247 research outputs found
Do You Know What You Owe? Students\u27 Understanding of Their Student Loans
Using a data set that augments a student survey with administrative data from the Iowa State University Office of Financial Aid, the authors posed two questions: Do students know whether they have student loans? Do students know how much they owe on outstanding student loans? We used logistic and ordered logit regressions to answer these questions. Results suggest that although the majority of students are aware that they owe on student loans, many underestimate the amount they owe. One eighth of students in the current study reported no student debt when, in fact, they had a loan. Over a quarter of the students underestimated the amount they owed by less than 10,000. This article discusses the roles that counselors, educators, and policy makers can play in improving students’ understanding of their student loan debt
THE EFFECT OF TONE ON THE SUCCESSIVE COMPARISON OF BRIGHTNESS
Last updated: 6/12/200
Validation of high gradient magnetic field based drug delivery to magnetizable implants under flow
IEEE Transactions on Biomedical Engineering, 55(2): pp. 643-649.The drug-eluting stent’s increasingly frequent occurrence
late stage thrombosis have created a need for new strategies
for intervention in coronary artery disease. This paper demonstrates
further development of our minimally invasive, targeted
drug delivery system that uses induced magnetism to administer
repeatable and patient specific dosages of therapeutic agents to specific
sites in the human body. Our first aim is the use of magnetizable
stents for the prevention and treatment of coronary restenosis;
however, future applications include the targeting of tumors, vascular
defects, and other localized pathologies. Future doses can
be administered to the same site by intravenous injection. This
implant-based drug delivery system functions by placement of a
weakly magnetizable stent or implant at precise locations in the
cardiovascular system, followed by the delivery of magnetically
susceptible drug carriers. The stents are capable of applying high
local magnetic field gradients within the body, while only exposing
the body to a modest external field. The local gradients created
within the blood vessel create the forces needed to attract and hold
drug-containing magnetic nanoparticles at the implant site. Once
these particles are captured, they are capable of delivering therapeutic
agents such as antineoplastics, radioactivity, or biological
cells
The WiggleZ Dark Energy Survey: Survey Design and First Data Release
The WiggleZ Dark Energy Survey is a survey of 240,000 emission line galaxies
in the distant universe, measured with the AAOmega spectrograph on the 3.9-m
Anglo-Australian Telescope (AAT). The target galaxies are selected using
ultraviolet photometry from the GALEX satellite, with a flux limit of NUV<22.8
mag. The redshift range containing 90% of the galaxies is 0.2<z<1.0. The
primary aim of the survey is to precisely measure the scale of baryon acoustic
oscillations (BAO) imprinted on the spatial distribution of these galaxies at
look-back times of 4-8 Gyrs. Detailed forecasts indicate the survey will
measure the BAO scale to better than 2% and the tangential and radial acoustic
wave scales to approximately 3% and 5%, respectively.
This paper provides a detailed description of the survey and its design, as
well as the spectroscopic observations, data reduction, and redshift
measurement techniques employed. It also presents an analysis of the properties
of the target galaxies, including emission line diagnostics which show that
they are mostly extreme starburst galaxies, and Hubble Space Telescope images,
which show they contain a high fraction of interacting or distorted systems. In
conjunction with this paper, we make a public data release of data for the
first 100,000 galaxies measured for the project.Comment: Accepted by MNRAS; this has some figures in low resolution format.
Full resolution PDF version (7MB) available at
http://www.physics.uq.edu.au/people/mjd/pub/wigglez1.pdf The WiggleZ home
page is at http://wigglez.swin.edu.au
Isolation of stable non cyclic 1,2-disulfoxides: revisiting the thermolysis of S-aryl sulfinimines
The thermolysis of S-aryl sulfinimines is shown to generate 1,2-disulfoxides and disulfides via initial Cope elimination, dimerisation of the produced sulfenic acid to a thiosulfinate, and subsequent disproportionation of the thiosulfinate
Progress report no. 4
Statement of responsibility on title-page reads: editors: M.J. Driscoll, D.D. Lanning, I. Kaplan, A.T. Supple ; contributors: A. Alvim, G.J. Brown, J.K. Chan, T.P. Choong, M.J. Driscoll, G. A. Ducat, I.A. Forbes, M.V. Gregory, S.Y. Ho, C.M. Hove, O. K. Kadiroglu, R.J. Kennerley, D.D. Lanning, J.L. Lazewatsky, L. Lederman, A.S. Leveckis, V.A. Miethe, P. A. Scheinert, A.M. Thompson, N.E. Todreas, C.P. Tzanos, and P.J. WoodIncludes bibliographical referencesProgress report; June 30, 1973U.S. Atomic Energy Commission contract: AT(11-1)225
Recommended from our members
The Irish potato famine pathogen Phytophthora infestans originated in central Mexico rather than the Andes
Phytophthora infestans is a destructive plant pathogen best known
for causing the disease that triggered the Irish potato famine and
remains the most costly potato pathogen to manage worldwide.
