An Assessment of Effective Fund-Raising Policies Used at Private, Church-Related Undergraduate Colleges

Problem. Much of what is known concerning fund-raising policies and practices at colleges in the United States is anecdotal. Few empirical studies have focused on any aspect of fund raising. No known empirical study has identified those fund-raising policies that might help church-related colleges to be more effective in generating gift income from private philanthropy. The purpose of this study was to bring to light those fund-raising policies that may be associated with effective fund-raising programs at church-related colleges. Method. Typically, fund-raising productivity is associated with total funds raised. An alternative way of assessing fund-raising effectiveness is to compare what each institution raises to its income potential, if this can be measured. Through multiple regression techniques, this study estimated the gift income potential of 234 church-related colleges using a set of financial resource and environmental position variables. By comparing the schools\u27 actual income to their potential income, groups of over-productive and underproductive colleges were identified. A survey was sent to colleges in each group to determine the extent to which they implemented 16 fund-raising policies identified in the fund-raising literature. Hypotheses were developed to highlight those policies that were significantly associated with over-productivity in fund raising. Findings. (1) Significantly more of the over-productive colleges had a full complement of fund-raising functions such as an annual fund, prospect research, capital giving, and deferred or planned giving. (2) Over-productive colleges assigned a higher number of staff to the function known as institutional advancement. (3) Over-productive colleges had larger mailing lists of prospects. (4) A significantly higher number of over-productive colleges published a President\u27s Report. (5) Significantly more of the over-productive colleges had active trustee committees for development. Conclusions. Productivity in fund raising among church-related colleges is associated with higher levels of fund-raising effort, institutional responsiveness and accountability, and trustee leadership and involvement

Leaflet trichome micromorphology in the Dolentes-Brevipedes taxonomic complex (Mimosa L., Mimosoideae)

We studied leaflets of 18 taxa of the genus Mimosa, specifically the Dolentes-Brevipedes taxonomic complex, focusing on micromorphology, type, shape, and density of trichomes. Within the nonglandular trichomes we described 3 types of nonbranched and 2 types of branched trichomes. We also described 2 types of stalked glandular trichomes, extending the recent classifications of trichomes in Mimosa. Multiseriate trichomes with lateral projections, which resemble incipient branching, are described here for many taxa. Most studied taxa have pubescent leaflets and show great variability in trichome density values. We also found 3 different types of blade margins with variation in type, alignment, and orientation of trichomes. Results show that the micromorphology of blade trichomes allows distinguishing groups of taxa in this complex, which could be a new tool for performing taxonomic treatment of both subseries.Instituto de Recursos BiológicosFil: Grohar, Mariana Cecilia. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Biodiversidad y Biología Experimental; Argentina.Fil: Rosenfeldt, Sonia. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Biodiversidad y Biología Experimental; ArgentinaFil: Morales, Matias. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Recursos Biológicos; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Morón. Facultad de Agronomía y Ciencias Agroalimentarias; Argentin

Polycation-π Interactions Are a Driving Force for Molecular Recognition by an Intrinsically Disordered Oncoprotein Family

Molecular recognition by intrinsically disordered proteins (IDPs) commonly involves specific localized contacts and target-induced disorder to order transitions. However, some IDPs remain disordered in the bound state, a phenomenon coined "fuzziness", often characterized by IDP polyvalency, sequence-insensitivity and a dynamic ensemble of disordered bound-state conformations. Besides the above general features, specific biophysical models for fuzzy interactions are mostly lacking. The transcriptional activation domain of the Ewing's Sarcoma oncoprotein family (EAD) is an IDP that exhibits many features of fuzziness, with multiple EAD aromatic side chains driving molecular recognition. Considering the prevalent role of cation-π interactions at various protein-protein interfaces, we hypothesized that EAD-target binding involves polycation- π contacts between a disordered EAD and basic residues on the target. Herein we evaluated the polycation-π hypothesis via functional and theoretical interrogation of EAD variants. The experimental effects of a range of EAD sequence variations, including aromatic number, aromatic density and charge perturbations, all support the cation-π model. Moreover, the activity trends observed are well captured by a coarse-grained EAD chain model and a corresponding analytical model based on interaction between EAD aromatics and surface cations of a generic globular target. EAD-target binding, in the context of pathological Ewing's Sarcoma oncoproteins, is thus seen to be driven by a balance between EAD conformational entropy and favorable EAD-target cation-π contacts. Such a highly versatile mode of molecular recognition offers a general conceptual framework for promiscuous target recognition by polyvalent IDPs. © 2013 Song et al

Las prácticas corporales culturales desde una multiperspectiva: Educación Física y enseñanza

Otras prácticas corporales distintas a las deportivas, gimnasticas, lúdicomotrices y en el medio natural, “traías” por nuestros y nuestras estudiantes del Profesorado de Educación Física desde hace tiempo, comenzaron a interperlarnos a un pequeño grupo de docentes. Esta cartografía situada, además, coincidió con lo que Pich (2014) sostiene como la inclusión de la mirada de las ciencias sociales en nuestro campo.Integrantes estudiantes: MÉNDEZ, Nadia; GARCÍA CASAVILLA, Ignacio, HUENPI, Lautaro.Integrantes externo: Lic. CAROSIO, Cristina.Asesor: Dr. DUKUEN, Juan.Código del Proyecto: B230 (2019-2022).Fuente de consulta: Secretaria de Ciencia, Técnica y Vinculación de UNCo Bariloche

