Regioselective Activation Of Glycosyl Acceptors By a Diarylborinic Acid Catalyst

The realization that oligosaccharides play a central role in many biological processes has led to increasing interest in the preparation of synthetic targets for use in medical or biochemical research and drug discovery. The preparation of oligosaccharides from simple carbohydrate derivatives requires efficient methods for the construction of O-glycosidic bonds. Much effort has been made towards the development of selective methods for the preparation of oligosaccharide targets. The most common method to overcome the challenge of regioselectivity is the use of protecting group manipulations to suppress glycosylation at undesired positions. This is highly inefficient in terms of atom and step economy. Organoboron catalysis is a recent strategy that imparts regioselective activation of the equatorial hydroxy group of cis-vicinal diols towards functionalization. Following the initial findings that diarylborinic acid catalyzes the regioselective acylation of carbohydrate derivatives, an analogous method for regioselective glycosylation under Koenigs-Knorr conditions has been developed.MAS

Correction to Rhodium(III)-Catalyzed Isoquinolone Synthesis: The N–O Bond as a Handle for C–N Bond Formation and Catalyst Turnover

Correction to Rhodium(III)-Catalyzed Isoquinolone Synthesis: The N–O Bond as a Handle for C–N Bond Formation and Catalyst Turnove

Correction to Rhodium(III)-Catalyzed Isoquinolone Synthesis: The N–O Bond as a Handle for C–N Bond Formation and Catalyst Turnover

Correction to Rhodium(III)-Catalyzed Isoquinolone Synthesis: The N–O Bond as a Handle for C–N Bond Formation and Catalyst Turnove

Correction to Rhodium(III)-Catalyzed Isoquinolone Synthesis: The N–O Bond as a Handle for C–N Bond Formation and Catalyst Turnover

Correction to Rhodium(III)-Catalyzed Isoquinolone Synthesis: The N–O Bond as a Handle for C–N Bond Formation and Catalyst Turnove

Seismic margin analysis of CANDU primary heat transport system

The Pickering Nuclear Generating Station A was designed in the late 1960s. Since that time, estimates of seismic hazard in eastern North America have changed. Ontario Hydro is currently performing a seismic margin assessment of the station. The reactor system is a heavy water CANDU system. A screening walkdown identified the primary heat transport system for analysis since it is much different from light water reactor primary coolant systems assessed in previous seismic margin assessments and seismic probabilistic risk assessments. The high confidence of low probability of failure (HCLPF) of the system was computed deterministically in terms of a uniform hazard spectrum for the Pickering site. This paper describes the modelling, analysis and seismic margin assessment of the system

Chiral Phosphoric Acid Directed Regioselective Acetalization of Carbohydrate‐Derived 1,2‐Diols

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/101842/1/13170_ftp.pdfhttp://deepblue.lib.umich.edu/bitstream/2027.42/101842/2/ange_201304298_sm_miscellaneous_information.pd