89 research outputs found
The Orbit, Mass, and Albedo of Transneptunian Binary 1999 RZ253
We have observed 1999 RZ253 with the Hubble Space Telescope at seven separate
epochs and have fit an orbit to the observed relative positions of this binary.
Two orbital solutions have been identified that differ primarily in the
inclination of the orbit plane. The best fit corresponds to an orbital period,
P=46.263 +0.006/-0.074 days, semimajor axis a=4,660 +/-170 km and orbital
eccentricity e=0.460 +/-0.013 corresponding to a system mass m=3.7 +/-0.4
x10^18 kg. For a density of rho = 1000 kg m^-3 the albedo at 477 nm is p = 0.12
+/-0.01, significantly higher than has been commonly assumed for objects in the
Kuiper Belt. Multicolor, multiepoch photometry shows this pair to have colors
typical for the Kuiper belt with a spectral gradient of 0.35 per 100 nm in the
range between 475 and 775 nm. Photometric variations at the four epochs we
observed were as large as 12 +/-3% but the sampling is insufficient to confirm
the existence of a lightcurve
The mass and density of the dwarf planet (225088) 2007 OR10
The satellite of (225088) 2007 OR10 was discovered on archival Hubble Space
Telescope images and along with new observations with the WFC3 camera in late
2017 we have been able to determine the orbit. The orbit's notable
eccentricity, e0.3, may be a consequence of an intrinsically eccentric
orbit and slow tidal evolution, but may also be caused by the Kozai mechanism.
Dynamical considerations also suggest that the moon is small, D 100
km. Based on the newly determined system mass of 1.75x10 kg, 2007 OR10
is the fifth most massive dwarf planet after Eris, Pluto, Haumea and Makemake.
The newly determined orbit has also been considered as an additional option in
our radiometric analysis, provided that the moon orbits in the equatorial plane
of the primary. Assuming a spherical shape for the primary this approach
provides a size of 123050 km, with a slight dependence on the satellite
orbit orientation and primary rotation rate chosen, and a bulk density of
1.750.07 g cm for the primary. A previous size estimate that
assumed an equator-on configuration (1535 km) would provide a
density of 0.92 g cm, unexpectedly low for a 1000
km-sized dwarf planet.Comment: Accepted for publication in Icaru
TCT-787 Evaluation of Cell Proliferation in Adaptive Neointimal Remodeling Following Arteriovenous Fistula in a Large Animal Model
Cell-wall synthesis and ribosome maturation are co-regulated by an RNA switch in Mycobacterium tuberculosis
The success of Mycobacterium tuberculosis relies on the ability to switch between active growth and non-replicating persistence, associated with latent TB infection. Resuscitation promoting factors (Rpfs) are essential for the transition between these states. Rpf expression is tightly regulated as these enzymes are able to degrade the cell wall, and hence potentially lethal to the bacterium itself. We have identified a regulatory element in the 5' untranslated region (UTR) of rpfB. We demonstrate that this element is a transcriptionally regulated RNA switch/riboswitch candidate, which appears to be restricted to pathogenic mycobacteria, suggesting a role in virulence. We have used translation start site mapping to re-annotate the RpfB start codon and identified and validated a ribosome binding site that is likely to be targeted by an rpfB antisense RNA. Finally, we show that rpfB is co-transcribed with ksgA and ispE downstream. ksgA encodes a universally conserved methyltransferase involved in ribosome maturation and ispE encodes an essential kinase involved in cell wall synthesis. This arrangement implies co-regulation of resuscitation, cell wall synthesis and ribosome maturation via the RNA switch
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