An international working group consensus report for the prioritization of molecular biomarkers for Ewing sarcoma

The advent of dose intensified interval compressed therapy has improved event-free survival for patients with localized Ewing sarcoma (EwS) to 78% at 5 years. However, nearly a quarter of patients with localized tumors and 60-80% of patients with metastatic tumors suffer relapse and die of disease. In addition, those who survive are often left with debilitating late effects. Clinical features aside from stage have proven inadequate to meaningfully classify patients for risk-stratified therapy. Therefore, there is a critical need to develop approaches to risk stratify patients with EwS based on molecular features. Over the past decade, new technology has enabled the study of multiple molecular biomarkers in EwS. Preliminary evidence requiring validation supports copy number changes, and loss of function mutations in tumor suppressor genes as biomarkers of outcome in EwS. Initial studies of circulating tumor DNA demonstrated that diagnostic ctDNA burden and ctDNA clearance during induction are also associated with outcome. In addition, fusion partner should be a pre-requisite for enrollment on EwS clinical trials, and the fusion type and structure require further study to determine prognostic impact. These emerging biomarkers represent a new horizon in our understanding of disease risk and will enable future efforts to develop risk-adapted treatment

Reproductive system and floral biology of Lantana camara (Verbenaceae) in a riparian population of the Río de la Plata

Introducción y objetivos: La biología floral de Lantana camara L., nativa del Centro y Sur de América e invasora cosmopolita, tiene aspectos desconocidos y controvertidos. El objetivo de este trabajo fue determinar el sistema reproductivo, atributos florales y polinizadores en una población ribereña del Río de la Plata.M&M: Se emplearon los métodos usuales de la biología de la polinización. El estudio se realizó en Ciudad Universitaria, Ciudad Autónoma de Buenos Aires, Argentina, en la primavera de 2012.Resultados: Las flores emiten olor leve y dulce mediante osmóforos que rodeanla entrada del tubo floral, coincidiendo con el patrón de absorción-reflexión en el espectro UV. El néctar se acumula en el tubo corolino, secretado probablemente por tricomas situados en la base. Durante la antesis, se suceden tres fases florales, distinguibles por cambios en la coloración de la corola, intensidad del aroma, cantidad de recompensa y madurez de las anteras y el estigma. Las flores, psicófilas, recibieron visitas de lepidópteros diurnos, y también de himenópteros, dípteros y colibríes. El mayor éxito reproductivo ocurrió con polinización libre; los índices de autocompatibilidad y P/O indicaron autocompatibilidad parcial y xenogamia facultativa, respectivamente.Conclusiones: L. camara se autopoliniza espontáneamente, probablemente unacausa de su propagación global. Debido a su actividad en las flores, fase floralvisitada, carga polínica y frecuencia de visitas sólo las mariposas Agraulis vanillae maculosa, Dryas iullia alcionea y Cymaenes sp. polinizarían en este sitio.Background and aims: The floral biology of Lantana camara, a native species of Central and South America and invasive cosmopolitan, still presents poorly-known and controversial aspects. The aim of this work was to determine the reproductive system, floral attributes and pollinators in a coastal population of Río de la Plata. M&M: The usual methods in pollination biology were employed. The study was performed in Ciudad Universitaria, Ciudad Autónoma de Buenos Aires, Argentina, during the spring of 2012. Results: The flowers emit mild and sweet odor by osmophores arranged around the floral tube entrance, in coincidence with the absorption-reflection pattern in the UV spectrum. Nectar accumulates in the floral tube, probably secreted by trichomes situated at the petals base. During anthesis, three floral phases succeed, distinguished by changes in corolla coloration, aroma intensity, reward quantity and anther and stigma maturity. The psychophilous flowers were visited by diurnal lepidopterans and by hymenopterans, dipterans and hummingbirds. The highest reproductive success occurred with free pollination; the self-incompatibility and P/O indexes showed partial self-compatibility and facultative xenogamy, respectively. Conclusions: L. camara is capable of successful spontaneous self-pollination, probably one reason of its global spread. Due to their activity on the flowers, visited floral phase, pollen load and frequency of visits, only the butterflies Agraulis vanillae maculosa, Dryas iullia alcionea and Cymaenes sp. would pollinate in this site.Fil: Amela Garcia, Maria Teresa. Universidad de Buenos Aires. Facultad de Cs.exactas y Naturales. Departamento de Biodiversidad y Biología Experimental. Laboratorio de Biología Reproductiva y Sistematica Experimental En Plantas Vasculares; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Micología y Botánica. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Micología y Botánica; ArgentinaFil: Aquino, Diego Sebastián. Universidad de Buenos Aires. Facultad de Cs.exactas y Naturales. Departamento de Biodiversidad y Biología Experimental. Laboratorio de Biología Reproductiva y Sistematica Experimental En Plantas Vasculares; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Bouza, Agustina. Universidad de Buenos Aires. Facultad de Cs.exactas y Naturales. Departamento de Biodiversidad y Biología Experimental. Laboratorio de Biología Reproductiva y Sistematica Experimental En Plantas Vasculares; ArgentinaFil: Grohar, Mariana Cecilia. Universidad de Buenos Aires. Facultad de Cs.exactas y Naturales. Departamento de Biodiversidad y Biología Experimental. Laboratorio de Biología Reproductiva y Sistematica Experimental En Plantas Vasculares; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Herrera Cano, Anahí Naymé. Universidad de Buenos Aires. Facultad de Cs.exactas y Naturales. Departamento de Biodiversidad y Biología Experimental. Laboratorio de Biología Reproductiva y Sistematica Experimental En Plantas Vasculares; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Centro de Estudios Farmacológicos y Botánicos. Universidad de Buenos Aires. Facultad de Medicina. Centro de Estudios Farmacológicos y Botánicos; ArgentinaFil: Lafuente Diaz, Maiten Amalia. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Museo Argentino de Ciencias Naturales "Bernardino Rivadavia"; Argentina. Universidad de Buenos Aires. Facultad de Cs.exactas y Naturales. Departamento de Biodiversidad y Biología Experimental. Laboratorio de Biología Reproductiva y Sistematica Experimental En Plantas Vasculares; ArgentinaFil: Miguez, María Belén. Universidad de Buenos Aires. Facultad de Cs.exactas y Naturales. Departamento de Biodiversidad y Biología Experimental. Laboratorio de Biología Reproductiva y Sistematica Experimental En Plantas Vasculares; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Biodiversidad y Biología Experimental y Aplicada. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Biodiversidad y Biología Experimental y Aplicada; ArgentinaFil: Scorza, María Victoria. Universidad de Buenos Aires. Facultad de Cs.exactas y Naturales. Departamento de Biodiversidad y Biología Experimental. Laboratorio de Biología Reproductiva y Sistematica Experimental En Plantas Vasculares; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Biodiversidad y Biología Experimental y Aplicada. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Biodiversidad y Biología Experimental y Aplicada; ArgentinaFil: Chamer, Ana Marina. Universidad de Buenos Aires. Facultad de Agronomía. Departamento de Recursos Naturales y Ambiente; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Cs.exactas y Naturales. Departamento de Biodiversidad y Biología Experimental. Laboratorio de Biología Reproductiva y Sistematica Experimental En Plantas Vasculares; Argentin

