Uncovering Environmental Change in the English Lake District:Using Computational Techniques to Trace Shifting Practice in the Historical Documentation of Flora

There is a lack of concrete knowledge about floristic change in Britain before the mid-twentieth century. Relevant evidence is available, but it is principally contained in disparate historical sources, and this is a major impediment to further research. In this article we demonstrate how these sources can be efficiently collated and analysed through the implementation of state-of-the-art computational-linguistic and historical-GIS techniques. We do so through a case study which focuses on the floristic history of the English Lake District. This region has been selected because of its outstanding cultural and environmental value and because it has been extensively and continuously documented since the late seventeenth century. We outline how Natural language processing (NLP) techniques can be integrated with Kew’s Plants of the World Online (POWO) database to enable temporal shifts in plant-naming conventions to be more accurately traced across a heterogeneous corpus of texts published between 1682 and 1904. Through collocate analysis and automated geoparsing techniques, the geographies associated with these plant names is then identified and extracted. Finally, we use geographic information systems (GIS) to demonstrate the potential of this dataset for geo-temporal analysis and for revealing the historical distribution of Lake District flora. In outlining our methodology, this article indicates how the spatial and digital humanities can benefit research both in environmental history and in the environmental sciences more widely

Nomenclatural changes in Coleus and Plectranthus (Lamiaceae): a tale of more than two genera

A synopsis of the genera Coleus Lour, Equilabium A.J.Paton, Mwany. & Culham and Plectranthus L’Hér. (Lamiaceae, Tribe Ocimeae, Subtribe Plecranthinae) is presented. Generic delimitation follows a recently published molecular phylogeny which identified Coleus as the sister of the remaining genera of Subtribe Plectranthinae; Plectranthus as sister to Tetradenia Benth. and Thorncroftia N.E.Br., and a separate phylogenetically distinct genus Equilabium comprising species previously placed in Plectranthus. In this treatment, 294 species of Coleus, 42 of Equilabium, and 72 of Plectranthus are recognized. All but one of the combinations in Equilabium are new as only the genus and type species have been previously published. Two-hundred and twelve names are changed to combinations in Coleus from Plectranthus, Pycnostachys Hook. and Anisochilus Benth

Croton laceratoglandulosus (Euphorbiaceae s.s. ), a new glandular-stipulate species from Brazil and Bolivia, and its systematic position based on molecular analysis

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/72371/1/j.1095-8339.2008.00844.x.pd

Linguistic Factors Influencing Speech Audiometric Assessment

In speech audiometric testing, hearing performance is typically measured by calculating the number of correct repetitions of a speech stimulus. We investigate to what extent the repetition accuracy of Dutch speech stimuli presented against a background noise is influenced by nonauditory processes. We show that variation in verbal repetition accuracy is partially explained by morpholexical and syntactic features of the target language. Verbs, prepositions, conjunctions, determiners, and pronouns yield significantly lower correct repetitions than nouns, adjectives, or adverbs. The reduced repetition performance for verbs and function words is probably best explained by the similarities in the perceptual nature of verbal morphology and function words in Dutch. For sentences, an overall negative effect of syntactic complexity on speech repetition accuracy was found. The lowest number of correct repetitions was obtained with passive sentences, reflecting the cognitive cost of processing a noncanonical sentence structure. Taken together, these findings may have important implications for the audiological practice. In combination with hearing loss, linguistic complexity may increase the cognitive demands to process sentences in noise, leading to suboptimal functional hearing in day-to-day listening situations. Using test sentences with varying degrees of syntactic complexity may therefore provide useful information to measure functional hearing benefits

Setting and Reaching Targets with Computer-Assisted Cochlear Implant Fitting

Objective. The paper aims to demonstrate the feasibility of defining a substantial set of psychoacoustic outcome measures with preset targets and to adopt a systematic methodology for reaching these targets in a large group of subjects, by more than one clinical centre. Design. Retrospective data analysis. Setting. Multicentre with 14 participating centres. Patients. 255 adults and children using the Advanced Bionics HiRes90k cochlear implant. Intervention. Target driven fitting with the fitting to outcomes expert (FOX) system. Main Outcome Measures. For each patient, 66 measurable psychoacoustical outcomes were recorded several times after cochlear implantation: free field audiometry (6 measures) and speech audiometry (4), spectral discrimination (20), and loudness growth (36), defined from the A§E test battery. These outcomes were reduced to 22 summary variables. The initial results were compared with the latest results. Results. The state of the fitting process could be well monitored by means of the measured variables. The use of the FOX computer assisted CI-programming significantly improved the proportion of the 22 variables on target. When recipients used the automated MAPs provided at switch-on, more than half (57%) of the 22 targets were already achieved before any further optimisation took place. Once the FOX system was applied there was a significant 24% (P<0.001) increase in the number of targets achieved. Conclusions. This study demonstrates that it is feasible to set targets and to report on the effectiveness of a fitting strategy in terms of these targets. FOX provides an effective tool for achieving a systematic approach to programming, allowing for better optimisation of recipients' MAPs. The setting of well-defined outcome targets allowed a range of different centres to successfully apply a systematic methodology to monitoring the quality of the programming provided

Selected strategies to fight pathogenic bacteria

Natural products and analogues are a source of antibacterial drug discovery. Considering drug resistance levels emerging for antibiotics, identification of bacterial metalloenzymes and the synthesis of selective inhibitors are interesting for antibacterial agent development. Peptide nucleic acids are attractive antisense and antigene agents representing a novel strategy to target pathogens due to their unique mechanism of action. Antisense inhibition and development of antisense peptide nucleic acids is a new approach to antibacterial agents. Due to the increased resistance of biofilms to antibiotics, alternative therapeutic options are necessary. To develop antimicrobial strategies, optimised in vitro and in vivo models are needed. In vivo models to study biofilm-related respiratory infections, device-related infections: ventilator-associated pneumonia, tissue-related infections: chronic infection models based on alginate or agar beads, methods to battle biofilm-related infections are discussed. Drug delivery in case of antibacterials often is a serious issue therefore this review includes overview of drug delivery nanosystems.Peer reviewe

The Phase Diagram of Fluid Random Surfaces with Extrinsic Curvature

We present the results of a large-scale simulation of a Dynamically Triangulated Random Surface with extrinsic curvature embedded in three-dimensional flat space. We measure a variety of local observables and use a finite size scaling analysis to characterize as much as possible the regime of crossover from crumpled to smooth surfaces.Comment: 29 pages. There are also 19 figures available from the authors but not included here - sorr