130 research outputs found
Beyond the Small-Angle Approximation For MBR Anisotropy from Seeds
In this paper we give a general expression for the energy shift of massless
particles travelling through the gravitational field of an arbitrary matter
distribution as calculated in the weak field limit in an asymptotically flat
space-time. It is {\it not} assumed that matter is non-relativistic. We
demonstrate the surprising result that if the matter is illuminated by a
uniform brightness background that the brightness pattern observed at a given
point in space-time (modulo a term dependent on the oberver's velocity) depends
only on the matter distribution on the observer's past light-cone. These
results apply directly to the cosmological MBR anisotropy pattern generated in
the immediate vicinity of of an object like a cosmic string or global texture.
We apply these results to cosmic strings, finding a correction to previously
published results for in the small-angle approximation. We also derive the
full-sky anisotropy pattern of a collapsing texture knot.Comment: 23 pages, FERMILAB-Pub-94/047-
Comparison of Insertional RNA Editing in Myxomycetes
RNA editing describes the process in which individual or short stretches of nucleotides in a messenger or structural RNA are inserted, deleted, or substituted. A high level of RNA editing has been observed in the mitochondrial genome of Physarum polycephalum. The most frequent editing type in Physarum is the insertion of individual Cs. RNA editing is extremely accurate in Physarum; however, little is known about its mechanism. Here, we demonstrate how analyzing two organisms from the Myxomycetes, namely Physarum polycephalum and Didymium iridis, allows us to test hypotheses about the editing mechanism that can not be tested from a single organism alone. First, we show that using the recently determined full transcriptome information of Physarum dramatically improves the accuracy of computational editing site prediction in Didymium. We use this approach to predict genes in the mitochondrial genome of Didymium and identify six new edited genes as well as one new gene that appears unedited. Next we investigate sequence conservation in the vicinity of editing sites between the two organisms in order to identify sites that harbor the information for the location of editing sites based on increased conservation. Our results imply that the information contained within only nine or ten nucleotides on either side of the editing site (a distance previously suggested through experiments) is not enough to locate the editing sites. Finally, we show that the codon position bias in C insertional RNA editing of these two organisms is correlated with the selection pressure on the respective genes thereby directly testing an evolutionary theory on the origin of this codon bias. Beyond revealing interesting properties of insertional RNA editing in Myxomycetes, our work suggests possible approaches to be used when finding sequence motifs for any biological process fails
Observers in an accelerated universe
If the current acceleration of our Universe is due to a cosmological
constant, then a Coleman-De Luccia bubble will nucleate in our Universe. In
this work, we consider that our observations could be likely in this framework,
consisting in two infinite spaces, if a foliation by constant mean curvature
hypersurfaces is taken to count the events in the spacetime. Thus, we obtain
and study a particular foliation, which covers the existence of most observers
in our part of spacetime.Comment: revised version, accepted in EPJ
Large Scale Structure of the Universe
Galaxies are not uniformly distributed in space. On large scales the Universe
displays coherent structure, with galaxies residing in groups and clusters on
scales of ~1-3 Mpc/h, which lie at the intersections of long filaments of
galaxies that are >10 Mpc/h in length. Vast regions of relatively empty space,
known as voids, contain very few galaxies and span the volume in between these
structures. This observed large scale structure depends both on cosmological
parameters and on the formation and evolution of galaxies. Using the two-point
correlation function, one can trace the dependence of large scale structure on
galaxy properties such as luminosity, color, stellar mass, and track its
evolution with redshift. Comparison of the observed galaxy clustering
signatures with dark matter simulations allows one to model and understand the
clustering of galaxies and their formation and evolution within their parent
dark matter halos. Clustering measurements can determine the parent dark matter
halo mass of a given galaxy population, connect observed galaxy populations at
different epochs, and constrain cosmological parameters and galaxy evolution
models. This chapter describes the methods used to measure the two-point
correlation function in both redshift and real space, presents the current
results of how the clustering amplitude depends on various galaxy properties,
and discusses quantitative measurements of the structures of voids and
filaments. The interpretation of these results with current theoretical models
is also presented.Comment: Invited contribution to be published in Vol. 8 of book "Planets,
Stars, and Stellar Systems", Springer, series editor T. D. Oswalt, volume
editor W. C. Keel, v2 includes additional references, updated to match
published versio
Black Holes on Thin 3-branes of Codimension-2 and their Extension into the Bulk
We discuss black hole solutions in six-dimensional gravity with a
Gauss-Bonnet term in the bulk and an induced gravity term on a thin 3-brane of
codimension-2. We show that these black holes can be localized on the brane,
and they can further be extended into the bulk by a warp function. These
solutions have regular horizons and no other curvature singularities appear
apart from the string-like ones. The projection of the Gauss-Bonnet term on the
brane imposes a constraint relation which requires the presence of matter in
the extra dimensions.Comment: 23 pages, no figures, minor corrections, version to appear in Nuclear
Physics
Can COBE see the shape of the universe?