Emerging novel agents for patients with advanced Ewing sarcoma: a report from the Children’s Oncology Group (COG) New Agents for Ewing Sarcoma Task Force [version 1; peer review: 3 approved]

Ewing sarcoma is a small round blue cell malignancy arising from bone or soft tissue and most commonly affects adolescents and young adults. Metastatic and relapsed Ewing sarcoma have poor outcomes and recurrences remain common. Owing to the poor outcomes associated with advanced disease and the need for a clear research strategy, the Children’s Oncology Group Bone Tumor Committee formed the New Agents for Ewing Sarcoma Task Force to bring together experts in the field to evaluate and prioritize new agents for incorporation into clinical trials. This group’s mission was to evaluate scientific and clinical challenges in moving new agents forward and to recommend agents and trial designs to the Bone Tumor Committee. The task force generated a framework for vetting prospective agents that included critical evaluation of each drug by using both clinical and non-clinical parameters. Representative appraisal of agents of highest priority, including eribulin, dinutuximab, cyclin-dependent kinase 4 and 6 (CDK4/6) inhibitors, anti-angiogenic tyrosine kinase inhibitors, and poly-ADP-ribose polymerase (PARP) inhibitors, is described. The task force continues to analyze new compounds by using the paradigm established

Masculinity and Non-Traditional Occupations : Men’s Talk in Women’s Work

This is the peer reviewed version of the following article: Joanne McDowell, ‘Masculinity and Non-Traditional Occupations: Men’s Talk in Women’s Work’, Gender, Work & Organization, Vol. 22 (3): 273-291, first published online 19 March 2015, which has been published in final form at doi: 10.1111/gwao.12078. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.Occupation segregation is a persistent aspect of the labour market, and scholars have often researched what happens when women and men enter into what are seen to be ‘non-traditional’ work roles for their sex. Research on men within women's roles has concentrated mainly on the challenges to a masculine identity, while research on workplace language has focused on women's linguistic behaviour in masculine occupations. To date, there has been relatively little research into the linguistic behaviour of men working in occupations seen as women's work (e.g., nursing, primary school teaching). To address this gap, this article focuses on men's discursive behaviour and identity construction within the feminized occupation of nursing. Empirical data collected by three male nurses in a hospital in Northern Ireland is explored using discourse analysis and the Community of Practice paradigm. This paper discusses how the participants linguistically present themselves as nurses by performing relational work and creating an in-group with their nurse colleagues by actively using an inherently ‘feminine’ discourse stylePeer reviewe