Condensation of beta-hydroxy sulfones and vinyl sulfones with aldehydes and ketones using phenyllithium as base

4 pages Merci à Elsevier pour l'autorisation de déposer cet article sur HAL.Condensation of beta-hydroxysulfones 7a-b with aldehydes and ketones were performed with diverse bases. Phenyllithium proved to be optimum, giving yields of compounds 9-12a-e ranging from 67 to 80%. Condensation of vinyl sulfones 15a-c with aldehydes also worked very well with PhLi, and the resulting adducts 16a-d were transformed into protected syn 1,3-diols flanked with an olefin at the a carbon by a new conjugate addition/elimination sequence. These products are models for the C21-C25 sub-unit of Dolabelides

Ugi post-condensation copper-triggered oxidative cascade towards pyrazoles

International audiencePyrazolidinones were prepared in a two-step sequence starting from a-hydrazonocarboxylic acids. After a four-component Ugi coupling, the resulting hydrazone was engaged in a copper triggered [3 + 2] cycloaddition/aerobic oxidation cascade. © 2011 Santos et al; licensee Beilstein-Institut

Transition-metal-free a-arylation of enolizable aryl ketones and mechanistic evidence for a radical process

The a-arylation of enolizable aryl ketones can be carried out with aryl halides under transition-metal-free conditions using KOtBu in DMF. The a-aryl ketones thus obtained can be used for step- and cost-economic syntheses of fused heterocycles and Tamoxifen. Mechanistic studies demonstrate the synergetic role of base and solvent for the initiation of the radical process

Data Management Plans: the Importance of Data Management in the BIG‐MAP Project[]**

Open access to research data is increasingly important for accelerating research. Grant authorities therefore request detailed plans for how data is managed in the projects they finance. We have recently developed such a plan for the EU−H2020 BIG-MAP project—a cross-disciplinary project targeting disruptive battery-material discoveries. Essential for reaching the goal is extensive sharing of research data across scales, disciplines and stakeholders, not limited to BIG-MAP and the European BATTERY 2030+ initiative but within the entire battery community. The key challenges faced in developing the data management plan for such a large and complex project were to generate an overview of the enormous amount of data that will be produced, to build an understanding of the data flow within the project and to agree on a roadmap for making all data FAIR (findable, accessible, interoperable, reusable). This paper describes the process we followed and how we structured the plan

Programme de recherches interdisciplinaires « Vérité et fiction »

Stéphane Breton, Jean-Paul Colleyn, André Gunthert, Jean-Claude Penrad, Annick Bouleau, Sabine Chalvon, Daniel Dayan, Renaud Dulong, Éliane de Latour, Catarina Pasqualino, Dominique Pasquier, Marc-Henri Piault, Jean-Pierre Bertin-Maghit, Jacqueline Chervin, Emmannuel Grimaud, Roger Odin, Laurence Allard Allard, Gilles Saussier, Elodie Perreau Nous avons poursuivi nos travaux sur la tension (majeure), entre la vérité et la fiction dans les formes d’expression audiovisuelles. Roger Odin (Univer..

Programme de recherches interdisciplinaires « Vérité et fiction »

Stéphane Breton, Jean-Paul Colleyn, André Gunthert, Jean-Claude Penrad, Annick Bouleau, Sabine Chalvon, Daniel Dayan, Renaud Dulong, Éliane de Latour, Catarina Pasqualino, Dominique Pasquier, Marc-Henri Piault, Jean-Pierre Bertin-Maghit, Jacqueline Chervin, Emmannuel Grimaud, Roger Odin, Laurence Allard Allard, Gilles Saussier, Elodie Perreau Nous avons poursuivi nos travaux sur la tension (majeure), entre la vérité et la fiction dans les formes d’expression audiovisuelles. Roger Odin (Univer..

Vers la synthèse totale de la paulitine (étude de nouvelles réactions de métathèse)

PALAISEAU-Polytechnique (914772301) / SudocSudocFranceF

Nouvelles réactions multicomposant avec des phenols et des isonitriles

PALAISEAU-Polytechnique (914772301) / SudocSudocFranceF

One or More C=C Bond(s) Formed by Condensation: Condensation of Nonheteroatom Linked Functions, Halides, Chalcogen or Nitrogen Functions.

56 page

Nouvelles réactions multicomposants avec des isonitriles

Dans une première partie est décrite une réaction de Ugi-Smiles avec des équivalents d'ammoniaque ainsi que des post-condensations à cette réaction. Dans une seconde partie, des nouvelles réactions de Passerini entre des isonitriles, des phosphonates d'acyle et différents partenaires acides ont été décrites. Dans une dernière partie, une synthèse originale de cétène-imines basée sur une séquence Nef-Perkow ainsi que des applications en synthèse hétérocyclique sont présentées.First, a Ugi-Smiles reaction with ammonia equivalent is presented. Post-condensations to this reaction are proposed. In a second part, new variants of the Passerini reaction with acyl phosphonate are described. At last, an original keteneimine synthesis and its applications in heterocyclic synthesis are exposedPALAISEAU-Polytechnique (914772301) / SudocSudocFranceF