Identification of P. infestan’s elusive center of origin is critical to
understanding the mechanisms of repeated global emergence of
this pathogen. There are two competing theories, placing the origin
in either South America or in central Mexico, both of which are
centers of diversity of Solanum host plants. To test these competing
hypotheses, we conducted detailed phylogeographic and approximate
Bayesian computation analyses, which are suitable approaches
to unraveling complex demographic histories. Our analyses used
microsatellite markers and sequences of four nuclear genes sampled
from populations in the Andes, Mexico, and elsewhere. To infer the
ancestral state, we included the closest known relatives Phytophthora
phaseoli, Phytophthora mirabilis, and Phytophthora ipomoeae,
as well as the interspecific hybrid Phytophthora andina. We
did not find support for an Andean origin of P. infestans; rather, the
sequence data suggest a Mexican origin. Our findings support the
hypothesis that populations found in the Andes are descendants
of the Mexican populations and reconcile previous findings of ancestral
variation in the Andes. Although centers of origin are well
documented as centers of evolution and diversity for numerous crop
plants, the number of plant pathogens with a known geographic
origin are limited. This work has important implications for our understanding
of the coevolution of hosts and pathogens, as well as
the harnessing of plant disease resistance to manage late blight.Keywords: coalescent analysis, biological invasion, oomycete, population genetics, stramenopil
Aptamer-based multiplexed proteomic technology for biomarker discovery
Interrogation of the human proteome in a highly multiplexed and efficient manner remains a coveted and challenging goal in biology. We present a new aptamer-based proteomic technology for biomarker discovery capable of simultaneously measuring thousands of proteins from small sample volumes (15 [mu]L of serum or plasma). Our current assay allows us to measure ~800 proteins with very low limits of detection (1 pM average), 7 logs of overall dynamic range, and 5% average coefficient of variation. This technology is enabled by a new generation of aptamers that contain chemically modified nucleotides, which greatly expand the physicochemical diversity of the large randomized nucleic acid libraries from which the aptamers are selected. Proteins in complex matrices such as plasma are measured with a process that transforms a signature of protein concentrations into a corresponding DNA aptamer concentration signature, which is then quantified with a DNA microarray. In essence, our assay takes advantage of the dual nature of aptamers as both folded binding entities with defined shapes and unique sequences recognizable by specific hybridization probes. To demonstrate the utility of our proteomics biomarker discovery technology, we applied it to a clinical study of chronic kidney disease (CKD). We identified two well known CKD biomarkers as well as an additional 58 potential CKD biomarkers. These results demonstrate the potential utility of our technology to discover unique protein signatures characteristic of various disease states. More generally, we describe a versatile and powerful tool that allows large-scale comparison of proteome profiles among discrete populations. This unbiased and highly multiplexed search engine will enable the discovery of novel biomarkers in a manner that is unencumbered by our incomplete knowledge of biology, thereby helping to advance the next generation of evidence-based medicine
Self-Reported Time in Bed and Sleep Quality in Association with Internalizing and Externalizing Symptoms in School-Age Youth
This study investigated the relationship between self-reported time in bed and sleep quality in association with self-reported internalizing and externalizing symptoms in a sample of 285 elementary school students (52% female) recruited from a rural Midwestern elementary school. Path models were used to estimate proposed associations, controlling for grade level and gender. Curvilinear associations were found between time in bed and anxiety, depressive symptoms, and irritability. Marginal curvilinear trends were found between time in bed and emotion dysregulation, reactive aggression, and proactive aggression. Sleep quality was negatively associated with anxiety, depressive symptoms, irritability, reactive aggression, and delinquency engagement. Gender and grade differences were found across models. Findings suggest that examining self-reported time in bed (both linear and quadratic) and sleep quality is important for understanding internalizing and externalizing symptoms associated with sleep in school-age youth. Incorporating self-reported sleep assessments into clinical practice and school-based evaluations may have implications for a child’s adjustment
The future of zoonotic risk prediction
In the light of the urgency raised by the COVID-19 pandemic, global investment in wildlife virology is likely to increase, and new surveillance programmes will identify hundreds of novel viruses that might someday pose a threat to humans. To support the extensive task of laboratory characterization, scientists may increasingly rely on data-driven rubrics or machine learning models that learn from known zoonoses to identify which animal pathogens could someday pose a threat to global health. We synthesize the findings of an interdisciplinary workshop on zoonotic risk technologies to answer the following questions. What are the prerequisites, in terms of open data, equity and interdisciplinary collaboration, to the development and application of those tools? What effect could the technology have on global health? Who would control that technology, who would have access to it and who would benefit from it? Would it improve pandemic prevention? Could it create new challenges? This article is part of the theme issue 'Infectious disease macroecology: parasite diversity and dynamics across the globe'.Peer reviewe
- …