induced toxicity. 15 genetic modifiers of the rough eye phenotype were isolated. These genes identify putative cellular processes unknown to be altered by CUG repeat RNA, and they include mRNA export factor Aly, apoptosis inhibitor Thread, chromatin remodelling factor Nurf-38, and extracellular matrix structural component Viking. Ten chemical compounds suppressed the semilethal phenotype. These compounds significantly improved viability of CUG expressing flies and included non-steroidal anti-inflammatory agents (ketoprofen), muscarinic, cholinergic and histamine receptor inhibitors (orphenadrine), and drugs that can affect sodium and calcium metabolism such as clenbuterol and spironolactone. These findings provide new insights into the DM1 phenotype, and suggest novel candidates for DM1 treatments
- âŠ