67 research outputs found
Combined PET/CT-perfusion in patients with head and neck cancers might predict failure after radio-chemotherapy: a proof of concept study
Uracil DNA glycosylase interacts with the p32 subunit of the replication protein A complex to modulate HIV-1 reverse transcription for optimal virus dissemination
Functional impairment of systemic scleroderma patients with digital ulcerations: Results from the DUO registry
Demographic, clinical and antibody characteristics of patients with digital ulcers in systemic sclerosis: data from the DUO Registry
OBJECTIVES: The Digital Ulcers Outcome (DUO) Registry was designed to describe the clinical and antibody characteristics, disease course and outcomes of patients with digital ulcers associated with systemic sclerosis (SSc).
METHODS: The DUO Registry is a European, prospective, multicentre, observational, registry of SSc patients with ongoing digital ulcer disease, irrespective of treatment regimen. Data collected included demographics, SSc duration, SSc subset, internal organ manifestations, autoantibodies, previous and ongoing interventions and complications related to digital ulcers.
RESULTS: Up to 19 November 2010 a total of 2439 patients had enrolled into the registry. Most were classified as either limited cutaneous SSc (lcSSc; 52.2%) or diffuse cutaneous SSc (dcSSc; 36.9%). Digital ulcers developed earlier in patients with dcSSc compared with lcSSc. Almost all patients (95.7%) tested positive for antinuclear antibodies, 45.2% for anti-scleroderma-70 and 43.6% for anticentromere antibodies (ACA). The first digital ulcer in the anti-scleroderma-70-positive patient cohort occurred approximately 5 years earlier than the ACA-positive patient group.
CONCLUSIONS: This study provides data from a large cohort of SSc patients with a history of digital ulcers. The early occurrence and high frequency of digital ulcer complications are especially seen in patients with dcSSc and/or anti-scleroderma-70 antibodies
Is it in the Game? Reconsidering play spaces, game definitions, theming and sports videogames
From the very first days of digital gaming, sport-themed videogames have been a constant and ever-popular presence. However, compared with many other genres of games, sports-themed videogames have remained relatively under-research. Using the case of âsports videogamesâ this paper advocates a critical and located approach to understanding videogames and gameplay. Unlike many existing theorisations of gameplay, such as the âmagic circleâ (Huizinga 1949 [1938]), which theorise play as a break from ordinary life, this paper argues for a consideration of play as a continuation of âthe control of the established orderâ (Lefebvre (1991 [1974]: 383). It argues that many videogames, and in particular sports videogames, can be understood as âthemedâ spaces; which share similarities to other themed locations, such as fast-food restaurants and theme parks. These are ânon-placesâ (AugĂ© 1995) themed to provide a sense of individuality, control and escape in a society that increasingly offers none
Fluorescent protein-tagged Vpr dissociates from HIV-1 core after viral fusion and rapidly enters the cell nucleus
The Compact Linear Collider (CLIC) - 2018 Summary Report
The Compact Linear Collider (CLIC) is a TeV-scale high-luminosity linear collider under development at CERN. Following the CLIC conceptual design published in 2012, this report provides an overview of the CLIC project, its current status, and future developments. It presents the CLIC physics potential and reports on design, technology, and implementation aspects of the accelerator and the detector. CLIC is foreseen to be built and operated in stages, at centre-of-mass energies of 380 GeV, 1.5 TeV and 3 TeV, respectively. CLIC uses a two-beam acceleration scheme, in which 12 GHz accelerating structures are powered via a high-current drive beam. For the first stage, an alternative with X-band klystron powering is also considered. CLIC accelerator optimisation, technical developments and system tests have resulted in an increased energy efficiency (power around 170 MW) for the 380 GeV stage, together with a reduced cost estimate at the level of 6 billion CHF. The detector concept has been refined using improved software tools. Significant progress has been made on detector technology developments for the tracking and calorimetry systems. A wide range of CLIC physics studies has been conducted, both through full detector simulations and parametric studies, together providing a broad overview of the CLIC physics potential. Each of the three energy stages adds cornerstones of the full CLIC physics programme, such as Higgs width and couplings, top-quark properties, Higgs self-coupling, direct searches, and many precision electroweak measurements. The interpretation of the combined results gives crucial and accurate insight into new physics, largely complementary to LHC and HL-LHC. The construction of the first CLIC energy stage could start by 2026. First beams would be available by 2035, marking the beginning of a broad CLIC physics programme spanning 25-30 years
Recommended from our members
Re-Envisioning the Brown University Model: Embedding A Disciplinary Writing Consultant in an Introductory U.S History Course
College writers often wish for a sympathetic
reader who can offer feedback on a draft or assist
during the invention or revision process. Established
in 1982, the Brown Universityâs Writing Fellows
Program was the first to formally pair small cohorts of
students with a writing tutor to receive individual
assistance for the duration of a course. According to
the university website, today the Writing Fellows
Program is a student-driven initiative in its 32nd year,
in which students âwork in a spirit of collegiality,
helping to extend intellectual discourse beyond the
classroom.â Inspired by the success of Writing Fellows
Programs that have emerged across the country, the
Disciplinary Writing Consultant (DWC) Program at
the University of Central Florida (UCF) was designed
to offer individual support to student writers without
mandating participation. Diverging from the Brown
model, only one DWC was embedded in a course of
approximately 50 students and offered voluntary writing
assistance both in class and in writing center
consultations. The goal was to bring the writing center
into the classroom to encourage ongoing
collaborations between students, instructor and the
DWC. Building and maintaining such complex
partnerships in higher education is a challenge.
Condon and Rutz insist that âsuccessful WAC requires
a complex partnership among faculty, administrators,
writing centers, [and] faculty development programsâ
an infrastructure that may well support general
education or first year seminar goalsâ (359). This
assertion outlines one of the driving questions at this
major research university: How can a network of
partnerships between faculty, administrators, and
writing consultants benefit students and support their
learning? Specifically, how can this work be done
effectively at the second largest public university in the
country?University Writing Cente
Health-related quality of life in oropharyngeal cancer survivors â a population-based study
Objective: The aim of this study was to compare QoL of oropharyngeal cancer survivors who had received different treatments. Subjects and methods: We contacted 954 survivors. Each survivor received the QoL questionnaires EORTC QLQ-C30 and EORTC QLQ-H&N35. Results: A total of 263 survivors completed the questionnaires (28% responses). Forty-five of them had undergone surgery, 20 had received definitive radiotherapy or chemo-radiotherapy, 85 surgery plus adjuvant radiotherapy, and 111 surgery plus adjuvant chemo-radiotherapy. Survivors who had received adjuvant radiotherapy and surgery reported significantly more problems with swallowing (B=13.43 [95% Confidence Interval (CI) 1.83-25.03]), senses (B=24,91 [CI 11.86-37.97]), eating (B=16.91 [CI 3.46-30.36]), dry mouth (B=26.42 [CI 12.17-40.67]), sticky saliva (B=22.37 [CI 6.23-38.50]) and nutritional supplements (B=18.59 [CI 0.62-36.56]) than those who had received surgery only. Survivors who had received adjuvant chemo-radiotherapy and surgery reported significantly many more problems with dry mouth (B=34.15 [CI 18.91-49.39]) and sticky saliva (B=22.90 [CI 5.65-40.16]), and fewer problems with physical functioning (B=-12.07 [CI 0.49-23-64]). Conclusion: Survivors who participated in this survey and who had undergone surgery alone reported in some head- and neck-specific domains a better health-related quality of life than patients who had undergone multi-modal treatment or adjuvant radiotherapy
- âŠ