Sistematización de experiencia de la estrategia del plan de egreso con enfoque de atención primaria en salud en estudiantes de medicina y pacientes participantes, Hospital Mario Catarino Rivas y Hospital Leonardo Martínez, San Pedro Sula, Honduras. 2017

El plan de egreso permite educar al paciente y a sus familiares, utilizando un lenguaje sencillo y de manejo común según la cultura propia de la población; le ayuda al paciente a ser autónomo ya que una vez educado interioriza la información y transforma su pensamiento y como consecuencia modifica su comportamiento para recuperar su salud, cumpliendo conscientemente con las indicaciones médicas; ayudó a los estudiantes de medicina que aplicaron el plan de egreso a desarrollar la competencia de una mejor relación médico paciente; el plan de egreso no solo contribuyó al desarrollo de la salud personal del participante sino que brindó la oportunidad de promover el desarrollo de la salud a un nivel comunitario, debido a que en las actividades de promoción y educación no solo participaba el paciente sino que también miembros de la familia o conocidos que convivían o se encargaban de sus cuidados. El plan de egreso resulta una estrategia efectiva para educar al paciente y sus familiares; es una importante herramienta académica para lograr una visión holística e integral en la atención; el grado de satisfacción por la aplicación del plan de egreso es general y la inseguridad y la violencia imperante en el país es una limitante muy grande para la aplicación del plan de egres

Radiative M1-decays of heavy-light mesons in the relativistic quark model

Radiative magnetic dipole decays of heavy-light vector mesons into pseudoscalar mesons V -> P\gamma are considered within the relativistic quark model. The light quark is treated completely relativistically, while for the heavy quark the 1/m_Q expansion is used. It is found that relativistic effects result in a significant reduction of decay rates. Comparison with previous predictions and recent experimental data is presented.Comment: 11 pages, 2 figures, few comments added, version to appear in Phys. Lett.

Weak Decay of Lambda Hypernuclei

In this review we discuss the present status of strange nuclear physics, with special attention to the weak decay of Lambda hypernuclei. The models proposed for the evaluation of the Lambda decay widths are summarized and their results are compared with the data. Despite the recent intensive investigations, the main open problem remains a sound theoretical interpretation of the large experimental values of the ratio G_n/G_p. Although recent works offer a step forward in the solution of the puzzle, further efforts must be invested in order to understand the detailed dynamics of the non-mesonic decay. Even if, by means of single nucleon spectra measurements, the error bars on G_n/G_p have been considerably reduced very recently at KEK, a clean extraction of G_n/G_p is needed. What is missing at present, but planned for the next future, are measurements of 1) nucleon energy spectra in double coincidence and 2) nucleon angular correlations: such observations allow to disentangle the nucleons produced in one- and two-body induced decays and lead to a direct determination of G_n/G_p. For the asymmetric non-mesonic decay of polarized hypernuclei the situation is even more puzzling. Indeed, strong inconsistencies appear already among data. A recent experiment obtained a positive intrinsic Lambda asymmetry parameter, a_{Lambda}, for 5_{Lambda}He. This is in complete disagreement with a previous measurement, which obtained a large and negative a_{Lambda} for p-shell hypernuclei, and with theory, which predicts a negative value moderately dependent on nuclear structure effects. Also in this case, improved experiments establishing with certainty the sign and magnitude of a_{Lambda} for s- and p-shell hypernuclei will provide a guidance for a deeper understanding of hypernuclear dynamics and decay mechanisms.Comment: 129 pages, 21 figures, Submitted to Phys. Rep

Conformation of peptides bound to the transporter associated with antigen processing (TAP)

The ATP-binding cassette transporter associated with antigen processing (TAP) plays a key role in the adaptive immune defense against infected or malignantly transformed cells by translocating proteasomal degradation products into the lumen of the endoplasmic reticulum for loading onto MHC class I molecules. The broad substrate spectrum of TAP, rendering peptides from 8 to 40 residues, including even branched or modified molecules, suggests an unforeseen structural flexibility of the substrate-binding pocket. Here we used EPR spectroscopy to reveal conformational details of the bound peptides. Side-chain dynamics and environmental polarity were derived from covalently attached 2,2,5,5-tetramethylpyrrolidine-1-oxyl spin probes, whereas 2,2,6,6-tetramethylpiperidine-1-oxyl-4-amino-4-carboxylic acid spin-labeled peptides were used to detect backbone properties. Dependent on the spin probe’s position, striking differences in affinity, dynamics, and polarity were found. The side-chains’ mobility was strongly restricted at the ends of the peptide, whereas the central region was flexible, suggesting a central peptide bulge. In the end, double electron electron resonance allowed the determination of intrapeptide distances in doubly labeled peptides bound to TAP. Simulations based on a rotamer library led to the conclusion that peptides bind to TAP in an extended kinked structure, analogous to those bound to MHC class I proteins