1,031 research outputs found
Service oriented architecture for scientific analysis at W7-X. An example of a field line tracer
Scintillation counter with MRS APD light readout
START, a high-efficiency and low-noise scintillation detector for ionizing
particles, was developed for the purpose of creating a high-granular system for
triggering cosmic muons. Scintillation light in START is detected by MRS APDs
(Avalanche Photo-Diodes with Metal-Resistance-Semiconductor structure),
operated in the Geiger mode, which have 1 mm^2 sensitive areas. START is
assembled from a 15 x 15 x 1 cm^3 scintillating plastic plate, two MRS APDs and
two pieces of wavelength-shifting optical fiber stacked in circular coils
inside the plastic. The front-end electronic card is mounted directly on the
detector. Tests with START have confirmed its operational consistency, over 99%
efficiency of MIP registration and good homogeneity. START demonstrates a low
intrinsic noise of about 10^{-2} Hz. If these detectors are to be
mass-produced, the cost of a mosaic array of STARTs is estimated at a moderate
level of 2-3 kUSD/m^2.Comment: 6 pages, 5 figure
Using landscape topology to compare continuous metaheuristics: a framework and case study on EDAs and ridge structure
In this paper we extend a previously proposed randomized landscape generator in combination with a comparative experimental methodology to study the behavior of continuous metaheuristic optimization algorithms. In particular, we generate twodimensional landscapes with parameterized, linear ridge structure, and perform pairwise comparisons of algorithms to gain insight into what kind of problems are easy and difficult for one algorithm instance relative to another.We apply thismethodology to investigate the specific issue of explicit dependency modeling in simple continuous estimation of distribution algorithms. Experimental results reveal specific examples of landscapes (with certain identifiable features) where dependency modeling is useful, harmful, or has little impact on mean algorithm performance. Heat maps are used to compare algorithm performance over a large number of landscape instances and algorithm trials. Finally, we perform ameta-search in the landscape parameter space to find landscapes which maximize the performance between algorithms. The results are related to some previous intuition about the behavior of these algorithms, but at the same time lead to new insights into the relationship between dependency modeling in EDAs and the structure of the problem landscape. The landscape generator and overall methodology are quite general and extendable and can be used to examine specific features of other algorithms
The O(2) model in polar coordinates at nonzero temperature
We study the restoration of spontaneously broken symmetry at nonzero
temperature in the framework of the O(2) model using polar coordinates. We
apply the CJT formalism to calculate the masses and the condensate in the
double-bubble approximation, both with and without a term that explicitly
breaks the O(2) symmetry. We find that, in the case with explicitly broken
symmetry, the mass of the angular degree of freedom becomes tachyonic above a
temperature of about 300 MeV. Taking the term that explicitly breaks the
symmetry to be infinitesimally small, we find that the Goldstone theorem is
respected below the critical temperature. However, this limit cannot be
performed for temperatures above the phase transition. We find that, no matter
whether we break the symmetry explicitly or not, there is no region of
temperature in which the radial and the angular degree of freedom become
degenerate in mass. These results hold also when the mass of the radial mode is
sent to infinity.Comment: 23 pages, 10 figure
Cyanophage MazG is a pyrophosphohydrolase but unable to hydrolyse magic spot nucleotides
Bacteriophage possess a variety of auxiliary metabolic genes (AMGs) of bacterial origin. These proteins enable them to maximise infection efficiency, subverting bacterial metabolic processes for the purpose of viral genome replication and synthesis of the next generation of virion progeny. Here, we examined the enzymatic activity of a cyanophage MazG protein ā a putative pyrophosphohydrolase previously implicated in regulation of the stringent response via reducing levels of the central alarmone molecule (p)ppGpp. We demonstrate however, that the purified viral MazG shows no binding or hydrolysis activity against (p)ppGpp. Instead, dGTP and dCTP appear to be the preferred substrates of this protein, consistent with a role preferentially hydrolysing deoxyribonucleotides from the high GC content host Synechococcus genome. This showcases a new example of the fineātuned nature of viral metabolic processes
Characterization of a periplasmic nitrate reductase in complex with its biosynthetic chaperone
Escherichia coliis a Gram-negative bacterium that can use nitrate during anaerobic respiration. The catalytic subunit of the periplasmic nitrate reductase, NapA, contains two types of redox cofactor and is exported across the cytoplasmic membrane by the twin-arginine protein transport pathway. NapD is a small cytoplasmic protein that is essential for the activity of the periplasmic nitrate reductase and binds tightly to the twin-arginine signal peptide of NapA. Here we show, using spin labelling and EPR, that the isolated twin-arginine signal peptide of NapA is structured in its unbound form and undergoes a small but significant conformational change upon interaction with NapD.In addition, a complex comprising the full-length NapA protein and NapD could be isolated by engineering an affinity tag onto NapD only. Analytical ultracentrifugation demonstrated that the two proteins in the NapDA complex were present in a 1:1 molar ratio, and small angle X-ray scattering analysis of the complex indicated that NapAwas at least partially folded when bound by its NapD partner. A NapDA complex could not be isolated in the absence of the NapA Tat signal peptide. Taken altogether, this work indicates that the NapD chaperone binds primarily at the NapA signal peptide in this system and points towards a role for NapD in the insertion of the molybdenum cofactor
Folksonomies and clustering in the collaborative system CiteULike
We analyze CiteULike, an online collaborative tagging system where users
bookmark and annotate scientific papers. Such a system can be naturally
represented as a tripartite graph whose nodes represent papers, users and tags
connected by individual tag assignments. The semantics of tags is studied here,
in order to uncover the hidden relationships between tags. We find that the
clustering coefficient reflects the semantical patterns among tags, providing
useful ideas for the designing of more efficient methods of data classification
and spam detection.Comment: 9 pages, 5 figures, iop style; corrected typo
Translation and validation of the German version of the Mother-Generated Index and its application during the postnatal period.
the Mother-Generated Index (MGI) is a validated tool to assess postnatal quality of life. It is usually administered several weeks or months after birth and correlates with indices of post partum mood states and physical complaints. The instrument had not been translated into German before or validated for use among German-speaking women, nor have the results of the tool been assessed specifically for the administration directly after birth. This paper aims to describe the systematic translation process of the MGI into German and to assess the convergent validity of the German version of the instrument directly after birth and seven weeks post partum
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