92 research outputs found
The influence of corporate governance on bank risk during a financial crisis
Using agency theory, we explore the relationship between corporate
governance mechanisms and bank risk. We employ panel data analysis
to study the 97 largest European listed banks between 2006 and 2010,
thereby covering the most recent international financial crisis. The
results show that corporate governance mechanisms influence bank
risk. During the financial crisis, different governance mechanisms can
minimise or accentuate the agency conflict between shareholders and
managers. In our model, bank size and G.D.P. per capita also exert a
considerable influence.info:eu-repo/semantics/publishedVersio
Using an A-10 Aircraft for Airborne measurements of TGFs
Plans are underway to convert an A-10 combat attack aircraft into a research aircraft for thunderstorm research. This aircraft would be configured and instrumented for flights into large, convective thunderstorms. It would have the capabilities of higher altitude performance and protection for thunderstorm conditions that exceed those of aircraft now in use for this research. One area of investigation for this aircraft would be terrestrial gamma ]ray flashes (TGFs), building on the pioneering observations made by the Airborne Detector for Energetic Lightning Emissions (ADELE) project several years ago. A new and important component of the planned investigations are the continuous, detailed correlations of TGFs with the electric fields near the aircraft, as well as detailed measurements of nearby lightning discharges. Together, the x-and gamma-radiation environments, the electric field measurements, and the lightning observations (all measured on microsecond timescales) should provide new insights into this TGF production mechanism. The A -10 aircraft is currently being modified for thunderstorm research. It is anticipated that the initial test flights for this role will begin next year
Long-term persistence of piscine orthoreovirus-1 (PRV-1) infection during the pre-smolt stages of Atlantic salmon in freshwater
publishedVersio
A Rapid Gamma-Ray Glow Flux Reduction Observed From 20 km Altitude
Two gamma-ray glows were observed by a high-altitude NASA ER-2 aircraft flying at 20 km altitude over a thunderstorm in Colorado, USA. The flux of the first glow rapidly intensified and then abruptly decreased within a few tens of milliseconds. On a timescale of seconds, the flux decrease occurred simultaneously with a hybrid intra-cloud/cloud-to-ground lightning discharge beneath the aircraft. However, a more detailed analysis of the discharge dynamics indicated that the discharge activity was unusually calm during the actual period of the flux decrease. The lightning was observed with on-board antennas, optical sensor, and ground-based lightning mapping and location networks. Its closest activity was 12 km away from the aircraft, below and slightly ahead the course. The gamma-ray flux reduction happened roughly in the middle of the lightning development process. The glow spectral analysis for the periods of a weak and strong flux enhancement has been done. The spectra were found to be background-like and similar to each other.publishedVersio
Gamma Ray Glow Observations at 20-km Altitude
In the spring of 2017 an ER‐2 aircraft campaign was undertaken over continental United States to observe energetic radiation from thunderstorms and lightning. The payload consisted of a suite of instruments designed to detect optical signals, electric fields, and gamma rays from lightning. Starting from Georgia, USA, 16 flights were performed, for a total of about 70 flight hours at a cruise altitude of 20 km. Of these, 45 flight hours were over thunderstorm regions. An analysis of two gamma ray glow events that were observed over Colorado at 21:47 UT on 8 May 2017 is presented. We explore the charge structure of the cloud system, as well as possible mechanisms that can produce the gamma ray glows. The thundercloud system we passed during the gamma ray glow observation had strong convection in the core of the cloud system. Electric field measurements combined with radar and radio measurements suggest an inverted charge structure, with an upper negative charge layer and a lower positive charge layer. Based on modeling results, we were not able to unambiguously determine the production mechanism. Possible mechanisms are either an enhancement of cosmic background locally (above or below 20 km) by an electric field below the local threshold or an enhancement of the cosmic background inside the cloud but then with normal polarity and an electric field well above the Relativistic Runaway Electron Avalanche threshold.publishedVersio
Association of Accelerometry-Measured Physical Activity and Cardiovascular Events in Mobility-Limited Older Adults: The LIFE (Lifestyle Interventions and Independence for Elders) Study.