In recent years, the large angle COBE--DMR data have been used to place
constraints on the size and shape of certain topologically compact models of
the universe. Here we show that this approach does not work for generic compact
models. In particular, we show that compact hyperbolic models do not suffer the
same loss of large angle power seen in flat or spherical models. This follows
from applying a topological theorem to show that generic hyperbolic three
manifolds support long wavelength fluctuations, and by taking into account the
dominant role played by the integrated Sachs-Wolfe effect in a hyperbolic
universe.Comment: 16 Pages, 5 Figures. Version published in Phys. Rev.
A qualitative evaluation of the impact of a palliative care course on preregistration nursing students' practice in Cameroon
Background
Current evidence suggests that palliative care education can improve preregistration nursing students’ competencies in palliative care. However, it is not known whether these competencies are translated into students’ practice in the care of patients who are approaching the end of life. This paper seeks to contribute to the palliative care evidence base by examining how nursing students in receipt of education report transfer of learning to practice, and what the barriers and facilitators may be, in a resource-poor country.
Methods
We utilised focus groups and individual critical incident interviews to explore nursing students’ palliative care learning transfer. Three focus groups, consisting of 23 participants and 10 individual critical incident interviews were conducted with preregistration nursing student who had attended a palliative care course in Cameroon and had experience caring for a patient approaching the end of life. Data was analysed thematically, using the framework approach.
Results
The results suggest that nursing students in receipt of palliative care education can transfer their learning to practice. Students reported recognizing patients with palliative care needs, providing patients with physical, psychosocial and spiritual support and communicating patient information to the wider care team. They did however perceive some barriers to this transfer which were either related to themselves, qualified nurses, the practice setting or family caregivers and patients.
Conclusion
The findings from this study suggest that nursing student in receipt of palliative care education can use their learning in practice to provide care to patients and their families approaching the end of life. Nevertheless, these findings need to be treated with some caution given the self-reported nature of the data. Demonstrating the link between preregistration palliative care education and patient care is vital to ensuring that newly acquired knowledge and skills are translated and embedded into clinical practice. This study also has implications for advocating for palliative care policies and adequately preparing clinical placement sites for students’ learning and transfer of learning
What is case management in palliative care? An expert panel study
Contains fulltext :
110207.pdf (publisher's version ) (Open Access)ABSTRACT: BACKGROUND: Case management is a heterogeneous concept of care that consists of assessment, planning, implementing, coordinating, monitoring, and evaluating the options and services required to meet the client's health and service needs. This paper describes the result of an expert panel procedure to gain insight into the aims and characteristics of case management in palliative care in the Netherlands. METHODS: A modified version of the RAND(R)/University of California at Los Angeles (UCLA) appropriateness method was used to formulate and rate a list of aims and characteristics of case management in palliative care. A total of 76 health care professionals, researchers and policy makers were invited to join the expert panel, of which 61% participated in at least one round. RESULTS: Nine out of ten aims of case management were met with agreement. The most important areas of disagreement with regard to characteristics of case management were hands-on nursing care by the case manager, target group of case management, performance of other tasks besides case management and accessibility of the case manager. CONCLUSIONS: Although aims are agreed upon, case management in palliative care shows a high level of variability in implementation choices. Case management should aim at maintaining continuity of care to ensure that patients and those close to them experience care as personalised, coherent and consistent
The Development of Understanding of Evidence in Pre-University Biology Education in the Netherlands
Effects of antiplatelet therapy on stroke risk by brain imaging features of intracerebral haemorrhage and cerebral small vessel diseases: subgroup analyses of the RESTART randomised, open-label trial
Background
Findings from the RESTART trial suggest that starting antiplatelet therapy might reduce the risk of recurrent symptomatic intracerebral haemorrhage compared with avoiding antiplatelet therapy. Brain imaging features of intracerebral haemorrhage and cerebral small vessel diseases (such as cerebral microbleeds) are associated with greater risks of recurrent intracerebral haemorrhage. We did subgroup analyses of the RESTART trial to explore whether these brain imaging features modify the effects of antiplatelet therapy
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