BACKGROUND:Data are sparse regarding the value of physical activity (PA) surveillance among older adults-particularly among those with mobility limitations. The objective of this study was to examine longitudinal associations between objectively measured daily PA and the incidence of cardiovascular events among older adults in the LIFE (Lifestyle Interventions and Independence for Elders) study. METHODS AND RESULTS:Cardiovascular events were adjudicated based on medical records review, and cardiovascular risk factors were controlled for in the analysis. Home-based activity data were collected by hip-worn accelerometers at baseline and at 6, 12, and 24 months postrandomization to either a physical activity or health education intervention. LIFE study participants (n=1590; age 78.9±5.2 [SD] years; 67.2% women) at baseline had an 11% lower incidence of experiencing a subsequent cardiovascular event per 500 steps taken per day based on activity data (hazard ratio, 0.89; 95% confidence interval, 0.84-0.96; P=0.001). At baseline, every 30 minutes spent performing activities ≥500 counts per minute (hazard ratio, 0.75; confidence interval, 0.65-0.89 [P=0.001]) were also associated with a lower incidence of cardiovascular events. Throughout follow-up (6, 12, and 24 months), both the number of steps per day (per 500 steps; hazard ratio, 0.90, confidence interval, 0.85-0.96 [P=0.001]) and duration of activity ≥500 counts per minute (per 30 minutes; hazard ratio, 0.76; confidence interval, 0.63-0.90 [P=0.002]) were significantly associated with lower cardiovascular event rates. CONCLUSIONS:Objective measurements of physical activity via accelerometry were associated with cardiovascular events among older adults with limited mobility (summary score >10 on the Short Physical Performance Battery) both using baseline and longitudinal data. CLINICAL TRIAL REGISTRATION:URL: http://www.clinicaltrials.gov. Unique identifier: NCT01072500
Genetic risk for schizophrenia and autism, social impairment and developmental pathways to psychosis
Stakeholder views on secondary findings in whole-genome and whole-exome sequencing:a systematic review of quantitative and qualitative studies
Purpose: As whole-exome and whole-genome sequencing (WES/WGS) move into routine clinical practice, it is timely to review data that might inform the debate around secondary findings (SF) and the development of policies that maximize participant benefit. Methods: We systematically searched for qualitative and quantitative studies that explored stakeholder views on SF in WES/WGS. Framework analysis was undertaken to identify major themes. Results: 44 articles reporting the views of 11,566 stakeholders were included. Stakeholders were broadly supportive of returning ‘actionable’ findings, but definitions of actionability varied. Stakeholder views on SF disclosure exist along a spectrum: potential WES/WGS recipients’ views were largely influenced by a sense of rights, while views of genomics professionals were informed by a sense of professional responsibility. Experience of genetic illness and testing resulted in greater caution about SF, suggesting that truly informed decisions require an understanding of the implications and limitations of WES/WGS and possible findings. Conclusion: This review suggests that bidirectional interaction during consent might best facilitate informed decision-making about SF, and that dynamic forms of consent, allowing for changing preferences, should be considered. Research exploring views from wider perspectives and from recipients who have received SF is critical if evidence-based policies are to be achieved.</p
The cosipy library: COSI's high-level analysis software
The Compton Spectrometer and Imager (COSI) is a selected Small Explorer
(SMEX) mission launching in 2027. It consists of a large field-of-view Compton
telescope that will probe with increased sensitivity the under-explored MeV
gamma-ray sky (0.2-5 MeV). We will present the current status of cosipy, a
Python library that will perform spectral and polarization fits, image
deconvolution, and all high-level analysis tasks required by COSI's broad
science goals: uncovering the origin of the Galactic positrons, mapping the
sites of Galactic nucleosynthesis, improving our models of the jet and emission
mechanism of gamma-ray bursts (GRBs) and active galactic nuclei (AGNs), and
detecting and localizing gravitational wave and neutrino sources. The cosipy
library builds on the experience gained during the COSI balloon campaigns and
will bring the analysis of data in the Compton regime to a modern open-source
likelihood-based code, capable of performing coherent joint fits with other
instruments using the Multi-Mission Maximum Likelihood framework (3ML). In this
contribution, we will also discuss our plans to receive feedback from the
community by having yearly software releases accompanied by publicly-available
data challenges
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